Cytochrome P4502B6 and 2C9 do not metabolize midazolam: Kinetic analysis and inhibition study with monoclonal antibodies

British Journal of Anaesthesia

Volumn 86, Issue 4, 2001, Pages 540-544

  Hamaoka, N ^a   Oda, Y ^a   Hase, I ^a   Asada, A ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Enzymes, cytochrome P4502B6; Enzymes, cytochrome P4503A4; Hypnotics benzodiazepine, midazolam

Indexed keywords

ALPHA HYDROXYMIDAZOLAM; ANTIFUNGAL AGENT; BARBITURIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A; CYTOCHROME P450 3A4; DRUG METABOLITE; ISOPROTEIN; MEPHENYTOIN; MIDAZOLAM; MONOCLONAL ANTIBODY; OPIATE; ORPHENADRINE; PROPOFOL; PROTEIN; STEROID; TROLEANDOMYCIN;

ANALYSIS; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG METABOLISM; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; HYDROXYLATION; IN VITRO STUDY; LIVER MICROSOME; METABOLIC RATE; MICHAELIS CONSTANT; PHARMACOKINETICS; PRIORITY JOURNAL;

EID: 0035060326     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/86.4.540     Document Type: Article

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