The biological sequelae of stromal cell-derived factor-1α in multiple myeloma

Molecular Cancer Therapeutics

Volumn 1, Issue 7, 2002, Pages 539-544

  Hideshima, Teru ^a   Chauhan, Dharminder ^a   Hayashi, Toshiaki ^a   Podar, Klaus ^a   Akiyama, Masaharu ^a   Gupta, Deepak ^a   Richardson, Paul ^a   Munshi, Nikhil ^a   Anderson, Kenneth C ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CHEMOKINE; BAD PROTEIN, HUMAN; CARRIER PROTEIN; DEXAMETHASONE; DNA; ENDOTHELIAL CELL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LYMPHOKINE; PROTEIN BAD; SIGNAL PEPTIDE; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN; VASCULOTROPIN A;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; BONE MARROW; BONE MARROW CELL; CELL CULTURE; CELL DIVISION; CELL MOTION; DOSE RESPONSE; FLOW CYTOMETRY; HUMAN; METABOLISM; MULTIPLE MYELOMA; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BLOTTING, WESTERN; BONE MARROW; BONE MARROW CELLS; CARRIER PROTEINS; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CHEMOKINES, CXC; DEXAMETHASONE; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL GROWTH FACTORS; FLOW CYTOMETRY; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-6; LYMPHOKINES; MULTIPLE MYELOMA; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036561859     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Nagasawa, T., Kikutani, H., and Kishimoto, T. Molecular cloning and structure of a pre-B-cell growth-stimulating factor. Proc. Natl. Acad. Sci. USA, 91: 2305-2309, 1994. (Pubitemid 24092092)
2. Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark-Lewis, I., Sodroski, J., and Springer, T. A. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature (Lond.), 382: 829-833, 1996. (Pubitemid 26299570)
3. Oberlin, E., Amara, A., Bachelerie, F., Bessia, C., Virelizier, J. L., Arenzana-Seisdedos, F., Schwartz, O., Heard, J. M., Clark-Lewis, I., Legler, D. F., Loetscher, M., Baggiolini, M., and Moser, B. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature (Lond.), 382: 833-835, 1996. (Pubitemid 26299571)
4. McGrath, K. E., Koniski, A. D., Maltby, K. M., McGann, J. K., and Palis, J. Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev. Biol., 213: 442-456, 1999. (Pubitemid 29444352)
5. Mohle, R., Bautz, F., Rafii, S., Moore, M. A., Brugger, W., and Kanz, L. The chemokine receptor CXCR-4 is expressed on CD34+ hematopoietic progenitors and leukemic cells and mediates transendothelial migration induced by stromal cell-derived factor-1. Blood, 91: 4523-4530, 1998. (Pubitemid 28270300)
6. Aiuti, A., Webb, I. J., Bleul, C. S., T., and Gutierrez-Ramos, J. C. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood. J. Exp. Med., 185: 111-120, 1997. (Pubitemid 27039446)
7. Dutt, P., Wang, J. F., and Groopman, J. E. Stromal cell-derived factor-1α and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis. J. Immunol., 161: 3652-3658, 1998.
8. Zhang, X-F., Wang, J-F., Matczak, E., Proper, J., and Groopman, J. E. Janus kinase 2 is involved in stromal cell-derived factor-1α-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells. Blood, 97: 3342-3348, 2001.
9. Wang, J-F., Park, I-W., and Groopman, J. E. Stromal cell-derived factor-1α stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood, 95: 2505-2513, 2000. (Pubitemid 30210527)
10. Kijowski, J., Baj-Krzyworzeka, M., Majka, M., Reca, R., Marrquez, L. A., Christofidou-Solomidou, M., Janowska-Wieczorek, A., and Ratajczak, M. Z. The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells. Stem Cell, 19: 453-466, 2001. (Pubitemid 32900088)
11. Vila-Coro, A. J., Rodriguez-Frade, J. M., Martin de Ana, A., Moreno- Ortiz, M. C., Martinez-A, C., and Mellado, M. The chemokine SDF-1α triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway. FASEB J., 13: 1699-1710, 1999. (Pubitemid 29473332)
12. Durig, J., Schmucker, U., and Duhsen, U. Differential expression of chemokine receptors in B cell malignancies. Leukemia (Baltimore), 15: 752-756, 2001. (Pubitemid 32492698)
13. Uchiyama, H., Barut, B. A., Mohrbacher, A. F., Chauhan, D., and Anderson, K. C. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates IL-6 secretion. Blood, 82: 3712-3720, 1993. (Pubitemid 24006055)
14. Hideshima, T., Chauhan, D., Schlossman, R., Richardson, P., and Anderson, K. C. The role of tumor necrosis factor α in the pathogenesis of human multiple myeloma: therapeutic applications. Oncogene, 20: 4519-4527, 2001. (Pubitemid 32772434)
15. Hideshima, T., Chauhan, D., Shima, Y., Raje, N., Davies, F. E., Tai, Y-T., Treon, S., Lin, B., Schlossman, R. L., Richardson, P., Muller, G., Stirling, D. I., and Anderson, K. C. Thalidomide and its analogues overcome drug resistance of human multiple myeloma cells to conventional therapy. Blood, 96: 2943-2950, 2000.
16. Podar, K., Tai, Y. T., Davies, F. E., Lentzsch, S., Sattler, M., Hideshima, T., Lin, B. K., Gupta, D., Shima, Y., Chauhan, D., Mitsiades, C., Raje, N., Richardson, P., and Anderson, K. C. Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood, 98: 428-435, 2001.
17. Hideshima, T., Richardson, P., Chauhan, D., Palombella, V. J., Elliot, P. J., Adams, J., and Anderson, K. C. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma. Cancer Res., 61: 3071-3076, 2001. (Pubitemid 32691956)
18. Hideshima, T., Nakamura, N., Chauhan, D., and Anderson, K. C. Biologic sequelae of interleukin-6 induced PI3-K/Akt signaling in multiple myeloma. Oncogene, 20: 5991-6000, 2001. (Pubitemid 32955041)
19. Ogata, A., Chauhan, D., Teoh, G., Treon, S. P., Urashima, M., Schlossman, R. L., and Anderson, K. C. Interleukin-6 triggers cell growth via the ras-dependent mitogen-activated protein kinase cascade. J. Immunol., 159: 2212-2221, 1997.
20. del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R., and Nunez, G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science (Wash. DC), 278: 687-697, 1997.
21. Hazlehurst, L. A., Damiano, J. S., Buyuksal, I., Pledger, W. J., and Dalton, W. S. Adhesion to fibronectin via β1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAMDR). Oncogene, 19: 4319-4327, 2000.
22. Sanz-Rodrigues, F., Hidalgo, A., and Teixido, J. Chemokine stromal cell-derived factor-1α modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1/fibronectin and VCAM-1. Blood, 97: 346-351, 2001. (Pubitemid 32060316)
23. Geminder, H., Sagi-Assif, O., Golgberg, L., Meshel, T., Rechavi, G., Witz, I. P., and Ben-Baruch, A. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases in neuroblastoma. J. Immunol., 167: 4747-4757, 2001. (Pubitemid 32954357)
24. Chauhan, D., Pandey, P., Ogata, A., Teoh, G., Treon, S., Urashima, M., Kharbanda, S., and Anderson, K. C. Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. Oncogene, 15: 837-843, 1997. (Pubitemid 27390136)
25. Chauhan, D., Pandey, P., Hideshima, T., Treon, S., Raje, N., Davies, F. E., Shima, Y., Tai, Y. T., Rosen, S., Avraham, S., Kharbanda, S., and Anderson, K. C. SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells. J. Biol. Chem., 275: 27845-27850, 2000.
26. Chauhan, D., Hideshima, T., Rosen, S., Reed, J. C., Kharbanda, S., and Anderson, K. C. Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells. J. Biol. Chem., 276: 24453-24456, 2001.
27. Chauhan, D., Uchiyama, H., Akbarali, Y., Urashima, M., Yamamoto, K. I., Libermann, T. A., and Anderson, K. C. Multiple myeloma cell adhesion- induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB. Blood, 87: 1104-1112, 1996. (Pubitemid 26043538)
28. Dankbar, B., Padro, T., Leo, R., Feldmann, B., Kropff, M., Mesters, R. M., Serve, H., Berdel, W. E., and Kienast, J. Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma. Blood, 95: 2630-2636, 2000. (Pubitemid 30210543)
29. Gupta, D., Treon, S., Shima, Y., Hideshima, T., Podar, K., Tai, Y. T., Lin, B., Lentzsch, S., Davies, F. E., Chauhan, D., Schlossman, R. L., Richardson, P. G., Ralph, P., Wu, L., Payvandi, F., Muller, G., Stirling, D. I., and Anderson, K. C. Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications. Leukemia (Baltimore), 15: 1950-1961, 2001. (Pubitemid 33115003)
30. Pelletier, A. J., van der Laan, L. J., Hildbrand, P., Siani, M. A., Thompson, D. A., Dawson, P. E., Torbett, B. E., and Salomon, D. R. Presentation of chemokine SDF-1- by fibronectin mediates directed migration of T cells. Blood, 96: 2682-2690, 2000.
31. Baldwin, A. S., Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol., 14: 649-683, 1996.
32. Beg, A. A., and Baldwin, A. S. J. The IκB proteins: multifunctional regulators of rel/NF-κB transcription factors. Genes Dev., 7: 2064-2070, 1993.
33. Baldwin, A. S. Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB. J. Clin. Investig., 107: 241-246, 2001. (Pubitemid 32157954)
34. Bargou, R. C., Emmerich, F., Krappmann, D., Bommert, K., Mapara, M. Y., Arnold, W., Royer, H. D., Grinstein, E., Greiner, A., Scheidereit, C., and Dorken, B. Constitutive nuclear factor-κB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells. J. Clin. Investig., 100: 2961-2969, 1997. (Pubitemid 28022832)
35. Mayo, M. W., Wang, C. Y., Cogswell, P. C., Rogers-Graham, K. S., Lowe, S. W., Der, C. J., and Baldwin, A. S., Jr. Requirement of NF-κB activation to suppress p53-independent apoptosis induced by oncogenic Ras. Science (Wash. DC), 278: 1812-1815, 1997. (Pubitemid 27527651)
36. Han, H., He, T., Huang, D., Pardo, C. A., and Ransohoff, R. M. TNF-α mediates SDF-1α-induced NF-κB activation and cytotoxic effects in primary astrocytes. J. Clin. Investig., 108: 425-435, 2001. (Pubitemid 32730789)
37. Chauhan, D., Hideshima, T., Pandey, P., Treon, S. P., Teoh, G., Rosen, S., Krett, N., Husson, H., Avraham, S., Kharbanda, S., and Anderson, K. C. RAFTK/PYK2-dependent and independent apoptosis in multiple myeloma cells. Oncogene, 18: 6733-6740, 1999.