Synthesis of a 5-Methylindolyl-Containing Macrocycle That Displays Ultrapotent Grb2 SH2 Domain-Binding Affinity

Journal of Medicinal Chemistry

Volumn 47, Issue 4, 2004, Pages 788-791

  Shi, Zhen Dan ^a   Lee, Kyeong ^a   Wei, Chang Qing ^a   Roberts, Lindsey R ^b   Worthy, Karen M ^b   Fisher, Robert J ^b   Burke Jr , Terrence R ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b SAIC FREDERICK INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [3 (5 METHYLINDOLYL)METHYL]PENT 4 ENYLAMINE; 5 METHYLINDOLE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MACROCYCLIC COMPOUND; PROTEIN SH2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; PROTEIN CONFORMATION; PROTEIN DOMAIN;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLIZATION; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; OLIGOPEPTIDES; PROTEIN BINDING; SRC HOMOLOGY DOMAINS; STEREOISOMERISM;

EID: 0842282688     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030440b     Document Type: Article

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