Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle

Circulation Research

Volumn 92, Issue 4, 2003, Pages 411-418

  Seko, Tetsuya ^a   Ito, Masaaki ^a   Kureishi, Yasuko ^a   Okamoto, Ryuji ^a   Moriki, Nobuyuki ^a   Onishi, Katsuya ^a   Isaka, Naoki ^a   Hartshorne, David J ^b   Nakano, Takeshi ^a  

^a MIE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Ca2+ sensitization; Hypertension; Myosin phosphatase; Rho kinase; RhoA

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 8 BROMO CYCLIC GMP; ANGIOTENSIN; CALCIUM ION; MYOSIN PHOSPHATASE; N(G) NITROARGININE METHYL ESTER; PHOSPHATASE; PHOSPHOPROTEIN; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; AORTA MEDIA; ARTICLE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STROKE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; AMIDES; ANGIOTENSIN II; ANIMALS; CELLS, CULTURED; CYCLIC GMP; ENDOTHELIN-1; ENZYME ACTIVATION; ENZYME INHIBITORS; HYPERTENSION; INDOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALEIMIDES; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOSIN-LIGHT-CHAIN PHOSPHATASE; NG-NITROARGININE METHYL ESTER; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; THREONINE;

EID: 0037423816     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000059987.90200.44     Document Type: Article

References (44)

1. Kaplan NM. Systemic hypertension: mechanisms and diagnosis. In: Braunwald E, Zipes DP, Libby P, eds. Heart Disease (6th Edition): A Textbook of Cardiovascular Medicine. Philadelphia, Pa; Saunders; 2001:941-971.
2. Hartshorne DJ. Biochemistry of the contractile process in smooth muscle. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract. New York, NY: Raven Press, 1987:432-482.
3. Somlyo AP, Somlyo AV. Signal transduction and regulation in smooth muscle. Nature. 1994;372:231-236.
4. Kubota Y, Nomura M, Kamm KE, Mumby MC, Stull JT. GTPγS-dependent regulation of smooth muscle contractile elements. Am J Physiol. 1992;262:C405-C410.
5. Somlyo AP, Somlyo AV. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol. 2000;522:177-185.
6. Kaibuchi K, Kuroda S, Amano M. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPase in mammalian cells. Ann Rev Biochem. 1999;68:459-486.
7. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, Kaibuchi K. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996;273:245-248.
8. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Nammiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990-994.
9. Hartshorne DJ, Ito M, Erdödi F. Myosin light chain phosphatase: subunit composition, interactions and regulation. J Muscle Res Cell Motil. 1998;19:325-341.
10. Feng J, Ito M, Ichikawa K, Isaka N, Nishikawa M, Hartshome DJ, Nakano T. Inhibitory phosphorylation site for Rho-associated kinase on the smooth muscle myosin phosphatase. J Biol Chem. 1999;274:37385-37390.
11. Eto M, Ohmori T, Suzuki M, Furuya K, Morita F. A novel protein phosphatase-1 inhibitory protein potentiated by protein kinase C. Isolation from porcine aorta and characterization. J Biochem (Tokyo). 1995;118:1104-1107.
12. Koyama M, Ito M, Feng J, Seko T, Shiraki K, Takase K, Hartshorne DJ, Nakano T. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett. 2000;475:197-200.
13. Wu X, Somlyo AV, Somlyo AP. Cyclic GMP-dependent stimulation reverses G-protein-coupled inhibition of smooth muscle myosin light chain phosphate. Biochem Biophys Res Commun. 1996;220:658-663.
14. 2+ desensitization in vascular smooth muscle by activating the myosin light chain phosphatase. J Biol Chem. 1997;272:5063-5068.
15. 2+ sensitization of contraction in vascular smooth muscle. J Biol Chem. 2000;275:21722-21729.
16. Mukai Y, Shimokawa H, Matoba T, Kandabashi T, Satoh S, Hiroki J, Kaibuchi K, Takeshitu A. Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J. 2001;15:1062-1064.
17. Chrissobolis S, Sobey CG. Evidence that Rho-kinase activity contributes to cereveral vascular tone in vivo and is enhanced during chronic hypertension. Cir Res. 2001;88:774-779.
18. Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, Higo T, Egashira K, Takahashi S, Kaibuchi K, Takeshita A. Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β. Circulation. 2000;101:1319-1323.
19. Utsunomiya T, Satoh S, Ikegaki I, Asano T, Shimokawa H. Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br J Pharmacol. 2001;134:1724-1730.
20. Kataoka C, Egashira K, Inoue S, Takemoto M, Ni W, Koyanagi M, Kitamoto S, Usui M, Kaibuchi K, Shimokawa H, Takeshita A. Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension. 2001;39:245-250.
21. Yanazume T, Hasegawa K, Wada H, Morimoto T, Abe M, Kawamura T, Sasayama S. Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy. J Biol Chem. 2002;277:8618-8625.
22. Essler M, Retzer M, Bauer M, Heemskerk JW, Aepfelbacher M, Siess. Mildly oxidized low density lipoprotein induces contraction of human endothelial cells through activation of Rho/Rho kinase and inhibition of myosin light chain phosphatase. J Biol Chem. 2002;274:30361-30364.
23. Mastumoto A, Hirooka Y, Shimokawa H, Hironaga K, Setoguchi S, Takeshita A. Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. Hypertension. 2001;38:1307-1310.
24. Inagaki N, Nishizawa M, Ito M, Fujioka M, Nakano T, Tsujino S, Matsuzawa K, Kimura K, Kaibuchi K, Inagaki M. Myosin binding subunit of smooth muscle myosin phosphatase at the cell-cell adhesion sites in MDCK cells. Biochem Biophys Res Commun. 1997;230:552-556.
25. Ito M, Guerriero VJ, Chen X, Hartshorne DJ. Definition of the inhibitory domain of smooth muscle myosin light chain kinase by site-directed mutagenesis. Biochemistry. 1991;30:3498-3503.
26. Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T, Ito M. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem. 1997;272:12257-12260.
27. Ren X-D, Kiosses WB, Schwartz MA. Regulation of the small GTP-binding protein Rho listtext1. by cell adhesion and the cytoskeleton. EMBO J. 1999;18:578-585.
28. Sakurada S, Okamoto H, Takuwa N, Sugimoto N, Takuwa Y. Rho activation in excitatory agonist-stimulated vascular smooth muscle. Am J Physiol Cell Physiol. 2001;281:C571-C578.
29. 13 in agonist-induced vascular smooth muscle cell contraction. Circ Res. 2000;87:221-227.
30. Kandabashi T, Shimokawa H, Mukai Y, Matoba T, Kunihiro I, Morikawa K, Ito M, Takahashi S, Kaibuchi K, Takeshita A. Involvement of Rhokinase in agonists-induced contractions of arteriosclerotic human arteries. Arterioscler Thromb Vasc Biol. 2002;22:243-248.
31. Dong JM, Leung T, Manser E, Lim L. cAMP-induced morphological changes are counteracted by the activated RhoA small GTPase and the Rho kinase ROKα. J Biol Chem. 1998;273:22554-22562.
32. Murányi A, MacDonald JA, Deng JT, Wilson DP, Haystead TA, Walsh MP, Erdödi F, Kiss E, Wu Y, Hartshorne DJ. Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. Biochem. J. 2002;366:211-216.
33. MacDonald JA, Borman MA, Murányi A, Somlyo AV, Hartshorne DJ, Haystead TA. Identification of the endogenous smooth muscle myosin phosphatase-associated kinase. Proc Natl Acad Sci USA. 2001;98:2419-2424.
34. Eto M, Kitazawa T, Yazawa M, Mukai H, Ono Y, Brautigan DL. Histamine-induced vasoconstriction involves phosphorylation of a specific inhibitor protein for myosin phosphatase by protein kinase C α and 8 isoforms. J Biol Chem. 2001;276:29072-29078.
35. Etter EF, Eto M, Wardle RL, Brautigan DL, Murphy RA. Activation of myosin light chain phosphatase in intact arterial smooth muscle during nitric oxide-induced relaxation. J Biol Chem. 2001;276:34681-34685.
36. Kip1 expression in the vasculature of hypertensive rats. Circ Res. 2001;89:488-495.
37. 2+ sensitization in erectile function. J Biol Chem. 2002;277:30614-30621.
38. Morishita R, Higaki J, Miyazaki M, Ogihara T. Possible role of the vascular renin-angiotensin system in hypertension and vascular hypertrophy. Hypertension. 1992;19(suppl II):II62-II67.
39. Schiffrin EL. Endothelin and endothelin antagonists in hypertension. J Hypertens. 1998;16:1891-1895.
40. Vapaatalo H, Mervaala E, Nurminen ML. Role of endothelium and nitric oxide in experimental hypertension. Physiol Res. 2000;49:1-10.
41. Numaguchi K, Eguchi S, Yamakawa T, Motley ED, Inagami T. Mechanotransduction of rat aortic vascular smooth muscle cells requires RhoA and intact actin filaments. Circ Res. 1999;85:5-11.
42. Bian K, Bukoski RD. Myofilament calcium sensitivity of normotensive and hypertensive resistance arteries. Hypertension. 1995;25:110-116.
43. Shaw LM, Ohanian J, Heagerty AM. Calcium sensitivity and agonist-induced calcium sensitization in small arteries of young and adult spontaneously hypertensive rats. Hypertension. 1997;30:442-448.
44. Herizi A, Jover B, Bouriquet N, Mimran A. Prevention of the cardiovascular and renal effects of angiotensin II by endothelin blockade. Hypertension. 1998;31:10-14.