Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam

Pharmaceutical Research

Volumn 17, Issue 3, 2000, Pages 321-327

  Cleton, Adriaan ^a   Ödman, Jonas ^a   Van Der Graaf, Piet Hein ^a   Ghijsen, Wim ^c   Voskuyl, Rob ^b   Danhof, Meindert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Benzodiazepines; EEG; Muscimol induced Cl uptake; Operarional model of agonism; Pharmacokinetics; Receptor binding

Indexed keywords

BENZODIAZEPINE RECEPTOR; MIDAZOLAM;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; LONG TERM CARE; MALE; MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; STEADY STATE;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; BIOLOGICAL TRANSPORT; BRAIN CHEMISTRY; CHLORINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROENCEPHALOGRAPHY; FLUNITRAZEPAM; GABA AGONISTS; GABA MODULATORS; MALE; MIDAZOLAM; MODELS, BIOLOGICAL; MUSCIMOL; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; TRITIUM;

EID: 0034005059     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007505223519     Document Type: Article

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