Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis

Acta Anaesthesiologica Scandinavica

Volumn 45, Issue 3, 2001, Pages 390-392

  Bouw, R ^a   Ederoth, P ^b   Lundberg, J ^b   Ungerstedt, U ^c   Nordstrom C H ^b   Hammarlund Udenaes, M ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Blood brain barrier permeability; Brain trauma; Clinical microdialysis; Humans; Morphine

Indexed keywords

MORPHINE;

ADIPOSE TISSUE; ADULT; ARTERIAL BLOOD; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INJURY; CASE REPORT; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG HALF LIFE; DRUG PENETRATION; DRUG TISSUE LEVEL; EXTRACELLULAR FLUID; HUMAN; MALE; MICRODIALYSIS; PRIORITY JOURNAL; SUBCUTANEOUS FAT;

BLOOD-BRAIN BARRIER; BRAIN INJURIES; HUMANS; MALE; MICRODIALYSIS; MIDDLE AGED; MORPHINE; NARCOTICS; PERMEABILITY;

EID: 0035129778     PISSN: 00015172     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-6576.2001.045003390.x     Document Type: Article

References (8)

1. Volume regulation of the central nervous system
2. Microdialysis in normal and injured brain
3. Methodological aspects of the use of a calibrator in in vivo microdialysis further development of the retrodialysis method
4. Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats - A microdialysis study
5. The role of P-glycoprotein in blood-brain barrier transport of morphine: Transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice
6. Microdialysis calibration using retrodialysis and zero-net flux: Application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus
7. Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate
8. Blood-brain barrier equilibration of codeine in rats studied with microdialysis