Development of Grb2 SH2 domain signaling antagonists: A potential new class of antiproliferative agents

International Journal of Peptide Research and Therapeutics

Volumn 12, Issue 1, 2006, Pages 33-48

  Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Grb2; Peptide mimetic; Phosphotyrosyl; SH2 domain; Signaling inhibitor

Indexed keywords

AMINO ACID; ANTINEOPLASTIC AGENT; ASPARAGINE; CGP 78850; CYCLOPEPTIDE; GLYCINE; LIGAND; MACROCYCLIC COMPOUND; NEW DRUG; POLYPEPTIDE; PROTEIN GRB2; PROTEIN SH2; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR; TRIPEPTIDE; TYROSINE; UNCLASSIFIED DRUG;

BINDING AFFINITY; BIOAVAILABILITY; CANCER THERAPY; CELL MEMBRANE TRANSPORT; CRYSTAL STRUCTURE; CYCLIZATION; DRUG DESIGN; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; MOLECULAR MODEL; NONHUMAN; REVIEW; RING CLOSING METATHESIS; SIGNAL TRANSDUCTION;

EID: 33645465610     PISSN: 15733149     EISSN: 15733904     Source Type: Journal    
DOI: 10.1007/s10989-006-9014-7     Document Type: Review

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