Factors influencing rates and clearance in P450-mediated reactions: QSARs for substrates of the xenobiotic-metabolizing hepatic microsomal P450s

Toxicology

Volumn 170, Issue 1-2, 2002, Pages 45-53

  Lewis, D F V ^a   Dickins, M ^b  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Cytochromes; Metabolic rates; P450

Indexed keywords

CYTOCHROME P450; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; EVALUATION; LIPOPHILICITY; METABOLIC CLEARANCE RATE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; XENOBIOTIC METABOLISM;

ALGORITHMS; ANIMALS; CHEMISTRY, PHYSICAL; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DATABASES, FACTUAL; HYDROGEN BONDING; KINETICS; MICROSOMES, LIVER; MOLECULAR WEIGHT; OCTANOLS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SOLUBILITY; SOLVENTS; WATER; XENOBIOTICS;

EID: 0037079889     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(01)00524-8     Document Type: Article

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