Development of L-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 12, 2004, Pages 3205-3208

  Song, Yan Li ^a   Roller, Peter P ^b   Long, Ya Qiu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cyclic peptide; Grb2 SH2 domain; L 3 Aminotyrosine; Nonphosphorylated ligand; SPR assay; Sulfoxide

Indexed keywords

2 AMINO 3 (3 AMINO 4 HYDROXYPHENYL)PROPIONIC ACID; 3 AMINOTYROSINE; ANTINEOPLASTIC AGENT; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; ISOPROTEIN; NANOPARTICLE; PEPTIDE DERIVATIVE; PROPIONIC ACID DERIVATIVE; PROTEIN INHIBITOR; PROTEIN SH2; SULFOXIDE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; PEPTIDE SYNTHESIS; PROTECTION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SOLID;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; GRB2 ADAPTOR PROTEIN; NANOTECHNOLOGY; OLIGOPEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; TYROSINE;

EID: 2442417484     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.103     Document Type: Article

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