Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27kip1 expression in the vasculature of hypertensive rats

Circulation Research

Volumn 89, Issue 6, 2001, Pages 488-495

  Seasholtz, Tammy M ^a   Zhang, Tong ^a   Morissette, Michael R ^a   Howes, Amy L ^a   Yang, Amy H ^a   Brown, Joan Heller ^a  

^a San Diego   (United States)

Author keywords

DNA synthesis; P27Kip1; Rho; Spontaneously hypertensive rats; Vascular smooth muscle

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; N(G) NITROARGININE METHYL ESTER; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P27; RHO FACTOR; THROMBIN; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA MEDIA; ARTERY MUSCLE; ARTICLE; BINDING AFFINITY; CELL CYCLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA SYNTHESIS; HYPERTENSION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 0035860840     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1801.096337     Document Type: Article

References (32)

1. Angiotensin II-induced proliferation of aortic myocytes in spontaneously hypertensive rats
2. Stimulation of two vascular smooth muscle-derived cell lines by angiotensin II: Differential second messenger responses leading to mitogenesis
3. Migration of vascular smooth muscle cells is enhanced in cultures derived from spontaneously hypertensive rat
4. Elevated vascular angiotensin converting enzyme mediates increased neointima formation after balloon injury in spontaneously hypertensive rats
5. Abnormal proliferative response of the carotid artery of spontaneously hypertensive rats after angioplasty may be related to the depolarized state of its smooth muscle cells
6. Translating data on antihypertensive drugs into clinical practice
7. The effects of antihypertensive agents on atherosclerosis-related parameters of human aorta intimal cells
8. G-protein-coupled receptors in vascular smooth muscle cells
9. Rho as a mediator of G protein-coupled receptor signaling
10. The role of Rho in G protein-coupled receptor signal transduction
11. Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction
12. 2+-sensitization
13. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
14. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation
15. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
16. Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration
17. Waf1/Cip1
18. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p27Kip1
19. Nitric oxide inhibits angiotensin II-induced migration of rat aortic smooth muscle cell: Role of cyclic-nucleotides and angiotensin, receptors
20. 12/13 subunits in neuronal cells: Induction of neurite retraction
21. q with Rho and its exchange factors
22. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
23. Differential translocation of Rho family GTPases by lysophosphatidic acid, endothelin-1, and platelet-derived growth factor
24. Angiotensin II activates RhoA in cardiac myocytes: A critical role of RhoA in angiotensin II-induced premyofibril formation
25. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27Kip1
26. 1-adrenoceptor in tail artery and aorta from spontaneously hypertensive and Wistar-Kyoto rats
27. 1-adrenoceptor-stimulated contraction in SHR caudal artery
28. 2+ sensitization of coronary artery contraction in genetically hypertensive rats: Evidence for altered signal transduction in the coronary smooth muscle cells
29. Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension
30. Effect of hypertension on arterial structure and wound repair at the microvascular anastomosis site using stroke-prone spontaneously hypertensive rats (SHRSP)
31. Sequestration of a G-protein βγ subunit or ADP-ribosylation of Rho can inhibit thrombin-induced activation of platelet phosphoinositide 3-kinases
32. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27