Involvement of a small GTP-binding protein (G protein) a regulator, small G protein GDP dissociation stimulator, in antiapoptotic cell survival signaling

Molecular Biology of the Cell

Volumn 11, Issue 5, 2000, Pages 1875-1886

  Takakura, Ayumi ^a   Miyoshi, Jun ^a   Ishizaki, Hiroyoshi ^a   Tanaka, Miki ^a   Togawa, Atsushi ^a   Nishizawa, Yasuko ^b   Yoshida, Hisahiro ^c   Nishikawa, Shin Ichi ^c   Takai, Yoshimi ^a,d  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ETOPOSIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; RAS PROTEIN; RHO FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLAST TRANSFORMATION; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; FIBROBLAST; HEART FAILURE; HEART MUSCLE CELL; HEART VENTRICLE OVERLOAD; MITOGENESIS; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; SIGNAL TRANSDUCTION; THYMOCYTE; ULTRAVIOLET IRRADIATION;

EID: 0034125425     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.5.1875     Document Type: Article

References (57)

1. Ando, S., et al. (1992). Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase. J. Biol. Chem. 267, 25709-25713.
2. Bergmann, A., Agapite, J., McCall, K., and Steller, H. (1998a). The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341.
3. Bergmann, A., Agapite, J., and Steller, H. (1998b). Mechanisms and control of programmed cell death in invertebrates. Oncogene 17, 3215-3223.
4. Bonfini, L., Karlovich, C.A., Dasgupta, C., and Banerjee, U. (1992). The Son of Sevenless gene product: a putative activator of Ras. Science 255, 603-606.
5. Bourne, H.R., Sanders, D.A., and McCormick, F. (1990). The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348, 125-132.
6. Bourne, H.R., Sanders, D.A., and McCormick, F. (1991). The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127.
7. Buday, L., and Downward, J. (1993). Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell 73, 611-620.
8. Crechet, J.B., Poullet, P., Mistou, M.Y., Parmeggiani, A., Camonis, J., Boy-Marcotte, E., Damak, F., and Jacquet, M. (1990). Enhancement of the GDP-GTP exchange of RAS proteins by the carboxyl-terminal domain of SCD25. Science 248, 866-868.
9. Deng, C., Zhang, P., Harper, J.W., Elledge, S.J., and Leder, P. (1995). Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675-684.
10. de Rooij, J., Zwartkruis, F.J., Verheijen, M.H., Cool, R.H., Nijman, S.M., Wittinghofer, A., and Bos, J.L. (1998). Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396, 474-477.
11. Egan, S.E., Giddings, B.W., Brooks, M.W., Buday, L., Sizeland, A.M., and Weinberg, R.A. (1993). Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 363, 45-51.
12. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998). A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391, 43-50.
13. Eves, E.M., Xiong, W., Bellacosa, A., Kennedy, S.G., Tsichlis, P.N., Rosner, M.R., and Hay, N. (1998). Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. Mol. Cell. Biol. 18, 2143-2152.
14. Fujioka, H., Kaibuchi, K., Kishi, K., Yamamoto, T., Kawamura, M. Sakoda, T., Mizuno, T., and Takai, Y. (1992). Transforming and c-fos promoter/enhancer-stimulating activities of a stimulatory GDP/ GTP exchange protein for small GTP-binding proteins. J. Biol. Chem. 267, 926-930.
15. Fushiki, S., Hyodo-Taguchi, Y., Kinoshita, C., Ishikawa, Y., and Hirobe, T. (1997). Short- and long-term effects of low-dose prenatal X-irradiation in mouse cerebral cortex, with special reference to neuronal migration. Acta Neuropathol. 93, 443-449.
16. Gotoh, T., et al. (1995). Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. Mol. Cell. Biol. 15, 6746-6753.
17. Harvey, M., Sands, A.T., Weiss, R.S., Hegi, M.E., Wiseman, R.W., Pantazis, P., Giovanella, B.C., Tainsky, M.A., Bradley, A., and Donehower, L.A. (1993). In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8, 2457-2467.
18. Hall, A. (1990). The cellular functions of small GTP-binding proteins. Science 249, 635-640.
19. Henning, S. Galandrini, W.R., Hall, A., and Cantrell, D.A. (1997). The GTPase Rho has a critical regulatory role in thymus development. EMBO J. 16, 2397-2407.
20. Hiraoka, K., et al. (1992). Both stimulatory and inhibitory GDP/GTP exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins. Biochem. Biophys. Res. Commun. 182, 921-930.
21. Hirota, H., Chen, J., Betz, U.A.K., Rajewsky, K., Gu, Y., Ross, J., Jr., Muler, W., and Chien, K.R. (1999). Cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell 97, 189-198.
22. Hughes, D.A., Fukui, Y., and Yamamoto, M. (1990). Homologous activators of ras in fission and budding yeast. Nature 344, 355-357.
23. Johnson, L., et al. (1997). K-ras is an essential gene in the mouse with partial functional overlap with N-ras. Genes. Dev. 11, 2468-2481.
24. Jones, S., Vignais, M.L., and Broach, J.R. (1991). The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras. Mol. Cell. Biol. 11, 2641-2646.
25. Kaibuchi, K., Mizuno, T., Fujioka, H., Yamamoto, T., Kishi, K., Fukumoto, Y., Hori, Y., and Takai, Y. (1991). Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Mol. Cell. Biol. 11, 2873-2880.
26. Kamijo, T., Zindy, F., Roussel, M.F., Quelle, D.E., Downing, J.R., Ashmun, R.A., Grosveld, G., and Sherr, C.J. (1997). Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649-659.
27. Kauffmann-Zeh, A., Rodriguez-Viciana, P., Ulrich, E., Gilbert, C., Coffer, P., Downward, J., and Evan, G. (1997). Suppression of c-Myc-induced apoptosis by Ras signaling through PI(3)K and PKB. Nature 385, 544-548.
28. Kawamura, M., Kaibuchi, K., Kishi, K., and Takai, Y. (1993). Translocation of Ki-ras p21 between membrane and cytoplasm by smg GDS. Biochem. Biophys. Res. Commun. 190, 832-841.
29. Kawasaki, H., Springett, G.M., Mochizuki, N., Toki, S., Matsuda, M., Housman, D.E., and Graybiel, A.M. (1998). A family of cAMP-binding proteins that directly activates rap1. Science 282, 2275-2279.
30. Kennedy, S.G., Wagner, A.J., Conzen, S.D., Jordan, J., Bellacosa, A., Tsichlis, P.N., and Hay, N. (1997). The PI3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes. Dev. 11, 701-713.
31. Kikuchi, A., Kuroda, S., Sasaki, T., Kotani, K., Hirata, K., Katayama, M., and Takai, Y. (1992). Functional interactions of stimulatory and inhibitory GDP/GTP exchange proteins and their common substrate small GTP-binding protein. J. Biol. Chem. 267, 14611-14615.
32. Koera, K., Nakamura, K., Nakao, K., Miyoshi, J., Toyoshima, K., Hatta, T., Otani, H., Aiba, A., and Katsuki, M. (1997). K-ras is essential for the development of the mouse embryo. Oncogene 15, 1151-1159.
33. Kotani, K., Kikuchi, A., Doi, K., Kishida, S., Sakoda, T., Kishi, K., and Takai, Y. (1992). The functional domain of the stimulatory GDP/GTP exchange protein (smg GDS) which interacts with the C-terminal geranylgeranylated region of rap1/Krev-1/smg p21. Oncogene 7, 1699-1704.
34. Kurada, V., and White, K. (1998). Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319-329.
35. Liu, B.X., Wei, W., and Broek, D. (1993). The catalytic domain of the mouse sosl gene product activates Ras proteins in vivo and in vitro. Oncogene 8, 3081-3084.
36. Liu, X., Zou, H., Slaughter, C., and Wang, X. (1997). DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89, 175-184.
37. Lowe, S.W., Ruley, H.E., Jacks, T., and Housman, D.E. (1993a). p53-dependent apoptosis modulates the cytotoxicity of anti-cancer agents. Cell 74, 957-967.
38. Lowe, S.W., Schmitt, E.M., Smith, S.W., Osborne, B.A., and Jacks, T. (1993b). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.
39. Lyons, I., Parsons, L.M., Hartley, L., Li, R., Andrews, J.E., Robb, L., and Harvey, R.P. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev 9, 1654-1666.
40. McCrea, P.D., Turck, C.W., and Gumbiner, B. (1991). A homolog of the armadillo protein in Drosophila (plakoglobin) associated with E-cadherin. Science 254, 1359-1361.
41. Meier, P., and Evan, G. (1998). Dying like flies. Cell 95, 295-298.
42. Mizuno, T., Kaibuchi, K., Yamamoto, T., Kawamura, M., Sakoda, T., Fujioka, H., Matsuura, Y., and Takai, Y. (1991). A stimulatory GDP/ GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21. Proc. Natl. Acad. Sci. USA 88, 6442-6446.
43. Moorman, J.P., Luu, D., Wickham, J., Bobak, D.A., and Hahn, C.S. (1999). A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival. Oncogene 18, 47-57.
44. Nakanishi, H., Kaibuchi, K., Orita, S., Ueno, N., and Takai, Y. (1994). Different functions of Smg GDS dissociation stimulator and mammalian counterpart of yeast Cdc25. J. Biol. Chem. 269, 15085-15091.
45. Nishida, K., Kaziro, Y., and Satoh, T. (1999). Anti-apoptotic function of Rac in hematopoietic cells. Oncogene 18, 407-415.
46. Orita, S., Kaibuchi, K., Kuroda, K., Shimizu, K., Nakanishi, H., and Takai, Y. (1993). Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine-releasing factor and smg GDP dissociation stimulator. J. Biol. Chem. 268, 25542-255461.
47. Simon, M.A., Bowtell, D.D., Dodson, G.S., Laverty, T.R., and Rubin, G.M. (1991). Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase. Cell 67, 701-716.
48. Takai, Y., Kaibuchi, K., Kikuchi, A., and Kawata, M. (1992). Small GTP-binding proteins. Int. Rev. Cytol. 133, 187-230.
49. Takai, Y., Kaibuchi, K., Kikuchi, A., Sasaki, T., and Shirataki, H. (1993). Regulators of small GTPases. Ciba Found. Symp. 176, 128-138.
50. Togawa, A., et al. (1999). Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIα. Oncogene 18, 5373-5380.
51. Umanoff, H., Edelmann, W., Pellicer, A., and Kucherlapati, R. (1995). The murine N-ras gene is not essential for growth and development. Proc. Natl. Acad. Sci. USA 92, 1709-1713.
52. Vithalani, K.K., Parent, C.A., Thorn, E.M., Penn, M., Larochelle, D.A., Devreotes, P.N., and De Lozanne, A. (1998). Identification of Darlin, a Dictyostelium protein with Armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells. Mol. Biol. Cell 8, 3095-3106.
53. Vojtek, A.B., Hollenberg, S.M., and Cooper, J.A. (1993). Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell 74, 205-214.
54. Walker, F., Kato, A., Gonez, L.J., Hibbs, M.L., Pouliot, N., Levitzki, A., and Burgess, A.W. (1998). Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation. Mol. Cell. Biol. 18, 7192-7204.
55. Yaku, H., Sasaki, T., and Takai, Y. (1994). The Dbl oncogene product as a GDP/GTP exchange protein for the Rho family: its properties in comparison with those of Smg GDS. Biochem. Biophys. Res. Commun. 198, 811-817.
56. Yamamoto, T., Kaibuchi, K., Mizuno, T., Hiroyoshi, M., Shirataki, H., and Takai, Y. (1990). Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins. J. Biol. Chem. 265, 16626-16634.
57. Yoshida, Y., Kawata, M., Miura, Y., Musha, T., Sasaki, T., Kikuchi, A., and Takai, Y. (1992). Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Mol. Cell. Biol. 12, 3407-3414.