Monocarboxylic-based phosphotyrosyl mimetics in the design of Grb2 SH2 domain inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 3, 1999, Pages 347-352

  Burke Jr , Terrence R ^a   Luo, Juliet ^b   Yao, Zhu Jun ^a   Gao, Yang ^a   Zhao, He ^a   Milne, George W A ^a   Guo, Ribo ^b   Voigt, Johannes H ^a   King, C Richter ^b   Yang, Dajun ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CARBOXYMETHYLTYROSINE; 4 (CARBOXYDIFLUOROMETHYL)PHENYLALANINE; CARBOXYLIC ACID DERIVATIVE; CARBOXYMETHYLPHENYLALANINE; PHENYLALANINE DERIVATIVE; PHOSPHOTYROSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CELL CULTURE; CELL LYSATE; LIGAND BINDING; SEQUENCE HOMOLOGY; SURFACE PLASMON RESONANCE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CARBOXYLIC ACIDS; GRB2 ADAPTOR PROTEIN; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEINS; SRC HOMOLOGY DOMAINS; SURFACE PLASMON RESONANCE; TUMOR CELLS, CULTURED;

EID: 0033535113     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00740-9     Document Type: Article

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