Glial-derived neurotrophic factor upregulates expression of functional SNS and NaN sodium channels and their currents in axotomized dorsal root ganglion neurons

Journal of Neuroscience

Volumn 20, Issue 23, 2000, Pages 8754-8761

  Cummins, T R ^a   Black, J A ^a   Dib Hajj, S D ^a   Waxman, S G ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ion channel; Nerve injury; Neurotrophins; Persistent current; Spinal sensory neurons; Tetrodotoxin resistant

Indexed keywords

SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; MALE; NERVE FIBER TRANSECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SODIUM CURRENT; SPINAL GANGLION;

EID: 0034554778     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-23-08754.2000     Document Type: Article

References (39)

1. A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons
2. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
3. A distinct subgroup of small DRG cells express GDNF receptor components and GDNF is protective for these neurons after nerve injury
4. + channel III and SNS gene expression in spinal sensory neurons
5. Abnormal expression of SNS/PN3 sodium channel in cerebellar Purkinje cells following loss of myelin in the taiep rat
6. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea
7. Three types of sodium channels in adult rat dorsal root ganglion neurons
8. Down-regulation of TTX-resistant sodium currents and upregulation of a rapidly repriming TTX-sensitive sodium current in small spinal sensory neurons after nerve injury
9. A novel persistent tetrodotoxin-resistant sodium current in small primary sensory neurons
10. Down-regulation of transcripts for Na channel α-SNS in spinal sensory neurons following axotomy
11. Rescue of α-SNS sodium channel expression in small dorsal root ganglion neurons after axotomy by nerve growth factor in vivo
12. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
13. Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons
14. Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene scn11a encoding the sodium channel NaN
15. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia
16. Slow Na+ channel inactivation and bursting discharge in a simple model axon: Implications for neuropathic pain
17. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons
18. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors
19. A novel method for real time quantitative RT-PCR
20. Real time quantitative PCR
21. Glial cell line-derived neurotrophic factor and nerve growth factor receptor mRNAs are expressed in distinct subgroups of dorsal root ganglion neurons and are differentially regulated by peripheral axotomy in the rat
22. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons. I. Sodium currents
23. Neurotrophic factors and the specification of neural function
24. Effects of GDNF on axotomized sensory and motor neurons in adult rats
25. Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve
26. Somal membrane properties of physiologically identified sensory neurons in the rat: Effects of nerve growth factor
27. Slow sodium conductances of dorsal root ganglion neurons: Intraneuronal homogeneity and interneutonal heterogeneity
28. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons
29. Structure and function of a novel voltage-gated tetrodotoxin-resistant sodium channel specific to sensory neurons
30. Experimental and modeling study of Na+ current heterogeneity in rat nodose neurons and its impact on neuronal discharge
31. + channels in PC12 cells
32. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons following sciatic nerve injury, but not rhizotomy
33. Isolectin B(4)-positive and -negative nociceptors are functionally distinct
34. Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC 12 cells
35. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons
36. A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction
37. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
38. Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro
39. Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons