Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to Mdr1a P-glycoprotein gene disruption

Neuropsychopharmacology

Volumn 22, Issue 4, 2000, Pages 380-387

  Uhr, Manfred ^a   Steckler, Thomas ^a   Yassouridis, Alexander ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Amitriptyline; Fluoxetine; Mousemutants; Multiple drug resistance gene; P Glycoprotein; Therapy resistance

Indexed keywords

AMITRIPTYLINE; FLUOXETINE; GLYCOPROTEIN P;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG METABOLISM; DRUG PENETRATION; ENDOTHELIUM CELL; GENE DISRUPTION; MALE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PSYCHOPHARMACOLOGY;

AMITRIPTYLINE; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD-BRAIN BARRIER; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUOXETINE; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; P-GLYCOPROTEINS;

EID: 0033952456     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(99)00095-0     Document Type: Article

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