Synthesis of a phosphotyrosyl analogue having χ1, χ2 and φ angles constrained to values observed for an SH2 domain-bound phosphotyrosyl residue

Tetrahedron

Volumn 59, Issue 32, 2003, Pages 6087-6093

  Wang, Xiang Zhu ^a   Yao, Zhu Jun ^a,d   Liu, Hongpeng ^b   Zhang, Manchao ^b   Yang, Dajun ^b   George, Clifford ^c   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c NAVAL RESEARCH LABORATORY   (United States)

^d SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Phosphotyrosyl analogue; Protein tyrosine kinase; SH2 domains

Indexed keywords

3 ACETYL 1,2,3,4,5,6 HEXAHYDRO 1 METHYL 1,5, METHANO 3 BENZAZOCIN 8 OL; 3 ACETYL 1,2,3,4,5,6 HEXAHYDRO 8 O PHOSPHORYL 1,5 METHANO 3 BENZAZOCINE 2 CARBOXYLIC ACID METHYL ESTER; BENZAZOCINE DERIVATIVE; CARBON; CARBOXYL GROUP; CARBOXYLIC ACID DERIVATIVE; IMINE; METHYL GROUP; MONOMER; N ACETYLTYROSINE; PEPTIDE; PHOSPHOTYROSINE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL BINDING; CYCLIZATION; DRUG CONFORMATION; DRUG SYNTHESIS; IC 50; MOLECULAR MODEL; PHOSPHORYLATION; PRIORITY JOURNAL; SRC HOMOLOGY DOMAIN; STEREOCHEMISTRY;

EID: 0041845355     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4020(03)00978-5     Document Type: Article

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