Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: Possible involvement of CYP2D and CYP3A

Drug Metabolism and Disposition

Volumn 28, Issue 9, 2000, Pages 1128-1134

  Niwa, Toshiro ^a   Shiraga, Toshifumi ^a   Mitani, Yasuyuki ^a   Terakawa, Masato ^a   Tokuma, Yoji ^a   Kagayama, Akira ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; BUFURALOL; CIBENZOLINE SUCCINATE; CYTOCHROME P450; CYTOCHROME P450 2D; CYTOCHROME P450 3A; DRUG METABOLITE; FURAFYLLINE; KETOCONAZOLE; MEPHENYTOIN; QUINIDINE; RECOMBINANT ENZYME; SULFAPHENAZOLE; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; DRUG HYDROXYLATION; DRUG METABOLISM; ENANTIOMER; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN TISSUE; LIVER MICROSOME; MALE; METABOLIC CLEARANCE RATE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STEREOCHEMISTRY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARYL HYDROCARBON HYDROXYLASES; BETA-NAPHTHOFLAVONE; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLOFIBRATE; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DEXAMETHASONE; FEMALE; HUMANS; IMIDAZOLES; KETOCONAZOLE; KINETICS; MALE; MICROSOMES; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOBARBITAL; QUINIDINE; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SEX FACTORS; STEREOISOMERISM;

EID: 0033840256     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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