Modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats - A microdialysis study

Pharmaceutical Research

Volumn 17, Issue 10, 2000, Pages 1220-1227

  Bouw, M R ^a   Gardmark M ^b   Hammarlund Udenaes, M ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDICAL PRODUCTS AGENCY   (Sweden)

Author keywords

Blood brain barrier transport; Electrical stimulation vocalisation method; Microdialysis; Modelling; Morphine; Nociceptive effect; Pharmacodynamics; Pharmacokinetics; Retrodialysis by drug

Indexed keywords

MORPHINE; NARCOTIC ANALGESIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTERIAL BLOOD; ARTICLE; BLOOD BRAIN BARRIER; BLOOD GAS ANALYSIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG MECHANISM; ELECTROSTIMULATION; EXTRACELLULAR FLUID; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; AREA UNDER THE CURVE; BIOLOGICAL MODEL; BLOOD; BRAIN; DRUG EFFECT; HALF LIFE TIME; METABOLISM; NOCICEPTIVE RECEPTOR; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; BLOOD-BRAIN BARRIER; BRAIN; HALF-LIFE; MALE; MICRODIALYSIS; MODELS, BIOLOGICAL; MORPHINE; NOCICEPTORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034293553     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026414713509     Document Type: Article

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