BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123

Pharmaceutical Research

Volumn 15, Issue 11, 1998, Pages 1657-1665

  De Lange, Elizabeth C M ^a   De Bock, Gertjan ^a   Schinkel, Alfred H ^b   De Boer, Albertus G ^a   Breimer, Douwe D ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Blood brain barrier; In vivo recovery; Intracerebral microdialysis; mdr1a ( ) mice; P glycoprotein; Rhodamine 123

Indexed keywords

GLYCOPROTEIN P; RHODAMINE 123;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; FLUORESCEIN; FLUORESCENT DYES; MALE; MICE; MICE, INBRED STRAINS; MICRODIALYSIS; P-GLYCOPROTEIN; RHODAMINE 123;

EID: 0031757312     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011988024295     Document Type: Article

References (38)

1. N. Kartner, J. R. Riordan, and V. Ling. Cell surface P-glycoprotein associated with multidrug resistance in mammalian cells. Science 221:1285-1288 (1983).
2. A. H. Schinkel and P. Borst. Multidrug resistance mediated by P-glycoproteins. Semin. Cancer Biol. 2:213-226 (1991).
3. P. Gros, Y. Ben-Neriah, J. Croop, and D. E. Housman. Isolation and overexpression of a complementary DNA that confers multidrug resistance. Nature 323:728-731 (1986).
4. S. Hsu, L. Lothstein, and S. B. Horwitz. Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. J. Biol. Chem. 246:12053-12062 (1989).
5. A. Devault and P. Gros. Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol. Cell. Biol. 10:1652-1663 (1990).
6. F. Thiebaut, T. Tsuruo, H. Hamada, M. M. Gottesman, I. Pastan, and M. C. Willingham. Cellular localization of the multidrug-resistant gene product P-glycoprotein in normal human tissues. Proc. Natl. Acad. Sci. USA 84:7735-7738 (1987).
7. B. Cordon-Cardo, J. P. O'Brien, D. Casals, L. Rittman-Grauer, J. L. Biedler, M. R. Melamed, and J. R. Bertino. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA 86:695-689 (1989).
8. F. Thiebaut, T. Tsuruo, H. Hamada, M. M. Gottesman, I. Pastan, and M.C. Willingham. Immunohistochemical localization in normal tissue of different epitopes in multidrug transport protein P170: Evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein. J. Histochem. Cytochem. 37:159-164 (1989).
9. I. Sugawara, H. Hirofumi, T. Tsuruo, and S. Mori. Specialized localization of P-glycoprotein recognized by MRK-16 monoclonal antibody in endothelial cells of the brain and the spinal cord. Jpn. J. Cancer Res. 81:727-730 (1990).
10. V. A. Levin. Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability. J. Med. Chem. 23:682-684 (1980).
11. N. H. Greig, T. T. Soncrant, H. U. Shetty, S. Momma, Q. Smith, and S. I. Rapoport. Brain uptake and anticancer activities of vincristine and vinblastine are restricted by their low cerebrovascular permeability and binding to plasma constituents in rat. Cancer Chemother. Pharmacol. 26:263-268 (1990).
12. J-S. Lee, M. Alvarez, C. Hose, A. Monks, M. Grever, A. T. Fojo, and S. E. Bates. Rhodamine efflux patterns predict P-glycoprotein substrates in the national cancer institute drug screen. Mol Pharmacol. 46:627-638 (1994).
13. A. H. Schinkel, J. J. M. Smit, O. Van Tellingen, E. Wagenaar, L. Van Deemter, C. A. A. M. Mol, M. A. Van der Valk, E. C. Robanus-Maandag, H. P. J. Te Riele, A. J. M. Berns, and P. Borst. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502 (1994).
14. A. H. Schinkel, E. Wagenaar, L. Van Deemter, C. A. A. M. Mol, and P. Borst. Absence of the mdr1a P-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96:1698-1705 (1995).
15. T. Tatsuta, M. Naito, T. Oh-Hara, I. Sugawara, and T. Tsuruo. Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267:20383-20391 (1992).
16. A. Tsuji, T. Terasaki, Y. Takabatake, Y. Tenda, I. Tamai, T. Yamashima, S. Moritani, T. Tsuruo, and J. Yamashita. P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells. Life Sci. 51:1427-1437 (1992).
17. E. J. Hegman, H. C. Bauer, and R. S. Kerbel. Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells. Cancer Res. 52:6969-6975 (1992).
18. K. Ueda, N. Okamura, M. Hirai, Y. Tanigawara, T. Saeki, N. Kioka, and R. Hori. Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone. J. Biol. Chem. 267:24248-24252 (1992).
19. M. Ichiwaka-Haraguchi, T. Sumizawa, A. Yoshimura, T. Furakawa, S. Hiramoto, M. Sugita, and S-I. Akayima. Progesterone and its metabolites: the potent inhibitors of the transporting activity of P-glycoprotein in the adrenal gland. Biochem. Biophys. Acta 996:201-208 (1993).
20. E. C. M. De Lange, M. Danhof, A. G. de Boer, and D. D. Breimer. Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain. Brain Res. 666:1-8 (1994).
21. E. C. M. De Lange, M. R. Bouw, J. W. Mandema, M. Danhof, A. G. de Boer, and D. D. Breimer. Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain. Br. J. Pharmacol. 116:2538-2544 (1995).
22. E. C. M. De Lange, J. D. de Vries, M. Danhof, A. G. de Boer, and D. D. Breimer. The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain. Pharm. Res. 12:1924-1931 (1995).
23. E. C. M. De Lange, M. B. Hesselink, M. Danhof, A. G. de Boer, and D. D. Breimer. The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics. Pharm. Res. 12:129-133 (1995).
24. E. C. M. De Lange, C. Zurcher, M. Danhof, A. G. de Boer, and D. D. Breimer. Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability. Brain Res. 702:261-265 (1995).
25. A. A. Neyfahk. The use of fluorescent dyes as molecular probes for the study of multidrug resistance. Exp. Cell Res. 174:168-176 (1988).
26. D. H. Kessel. Exploring multidrug resistance using Rhodamine-123. Cancer Comm. 1:142-149 (1989).
27. P. Lonnroth, P. A. Johnson, and U. Smith. A microdialysis method allowing characterization of intercellular water space in humans. Am. J. Physiol. 253:(Endocrinol. Metab. 16), E228-E231 (1987).
28. B. Moghaddam and B. S. Bunney. Ionic composition of microdialysis perfusing solution alters the pharmacological responsiveness and basal outflow of striatal dopamine. J. Neurochem. 53:652-654 (1989).
29. C. McCormick. The elementary statistics of calibration. In: D. McCormick and A. Roach. Measurement, statistics and computation analytical chemistry by open learning, John Wiley and Sons, Chichester, New York, Brisbane, Toronto, Singapore, 1987, p. 331-353.
30. S. I. Rapoport. Transport in cells and tissues. In: (ed) S. I. Rapoport, Blood-brain barrier in physiology and medicine, Raven Press, New York, 1976, p. 17-42.
31. J. B. M. M. Van Bree, A. G. de Boer, M. Danhof, L. A. van Ginsel, and D. D. Breimer. Characterization of an "in vitro" bloodbrain barrier (BBB): Effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs. J. Pharmacol. Exp. Ther. 247:1233-1239 (1988).
32. M. W. Nabors, M. D. Griffin, B. A. Zehnbauer, R. H. Hruban, P. C. Philips, S. A. Grossman, H. Brem, and O. M. Colvin. Multidrug resistance gene (MDR1) expression in human brain tumors. J. Neurosurg. 75:941-946 (1991).
33. A. Yoshimura, Y. Kuwazuri, T. Sumizawa, S-I. Ikeda, M. Ichiwaka, T. Usagawa, and S-I. Akiyama. Biosynthesis, processing and half-life of P-glycoprotein in a human multidrug-resistant KB cell. Biochem. Biophys. Acta 992:307-413 (1989).
34. S. McClean and T. H. Bridget. Evidence of post-translational regulation of P-glycoprotein associated with the expression of a distinctive multiple drug-resistant phenotype in Chinese hamster ovary cells. Eur. J. Cancer 29A:2243-2248 (1993).
35. T. C. Chambers, E. M. McAvoy, J. W. Jacobs, and G. Eilon. Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells. J. Biol. Chem. 265:7679-7686 (1990).
36. S. E. Bates, J. S. Lee, B. Dickstein, M. Spolnar, and A. T. Fojo. Differential modulation of P-glycoprotein transport by protein kinase inhibition. Biochem. 7:9156-9164 (1993).
37. P. M. Bungay, P. F. Morrison, and R. L. Dedrick. Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sci. 46:105-119 (1990).
38. Q. Wang, H. Yang, D. W. Miller, and W. F. Elmquist. Effect of the P-glycoprotein inhibitor cyclosporin A, on the distribution of rhodamine-123 to the brain: An in vivo microdialysis study in freely moving rats. Biochem. Biophys. Res. Comm. 211:719-726 (1995).