Inhibition of β-amyloid-induced neurotoxicity by imidazopyridoindoles derived from a synthetic combinatorial library

Journal of Structural Biology

Volumn 130, Issue 2-3, 2000, Pages 247-258

  Reixach, Natàlia ^a   Crooks, Ema ^a   Ostresh, John M ^a   Houghten, Richard A ^a   Blondelle, Sylvie E ^a  

^a TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Heterocyclic compounds; Inhibitors; Neurotoxicity; Self aggregation process; Synthetic combinatorial libraries; amyloid peptides

Indexed keywords

AMYLOID BETA PROTEIN; CARBOLINE DERIVATIVE; IMIDAZOPYRIDOINDOLE DERRIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG PROTEIN BINDING; FLUORESCENCE SPECTROSCOPY; NEUROTOXICITY; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CONFORMATION; RAT;

EID: 0033849749     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.2000.4245     Document Type: Article

References (51)

1. Solution structures of β-peptide and its constituent fragments: Relation to amyloid deposition
2. Vitamin E protects nerve cells from amyloid β-protein toxicity
3. Hydrogen peroxide mediates amyloid β-protein toxicity
4. Novel, potent calmodulin antagonists derived from an all-D hexapeptide combinatorial library that inhibit in vivo cell proliferation: Activity and structural characterization
5. All D-amino acid hexapeptide inhibitors of melittin's cytolytic activity derived from synthetic combinatorial libraries
6. Identification of inhibitors of melittin using nonsupport-bound combinatorial libraries
7. Bringing back the memories
8. Methodological variables in the assessment of beta amyloid neurotoxicity
9. β-Cyclodextrin interacts with Alzheimer amyloid β-A4 peptide
10. Neuroblastoma Neuro(2A) cells stably expressing a cloned μ-opioid receptor: A specific cellular model to study acute and chronic effects of morphine
11. Possible role of apoptosis in Alzheimer's disease
12. All-D-enantiomers of β-amyloid exhibit similar biological properties to all-L-β-amyloids
13. Apoptosis mediated neurotoxicity induced by chronic application of β-amyloid fragment 25-35
14. Effects of injected Alzheimer beta-amyloid cores in rat brain
15. A strategy for designing inhibitors of β-amyloid toxicity
16. General method for the rapid solid-phase synthesis of large numbers of peptides: Specificity of antigen-antibody interaction at the level of individual amino acids
17. Simplified procedure for carrying out simultaneous muliple hydrogen fluoride cleavages of protected peptide resins
18. Mixture-based synthetic combinatorial libraries
19. Hemin and related porphyrins inhibit β-amyloid aggregation
20. Two-hybrid system as a model to study the interaction of β-amyloid peptide monomers
21. Protein secondary structure and circular dichroism: A practical guide
22. Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: Implication for Alzheimer's disease
23. Chrysamine-G, a lipophilic analogue of Congo red, inhibits Aβ-induced toxicity in PC12 cells
24. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P
25. In pursuit of the molecular structure of amyloid plaque: New technology provides unexpected and critical information
26. Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution
27. Apoptosis is induced by β-amyloid in cultured central nervous system neurons
28. β-Amyloid neurotoxicity requires fibril formation and is inhibited by congo red
29. β-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
30. 2+ concentration
31. The inhibitory effect of laminin 1 and synthetic peptides deduced from the sequence in the laminin α1 chain on Aβ40 fibril formation in vitro
32. The current status of heterocyclic combinatorial libraries
33. Aggregation and conformation of β-amyloid peptide
34. 'Libraries from libraries': Chemical transformation of combinatorial libraries to extend the range and repertoire of chemical diversity
35. Peptide libraries: Determination of relative reaction rates of protected amino acids in competitive couplings
36. Neurodegeneration induced by β-amyloid peptides in vitro: The role of peptide assembly state
37. Structure-activity analyses of β-amyloid peptides: Contributions of the β25-35 region to aggregation and neurotoxicity
38. In vitro aging of β-amyloid protein causes peptide aggregation and neurotoxicity
39. Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries
40. Sulfonated dyes attenuate the toxic effects of β-amyloid in a structure-specific fashion
41. Inhibition of PC12 cell redox activity is a specific, early indicator of the mechanism of β-amyloid-mediated cell death
42. Solvent effects on self-assembly of β-amyloid peptide
43. Inhibition of Alzheimer's amyloidosis by peptides that prevent β-sheet conformation
44. β-Sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
45. Reversible random coil-β-sheet transition of the Alzheimer β-amyloid fragment (25-35)
46. Controlling amyloid β-peptide fibril formation with protease-stable ligands
47. Arrest of β-amyloid fibril formation by a pentapeptide ligand
48. Rifampicin prevents the aggregation and neurotoxicity of amyloid β-protein in vitro
49. Neurotrophic and neurotoxic effects of amyloid β-protein: Reversal by tachykinin neuropeptides