A literature review of enzyme kinetic parameters for CYP3A4-mediated metabolic reactions of 113 drugs in human liver microsomes: Structure-kinetics relationship assessment

Current Drug Metabolism

Volumn 7, Issue 3, 2006, Pages 231-249

  Bu, Hai Zhi ^a  

^a PFIZER INC   (United States)

Author keywords

CYP3A4; Human liver microsomes; Kinetics; Lipophilicity; P450

Indexed keywords

1 [2 (3 FLUOROPHENYL)ETHYL] 4 [3 [5 (1,2,4 TRIAZOL 4 YL) 1H INDOL 3 YL]PROPYL]PIPERAZINE; 1 NITROPYRENE; 3 (3 CYCLOPENTYLOXY 4 METHOXYBENZYL) 6 ETHYLAMINO 8 ISOPROPYL 3H PURINE; ALPRAZOLAM; ATORVASTATIN; BUSPIRONE; CILOSTAZOL; CINEOLE; CISAPRIDE; CYCLOPHOSPHAMIDE; CYTOCHROME P450 3A4; DEXAMETHASONE; DIAZEPAM; ECABAPIDE; EPLERENONE; ETOPERIDONE; EZLOPITANT; FLUNITRAZEPAM; HYDROCORTISONE; LAQUINIMOD; MEVINOLIN; MIDAZOLAM; NEFAZODONE; NEVIRAPINE; PHENPROCOUMON; REBAMIPIDE; RITONAVIR; TRIAZOLAM; UNINDEXED DRUG; ZOLPIDEM;

BIOTRANSFORMATION; CALCULATION; COMPUTER PROGRAM; CORRELATION ANALYSIS; DATA ANALYSIS; DATA BASE; DEALKYLATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG RESEARCH; DRUG STRUCTURE; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; LIPOPHILICITY; LIVER MICROSOME METABOLISM; MEDICAL LITERATURE; METABOLIC PARAMETERS; MICHAELIS CONSTANT; MOLECULAR MODEL; OXIDATION; PHYSICAL CHEMISTRY; REVIEW; VELOCITY;

ANIMALS; BIOTRANSFORMATION; CHEMISTRY, PHYSICAL; CYTOCHROME P-450 ENZYME SYSTEM; DATA COLLECTION; HUMANS; KINETICS; LIPIDS; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 33645990311     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920006776359329     Document Type: Review

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