The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: Microdialysis and maximum electroshock seizures studies

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 2, 1999, Pages 543-550

  Hesselink, M B ^a,b,c   Smolders, H ^a,b   Eilbacher, B ^a   De Boer, A G ^b   Breimer, D D ^b   Danysz, Wojciech ^a  

^a MERZ PHARMACEUTICALS GMBH   (Germany)

^b LEIDEN UNIVERSITY   (Netherlands)

^c Cerebrus Limited   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

7 CHLORO 4 HYDROXY 3 (3 PHENOXYPHENYL) 2 QUINOLONE; 8 BROMO 4 HYDROXY 1 OXO 1,2 DIHYDROPYRIDALIONO[4,5 B]QUINOLINE 5 OXIDE CHOLINE; 8 CHLORO 4 HYDROXY 1 OXO 1,2 DIHYDROPYRIDALIONO[4,5 B]QUINOLINE 5 OXIDE CHOLINE; 8 FLUORO 4 HYDROXY 1 OXO 1,2 DIHYDROPYRIDALIONO[4,5 B]QUINOLINE 5 OXIDE CHOLINE; MEMANTINE; MRZ 2 570; MRZ 2 571; MRZ 2 576; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROBENECID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; DOSE RESPONSE; DRUG CLEARANCE; DRUG EFFECT; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG TISSUE LEVEL; ELECTRIC SHOCK; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MICRODIALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEADY STATE;

ANIMALS; ANION TRANSPORT PROTEINS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; DRUG INTERACTIONS; ELECTROSHOCK; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MALE; MEMANTINE; MICE; MICRODIALYSIS; PHTHALAZINES; PROBENECID; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLYCINE; RECEPTORS, N-METHYL-D-ASPARTATE; SEIZURES;

EID: 0032840594     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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