메뉴 건너뛰기




Volumn 55, Issue 2, 2006, Pages 276-284

Layers of mutualism with commensal bacteria protect us from intestinal inflammation

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15;

EID: 30944458581     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.054098     Document Type: Review
Times cited : (80)

References (134)
  • 1
    • 0002432214 scopus 로고    scopus 로고
    • Origin and evolution of the immune system
    • Paul WE, eds. Philadelphia: Lippincott-Raven
    • Du Pasquier L, Flajnik M. Origin and evolution of the immune system. In: Paul WE, eds. Fundamental immunology, 4th edn. Philadelphia: Lippincott-Raven, 1999:605-99.
    • (1999) Fundamental Immunology, 4th Edn. , pp. 605-699
    • Du Pasquier, L.1    Flajnik, M.2
  • 2
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the immune system
    • Macpherson AJ, Harris N. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol 2004;4:478-85.
    • (2004) Nat Rev Immunol , vol.4 , pp. 478-485
    • Macpherson, A.J.1    Harris, N.2
  • 3
    • 0035843993 scopus 로고    scopus 로고
    • Commensal host-bacterial relationships in the gut
    • Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science 2001;292:1115-18.
    • (2001) Science , vol.292 , pp. 1115-1118
    • Hooper, L.V.1    Gordon, J.I.2
  • 4
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine (cites personal communication from Joshua Lederberg)
    • Hooper LV, Wong MH, Thelin A, et al. Molecular analysis of commensal host-microbial relationships in the intestine (cites personal communication from Joshua Lederberg). Science 2001;291:881-4.
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1    Wong, M.H.2    Thelin, A.3
  • 5
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Backhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004;101:15718-23.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15718-15723
    • Backhed, F.1    Ding, H.2    Wang, T.3
  • 6
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: A new class of microbicidal proteins involved in innate immunity
    • Hooper LV, Stappenbeck TS, Hong CV, et al. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat Immunol 2003;4:269-73.
    • (2003) Nat Immunol , vol.4 , pp. 269-273
    • Hooper, L.V.1    Stappenbeck, T.S.2    Hong, C.V.3
  • 7
    • 0015173745 scopus 로고
    • Serum and secretory IgA in axenic and holoxenic mice
    • Benveniste J, Lespinats G, Solomon J. Serum and secretory IgA in axenic and holoxenic mice. J Immunol 1971;107:1656-62.
    • (1971) J Immunol , vol.107 , pp. 1656-1662
    • Benveniste, J.1    Lespinats, G.2    Solomon, J.3
  • 8
    • 0015177024 scopus 로고
    • Immunoglobulins in intact, immunized, and contaminated axenic mice: Study of serum IgA
    • Benveniste J, Lespinats G, Adam C, et al. Immunoglobulins in intact, immunized, and contaminated axenic mice: study of serum IgA. J Immunol 1971;107:1647-55.
    • (1971) J Immunol , vol.107 , pp. 1647-1655
    • Benveniste, J.1    Lespinats, G.2    Adam, C.3
  • 9
    • 0018248719 scopus 로고
    • The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions
    • Guy-Grand D, Griscelli C, Vassalli P. The mouse gut T lymphocyte, a novel type of T cell. Nature, origin, and traffic in mice in normal and graft-versus-host conditions. J Exp Med 1978;148:1661-77.
    • (1978) J Exp Med , vol.148 , pp. 1661-1677
    • Guy-Grand, D.1    Griscelli, C.2    Vassalli, P.3
  • 10
    • 0030862546 scopus 로고    scopus 로고
    • Regional phenotypic specialization of intraepithelial lymphocytes in the rat intestine does not depend on microbial colonization
    • Helgeland L, Vaage JT, Rolstad B, et al. Regional phenotypic specialization of intraepithelial lymphocytes in the rat intestine does not depend on microbial colonization. Scand J Immunol 1997;46:349-57.
    • (1997) Scand J Immunol , vol.46 , pp. 349-357
    • Helgeland, L.1    Vaage, J.T.2    Rolstad, B.3
  • 11
    • 0029908813 scopus 로고    scopus 로고
    • Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine
    • Helgeland L, Vaage JT, Rolstad B, et al. Microbial colonization influences composition and T-cell receptor V beta repertoire of intraepithelial lymphocytes in rat intestine. Immunology 1996;89:494-501.
    • (1996) Immunology , vol.89 , pp. 494-501
    • Helgeland, L.1    Vaage, J.T.2    Rolstad, B.3
  • 12
    • 0037438711 scopus 로고    scopus 로고
    • Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches
    • Yamanaka T, Helgeland L, Farstad IN, et al. Microbial colonization drives lymphocyte accumulation and differentiation in the follicle-associated epithelium of Peyer's patches. J Immunol 2003;170:816-22.
    • (2003) J Immunol , vol.170 , pp. 816-822
    • Yamanaka, T.1    Helgeland, L.2    Farstad, I.N.3
  • 13
    • 0024800242 scopus 로고
    • Serum immunoglobulin levels and naturally occurring antibodies against carbohydrate antigens in germ-free BALB/c mice fed chemically defined ultrafiltered diet
    • Bos NA, Kimura H, Meeuwsen CG, et al. Serum immunoglobulin levels and naturally occurring antibodies against carbohydrate antigens in germ-free BALB/c mice fed chemically defined ultrafiltered diet. Eur J Immunol 1989;19:2335-9.
    • (1989) Eur J Immunol , vol.19 , pp. 2335-2339
    • Bos, N.A.1    Kimura, H.2    Meeuwsen, C.G.3
  • 14
    • 0028118357 scopus 로고
    • Humoral immune response to 2,4-dinitrophenyl-keyhole limpet hemocyanin in antigen-free, germ-free and conventional BALB/c mice
    • Bos NA, Ploplis VA. Humoral immune response to 2,4-dinitrophenyl-keyhole limpet hemocyanin in antigen-free, germ-free and conventional BALB/c mice. Eur J Immunol 1994;24:59-65.
    • (1994) Eur J Immunol , vol.24 , pp. 59-65
    • Bos, N.A.1    Ploplis, V.A.2
  • 16
    • 0025991047 scopus 로고
    • The germ-free animal fed chemically defined diet: A unique tool
    • Wostmann BS, Pleasants JR. The germ-free animal fed chemically defined diet: a unique tool. Proc Soc Exp Biol Med 1991;198:539-46.
    • (1991) Proc Soc Exp Biol Med , vol.198 , pp. 539-546
    • Wostmann, B.S.1    Pleasants, J.R.2
  • 17
    • 10244226689 scopus 로고    scopus 로고
    • War and peace at mucosal surfaces
    • Sansonetti PJ. War and peace at mucosal surfaces. Nat Rev Immunol 2004;4:953-64.
    • (2004) Nat Rev Immunol , vol.4 , pp. 953-964
    • Sansonetti, P.J.1
  • 18
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-41.
    • (2004) Cell , vol.118 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3
  • 19
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005;307:731-4.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 20
    • 0025887076 scopus 로고
    • Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
    • Rutgeerts P, Goboes K, Peeters M, et al. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet 1991;338:771-4.
    • (1991) Lancet , vol.338 , pp. 771-774
    • Rutgeerts, P.1    Goboes, K.2    Peeters, M.3
  • 21
    • 0032992303 scopus 로고    scopus 로고
    • Colonization of microflora in mice: Mucosal defense against luminal bacteria
    • Fukushima K, Sasaki I, Ogawa H, et al. Colonization of microflora in mice: mucosal defense against luminal bacteria. J Gastroenterol 1999;34:54-60.
    • (1999) J Gastroenterol , vol.34 , pp. 54-60
    • Fukushima, K.1    Sasaki, I.2    Ogawa, H.3
  • 22
    • 0033214433 scopus 로고    scopus 로고
    • Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense
    • Wilson CL, Ouellette AJ, Satchell DP, et al. Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 1999;286:113-7.
    • (1999) Science , vol.286 , pp. 113-117
    • Wilson, C.L.1    Ouellette, A.J.2    Satchell, D.P.3
  • 23
    • 0034252293 scopus 로고    scopus 로고
    • Secretion of microbicidal alpha-defensins by intestinal paneth cells in response to bacteria
    • Ayabe T, Satchell DP, Wilson CL, et al. Secretion of microbicidal alpha-defensins by intestinal paneth cells in response to bacteria. Nature Immunol 2000;1:113-18.
    • (2000) Nature Immunol , vol.1 , pp. 113-118
    • Ayabe, T.1    Satchell, D.P.2    Wilson, C.L.3
  • 24
    • 0035793372 scopus 로고    scopus 로고
    • Molecular analysis of commensal host-microbial relationships in the intestine
    • Hooper LV, Wong MH, Thelin A, et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science 2001;291:881-4.
    • (2001) Science , vol.291 , pp. 881-884
    • Hooper, L.V.1    Wong, M.H.2    Thelin, A.3
  • 26
    • 0030067724 scopus 로고    scopus 로고
    • Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease
    • Daig R, Andus T, Aschenbrenner E, et al. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut 1996;38:216-22.
    • (1996) Gut , vol.38 , pp. 216-222
    • Daig, R.1    Andus, T.2    Aschenbrenner, E.3
  • 27
    • 0028275028 scopus 로고
    • Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation
    • Mazzucchelli L, Hauser C, Zgraggen K, et al. Expression of interleukin-8 gene in inflammatory bowel disease is related to the histological grade of active inflammation. Am J Pathol 1994;144:997-1007.
    • (1994) Am J Pathol , vol.144 , pp. 997-1007
    • Mazzucchelli, L.1    Hauser, C.2    Zgraggen, K.3
  • 28
    • 0030768826 scopus 로고    scopus 로고
    • The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease
    • Z'Graggen K, Walz A, Mazzucchelli L, et al. The C-X-C chemokine ENA-78 is preferentially expressed in intestinal epithelium in inflammatory bowel disease. Gastroenterology 1997;113:808-16.
    • (1997) Gastroenterology , vol.113 , pp. 808-816
    • Z'Graggen, K.1    Walz, A.2    Mazzucchelli, L.3
  • 29
    • 0030860713 scopus 로고    scopus 로고
    • Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis
    • Keates S, Keates AC, Mizoguchi E, et al. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol 1997;273:G75-82.
    • (1997) Am J Physiol , vol.273
    • Keates, S.1    Keates, A.C.2    Mizoguchi, E.3
  • 30
    • 0035166858 scopus 로고    scopus 로고
    • Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes
    • Shibahara T, Wilcox JN, Couse T, et al. Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes. Gastroenterology 2001;120:60-70.
    • (2001) Gastroenterology , vol.120 , pp. 60-70
    • Shibahara, T.1    Wilcox, J.N.2    Couse, T.3
  • 31
    • 0035165138 scopus 로고    scopus 로고
    • Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells
    • Dwinell MB, Luegering N, Eckmann L, et al. Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. Gastroenterology 2001;120:49-59.
    • (2001) Gastroenterology , vol.120 , pp. 49-59
    • Dwinell, M.B.1    Luegering, N.2    Eckmann, L.3
  • 32
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed tlr5 to induce epithelial proinflammatory gene expression
    • Gewirtz AT, Navas TA, Lyons S, et al. Cutting edge: bacterial flagellin activates basolaterally expressed tlr5 to induce epithelial proinflammatory gene expression. J Immunol 2001;167:1882-5.
    • (2001) J Immunol , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3
  • 33
    • 0028972499 scopus 로고
    • Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    • Hermiston ML, Gordon JI. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 1995;270:1203-7.
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.L.1    Gordon, J.I.2
  • 34
    • 0028306194 scopus 로고
    • Morphometric analysis of intestinal mucosa. VI-Principles in enumerating intra-epithelial lymphocytes
    • Crowe PT, Marsh MN. Morphometric analysis of intestinal mucosa. VI-Principles in enumerating intra-epithelial lymphocytes. Virchows Arch 1994;424:301-6.
    • (1994) Virchows Arch , vol.424 , pp. 301-306
    • Crowe, P.T.1    Marsh, M.N.2
  • 35
    • 0025884448 scopus 로고
    • Phenotypic and functional characterization of human TCR gamma delta+ intestinal intraepithelial lymphocytes
    • Deusch K, Pfeffer K, Reich K, et al. Phenotypic and functional characterization of human TCR gamma delta+ intestinal intraepithelial lymphocytes. Curr Top Microbiol Immunol 1991;173:279-83.
    • (1991) Curr Top Microbiol Immunol , vol.173 , pp. 279-283
    • Deusch, K.1    Pfeffer, K.2    Reich, K.3
  • 36
    • 0023875745 scopus 로고
    • Expression of the gamma-delta T-cell receptor on intestinal CD8+ intraepithelial lymphocytes
    • Goodman T, Lefranccois L. Expression of the gamma-delta T-cell receptor on intestinal CD8+ intraepithelial lymphocytes. Nature 1988;333:855-8.
    • (1988) Nature , vol.333 , pp. 855-858
    • Goodman, T.1    Lefranccois, L.2
  • 37
    • 0036971220 scopus 로고    scopus 로고
    • The functions of mucosal T cells in containing the indigenous flora of the intestine
    • Macpherson AJ, Martinic MM, Harris N. The functions of mucosal T cells in containing the indigenous flora of the intestine. Cell Mol Life Sci 2003;59:2088-96.
    • (2003) Cell Mol Life Sci , vol.59 , pp. 2088-2096
    • Macpherson, A.J.1    Martinic, M.M.2    Harris, N.3
  • 38
    • 0142061069 scopus 로고    scopus 로고
    • The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells
    • Pennington DJ, Silva-Santos B, Shires J, et al. The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol 2003;4:991-8.
    • (2003) Nat Immunol , vol.4 , pp. 991-998
    • Pennington, D.J.1    Silva-Santos, B.2    Shires, J.3
  • 39
    • 0028356473 scopus 로고
    • Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation
    • Guy Grand D, Rocha B, Mintz P, et al. Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation. J Exp Med 1994;180:673-9.
    • (1994) J Exp Med , vol.180 , pp. 673-679
    • Guy Grand, D.1    Rocha, B.2    Mintz, P.3
  • 40
    • 0027515153 scopus 로고
    • Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium
    • Poussier P, Teh HS, Julius M. Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium. J Exp Med 1993;178:1947-57.
    • (1993) J Exp Med , vol.178 , pp. 1947-1957
    • Poussier, P.1    Teh, H.S.2    Julius, M.3
  • 41
    • 0026694668 scopus 로고
    • Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut
    • Rocha B, von Boehmer H, Guy-Grand D. Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut. Proc Natl Acad Sci U S A 1992;89:5336-40.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5336-5340
    • Rocha, B.1    Von Boehmer, H.2    Guy-Grand, D.3
  • 42
    • 0036199258 scopus 로고    scopus 로고
    • Precursors of functional MHC class I- Or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides
    • Leishman AJ, Gapin L, Capone M, et al. Precursors of functional MHC class I- or class II-restricted CD8alphaalpha(+) T cells are positively selected in the thymus by agonist self-peptides. Immunity 2002;16:355-64.
    • (2002) Immunity , vol.16 , pp. 355-364
    • Leishman, A.J.1    Gapin, L.2    Capone, M.3
  • 43
    • 0034610972 scopus 로고    scopus 로고
    • Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph
    • Arstila T, Arstila TP, Calbo S, et al. Identical T cell clones are located within the mouse gut epithelium and lamina propia and circulate in the thoracic duct lymph. J Exp Med 2000;191:823-34.
    • (2000) J Exp Med , vol.191 , pp. 823-834
    • Arstila, T.1    Arstila, T.P.2    Calbo, S.3
  • 44
    • 0030239819 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions
    • Lundqvist C, Melgar S, Yeung MM, et al. Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions. J Immunol 1996;157:1926-34.
    • (1996) J Immunol , vol.157 , pp. 1926-1934
    • Lundqvist, C.1    Melgar, S.2    Yeung, M.M.3
  • 45
    • 0043168003 scopus 로고    scopus 로고
    • Human small-intestinal epithelium contains functional natural killer lymphocytes
    • Leon F, Roldan E, Sanchez L, et al. Human small-intestinal epithelium contains functional natural killer lymphocytes. Gastroenterology 2003;125:345-56.
    • (2003) Gastroenterology , vol.125 , pp. 345-356
    • Leon, F.1    Roldan, E.2    Sanchez, L.3
  • 46
    • 0030857576 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function
    • Chott A, Gerdes D, Spooner A, et al. Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function. Am J Pathol 1997;151:435-42.
    • (1997) Am J Pathol , vol.151 , pp. 435-442
    • Chott, A.1    Gerdes, D.2    Spooner, A.3
  • 47
    • 2642706700 scopus 로고    scopus 로고
    • Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease
    • Muller S, Lory J, Corazza N, et al. Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease. Am J Pathol 1998;152:261-8.
    • (1998) Am J Pathol , vol.152 , pp. 261-268
    • Muller, S.1    Lory, J.2    Corazza, N.3
  • 48
    • 0035282433 scopus 로고    scopus 로고
    • Visualizing the generation of memory CD4 T cells in the whole body
    • Reinhardt RL, Khoruts A, Merica R, et al. Visualizing the generation of memory CD4 T cells in the whole body. Nature 2001;410:101-5.
    • (2001) Nature , vol.410 , pp. 101-105
    • Reinhardt, R.L.1    Khoruts, A.2    Merica, R.3
  • 49
    • 0031278410 scopus 로고    scopus 로고
    • Activation and migration of CD8 T cells in the intestinal mucosa
    • Kim SK, Reed DS, Heath WR, et al. Activation and migration of CD8 T cells in the intestinal mucosa. J Immunol 1997;159:4295-306.
    • (1997) J Immunol , vol.159 , pp. 4295-4306
    • Kim, S.K.1    Reed, D.S.2    Heath, W.R.3
  • 50
    • 0343920681 scopus 로고    scopus 로고
    • Intestinal intraepithelial lymphocytes exert potent protective cytotoxic activity during an acute virus infection
    • Muller S, Buhler-Jungo M, Mueller C. Intestinal intraepithelial lymphocytes exert potent protective cytotoxic activity during an acute virus infection. J Immunol 2000;164:1986-94.
    • (2000) J Immunol , vol.164 , pp. 1986-1994
    • Muller, S.1    Buhler-Jungo, M.2    Mueller, C.3
  • 51
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • Powrie F, Leach MW, Mauze S, et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol 1993;5:1461-71.
    • (1993) Int Immunol , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3
  • 52
    • 0027163182 scopus 로고
    • CD4+ T cells that express high levels of CD45RB induce wasting disease transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells
    • Morrissey PJ, Charrier K, Braddy S, et al. CD4+ T cells that express high levels of CD45RB induce wasting disease transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells. J Exp Med 1993;178:237-44.
    • (1993) J Exp Med , vol.178 , pp. 237-244
    • Morrissey, P.J.1    Charrier, K.2    Braddy, S.3
  • 53
    • 1642313753 scopus 로고    scopus 로고
    • Virus-induced activation of self-specific TCRαβ CD8αα intraepithelial lymphocytes does not abolish their self-tolerance in the intestine
    • Saurer L, Seibold I, Rihs S, et al. Virus-induced activation of self-specific TCRαβ CD8αα intraepithelial lymphocytes does not abolish their self-tolerance in the intestine. J Immunol 2004;172:4176-83.
    • (2004) J Immunol , vol.172 , pp. 4176-4183
    • Saurer, L.1    Seibold, I.2    Rihs, S.3
  • 54
    • 0037013968 scopus 로고    scopus 로고
    • A unique subset of self-specific intraintestinal T cells maintains gut integrity
    • Poussier P, Ning T, Banerjee D, et al. A unique subset of self-specific intraintestinal T cells maintains gut integrity. J Exp Med 2002;195:1491-7.
    • (2002) J Exp Med , vol.195 , pp. 1491-1497
    • Poussier, P.1    Ning, T.2    Banerjee, D.3
  • 55
    • 0036828289 scopus 로고    scopus 로고
    • Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells
    • Allez M, Brimnes J, Dotan I, et al. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology 2002;123:1516-26.
    • (2002) Gastroenterology , vol.123 , pp. 1516-1526
    • Allez, M.1    Brimnes, J.2    Dotan, I.3
  • 56
    • 0020676659 scopus 로고
    • Isolation and preliminary characterization of human intestinal macrophages
    • Colder JP, Doe WF. Isolation and preliminary characterization of human intestinal macrophages. Gastroenterology 1983;84:795-802.
    • (1983) Gastroenterology , vol.84 , pp. 795-802
    • Colder, J.P.1    Doe, W.F.2
  • 57
    • 3242662009 scopus 로고    scopus 로고
    • Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease
    • Bilsborough J, Viney JL. Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology 2004;127:300-9.
    • (2004) Gastroenterology , vol.127 , pp. 300-309
    • Bilsborough, J.1    Viney, J.L.2
  • 58
    • 0038281478 scopus 로고    scopus 로고
    • Intestinal myofibroblasts in innate immune responses of the intestine
    • Otte JM, Rosenberg IM, Podolsky DK. Intestinal myofibroblasts in innate immune responses of the intestine. Gastroenterology 2003;124:1866-78.
    • (2003) Gastroenterology , vol.124 , pp. 1866-1878
    • Otte, J.M.1    Rosenberg, I.M.2    Podolsky, D.K.3
  • 59
    • 0036854676 scopus 로고    scopus 로고
    • Role of the innate immune system in the development of chronic colitis
    • Kanai T, Ilyama R, Ishikura T, et al. Role of the innate immune system in the development of chronic colitis. J Gastroenterol 2002;37(suppl 14):38-42.
    • (2002) J Gastroenterol , vol.37 , Issue.SUPPL. 14 , pp. 38-42
    • Kanai, T.1    Ilyama, R.2    Ishikura, T.3
  • 60
    • 0035451799 scopus 로고    scopus 로고
    • Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities
    • Smith PD, Smythies LE, Mosteller-Barnum M, et al. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J Immunol 2001;167:2651-6.
    • (2001) J Immunol , vol.167 , pp. 2651-2656
    • Smith, P.D.1    Smythies, L.E.2    Mosteller-Barnum, M.3
  • 61
    • 0036080092 scopus 로고    scopus 로고
    • Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation
    • Hausmann M, Kiessling S, Mestermann S, et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 2002;122:1987-2000.
    • (2002) Gastroenterology , vol.122 , pp. 1987-2000
    • Hausmann, M.1    Kiessling, S.2    Mestermann, S.3
  • 62
    • 0035953547 scopus 로고    scopus 로고
    • TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    • Bouchon A, Facchetti F, Weigand MA, et al. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001;410:1103-7.
    • (2001) Nature , vol.410 , pp. 1103-1107
    • Bouchon, A.1    Facchetti, F.2    Weigand, M.A.3
  • 63
    • 10844268749 scopus 로고    scopus 로고
    • Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine
    • Schenk M, Bouchon A, Birrer S, et al. Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine. J Immunol 2005;174:517-24.
    • (2005) J Immunol , vol.174 , pp. 517-524
    • Schenk, M.1    Bouchon, A.2    Birrer, S.3
  • 64
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
    • Takeda K, Clausen BE, Kaisho T, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 1999;10:39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3
  • 65
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 66
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 67
    • 0035897904 scopus 로고    scopus 로고
    • Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations
    • Hampe J, Cuthbert A, Croucher PJP, et al. Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations. Lancet 2001;357:1925-8.
    • (2001) Lancet , vol.357 , pp. 1925-1928
    • Hampe, J.1    Cuthbert, A.2    Croucher, P.J.P.3
  • 68
    • 0037380969 scopus 로고    scopus 로고
    • CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells
    • Hisamatsu T, Suzuki M, Reinecker HC, et al. CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 2003;124:993-1000.
    • (2003) Gastroenterology , vol.124 , pp. 993-1000
    • Hisamatsu, T.1    Suzuki, M.2    Reinecker, H.C.3
  • 69
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003;278:8869-72.
    • (2003) J Biol Chem , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 70
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara N, Ogura Y, Fontalba A, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 2003;278:5509-12.
    • (2003) J Biol Chem , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 71
    • 0142180157 scopus 로고    scopus 로고
    • Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2
    • Girardin SE, Travassos LH, Herve M, et al. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003;278:41702-8.
    • (2003) J Biol Chem , vol.278 , pp. 41702-41708
    • Girardin, S.E.1    Travassos, L.H.2    Herve, M.3
  • 72
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type-1 responses
    • Watanabe T, Kitani A, Murray P, et al. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type-1 responses. Nat Immunol 2004;5:800-8.
    • (2004) Nat Immunol , vol.5 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.3
  • 73
    • 13244277880 scopus 로고    scopus 로고
    • Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
    • Maeda S, Hsu LC, Liu H, et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 2005;307:734-8.
    • (2005) Science , vol.307 , pp. 734-738
    • Maeda, S.1    Hsu, L.C.2    Liu, H.3
  • 74
    • 0142123222 scopus 로고    scopus 로고
    • Role of Nod2 in the response of macrophages to toll-like receptor agonists
    • Pauleau AL, Murray PJ. Role of Nod2 in the response of macrophages to toll-like receptor agonists. Mol Cell Biol 2003;23:7531-9.
    • (2003) Mol Cell Biol , vol.23 , pp. 7531-7539
    • Pauleau, A.L.1    Murray, P.J.2
  • 75
    • 0036202336 scopus 로고    scopus 로고
    • The molecular classification of the clinical manifestations of Crohn's disease
    • Ahmad T, Armuzzi A, Bunce M, et al. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology 2002;122:854-66.
    • (2002) Gastroenterology , vol.122 , pp. 854-866
    • Ahmad, T.1    Armuzzi, A.2    Bunce, M.3
  • 76
    • 0036202885 scopus 로고    scopus 로고
    • The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease
    • Cuthbert AP, Fisher SA, Mirza MM, et al. The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 2002;122:867-74.
    • (2002) Gastroenterology , vol.122 , pp. 867-874
    • Cuthbert, A.P.1    Fisher, S.A.2    Mirza, M.M.3
  • 77
    • 0027441514 scopus 로고
    • Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa
    • Breese E, Braegger CP, Corrigan CJ, et al. Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. Immunology 1993;78:127-31.
    • (1993) Immunology , vol.78 , pp. 127-131
    • Breese, E.1    Braegger, C.P.2    Corrigan, C.J.3
  • 78
    • 0035321325 scopus 로고    scopus 로고
    • Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
    • Rescigno M, Urbano M, Valzasina B, et al. Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2001;2:361-7.
    • (2001) Nat Immunol , vol.2 , pp. 361-367
    • Rescigno, M.1    Urbano, M.2    Valzasina, B.3
  • 79
    • 0034614894 scopus 로고    scopus 로고
    • A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to t cell areas of mesenteric lymph nodes
    • Huang F-P, Platt N, Wykes M, et al. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to t cell areas of mesenteric lymph nodes. J Exp Med 2000;191:435-44.
    • (2000) J Exp Med , vol.191 , pp. 435-444
    • Huang, F.-P.1    Platt, N.2    Wykes, M.3
  • 80
    • 0030067796 scopus 로고    scopus 로고
    • Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch
    • Kelsall BL, Strober W. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J Exp Med 1996;183:237-47.
    • (1996) J Exp Med , vol.183 , pp. 237-247
    • Kelsall, B.L.1    Strober, W.2
  • 81
    • 0035871705 scopus 로고    scopus 로고
    • Unique functions of cd11b(+), cd8alpha(+), and double-negative peyer's patch dendritic cells
    • Iwasaki A, Kelsall BL. Unique functions of cd11b(+), cd8alpha(+), and double-negative peyer's patch dendritic cells. J Immunol 2001;166:4884-90.
    • (2001) J Immunol , vol.166 , pp. 4884-4890
    • Iwasaki, A.1    Kelsall, B.L.2
  • 82
    • 0141835046 scopus 로고    scopus 로고
    • Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
    • Becker C, Wirtz S, Blessing M, et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 2003;112:693-706.
    • (2003) J Clin Invest , vol.112 , pp. 693-706
    • Becker, C.1    Wirtz, S.2    Blessing, M.3
  • 83
    • 2342646956 scopus 로고    scopus 로고
    • Bacterial flagellin is a dominant antigen in Crohn disease
    • Lodes MJ, Cong Y, Elson CO, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 2004;113:1296-306.
    • (2004) J Clin Invest , vol.113 , pp. 1296-1306
    • Lodes, M.J.1    Cong, Y.2    Elson, C.O.3
  • 84
    • 0034705397 scopus 로고    scopus 로고
    • A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    • Macpherson AJ, Gatto D, Sainsbury E, et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 2000;288:2222-6.
    • (2000) Science , vol.288 , pp. 2222-2226
    • Macpherson, A.J.1    Gatto, D.2    Sainsbury, E.3
  • 85
    • 0032857965 scopus 로고    scopus 로고
    • Human colonic subepithelial myofibroblasts modulate transepithelial resistance and secretory response
    • Beltinger J, McKaig BC, Makh S, et al. Human colonic subepithelial myofibroblasts modulate transepithelial resistance and secretory response. Am J Physiol 1999;277:C271-9.
    • (1999) Am J Physiol , vol.277
    • Beltinger, J.1    McKaig, B.C.2    Makh, S.3
  • 86
    • 0032805892 scopus 로고    scopus 로고
    • Colitis in transgenic and knockout animals as models of human inflammatory bowel disease
    • Bhan AK, Mizoguchi E, Smith RN, et al. Colitis in transgenic and knockout animals as models of human inflammatory bowel disease. Immunol Rev 1999;169:195-207.
    • (1999) Immunol Rev , vol.169 , pp. 195-207
    • Bhan, A.K.1    Mizoguchi, E.2    Smith, R.N.3
  • 87
    • 0142121296 scopus 로고    scopus 로고
    • Immune networks in animal models of inflammatory bowel disease
    • Mizoguchi A, Mizoguchi E, Bhan AK. Immune networks in animal models of inflammatory bowel disease. Inflamm Bowel Dis 2003;9:246-59.
    • (2003) Inflamm Bowel Dis , vol.9 , pp. 246-259
    • Mizoguchi, A.1    Mizoguchi, E.2    Bhan, A.K.3
  • 88
    • 0142053206 scopus 로고    scopus 로고
    • The immunological and genetic basis of inflammatory bowel disease
    • Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003;3:521.
    • (2003) Nat Rev Immunol , vol.3 , pp. 521
    • Bouma, G.1    Strober, W.2
  • 89
    • 0028006855 scopus 로고
    • Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
    • Dieleman LA, Ridwan BU, Tennyson GS, et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology 1994;107:1643-52.
    • (1994) Gastroenterology , vol.107 , pp. 1643-1652
    • Dieleman, L.A.1    Ridwan, B.U.2    Tennyson, G.S.3
  • 90
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-73.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 91
    • 0036604901 scopus 로고    scopus 로고
    • T helper cell differentiation: On again, off again
    • Grogan JL, Locksley RM. T helper cell differentiation: on again, off again. Curr Opin Immunol 2002;14:366-72.
    • (2002) Curr Opin Immunol , vol.14 , pp. 366-372
    • Grogan, J.L.1    Locksley, R.M.2
  • 92
    • 0027922467 scopus 로고
    • Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    • Mombaerts P, Mizoguchi E, Grusby MJ, et al. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993;75:274-82.
    • (1993) Cell , vol.75 , pp. 274-282
    • Mombaerts, P.1    Mizoguchi, E.2    Grusby, M.J.3
  • 93
    • 0025931643 scopus 로고
    • Activation and signaling status of human lamina propria T lymphocytes
    • Qiao L, Schurmann G, Betzler M, et al. Activation and signaling status of human lamina propria T lymphocytes. Gastroenterology 1991;101:1529-36.
    • (1991) Gastroenterology , vol.101 , pp. 1529-1536
    • Qiao, L.1    Schurmann, G.2    Betzler, M.3
  • 94
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory T cells in the control of immune pathology
    • Maloy KJ, Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol 2001;2:816-22.
    • (2001) Nat Immunol , vol.2 , pp. 816-822
    • Maloy, K.J.1    Powrie, F.2
  • 95
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory T cells
    • Huang CT, Workman CJ, Flies D, et al. Role of LAG-3 in regulatory T cells. Immunity 2004;21:503-13.
    • (2004) Immunity , vol.21 , pp. 503-513
    • Huang, C.T.1    Workman, C.J.2    Flies, D.3
  • 96
    • 0031569530 scopus 로고    scopus 로고
    • CD4+ T cell down-regulation in human intestinal mucosa: Evidence for intestinal tolerance to luminal bacterial antigens
    • Khoo UY, Proctor IE, Macpherson AJ. CD4+ T cell down-regulation in human intestinal mucosa: evidence for intestinal tolerance to luminal bacterial antigens. J Immunol 1997;158:3626-34.
    • (1997) J Immunol , vol.158 , pp. 3626-3634
    • Khoo, U.Y.1    Proctor, I.E.2    Macpherson, A.J.3
  • 97
    • 13544266171 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor FOXP3
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor FOXP3. Science 2003;9:9.
    • (2003) Science , vol.9 , pp. 9
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 98
    • 4344682025 scopus 로고    scopus 로고
    • CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells
    • Makita S, Kanai T, Oshima S, et al. CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells. J Immunol 2004;173:3119-30.
    • (2004) J Immunol , vol.173 , pp. 3119-3130
    • Makita, S.1    Kanai, T.2    Oshima, S.3
  • 99
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • Kuhn R, Lohler J, Rennick D, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993;75:263-74.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3
  • 100
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    • Shull MM, Ormsby I, Kier AB, et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 1992;359:693-9.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1    Ormsby, I.2    Kier, A.B.3
  • 101
    • 0037446531 scopus 로고    scopus 로고
    • Cutting edge: Cure of colitis by CD4+CD25+ regulatory T cells
    • Mottet C, Uhlig HH, Powrie F. Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol 2003;170:3939-43.
    • (2003) J Immunol , vol.170 , pp. 3939-3943
    • Mottet, C.1    Uhlig, H.H.2    Powrie, F.3
  • 102
    • 0033571441 scopus 로고    scopus 로고
    • Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2-/- mice upon transfer of CD4+CD45RBhi T cells
    • Corazza N, Eichenberger S, Eugster H-P, et al. Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2-/- mice upon transfer of CD4+CD45RBhi T cells. J Exp Med 1999;190:1479-92.
    • (1999) J Exp Med , vol.190 , pp. 1479-1492
    • Corazza, N.1    Eichenberger, S.2    Eugster, H.-P.3
  • 103
    • 0141449950 scopus 로고    scopus 로고
    • Selective generation of gut tropic T cells in gut-associated lymphoid tissue: Requirement for GALT dendritic cells and adjuvant
    • Johansson-Lindbom B, Svensson M, Wurbel MA, et al. Selective generation of gut tropic T cells in gut-associated lymphoid tissue: requirement for GALT dendritic cells and adjuvant. J Exp Med 2003;198:963-9.
    • (2003) J Exp Med , vol.198 , pp. 963-969
    • Johansson-Lindbom, B.1    Svensson, M.2    Wurbel, M.A.3
  • 104
    • 15744391229 scopus 로고    scopus 로고
    • Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation
    • Bamias G, Martin C, Mishina M, et al. Proinflammatory effects of TH2 cytokines in a murine model of chronic small intestinal inflammation. Gastroenterology 2005;128:654-66.
    • (2005) Gastroenterology , vol.128 , pp. 654-666
    • Bamias, G.1    Martin, C.2    Mishina, M.3
  • 105
    • 0034598357 scopus 로고    scopus 로고
    • The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
    • Warnock RA, Campbell JJ, Dorf ME, et al. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules. J Exp Med 2000;191:77-88.
    • (2000) J Exp Med , vol.191 , pp. 77-88
    • Warnock, R.A.1    Campbell, J.J.2    Dorf, M.E.3
  • 106
    • 5644300399 scopus 로고    scopus 로고
    • Retinoic acid imprints gut-homing specificity on T cells
    • Iwata M, Hirakiyama A, Eshima Y, et al. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004;21:527-38.
    • (2004) Immunity , vol.21 , pp. 527-538
    • Iwata, M.1    Hirakiyama, A.2    Eshima, Y.3
  • 107
    • 0028978113 scopus 로고
    • Transforming growth factor-beta 1-induced expression of the mucosa- Related integrin alpha e on lymphocytes is not associated with mucosa-specific homing
    • Austrup F, Rebstock S, Kilshaw PJ, et al. Transforming growth factor-beta 1-induced expression of the mucosa- related integrin alpha E on lymphocytes is not associated with mucosa-specific homing. Eur J Immunol 1995;25:1487-91.
    • (1995) Eur J Immunol , vol.25 , pp. 1487-1491
    • Austrup, F.1    Rebstock, S.2    Kilshaw, P.J.3
  • 108
    • 0037382166 scopus 로고    scopus 로고
    • CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells
    • Kunkel EJ, Kim CH, Lazarus NH, et al. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest 2003;111:1001-10.
    • (2003) J Clin Invest , vol.111 , pp. 1001-1010
    • Kunkel, E.J.1    Kim, C.H.2    Lazarus, N.H.3
  • 109
    • 0036218221 scopus 로고    scopus 로고
    • The immunology of mucosal models of inflammation
    • Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol 2002;20:495-549.
    • (2002) Annu Rev Immunol , vol.20 , pp. 495-549
    • Strober, W.1    Fuss, I.J.2    Blumberg, R.S.3
  • 110
    • 0033158529 scopus 로고    scopus 로고
    • Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium
    • Kitajima S, Takuma S, Morimoto M. Changes in colonic mucosal permeability in mouse colitis induced with dextran sulfate sodium. Exp Anim 1999;48:137-43.
    • (1999) Exp Anim , vol.48 , pp. 137-143
    • Kitajima, S.1    Takuma, S.2    Morimoto, M.3
  • 111
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
    • Boirivant M, Fuss IJ, Chu A, et al. Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998;188:1929-39.
    • (1998) J Exp Med , vol.188 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3
  • 112
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995;182:1281-90.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3
  • 113
    • 0031811879 scopus 로고    scopus 로고
    • Inflammatory bowel disease-like enteritis and coecitis in a senescence accelerated mouse 1l/Yit strain
    • Matsumoto S, Okabe Y, Setoyama H, et al. Inflammatory bowel disease-like enteritis and coecitis in a senescence accelerated mouse 1l/Yit strain. Gut 1998;43:71-8.
    • (1998) Gut , vol.43 , pp. 71-78
    • Matsumoto, S.1    Okabe, Y.2    Setoyama, H.3
  • 114
    • 0035106502 scopus 로고    scopus 로고
    • Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease
    • Kosiewicz MM, Nast CC, Krishnan A, et al. Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's disease. J Clin Invest 2001;107:695-702.
    • (2001) J Clin Invest , vol.107 , pp. 695-702
    • Kosiewicz, M.M.1    Nast, C.C.2    Krishnan, A.3
  • 115
    • 0037033434 scopus 로고    scopus 로고
    • T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis
    • Iqbal N, Oliver JR, Wagner FH, et al. T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J Exp Med 2002;195:71-84.
    • (2002) J Exp Med , vol.195 , pp. 71-84
    • Iqbal, N.1    Oliver, J.R.2    Wagner, F.H.3
  • 116
    • 0027988256 scopus 로고
    • Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice
    • Sundberg JP, Elson CO, Bedigian H, et al. Spontaneous, heritable colitis in a new substrain of C3H/HeJ mice. Gastroenterology 1994;107:1726-35.
    • (1994) Gastroenterology , vol.107 , pp. 1726-1735
    • Sundberg, J.P.1    Elson, C.O.2    Bedigian, H.3
  • 117
    • 0029828745 scopus 로고    scopus 로고
    • Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
    • Mashimo H, Wu DC, Podolsky DK, et al. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996;274:262-5.
    • (1996) Science , vol.274 , pp. 262-265
    • Mashimo, H.1    Wu, D.C.2    Podolsky, D.K.3
  • 118
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis
    • Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol 1998;161:5733-44.
    • (1998) J Immunol , vol.161 , pp. 5733-5744
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 119
    • 0036169116 scopus 로고    scopus 로고
    • Helicobacter bills infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) mice
    • Maggio-Price L, Shows D, Waggie K, et al. Helicobacter bills infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) mice. Am J Pathol 2002;160:739-51.
    • (2002) Am J Pathol , vol.160 , pp. 739-751
    • Maggio-Price, L.1    Shows, D.2    Waggie, K.3
  • 120
    • 0038247593 scopus 로고    scopus 로고
    • Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis
    • Fiorucci S, Distrutti E, Mencarelli A, et al. Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis. Digestion 2002;66:246-56.
    • (2002) Digestion , vol.66 , pp. 246-256
    • Fiorucci, S.1    Distrutti, E.2    Mencarelli, A.3
  • 121
    • 0033558364 scopus 로고    scopus 로고
    • Chronic intestinal inflammation in STAT-4 transgenic mice: Characterization of disease and adoptive transfer by TNF-plus IFN- Gamma-producing CD4+ T cells that respond to bacterial antigens
    • Wirtz S, Finotto S, Kanzler S, et al. Chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF-plus IFN- gamma-producing CD4+ T cells that respond to bacterial antigens. J Immunol 1999;162:1884-8.
    • (1999) J Immunol , vol.162 , pp. 1884-1888
    • Wirtz, S.1    Finotto, S.2    Kanzler, S.3
  • 122
    • 0032540266 scopus 로고    scopus 로고
    • Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice
    • Bush TG, Savidge TC, Freeman TC, et al. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 1998;93:189-201.
    • (1998) Cell , vol.93 , pp. 189-201
    • Bush, T.G.1    Savidge, T.C.2    Freeman, T.C.3
  • 123
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- Rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis D, Pasparakis M, Pizarro TT, et al. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies. Immunity 1999;10:387-98.
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3
  • 124
    • 0034924028 scopus 로고    scopus 로고
    • Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease
    • Hahm KB, Im YH, Parks TW, et al. Loss of transforming growth factor beta signalling in the intestine contributes to tissue injury in inflammatory bowel disease. Gut 2001;49:190-8.
    • (2001) Gut , vol.49 , pp. 190-198
    • Hahm, K.B.1    Im, Y.H.2    Parks, T.W.3
  • 125
    • 0034116557 scopus 로고    scopus 로고
    • Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice
    • Madsen KL, Doyle JS, Tavernini MM, et al. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology 2000;118:1094-105.
    • (2000) Gastroenterology , vol.118 , pp. 1094-1105
    • Madsen, K.L.1    Doyle, J.S.2    Tavernini, M.M.3
  • 126
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, et al. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993;75:253-61.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3
  • 127
    • 0033000343 scopus 로고    scopus 로고
    • IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation
    • Schultz M, Tonkonogy SL, Sellon RK, et al. IL-2-deficient mice raised under germfree conditions develop delayed mild focal intestinal inflammation. Am J Physiol 1999;276:G1461-72.
    • (1999) Am J Physiol , vol.276
    • Schultz, M.1    Tonkonogy, S.L.2    Sellon, R.K.3
  • 128
    • 0035260357 scopus 로고    scopus 로고
    • Typhlocolitis in NF-kappa B-deficient mice
    • Erdman S, Fox JG, Dangler CA, et al. Typhlocolitis in NF-kappa B-deficient mice. J Immunol 2001;166:1443-7.
    • (2001) J Immunol , vol.166 , pp. 1443-1447
    • Erdman, S.1    Fox, J.G.2    Dangler, C.A.3
  • 129
    • 0035120185 scopus 로고    scopus 로고
    • Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice
    • Veltkamp C, Tonkonogy SL, De Jong YP, et al. Continuous stimulation by normal luminal bacteria is essential for the development and perpetuation of colitis in Tg(epsilon26) mice. Gastroenterology 2001;120:900-13.
    • (2001) Gastroenterology , vol.120 , pp. 900-913
    • Veltkamp, C.1    Tonkonogy, S.L.2    De Jong, Y.P.3
  • 130
    • 0032472838 scopus 로고    scopus 로고
    • Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa
    • Watanabe M, Ueno Y, Yajima T, et al. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 1998;187:389-402.
    • (1998) J Exp Med , vol.187 , pp. 389-402
    • Watanabe, M.1    Ueno, Y.2    Yajima, T.3
  • 131
    • 0034162570 scopus 로고    scopus 로고
    • Systemic activation and antigen-driven oligoclonal expansion of T cells in a mouse model of colitis
    • Matsuda JL, Gapin L, Sydora BC, et al. Systemic activation and antigen-driven oligoclonal expansion of T cells in a mouse model of colitis. J Immunol 2000;164:2797-806.
    • (2000) J Immunol , vol.164 , pp. 2797-2806
    • Matsuda, J.L.1    Gapin, L.2    Sydora, B.C.3
  • 132
    • 0029061801 scopus 로고
    • Ulcerative colitis and adenocarcinoma of the colon in G alpha i2- Deficient mice
    • Rudolph U, Finegold MJ, Rich SS, et al. Ulcerative colitis and adenocarcinoma of the colon in G alpha i2- deficient mice. Nat Genet 1995;10:143-50.
    • (1995) Nat Genet , vol.10 , pp. 143-150
    • Rudolph, U.1    Finegold, M.J.2    Rich, S.S.3
  • 133
    • 0032118427 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
    • Snapper SB, Rosen FS, Mizoguchi E, et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 1998;9:81-91.
    • (1998) Immunity , vol.9 , pp. 81-91
    • Snapper, S.B.1    Rosen, F.S.2    Mizoguchi, E.3
  • 134
    • 0036841277 scopus 로고    scopus 로고
    • Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease
    • Bamias G, Marini M, Moskaluk CA, et al. Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's disease. J Immunol 2002;169:5308-14.
    • (2002) J Immunol , vol.169 , pp. 5308-5314
    • Bamias, G.1    Marini, M.2    Moskaluk, C.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.