Structure-based design of a non-peptidic antagonist of the SH2 domain of Grb2

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 14, 1999, Pages 1973-1978

  Caravatti, Giorgio ^a   Rahuel, Joseph ^a   Brigitte, Gay ^a   Furet, Pascal ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR RECEPTOR; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2 ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; COMPUTER SIMULATION; DRUG DESIGN; ENZYME-LINKED IMMUNOSORBENT ASSAY; GRB2 ADAPTOR PROTEIN; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PEPTIDES; PHOSPHATES; PHOSPHOPROTEINS; PROTEINS; PYRAZINES; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0033584155     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00299-1     Document Type: Article

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