In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-Methyl-14C]-erythromycin

Journal of Pharmacological and Toxicological Methods

Volumn 38, Issue 4, 1998, Pages 189-193

  Riley, Robert J ^a   Howbrook, D ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

N Methyl 14C erythromycin; Human CYP3A4; Human liver microsomes; Ketoconazole

Indexed keywords

ERYTHROMYCIN; KETOCONAZOLE; LIVER ENZYME;

ARTICLE; AUTOMATION; COLORIMETRY; DEMETHYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; FLUOROMETRY; LIVER MICROSOME; MICHAELIS CONSTANT; PHENOTYPE;

ARYL HYDROCARBON HYDROXYLASES; CARBON RADIOISOTOPES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; ERYTHROMYCIN; FORMALDEHYDE; FORMIC ACIDS; HUMANS; KETOCONAZOLE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; OXIDOREDUCTASES, N-DEMETHYLATING; REPRODUCIBILITY OF RESULTS;

EID: 0031432829     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(97)00103-2     Document Type: Article

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