Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons

Journal of Neuroscience

Volumn 16, Issue 5, 1996, Pages 1659-1667

  Oh, Uhtaek ^a   Hwang, Sun Wook ^a   Kim, Donghee ^b  

^a Seoul National University   (South Korea)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

capsaicin; capsazepine; DRG; nonselective cation channel; pain; resiniferatoxin

Indexed keywords

CAPSAICIN; CATION CHANNEL; CESIUM; LITHIUM ION; NEUROTOXIN; POTASSIUM ION; RUBIDIUM; SODIUM ION;

ANIMAL CELL; ARTICLE; LUMBAR SPINAL CORD; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD NERVE CELL; SPINAL GANGLION; THORACIC SPINAL CORD;

EID: 9244243039     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-05-01659.1996     Document Type: Article

References (42)

1. Betz H (1990) Ligand-gated ion channels in the brain: the amino acid and receptor superfamily. Neuron 5:383-392.
2. Bevan S, Geppetti P (1994) Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neuroses 17:509-512.
3. Bevan S, Yeats J (1991) Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurons. J Physiol (Lond) 433:145-161.
4. Bevan S, Hothi S, Hughes G, James IF, Rang HP, Shah K, Walpole CSJ, Yeats JC (1992) Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin. Br J Pharmacol 107:544-552.
5. Dickenson AH, Dray A (1991) Selective antagonism of capsaicin by capsazepine: evidence for a spinal receptor site in capsaicin-induced antinociception. Br J Pharmacol 104:1045-1049.
6. Dray A, Bettaney J, Forster P (1989) Capsaicin desensitization of peripheral nociceptive fibers does not impair sensitivity to other noxious stimuli. Neurosci Lett 99:50-54.
7. Dray A, Bettaney J, Forster P (1990) Resiniferatoxin: a potent capsaicin-like stimulator of peripheral nociceptors in the neonatal rat tail in vitro. Br J Pharmacol 99:323-326.
8. Ellis CA, Brooks SF, Brooks G, Evans AT, Morrice N, Evans FT, Aitken A (1987) The effects of phorbol esters with different biological activities on protein kinase C. Phytother Res 1:187-190.
9. Fatt P, Ginsborg BL (1958) The ionic requirements for the production of action potentials in crustacean muscle fibers. J Physiol (Lond) 142:516-543.
10. Geppetti P, Fusco B, Marabini S, Maggi CA, Fanciullacci M, Sicuteri F (1988) Secretion, pain and sneezing induced by the application of capsaicin to the nasal mucosa in man. Br J Pharmacol 93:509-514.
11. Geppetti P, Del Bianco E, Patacchini R, Santicioli P, Maggi CA, Tramontana M (1991) Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves: mechanism of action and biological response. Neuroscience 41:295-301.
12. Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85-100.
13. Hayes AG, Skingle M, Tyres MB (1981) Effect of single doses of capsaicin on nociceptive thresholds in the rodent. Neuropharmacology 20:505-511.
14. Holzer P (1991) Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 43:143-201.
15. Jacobus WE, Taylor GJ, Hollis DP, Nunnally RL (1977) Phosphorus nuclear magnetic resonance of perfused working rat heart. Nature 265:756-758.
16. Jancsó G, Kiraly E, Jancsó-Gabor A (1977) Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 270:741-743.
17. LaMotte RH, Simone DA, Baumann TK, Shain CN, Alreja M (1988) Hypothesis for novel classes chemoreceptors mediating chemogenic pain and itch. In: Pain research and clinical management (Dubner R, Gebhart GF, Bond MR, eds), pp 529-535. Amsterdam: Elsevier.
18. Lang E, Novak A, Reeh PW, Handwerker HO (1990) Chemosensitivity of fine afferents from rat skin in vitro. J Neurophysiol 63:887-901.
19. Liu L, Simon SA (1994) A rapid capsaicin-activated current in rat trigeminal ganglion neurons. Proc Natl Acad Sci USA 91:738-741.
20. Maggi CA, Patacchini R, Santicioli P, Guiliani S, Geppetti P, Meli A (1988) Protective action of ruthenium red toward capsaicin desensitization of sensory fibers. Neurosci Lett 88:201-205.
21. Maggi CA, Lippe IT, Giuliani S, Abelli L, Somma V, Geppetti P, Jancsó G, Santicioli P, Meli A (1989) Topical versus systemic capsaicin desensitization: specific and unspecific effects as indicated by modification of reflex micturition in rats. Neuroscience 31:745-756.
22. Marsh SJ, Stansfeld CE, Brown DA, Davey R, McCarthy D (1987) The mechanism of action of capsaicin on sensory c-type neurons and their axons in vitro. Neuroscience 23:275-289.
23. Nagy JI, Hunt SP (1983) The termination of primary afferents within the dorsal horn: evidence for rearrangement following capsaicin treatment. J Comp Neurol 218:145-158.
24. Nagy JI, Iversen LL, Goedert M, Chapman D, Hunt SP (1983) Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci 3:399-406.
25. Ninkina NN, Willoughby JJ, Beech MM, Coote PR, Wood JN (1994) Molecular cloning of a resiniferatoxin-binding protein. Mol Brain Res 22:39-48.
26. Peer LA (1955) Transplantation of tissues. Baltimore: Williams & Wilkins.
27. Santicioli P, Del Bianco E, Figini M, Bevan S, Maggi CA (1993) Effect of capsazepine on the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) induced by low pH, capsaicin and potassium in rat soleus muscle. Br J Pharmacol 110:609-612.
28. Simone DA, Ngeow JYF, Putterman GJ, LaMotte RH (1987) Hyperalgesia to heat after intradermal injection of capsaicin. Brain Res 418:201-203.
29. Simone DA, Baumann TK, LaMotte RH (1989) Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin. Pain 38:99-107.
30. Simone DA, Sorkin LS, Oh U, Chung JM, Owens C, LaMotte RH, Willis WD (1991) Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. J Neurophysiol 66:228-246.
31. Steen KH, Reeh PW, Anton F, Handwerker HO (1992) Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin in vitro. J Neurosci 12:86-95.
32. Szallasi A, Blumberg PM (1989) Resiniferatoxin: a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red peppers. Neuroscience 30:515-520.
33. Szallasi A, Blumberg PM (1990) Specific binding of resiniferatoxin, an ultrapotent capsaicin analog, by dorsal root ganglion membranes. Brain Res 524:106-111.
34. Szallasi A, Blumberg PM (1991) Characterization of vanilloid receptors in the dorsal horn of pig spinal cord. Brain Res 547:335-338.
35. Szallasi A, Blumberg PM (1993) Mechanisms and therapeutic potential of vanilloids (capsaicin-like molecules). Adv Pharmacol 24:123-155.
36. Szolcsanyi J (1987) Selective responsiveness of polymocial nociceptors of rabbit ear to capsaicin, bradykinin and ultra-violet irradiation. J Physiol (Lond) 388:9-23.
37. Szolcsanyi J, Jancsó-Gabor A (1975) Sensory effects of capsaicin congeners. I. Relationship between chemical structure and pain producing potency of pungent agents. Drug Res 25:1877-1881.
38. Szolcsanyi J, Jancsó-Gabor A (1976) Sensory effects of capsaicin congeners. II. Importance of chemical structure and pungency in desensitizing activity of capsaicin-rype compounds. Drug Res 26:33-37.
39. Walpole CSJ, Wrigglesworth R, Bevan S, Campbell EA, Dray A, James IF, Perkins MN, Reid DJ, Winter J (1993) Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. I. The aromatic "A-region." J Med Chem 36:2362-2372.
40. Winter J, Dray A, Wood JN, Yeats JC, Bevan S (1990) Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res 520:131-140.
41. Winter J, Walpole CSJ, Bevan S, James IF (1993) Characterization of resiniferatoxin binding sites on sensory neurons: co-regulation of resiniferatoxin binding and capsaicin sensitivity in adult rat dorsal root ganglia. Neuroscience 57:747-757.
42. Wood JN, Winter J, James IF, Rang HP, Yeats J, Bevan S (1988) Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J Neurosci 8:3208-3220.