A dual role of the GTPase Rac in cardiac differentiation of stem cells

Molecular Biology of the Cell

Volumn 14, Issue 7, 2003, Pages 2781-2792

  Pucéat, Michel ^a   Travo, Pierre ^a   Quinn, Mark T ^b   Fort, Philipe ^a  

^a Centre National de la Recherche Scientifique   (France)

^b MONTANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; GENE PRODUCT; GROWTH FACTOR; GUANOSINE TRIPHOSPHATASE; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN 2; PROTEIN MEF2C; RAC PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; GENE INSERTION; GENE OVEREXPRESSION; HEART DEVELOPMENT; HEART MUSCLE CELL; MOUSE; MUSCLE CONTRACTILITY; MUSCLE FIBRIL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SARCOMERE; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; MICE; MUSCLE DEVELOPMENT; MUTATION; MYOCYTES, CARDIAC; MYOGENIC REGULATORY FACTORS; MYOSIN LIGHT CHAINS; NADPH OXIDASE; RAC1 GTP-BINDING PROTEIN; RATS; REACTIVE OXYGEN SPECIES; SARCOMERES; STEM CELLS;

ANIMALIA;

EID: 0038446797     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E02-09-0562     Document Type: Article

References (42)

1. Archer, H., and Bar-Sagi, D. (2002). Ras and Rac as activators of reactive oxygen species (ROS). Methods Mol. Biol. 189, 67-73.
2. Atfi, A., Djelloul, S., Chastre, E., Davis, R., and Gespach, C. (1997). Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J. Biol. Chem. 272, 1429-1432.
3. Babior, B.M. (1999). NADPH oxidase: an update. Blood 93, 1464- 1476.
4. Behfar, A., Zingman, L., Hodgson, D., Rauzier, J., Kane, G., Terzic, A., and Pucéat, M. (2002). Stem cell differentiation requires a paracrine pathway in the heart. FASEB J. 16, 1558-1566.
5. Bishop, A.L., and Hall, A. (2000). Rho GTPases and their effector proteins. Biochem J. 348(Pt 2):241-255.
6. 2+ oscillations in cardiac cells. J. Cell Biol. 152, 717-728.
7. Chen, J., Kubalak, S.W., Minamisawa, S., Price, R.L., Becker, K.D., Hickey, R., Ross, J., and Chien, K.R. (1998). Selective requirement of myosin light chain 2v in embryonic heart function. J. Biol. Chem. 273, 1252-1256.
8. Cheng, G., Cao, Z., Xu, X., van Meir, E.G., and Lambeth, J.D. (2001). Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 269, 131-140.
9. Chomczynski, P., and Sacchi, N. (1987). Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162, 156-159.
10. Coleman, M.L., and Marshall, C.J. (2001). A family outing: small GTPases cyclin' through G1. Nat. Cell Biol. 3, E250-E251.
11. De Leo, F.R., Ulman, K.V., Davis, A.R., Jutila, K.L., and Quinn, M.T. (1996). Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox. J. Biol. Chem. 271, 17013-17020.
12. Freeman, J.L., Abo, A., and Lambeth, J.D. (1996). Rac "insert region" is a novel effector region that is implicated in the activation of NADPH oxidase, but not PAK65. J. Biol. Chem. 271, 19794-19801.
13. Gjoerup, O., Lukas, J., Bartek, J., and Willumsen, B.M. (1998). Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation. J. Biol. Chem. 273, 18812-18818.
14. Harvey, R. (1999). Seeking a regulatory roadmap for heart morphogenesis. Semin. Cell Dev. Biol. 10, 99-107.
15. Joneson, T., and Bar-Sagi, D. (1998). A Rac1 effector site controlling mitogenesis through superoxide production. J. Biol. Chem. 273, 17991-17994.
16. Joyce, D. et al. (1999). Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway. J. Biol. Chem. 274, 25245-25249.
17. Knight, B., Laukaitis, C., Akhtar, N., Hotchin, N.A., Edlund, M., and Horwitz, A.R. (2000). Visualizing muscle cell migration in situ. Curr. Biol. 10, 576-585.
18. Leahy, A., Xiong, J.W., Kuhnert, F., and Stuhlmann, H. (1999). Use of developmental marker genes to define temporal and spatial patterns of differentiation during embryoid body formation. J Exp Zool. 284, 67-81.
19. Lin, R., Cerione, R.A., and Manor, D. (1999). Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J. Biol. Chem. 274, 23633-23641.
20. Linask, K.K., Knudsen, K.A., and Gui, Y.H. (1997). N-cadherin-catenin interaction: necessary component of cardiac cell compartmentalization during early vertebrate heart development. Dev. Biol. 185, 148-164.
21. Meyer, N., Jaconi, M., Ladopoulou, A., Fort, P., and Puceat, M. (2000). A fluorescent reporter gene as a marker for ventricular specification in ES-derived cardiac cells. FEBS Lett. 478, 151-158.
22. Morel, Y., and Barouki, R. (1999). Repression of gene expression by oxidative stress. Biochem. J. 342(Pt 3):481-496.
23. Mucsi, I., Skorecki, K.L., and Goldberg, H.J. (1996). Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-betal on gene expression. J. Biol. Chem. 271, 16567-16572.
24. Nisimoto, Y., Freeman, J.L.R., Motalebi, S.A., Hirshberg, M., and Lambeth, J.D. (1997). Rac binding to p67(phox). Structural basis for interactions of the Rac1 effector region and insert region with components of the respiratory burst oxidase. J. Biol. Chem. 272, 18834-18841.
25. Pampfer, S. (2000). Apoptosis in rodent peri-implantation embryos: differential susceptibility of inner cell mass and trophectoderm cell lineages - a review. Placenta 21(Suppl A):S3-S10.
26. Poelmann, R.E., Molin, D., Wisse, L.J., and Gittenberger-de Groot, A.C. (2000). Apoptosis in cardiac development. Cell Tissue Res. 301, 43-52.
27. Price, M.O., Atkinson, S.J., Knaus, U.G., and Dinauer, M.C. (2002). Rac activation induces NADPH oxidase activity in transgenic COSphox cells and level of superoxide production is exchange factor-dependent. J. Biol. Chem. 27, 19220-19228.
28. Roux, P., Gauthier-Rouviere, C., Doucet-Brutin, S., and Fort, P. (1997). The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells. Curr. Biol. 7, 629-637.
29. Sah, V.P., Minamisawa, S., Tam, S.P., Wu, T.H., Dorn, G.W., 2nd, Ross, J., Jr., Chien, K.R., and Brown, J.H. (1999). Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure. J. Clin. Invest. 103, 1627-1634.
30. Sah, V.P., Seasholtz, T.M., Sagi, S.A., and Brown, J.H. (2000). The role of Rho in G protein-coupled receptor signal transduction. Annu. Rev. Pharmacol. Toxicol. 40, 459-489.
31. Sanger, J.W., Ayoob, J.C., Chowrashi, P., Zurawski, D., and Sanger, J.M. (2000). Assembly of myofibrils in cardiac muscle cells. Adv. Exp. Med. Biol. 481, 89-102; discussion 103-105.
32. Sauer, H., Rahimi, G., Hescheler, J., and Wartenberg, M. (2000). Role of reactive oxygen species and phosphatidylinositol 3-kinase in cardiomyocyte differentiation of embryonic stem cells. FEBS Lett. 476, 218-223.
33. Scholzen, T., and Gerdes, J. (2000). The Ki-67 protein: from the known and the unknown. J. Cell. Physiol. 182, 311-322.
34. Settleman, J. (1999). Rho GTPases in development. Prog. Mol. Subcell. Biol. 22, 201-229.
35. Settleman, J. (2000). Getting in shape with Rho. Nat. Cell Biol. 2, E7-E9.
36. Settleman, J. (2001). Rac 'n Rho: the music that shapes a developing embryo. Dev. Cell 1, 321-331.
37. Sugihara, K. et al. (1998). Rac1 is required for the formation of three germ layers during gastrulation. Oncogene 17, 3427-3433.
38. Sussman, M.A., Welch, S., Walker, A., Klevitsky, R., Hewett, T.E., Price, R.L., Schaefer, E., and Yager, K. (2000). Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac1. J. Clin. Invest. 105, 875-886.
39. Takai, Y., Sasaki, T., and Matozaki, T. (2001). Small GTP-binding proteins. Physiol. Rev. 81, 153-208.
40. Van Aelst, L., and D'Souza-Schorey, C. (1997). Rho GTPases and signaling networks. Genes Dev. 11, 2295-2322.
41. van Wetering, S., van Buul, J.D., Quik, S., Mul, F.P., Anthony, E.C., ten Klooster, J.P., Collard, J.G., and Hordijk, P.L. (2002). Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J. Cell Sci. 115, 1837-1846.
42. Wei, L., Imanaka-Yoshida, K., Wang, L., Zhan, S., Schneider, M.D., DeMayo, F.J., and Schwartz, R.J. (2002). Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation. Development 129:1705-1714.