Convergent synthesis of potent peptide inhibitors of the Grb2-SH2 domain by palladium catalyzed coupling of a terminal alkyne

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 9, 2001, Pages 1201-1203

  Schoepfer, Joseph ^a   Gay, Brigitte ^a   End, Nicole ^a   Muller, Evelyne ^a   Scheffel, Gisela ^a   Caravatti, Giorgio ^a   Furet, Pascal ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYNE DERIVATIVE; IODINE DERIVATIVE; TRIFLUOROMETHANESULFONIC ACID; TRIPEPTIDE;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYST; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGENATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRB2 ADAPTOR PROTEIN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OLIGOPEPTIDES; PALLADIUM; PROTEINS; SRC HOMOLOGY DOMAINS;

EID: 0035821378     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00173-1     Document Type: Article

References (16)