Inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. 2. 4-(2-Malonyl)phenylalanine as a potent phosphotyrosyl mimetic

Journal of Medicinal Chemistry

Volumn 43, Issue 5, 2000, Pages 911-920

  Gao, Yang ^a   Luo, Juliet ^b   Yao, Zhu Jun ^a   Guo, Ribo ^b   Zou, Hong ^b   Kelley, James ^a   Voigt, Johannes H ^a   Yang, Dajun ^b   Burke Jr , Terrence R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PHENYLALANINE DERIVATIVE; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

ARTICLE; BREAST CANCER; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; LIGAND BINDING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRB2 ADAPTOR PROTEIN; HUMANS; LIGANDS; MALONATES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR MIMICRY; PHENYLALANINE; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEINS; RECEPTOR, ERBB-2; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034624812     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9904248     Document Type: Article

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