The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells

Nature Immunology

Volumn 4, Issue 10, 2003, Pages 991-998

  Pennington, Daniel J ^a   Silva Santos, Bruno ^a   Shires, John ^a,c,d   Theodoridis, Efstathios ^a   Pollitt, Christopher ^a   Wise, Emma L ^a   Tigelaar, Robert E ^b   Owen, Michael J ^c,d   Hayday, Adrian C ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL MATURATION; CONTROLLED STUDY; GENE EXPRESSION PROFILING; IMMUNE RESPONSE; LYMPHOCYTE FUNCTION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; T LYMPHOCYTE;

ANIMALS; CELL DIFFERENTIATION; CYCLIC AMP RESPONSE ELEMENT MODULATOR; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENES, T-CELL RECEPTOR; H-Y ANTIGEN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; T-LYMPHOCYTES;

EID: 0142061069     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni979     Document Type: Article

References (47)

1. Raulet, D.H. The structure, function, and molecular genetics of the γδ Tcell receptor. Annu. Rev. Immunol. 7, 175-207 (1989).
2. Haas, W., Pereira, P. & Tonegawa, S. γδ cells. Annu. Rev. Immunol. 11, 637-685 (1993).
3. Born, W. et al. Immunoregulatory functions of γδ T cells. Adv. Immunol. 71, 77-144 (1999).
4. Hayday, A.C. γδ cells: a right time and a right place for a conserved third way of protection. Annu. Rev. Immunol. 18, 975-1026 (2000).
5. Chien, Y.H., Jores, R. & Crowley, M.P. Recognition by γδ T cells. Annu. Rev. Immunol. 14, 511-532 (1996).
6. Mombaerts, P., Arnoldi, J., Russ, F., Tonegawa, S. & Kaufmann, S.H. Different roles of αβ and γδ T cells in immunity against an intracellular bacterial pathogen. Nature 365, 53-56 (1993).
7. Girardi, M. et al. Regulation of cutaneous malignancy by γδ T cells. Science 294, 605-609 (2001).
8. Jameson, J. et al. A role for skin γδ T cells in wound repair. Science 296, 747-749 (2002).
9. Mukasa, A. et al. Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of αβ and γδ T cells. J. Immunol. 155, 2047-2056 (1995).
10. Roberts, S.J. et al. T-cell αβ and γδ deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium. Proc. Natl. Acad. Sci. USA 93, 11774-11779 (1996).
11. Girardi, M. et al. Resident skin-specific γδ T cells provide local, nonredundant regulation of cutaneous inflammation. J. Exp. Med. 195, 855-867 (2002).
12. Bucy, R.P., Chen, C.L., Cihak, J., Losch, U. & Cooper, M.D. Avian T cells expressing γδ receptors localize in the splenic sinusoids and the intestinal epithelium. J. Immunol. 141, 2200-2205 (1988).
13. Boismenu, R. & Havran, W.L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266, 1253-1255 (1994).
14. Fahrer, A.M. et al. Attributes of γδ intraepithelial lymphocytes as suggested by their transcriptional profile. Proc. Natl. Acad. Sci. USA 98, 10261-10266 (2001).
15. + intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity 15, 419-434 (2001).
16. Hubank, M. & Schatz, D.G. Identifying differences in mRNA expression by representational difference analysis of cDNA. Nucleic Acids Res. 22, 5640-5648 (1994).
17. Petrie, H.T., Scollay, R. & Shortman, K. Commitment to the T cell receptor-αβ or -γδ lineages can occur just prior to the onset of CD4 and CD8 expression among immature thymocytes. Eur. J. Immunol. 22, 2185-2188 (1992).
18. Philpott, K.L. et al. Lymphoid development in mice congenitally lacking T cell receptor αβ-expressing cells. Science 256, 1448-1452 (1992).
19. Kehrl, J.H. & Sinnarajah, S. RGS2: a multifunctional regulator of G-protein signaling. Int. J. Biochem. Cell. Biol. 34, 432-438 (2002).
20. He, Y.W. Orphan nuclear receptors in T lymphocyte development. J. Leukoc. Biol. 72, 440-446 (2002).
21. Sassone-Corsi, P. Goals for signal transduction pathways: linking up with transcriptional regulation. EMBO J. 13, 4717-4728 (1994).
22. Bruno, L., Fehling, H.J. & von Boehmer, H. The αβ T cell receptor can replace the γδ receptor in the development of γδ lineage cells. Immunity 5, 343-352 (1996).
23. Mombaerts, P. et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 360, 225-231 (1992).
24. Passoni, L. et al. Intrathymic δ selection events in γδ cell development. Immunity 7, 83-95 (1997).
25. - lymphocytes isolated from normal human gut epithelium display phenotypical features different from their counterparts in peripheral blood. Eur. J. Immunol. 20, 1097-1103 (1990).
26. Lefrançois, L. Phenotypic complexity of intraepithelial lymphocytes of the small intestine. J. Immunol. 147, 1746-1751 (1991).
27. Hayday, A., Theodoridis, E., Ramsburg, E. & Shires, J. Intraepithelial lymphocytes: exploring the Third Way in immunology. Nat. Immunol. 2, 997-1003 (2001).
28. Arstila, T. et al. Identical T cell clones are located within the mouse gut epithelium and lamina propria and circulate in the thoracic duct lymph. J. Exp. Med. 191, 823-834 (2000).
29. Eiseman, E. & Bolen, J.B. Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature 355, 78-80 (1992).
30. Heiken, H., Schulz, R.J., Ravetch, J.V., Reinherz, E.L. & Koyasu, S.T lymphocyte development in the absence of FcE receptor Iγ subunit: analysis of thymic-dependent and independent αβ and γδ pathways. Eur. J. Immunol. 26, 1935-1943 (1996).
31. Laky, K., Lefrancois, L. & Puddington, L. Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine. J. Immunol. 158, 1417-1427 (1997).
32. Suzuki, H., Duncan, G.S., Takimoto, H. & Mak, T.W. Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor β chain. J. Exp. Med. 185, 499-505 (1997).
33. Diefenbach, A. et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3, 1142-1149 (2002).
34. Gilfillan, S., Ho, E.L., Cella, M., Yokoyama, W.M. & Colonna, M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3, 1150-1155 (2002).
35. Kohyama, M. et al. Cytolytic and IFN-γ-producing activities of γδ T cells in the mouse intestinal epithelium are T cell receptor-β-chain dependent. Proc. Natl. Acad. Sci. USA 96, 7451-7455 (1999).
36. Fehling, H.J., Krotkova, A., Saint-Ruf, C. & von Boehmer, H. Crucial role of the pre-T-cell receptor a gene in development of αβ but not γδ T cells. Nature 375, 795-798 (1995).
37. Wilson, A. & MacDonald, H.R. A limited role for β-selection during γδ T cell development. J. Immunol. 161, 5851-5854 (1998).
38. Blendy, J.A., Kaestner, K.H., Weinbauer, G.F., Nieschlag, E. & Schutz, G. Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature 380, 162-165 (1996).
39. + dendritic epidermal cells of adult mice from fetal thymic precursors. Nature 344, 68-70 (1990).
40. Cerdan, C. et al. CD28 costimulation up-regulates long-term IL-2Rβ expression in human T cells through combined transcriptional and post-transcriptional regulation. J. Immunol. 154, 1007-1013 (1995).
41. + T cells in response to CD3-mediated stimulation. J. Leukoc. Biol. 70, 219-224 (2001).
42. Poussier, P., Ning, T., Banerjee, D. & Julius, M. A unique subset of self-specific intraintestinal T cells maintains gut integrity. J. Exp. Med. 195, 1491-1497 (2002).
43. Rabinowich, H. et al. Physical and functional association of Fcμ receptor on human natural killer cells with the ζ- and FcERIγ-chains and with src family protein tyrosine kinases. J. Immunol. 157, 1485-1491 (1996).
44. + T cells by CD1-expressing cortical thymocytes. J. Exp. Med. 182, 2091-2096 (1995).
45. Jenkinson, E.J., Anderson, G. & Owen, J.J. Studies on T cell maturation on defined thymic stromal cell populations in vitro. J. Exp. Med. 176, 845-853 (1992).
46. + T cells during mycobacterial infections. Science 295, 2255-2258 (2002).
47. Wen, L. et al. Primary γδ cell clones can be defined phenotypically and functionally as Th1/Th2 cells and illustrate the association of CD4 with Th2 differentiation. J. Immunol. 160, 1965-1974 (1998).