메뉴 건너뛰기




Volumn 151, Issue 2, 1997, Pages 435-442

Intraepithelial lymphocytes in normal human intestine do not express proteins associated with cytolytic function

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GRANZYME A; GRANZYME B; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 0030857576     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (40)

References (55)
  • 1
    • 0019491228 scopus 로고
    • Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract
    • Selby WS, Janossy G, Jewell DP: Immunohistological characterisation of intraepithelial lymphocytes of the human gastrointestinal tract. Gut 1981, 22:169-176
    • (1981) Gut , vol.22 , pp. 169-176
    • Selby, W.S.1    Janossy, G.2    Jewell, D.P.3
  • 2
    • 0020560187 scopus 로고
    • Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies
    • Cerf-Bensussan N, Schneeberger EE, Bhan AK: Immunohistologic and immunoelectron microscopic characterization of the mucosal lymphocytes of human small intestine by the use of monoclonal antibodies, J Immunol 1983, 130:2615-2622
    • (1983) J Immunol , vol.130 , pp. 2615-2622
    • Cerf-Bensussan, N.1    Schneeberger, E.E.2    Bhan, A.K.3
  • 3
    • 46549098777 scopus 로고
    • Leukocytes in the intestinal epithelium: An unusual immunological compartment
    • Ernst PB, Befus AD, Bienenstock J: Leukocytes in the intestinal epithelium: an unusual immunological compartment. Immunol Today 1985, 6:50-55
    • (1985) Immunol Today , vol.6 , pp. 50-55
    • Ernst, P.B.1    Befus, A.D.2    Bienenstock, J.3
  • 4
    • 0015183229 scopus 로고
    • Quantitaten of intraepithelial lymphocytes in human jejunum
    • Ferguson A, Murray D: Quantitaten of intraepithelial lymphocytes in human jejunum. Gut 1971, 12:988-994
    • (1971) Gut , vol.12 , pp. 988-994
    • Ferguson, A.1    Murray, D.2
  • 5
    • 0024413527 scopus 로고
    • T lymphocytes in human gut epithelium preferentially express the α/β antigen receptor and are often CD45/UCHL1-positive
    • Brandtzaeg P, Bosnes V, Halstensen TS, Scott H, Sollid LM, Valnes KN: T lymphocytes in human gut epithelium preferentially express the α/β antigen receptor and are often CD45/UCHL1-positive. Scand J Immunol 1989, 30:123-128
    • (1989) Scand J Immunol , vol.30 , pp. 123-128
    • Brandtzaeg, P.1    Bosnes, V.2    Halstensen, T.S.3    Scott, H.4    Sollid, L.M.5    Valnes, K.N.6
  • 7
    • 0025310166 scopus 로고
    • - lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood
    • - lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur J Immunol 1990, 20:1097-2103
    • (1990) Eur J Immunol , vol.20 , pp. 1097-2103
    • Jarry, A.1    Cerf-Bensussan, N.2    Brousse, N.3    Selz, F.4    Guy-Grand, D.5
  • 8
    • 0025782480 scopus 로고
    • A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment
    • Deusch K, Luling F, Reich K, Classen M, Wagner H, Pfeffer K: A major fraction of human intraepithelial lymphocytes simultaneously expresses the γ/δ T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment. Eur J Immunol 1991, 21:1053-1059
    • (1991) Eur J Immunol , vol.21 , pp. 1053-1059
    • Deusch, K.1    Luling, F.2    Reich, K.3    Classen, M.4    Wagner, H.5    Pfeffer, K.6
  • 9
    • 0029131501 scopus 로고
    • Intra-epithelial lymphocytes: Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium
    • Lundqvist C, Baranov V, Hammarstrom S, Athlin L, Hammarstrom ML: Intra-epithelial lymphocytes: evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol 1995, 7:1473-1487
    • (1995) Int Immunol , vol.7 , pp. 1473-1487
    • Lundqvist, C.1    Baranov, V.2    Hammarstrom, S.3    Athlin, L.4    Hammarstrom, M.L.5
  • 13
    • 0027270344 scopus 로고
    • Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V β T cell receptor genes
    • Blumberg RS, Yockey CE, Gross GG, Ebert EC, Balk SP: Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V β T cell receptor genes. J Immunol. 1993, 150:5144-5153
    • (1993) J Immunol , vol.150 , pp. 5144-5153
    • Blumberg, R.S.1    Yockey, C.E.2    Gross, G.G.3    Ebert, E.C.4    Balk, S.P.5
  • 16
    • 0028875431 scopus 로고
    • In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis
    • Strater J, Koretz K, Gunthert AR, Moller P: In situ detection of enterocytic apoptosis in normal colonic mucosa and in familial adenomatous polyposis. Gut 1995, 37:819-825
    • (1995) Gut , vol.37 , pp. 819-825
    • Strater, J.1    Koretz, K.2    Gunthert, A.R.3    Moller, P.4
  • 19
    • 0022455930 scopus 로고
    • Ultrastructural features of epithelial cell degeneration in rectal crypts of patients with AIDS
    • Kotler DP, Weaver SC, Terzakis JA: Ultrastructural features of epithelial cell degeneration in rectal crypts of patients with AIDS. Am J Surg Pathol 1986, 10:531-538
    • (1986) Am J Surg Pathol , vol.10 , pp. 531-538
    • Kotler, D.P.1    Weaver, S.C.2    Terzakis, J.A.3
  • 20
    • 0027461071 scopus 로고
    • Importance of apoptosis in the histopathology of drug related lesions in the large intestine
    • Lee FD: Importance of apoptosis in the histopathology of drug related lesions in the large intestine. J Clin Pathol 1993, 46:118-122
    • (1993) J Clin Pathol , vol.46 , pp. 118-122
    • Lee, F.D.1
  • 21
    • 0022599629 scopus 로고
    • Examination of the low proliferate capacity of human jejunal intraepithelial lymphocytes
    • Ebert EC, Roberts AI, Brolin RE, Raska K: Examination of the low proliferate capacity of human jejunal intraepithelial lymphocytes. Clin Exp Immunol 1986, 65:148-157
    • (1986) Clin Exp Immunol , vol.65 , pp. 148-157
    • Ebert, E.C.1    Roberts, A.I.2    Brolin, R.E.3    Raska, K.4
  • 22
    • 0024331733 scopus 로고
    • Proliferate responses of human intraepithelial lymphocytes to various T-cell stimuli
    • Ebert EC: Proliferate responses of human intraepithelial lymphocytes to various T-cell stimuli, Gastroenterology 1989, 97:1372-1381
    • (1989) Gastroenterology , vol.97 , pp. 1372-1381
    • Ebert, E.C.1
  • 23
    • 0025027664 scopus 로고
    • Differential responsiveness to CD3-Ti vs. CD2-dependent activation of human intestinal T lymphocytes
    • Pirzer UC, Schurmann G, Post S, Betzler M, Meuer SC: Differential responsiveness to CD3-Ti vs. CD2-dependent activation of human intestinal T lymphocytes. Eur J Immunol 1990, 20:2339-2342
    • (1990) Eur J Immunol , vol.20 , pp. 2339-2342
    • Pirzer, U.C.1    Schurmann, G.2    Post, S.3    Betzler, M.4    Meuer, S.C.5
  • 24
    • 0029074399 scopus 로고
    • Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes
    • Watanabe M, Ueno Y, Yajima T, Iwao Y, Tsuchiya M, Ishikawa H, Aiso S, Hibi T, Ishii H: Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes. J Clin Invest 1995, 95:2945-2953
    • (1995) J Clin Invest , vol.95 , pp. 2945-2953
    • Watanabe, M.1    Ueno, Y.2    Yajima, T.3    Iwao, Y.4    Tsuchiya, M.5    Ishikawa, H.6    Aiso, S.7    Hibi, T.8    Ishii, H.9
  • 25
    • 0024535961 scopus 로고
    • + intraepithelial lymphocytes
    • + intraepithelial lymphocytes. Science 1989, 243:1716-1718
    • (1989) Science , vol.243 , pp. 1716-1718
    • Lefrancois, L.1    Goodman, T.2
  • 26
    • 0025794105 scopus 로고
    • Cytotoxic differentiation of mouse gut thymoaependent and independent intraepithelial T lymphocytes is induced locally: Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules
    • Guy-Grand D, Malassis-Seris M, Briottet C, Vassalli P: Cytotoxic differentiation of mouse gut thymoaependent and independent intraepithelial T lymphocytes is induced locally: correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules. J Exp Med 1991, 173:1549-1552
    • (1991) J Exp Med , vol.173 , pp. 1549-1552
    • Guy-Grand, D.1    Malassis-Seris, M.2    Briottet, C.3    Vassalli, P.4
  • 29
    • 0027286575 scopus 로고
    • Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals
    • Sydora BC, Mixter PF, Holcombe HR, Eghtesady P, Williams K, Amaral MC, Nel A, Kronenberg M: Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals. J Immunol 1993, 150:2179-2191
    • (1993) J Immunol , vol.150 , pp. 2179-2191
    • Sydora, B.C.1    Mixter, P.F.2    Holcombe, H.R.3    Eghtesady, P.4    Williams, K.5    Amaral, M.C.6    Nel, A.7    Kronenberg, M.8
  • 30
    • 0026571296 scopus 로고
    • Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors
    • Taunk J, Roberts Al, Ebert EC: Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors, Gastroenterology 1992, 102:69-75
    • (1992) Gastroenterology , vol.102 , pp. 69-75
    • Taunk, J.1    Al, R.2    Ebert, E.C.3
  • 31
    • 0027755228 scopus 로고
    • Cytotoxic potential of intraepithelial lymphocytes (lELs): Presence of TIA-1, the cytolytic granule-associated protein, in human lELs in normal and diseased intestine
    • Russell GJ, Nagler-Anderson C, Anderson P, Bhan AK: Cytotoxic potential of intraepithelial lymphocytes (lELs): presence of TIA-1, the cytolytic granule-associated protein, in human lELs in normal and diseased intestine. Am J Pathol 1993, 143:350-354
    • (1993) Am J Pathol , vol.143 , pp. 350-354
    • Russell, G.J.1    Nagler-Anderson, C.2    Anderson, P.3    Bhan, A.K.4
  • 32
    • 0029864897 scopus 로고    scopus 로고
    • Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis
    • Oberhuber G, Vogelsang H, Stolte M, Muthenthaler S, Kummer AJ, Radaszkiewicz T: Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis. Am J Pathol 1996, 148:1351-1357
    • (1996) Am J Pathol , vol.148 , pp. 1351-1357
    • Oberhuber, G.1    Vogelsang, H.2    Stolte, M.3    Muthenthaler, S.4    Kummer, A.J.5    Radaszkiewicz, T.6
  • 34
    • 0028258577 scopus 로고
    • Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
    • Heusel JW, Wesselschmidt RL, Shresta S, Russell JH, Ley TJ: Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells. Cell 1994, 76:977-987
    • (1994) Cell , vol.76 , pp. 977-987
    • Heusel, J.W.1    Wesselschmidt, R.L.2    Shresta, S.3    Russell, J.H.4    Ley, T.J.5
  • 36
    • 0029914331 scopus 로고    scopus 로고
    • Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
    • Kagi D, Ledermann B, Burki K, Zinkernagel RM, Hengartner H: Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo. Annu Rev Immunol 1996, 14:207-232
    • (1996) Annu Rev Immunol , vol.14 , pp. 207-232
    • Kagi, D.1    Ledermann, B.2    Burki, K.3    Zinkernagel, R.M.4    Hengartner, H.5
  • 38
    • 0027937745 scopus 로고
    • Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
    • Lowin B, Hahne M, Mattmann C, Tschopp J: Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 1994, 370:650-652
    • (1994) Nature , vol.370 , pp. 650-652
    • Lowin, B.1    Hahne, M.2    Mattmann, C.3    Tschopp, J.4
  • 41
    • 0027311963 scopus 로고
    • + cytotoxic T lymphocyte-mediated lysis
    • + cytotoxic T lymphocyte-mediated lysis. J Immunol 1993, 150:4303-4314
    • (1993) J Immunol , vol.150 , pp. 4303-4314
    • Ratner, A.1    Clark, W.R.2
  • 44
    • 0028053599 scopus 로고
    • Human Fas ligand: Gene structure, chromosomal location and species specificity
    • Takahashi T, Tanaka M, Inazawa J, Abe T, Suda T, Nagata S: Human Fas ligand: gene structure, chromosomal location and species specificity. Int Immunol 1994, 6:1567-1574
    • (1994) Int Immunol , vol.6 , pp. 1567-1574
    • Takahashi, T.1    Tanaka, M.2    Inazawa, J.3    Abe, T.4    Suda, T.5    Nagata, S.6
  • 46
    • 0029982827 scopus 로고    scopus 로고
    • Paneth cells express high levels of CD95 ligand transcripts: A unique property among gastrointestinal epithelia
    • Moller P, Walczak H, Reidl S, Strater J, Krammer PH: Paneth cells express high levels of CD95 ligand transcripts: a unique property among gastrointestinal epithelia. Am J Pathol 1996, 149:9-13
    • (1996) Am J Pathol , vol.149 , pp. 9-13
    • Moller, P.1    Walczak, H.2    Reidl, S.3    Strater, J.4    Krammer, P.H.5
  • 47
    • 0028117098 scopus 로고
    • Modulation of epithelial cell growth by intraepithelial γδ T cells
    • Boismenu R, Havran WL: Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 1994, 266:1253-1255
    • (1994) Science , vol.266 , pp. 1253-1255
    • Boismenu, R.1    Havran, W.L.2
  • 48
    • 0027145632 scopus 로고
    • Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
    • Suda T, Takahashi T, Golstein P, Nagata S: Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 1993, 75:1169-1178
    • (1993) Cell , vol.75 , pp. 1169-1178
    • Suda, T.1    Takahashi, T.2    Golstein, P.3    Nagata, S.4
  • 49
    • 0030050848 scopus 로고    scopus 로고
    • Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes: A potential role for the acidic sphingomyelinase pathway in normal immunoregulation
    • De Maria R, Boirivant M, Cifone MG, Roncaioli P, Hahne M, Tschopp J, Pallone F, Santoni A, Testi R: Functional expression of Fas and Fas ligand on human gut lamina propria T lymphocytes: a potential role for the acidic sphingomyelinase pathway in normal immunoregulation. J Clin Invest 1996, 97:316-322
    • (1996) J Clin Invest , vol.97 , pp. 316-322
    • De Maria, R.1    Boirivant, M.2    Cifone, M.G.3    Roncaioli, P.4    Hahne, M.5    Tschopp, J.6    Pallone, F.7    Santoni, A.8    Testi, R.9
  • 50
    • 0027761955 scopus 로고
    • Cellular localization of tumor necrosis factor (TNF)-α transcripts in normal bowel and in necrotizing enterocolitis: TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages
    • Tan X, Hsueh W, Gonzalez-Crussi F: Cellular localization of tumor necrosis factor (TNF)-α transcripts in normal bowel and in necrotizing enterocolitis: TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages. Am J Pathol 1993, 142:1858-1865
    • (1993) Am J Pathol , vol.142 , pp. 1858-1865
    • Tan, X.1    Hsueh, W.2    Gonzalez-Crussi, F.3
  • 51
    • 0027486125 scopus 로고
    • Location of tumour necrosis factor α by immunohistochemistry in chronic inflammatory bowel disease
    • Murch SH, Braegger CP, Walker-Smith JA, MacDonald TT: Location of tumour necrosis factor α by immunohistochemistry in chronic inflammatory bowel disease. Gut 1993, 34:1705-1709
    • (1993) Gut , vol.34 , pp. 1705-1709
    • Murch, S.H.1    Braegger, C.P.2    Walker-Smith, J.A.3    MacDonald, T.T.4
  • 52
    • 0029135377 scopus 로고
    • Ultrastructural immunogold localization of subcellular sites of TNF-α in colonie Crohn's disease
    • Beil WJ, Weller PF, Peppercorn MA, Galli SJ, Dvorak AM: Ultrastructural immunogold localization of subcellular sites of TNF-α in colonie Crohn's disease. J Leukocyte Biol 1995, 58:284-298
    • (1995) J Leukocyte Biol , vol.58 , pp. 284-298
    • Beil, W.J.1    Weller, P.F.2    Peppercorn, M.A.3    Galli, S.J.4    Dvorak, A.M.5
  • 55
    • 0030239819 scopus 로고    scopus 로고
    • Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions
    • Lundqvist C, Melgar S, Yeung MM, Hammarstrom S, Hammarstrom M-L: Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions. J Immunol 1996, 157:1926-1934
    • (1996) J Immunol , vol.157 , pp. 1926-1934
    • Lundqvist, C.1    Melgar, S.2    Yeung, M.M.3    Hammarstrom, S.4    Hammarstrom, M.-L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.