GRB2: A pivotal protein in signal transduction

Seminars in Oncology

Volumn 28, Issue 5 SUPPL. 16, 2001, Pages 142-147

  Tari, Ana M ^a   Lopez Berestein, Gabriel ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; CHROMOSOME 17Q; CONFERENCE PAPER; ENZYME REGULATION; GROWTH REGULATION; HUMAN; MALIGNANT TRANSFORMATION; NONHUMAN; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035161915     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/sonc.2001.28555     Document Type: Conference Paper

References (56)

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4. A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos
5. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and SOS proteins in vitro
6. The human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5
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13. Crystal structure of the mammalian Grb 2 adaptor
14. SH2 domains recognize specific phosphopeptide sequences
15. The function of GRB 2 in linking the insulin receptor to Ras signaling pathways
16. Two binding orientations for peptides to the Src SH3 domain: Development of a general model for SH3-ligand interactions
17. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins
18. The proline-rich region of Vav binds to Grb2 and Grb3- 3
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20. Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1) and Grb2 (GRB2)
21. Bcr-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB- 2 adaptor protein
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48. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
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50. The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor
51. Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I
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53. A new function for phospholipase C-γ1: Coupling to the adaptor protein GRB2
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55. The GTPase dynamine binds to and is activated by a subset of SH3 domains
56. 5-Lipooxygenase contains a functional Src homology 3-binding motif that interacts with the Src homology 3 domain of Grb2 and cytoskeletal proteins