Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain

Journal of Medicinal Chemistry

Volumn 41, Issue 18, 1998, Pages 3442-3449

  Furet, Pascal ^a   Gay, Brigitte ^a   Caravatti, Giorgio ^a   García Echeverría, Carlos ^a   Rahuel, Joseph ^a   Schoepfer, Joseph ^a   Fretz, Heinz ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPEPTIDE;

ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG SYNTHESIS; HYDROPHOBICITY; LIGAND BINDING; PEPTIDE ANALYSIS; PROTEIN DOMAIN; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRB2 ADAPTOR PROTEIN; LIGANDS; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SRC HOMOLOGY DOMAINS;

EID: 0032572836     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980159a     Document Type: Article

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