메뉴 건너뛰기




Volumn 16, Issue 8, 1997, Pages 1888-1900

MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

Author keywords

Actin morphology; Cardiac hypertrophy; MAP kinase; MEKK; Rho

Indexed keywords

ACTIN; ATRIAL NATRIURETIC FACTOR; HEAT SHOCK PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHENYLEPHRINE; RHO FACTOR;

EID: 0030893060     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.8.1888     Document Type: Article
Times cited : (131)

References (49)
  • 1
    • 0028176713 scopus 로고
    • p21 Ras as a governor of global gene expression
    • Abdellatif, M., MacLellan, W.R. and Schneider, M.D. (1994) p21 Ras as a governor of global gene expression. J. Biol. Chem., 269, 15423-15426.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15423-15426
    • Abdellatif, M.1    MacLellan, W.R.2    Schneider, M.D.3
  • 2
    • 0027727654 scopus 로고
    • Rapid transcription assay for the expression of two distinct reporter genes by microinjection
    • Alberts, A.S., Frost, J.A. and Thorburn, A.M. (1993) Rapid transcription assay for the expression of two distinct reporter genes by microinjection. DNA Cell Biol., 12, 935-943.
    • (1993) DNA Cell Biol. , vol.12 , pp. 935-943
    • Alberts, A.S.1    Frost, J.A.2    Thorburn, A.M.3
  • 3
    • 0027306121 scopus 로고
    • The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts
    • Alessi, D.R., Smythe, C. and Keyse, S.M. (1993) The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts. Oncogene, 8, 2015-2020.
    • (1993) Oncogene , vol.8 , pp. 2015-2020
    • Alessi, D.R.1    Smythe, C.2    Keyse, S.M.3
  • 4
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi, D.R., Cuenda, A., Cohen, P., Dudley, D.T. and Saltiel, A.R. (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem., 270, 27489-27494.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 5
    • 0029591827 scopus 로고
    • Cellular stresses differentially activate c-Jun N-terminal protein kinases and extracellular signal-regulated protein kinases in cultured ventricular myocytes
    • Bogoyevitch, M.A., Ketterman, A.J. and Sugden, P.H. (1995a) Cellular stresses differentially activate c-Jun N-terminal protein kinases and extracellular signal-regulated protein kinases in cultured ventricular myocytes. J. Biol. Chem., 270, 29710-29717.
    • (1995) J. Biol. Chem. , vol.270 , pp. 29710-29717
    • Bogoyevitch, M.A.1    Ketterman, A.J.2    Sugden, P.H.3
  • 6
    • 0028839220 scopus 로고
    • Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes
    • Bogoyevitch, M.A., Marshall, C. and Sugden, P.H. (1995b) Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes. J. Biol. Chem., 270, 26303-26310.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26303-26310
    • Bogoyevitch, M.A.1    Marshall, C.2    Sugden, P.H.3
  • 8
    • 0028793798 scopus 로고
    • Induction of c-fos expression through JNK-mediated TCF-Elk-1 phosphorylation
    • Cavigelli, M., Dolfi, F., Claret, F.-X. and Karin, M. (1995) Induction of c-fos expression through JNK-mediated TCF-Elk-1 phosphorylation. EMBO J., 14, 5957-5964.
    • (1995) EMBO J. , vol.14 , pp. 5957-5964
    • Cavigelli, M.1    Dolfi, F.2    Claret, F.-X.3    Karin, M.4
  • 9
    • 0026349336 scopus 로고
    • Regulation of cardiac gene expression during myocardial growth and hypertrophy: Molecular studies of an adaptive response
    • Chien, K.R., Knowlton, K.U., Zhu, H. and Chien, S. (1991) Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive response. FASEB J., 5, 3037-3046.
    • (1991) FASEB J. , vol.5 , pp. 3037-3046
    • Chien, K.R.1    Knowlton, K.U.2    Zhu, H.3    Chien, S.4
  • 10
    • 0030047481 scopus 로고    scopus 로고
    • Signaling from G protein-coupled receptors to c-Jun kinase involves βγ subunits of heterotrimeric G proteins acting on a ras and Rac1-dependent pathway
    • Coso, O.A., Teramoto, H., Simonds, W.F. and Gutkind, J.S. (1996) Signaling from G protein-coupled receptors to c-Jun kinase involves βγ subunits of heterotrimeric G proteins acting on a ras and Rac1-dependent pathway. J. Biol. Chem., 271, 3963-3966.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3963-3966
    • Coso, O.A.1    Teramoto, H.2    Simonds, W.F.3    Gutkind, J.S.4
  • 11
    • 0028935974 scopus 로고
    • Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
    • Derijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R.J. and Davis, R.J. (1995) Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science, 267, 682-685.
    • (1995) Science , vol.267 , pp. 682-685
    • Derijard, B.1    Raingeaud, J.2    Barrett, T.3    Wu, I.-H.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 13
    • 0029379778 scopus 로고
    • Activation of ternary complex factor Elk-1 by stress-activated protein kinases
    • Gille, H., Srahl, T. and Shaw, P.E. (1995) Activation of ternary complex factor Elk-1 by stress-activated protein kinases. Curr. Biol., 5, 1191-1200.
    • (1995) Curr. Biol. , vol.5 , pp. 1191-1200
    • Gille, H.1    Srahl, T.2    Shaw, P.E.3
  • 14
    • 0028805807 scopus 로고
    • The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes
    • Gillespie-Brown, J., Fuller, S.J., Bogoyevitch, M.A., Cowley, S. and Sugden, P.H. (1995) The mitogen-activated protein kinase kinase MEK1 stimulates a pattern of gene expression typical of the hypertrophic phenotype in rat ventricular cardiomyocytes. J. Biol. Chem., 270, 28092-28096.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28092-28096
    • Gillespie-Brown, J.1    Fuller, S.J.2    Bogoyevitch, M.A.3    Cowley, S.4    Sugden, P.H.5
  • 15
    • 0029948892 scopus 로고    scopus 로고
    • Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in cardiac myocytes
    • Glennon, P.E., Kaddoura, S., Sale, E.M., Sale, G.J., Fuller, S.J. and Sugden, P.H. (1996) Depletion of mitogen-activated protein kinase using an antisense oligodeoxynucleotide approach downregulates the phenylephrine-induced hypertrophic response in cardiac myocytes. Circ. Res., 78, 954-961.
    • (1996) Circ. Res. , vol.78 , pp. 954-961
    • Glennon, P.E.1    Kaddoura, S.2    Sale, E.M.3    Sale, G.J.4    Fuller, S.J.5    Sugden, P.H.6
  • 17
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham, J., Babij, C. Whitfield, J., Pfarr, C.M., Lallemond, D., Yaniv, M. and Rubin, L.L. (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron, 14, 927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitfield, J.3    Pfarr, C.M.4    Lallemond, D.5    Yaniv, M.6    Rubin, L.L.7
  • 18
    • 0029015774 scopus 로고
    • The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF
    • Hill, C.S., Wynne, J. and Treisman, R. (1995) The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell, 81, 1159-1170.
    • (1995) Cell , vol.81 , pp. 1159-1170
    • Hill, C.S.1    Wynne, J.2    Treisman, R.3
  • 19
    • 0029091356 scopus 로고
    • Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice
    • Hunter, J.J., Tanaka, N., Rockman, H.A., Ross, J. and Chien, K.R. (1995) Ventricular expression of a MLC-2v-ras fusion gene induces cardiac hypertrophy and selective diastolic dysfunction in transgenic mice. J. Biol. Chem., 270, 23173-23178.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23173-23178
    • Hunter, J.J.1    Tanaka, N.2    Rockman, H.A.3    Ross, J.4    Chien, K.R.5
  • 20
    • 0030052368 scopus 로고    scopus 로고
    • Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS
    • Joneson, T. White, M.A., Wigler, M.H. and Bar-Sagi, D. (1996) Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science, 271, 810-812.
    • (1996) Science , vol.271 , pp. 810-812
    • Joneson, T.1    White, M.A.2    Wigler, M.H.3    Bar-Sagi, D.4
  • 21
    • 0028889199 scopus 로고
    • M-CAT, CArG, and Sp1 elements are required for α-adrenergic induction of the skeletal α-actin promoter during cardiac myocyte hypertrophy
    • Karns, L.R., Keriya, K. and Simpson, P.C. (1995) M-CAT, CArG, and Sp1 elements are required for α-adrenergic induction of the skeletal α-actin promoter during cardiac myocyte hypertrophy. J. Biol. Chem., 270, 410-417.
    • (1995) J. Biol. Chem. , vol.270 , pp. 410-417
    • Karns, L.R.1    Keriya, K.2    Simpson, P.C.3
  • 22
    • 0027215820 scopus 로고
    • A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
    • Lange-Carter, C.A., Pleiman, C.M, Gardner, A.M., Blumer, K.J. and Johnson, G.L. (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 260, 315-319.
    • (1993) Science , vol.260 , pp. 315-319
    • Lange-Carter, C.A.1    Pleiman, C.M.2    Gardner, A.M.3    Blumer, K.J.4    Johnson, G.L.5
  • 23
    • 0025280867 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular muss in the Framingham heart study
    • Levy, D., Garrison, R.J., Savage, D.D., Kannel, W.B. and Castelli, W.P. (1990) Prognostic implications of echocardiographically determined left ventricular muss in the Framingham heart study. New Engl. J. Med., 322, 1561-1566.
    • (1990) New Engl. J. Med. , vol.322 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3    Kannel, W.B.4    Castelli, W.P.5
  • 24
    • 0028178720 scopus 로고
    • Transforming growth factor-β response elements of the skeletal α actin gene
    • MacLellan, W.R., Lee, T.-C., Schwartz, R.J. and Schneider, M.D. (1994) Transforming growth factor-β response elements of the skeletal α actin gene. J. Biol. Chem., 269, 16754-16760.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16754-16760
    • MacLellan, W.R.1    Lee, T.-C.2    Schwartz, R.J.3    Schneider, M.D.4
  • 27
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden, A., Lin, A., Claret, F.-X., Abo, A. and Karin, M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell, 81, 1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.-X.3    Abo, A.4    Karin, M.5
  • 28
    • 0028961293 scopus 로고
    • Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • Nobes, C.D. and Hall, A. (1995) Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell, 81, 53-62.
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2
  • 29
    • 0025173947 scopus 로고
    • Peptide growth factors can provoke 'fetal' contractile protein gene expression in rat cardiac myocytes
    • Parker, T.G., Packer, S.E. and Schneider, M.D. (1990) Peptide growth factors can provoke 'fetal' contractile protein gene expression in rat cardiac myocytes. J. Clin. Invest., 85, 507-514.
    • (1990) J. Clin. Invest. , vol.85 , pp. 507-514
    • Parker, T.G.1    Packer, S.E.2    Schneider, M.D.3
  • 30
    • 0027946514 scopus 로고
    • The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion
    • Pombo, C.M., Benventre, J.V., Avruch, J., Woodgett, J.R., Kyriakis, J.M. and Force, T. (1994) The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J. Biol. Chem., 269, 26546-26551.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26546-26551
    • Pombo, C.M.1    Benventre, J.V.2    Avruch, J.3    Woodgett, J.R.4    Kyriakis, J.M.5    Force, T.6
  • 31
    • 0029942783 scopus 로고    scopus 로고
    • Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes
    • Post, G.R., Goldstein, D., Thuerauf, D.J., Glembotski, C.C. and Brown, J.H. (1996) Dissociation of p44 and p42 mitogen-activated protein kinase activation from receptor-induced hypertrophy in neonatal rat ventricular myocytes. J. Biol. Chem., 271, 8452-8457.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8452-8457
    • Post, G.R.1    Goldstein, D.2    Thuerauf, D.J.3    Glembotski, C.C.4    Brown, J.H.5
  • 32
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley, A.J. and Hall, A. (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell, 70, 389-400.
    • (1992) Cell , vol.70 , pp. 389-400
    • Ridley, A.J.1    Hall, A.2
  • 33
    • 0028321785 scopus 로고
    • Signal transduction pathways regulating Rho-mediated stress fibre formation: Requirement for a tyrosine kinase
    • Ridley, A.J. and Hall, A. (1994) Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase. EMBO J., 13, 2600-2610.
    • (1994) EMBO J. , vol.13 , pp. 2600-2610
    • Ridley, A.J.1    Hall, A.2
  • 34
    • 0029077563 scopus 로고
    • Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1)
    • Russell, M., Lange-Carter, C.A. and Johnson, G.L. (1995) Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). J. Biol. Chem., 270, 11757-11760.
    • (1995) J. Biol. Chem. , vol.270 , pp. 11757-11760
    • Russell, M.1    Lange-Carter, C.A.2    Johnson, G.L.3
  • 35
    • 0027521065 scopus 로고
    • Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: Potential involvement of an autocrine/paracrine mechanism
    • Sadoshima, J. and Izumo, S. (1993a) Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism. EMBO J., 12, 1681-1692.
    • (1993) EMBO J. , vol.12 , pp. 1681-1692
    • Sadoshima, J.1    Izumo, S.2
  • 36
    • 0027182438 scopus 로고
    • Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts
    • Sadoshima, J. and Izumo, S. (1993b) Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Circ. Res., 73, 413-423.
    • (1993) Circ. Res. , vol.73 , pp. 413-423
    • Sadoshima, J.1    Izumo, S.2
  • 37
    • 0029670826 scopus 로고    scopus 로고
    • ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes
    • ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. EMBO J., 15, 775-787.
    • (1996) EMBO J. , vol.15 , pp. 775-787
    • Sadoshima, J.1    Izumo, S.2
  • 38
    • 0028871928 scopus 로고
    • Involvement of multiple cis elements in basal- and α-adrenergic agonist-inducible atrial natriuretic factor transcription
    • Sprenkle, A., Murray, S.F. and Glembotski, C.C. (1995) Involvement of multiple cis elements in basal-and α-adrenergic agonist-inducible atrial natriuretic factor transcription. Circ. Res., 11, 1060-1069.
    • (1995) Circ. Res. , vol.11 , pp. 1060-1069
    • Sprenkle, A.1    Murray, S.F.2    Glembotski, C.C.3
  • 39
    • 0028089986 scopus 로고
    • Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1
    • Sun, H., Tonks, N.K. and Bar-Sagi, D. (1994) Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1. Science, 266, 285-288.
    • (1994) Science , vol.266 , pp. 285-288
    • Sun, H.1    Tonks, N.K.2    Bar-Sagi, D.3
  • 40
    • 0028631035 scopus 로고
    • Ras activity is required for phenylephrine-mduced activation of mitogen-activated protein kinase in cardiac muscle cells
    • Thorburn, A. (1994) Ras activity is required for phenylephrine-mduced activation of mitogen-activated protein kinase in cardiac muscle cells. Biochem. Biophys. Res. Commun., 205, 1417-1422.
    • (1994) Biochem. Biophys. Res. Commun. , vol.205 , pp. 1417-1422
    • Thorburn, A.1
  • 42
    • 0027942515 scopus 로고
    • Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy
    • Thorburn, J., McMahon, M. and Thorburn, A. (1994a) Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy. J. Biol. Chem., 269, 30580-30586.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30580-30586
    • Thorburn, J.1    McMahon, M.2    Thorburn, A.3
  • 43
    • 0028133410 scopus 로고
    • Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy
    • Thorburn, J.S., Frost, J.A. and Thorburn, A.M. (1994b) Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy. J. Cell Biol., 126, 1565-1572.
    • (1994) J. Cell Biol. , vol.126 , pp. 1565-1572
    • Thorburn, J.S.1    Frost, J.A.2    Thorburn, A.M.3
  • 44
    • 0028839662 scopus 로고
    • Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase
    • Thorburn, J., Carlson, M., Mansour, S.J., Chien, K.R., Ahn, N.G. and Thorburn, A. (1995) Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase. Mol. Biol. Cell, 6, 1479-1490.
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1479-1490
    • Thorburn, J.1    Carlson, M.2    Mansour, S.J.3    Chien, K.R.4    Ahn, N.G.5    Thorburn, A.6
  • 45
    • 0029125757 scopus 로고
    • Integration of MAP kinase signal transduction pathways at the serum response element
    • Whitmarsh, A.J., Shore, P., Sharrocks, A.D. and Davis, R.J. (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science, 269, 403-407.
    • (1995) Science , vol.269 , pp. 403-407
    • Whitmarsh, A.J.1    Shore, P.2    Sharrocks, A.D.3    Davis, R.J.4
  • 46
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R.J. and Greenberg, M.E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science, 210, 1326-1331.
    • (1995) Science , vol.210 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 47
    • 0029081006 scopus 로고
    • MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase
    • Xu, S., Robbins, D., Frost, J., Dang, A., Lange-Carter, C. and Cobb, M.H. (1995) MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc. Natl Acad. Sci. USA, 92, 6808-6812.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 6808-6812
    • Xu, S.1    Robbins, D.2    Frost, J.3    Dang, A.4    Lange-Carter, C.5    Cobb, M.H.6
  • 48
    • 0029942952 scopus 로고    scopus 로고
    • Cloning of rat MEK kinase 1 cDNa reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
    • Xu, S., Robbins, D.J., Christerson, L.B., English, J.M., Vanderbilt, C.A. and Cobb, M.H. (1996) Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc. Natl Acad. Sci. USA, 93, 5291-5295.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5291-5295
    • Xu, S.1    Robbins, D.J.2    Christerson, L.B.3    English, J.M.4    Vanderbilt, C.A.5    Cobb, M.H.6
  • 49
    • 0028670788 scopus 로고
    • Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
    • Yan, M., Dai, T., Deak, J.C., Kyriakis, J.M., Zon, L.I., Woodgett, J.R. and Templeton, D.J. (1994) Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature, 372, 798-800.
    • (1994) Nature , vol.372 , pp. 798-800
    • Yan, M.1    Dai, T.2    Deak, J.C.3    Kyriakis, J.M.4    Zon, L.I.5    Woodgett, J.R.6    Templeton, D.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.