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Volumn 169, Issue , 1999, Pages 195-207

Colitis in transgenic and knockout animals as models of human inflammatory bowel disease

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

EID: 0032805892     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-065X.1999.tb01316.x     Document Type: Review
Times cited : (142)

References (135)
  • 2
    • 0026432216 scopus 로고
    • Inflammatory bowel disease
    • 2. Podolsky DK. Inflammatory bowel disease. N Engl J Med 1991;325:928-937.
    • (1991) N Engl J Med , vol.325 , pp. 928-937
    • Podolsky, D.K.1
  • 3
    • 0025633436 scopus 로고
    • Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders
    • 3. Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: an animal model of HLA-B27-associated human disorders. Cell 1990;63:1099-1112.
    • (1990) Cell , vol.63 , pp. 1099-1112
    • Hammer, R.E.1    Maika, S.D.2    Richardson, J.A.3    Tang, J.P.4    Taurog, J.D.5
  • 4
    • 0027922467 scopus 로고
    • Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    • 4. Mombaerts P, Mizoguchi E, Grusby MJ, Glimcher LH, Bhan AK, Tonegawa S. Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice. Cell 1993;75:274-282.
    • (1993) Cell , vol.75 , pp. 274-282
    • Mombaerts, P.1    Mizoguchi, E.2    Grusby, M.J.3    Glimcher, L.H.4    Bhan, A.K.5    Tonegawa, S.6
  • 5
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • 5. Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993;75:253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 6
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • 6. Kuhn R, Lohler J, Rennnick D, Rajewsky K, Muller W. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993;75:263-274.
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennnick, D.3    Rajewsky, K.4    Muller, W.5
  • 7
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    • 7. Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995;3:521-530.
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 8
    • 0032901919 scopus 로고    scopus 로고
    • The critical role of interleukin-4 but not interferon-γ in the pathogenesis of colitis in T cell receptor α mutant mice
    • 8. Mizoguchi A, Mizoguchi E, Bhan AK. The critical role of interleukin-4 but not interferon-γ in the pathogenesis of colitis in T cell receptor α mutant mice. Gastroenterology 1999;116:320-326.
    • (1999) Gastroenterology , vol.116 , pp. 320-326
    • Mizoguchi, A.1    Mizoguchi, E.2    Bhan, A.K.3
  • 9
    • 9544226450 scopus 로고    scopus 로고
    • Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human β2 microglobulin transgenic rats
    • 9. Rath HC, et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human β2 microglobulin transgenic rats. J Clin Invest 1996;98:945-953.
    • (1996) J Clin Invest , vol.98 , pp. 945-953
    • Rath, H.C.1
  • 10
    • 0031114247 scopus 로고    scopus 로고
    • high T cells to SCID recipients
    • high T cells to SCID recipients. J Immunol 1997;158:3464-3473.
    • (1997) J Immunol , vol.158 , pp. 3464-3473
    • Aranda, R.1
  • 11
    • 0031012926 scopus 로고    scopus 로고
    • T cell receptor-α β-deficient mice fail to develop colitis in the absence of a microbial environment
    • 11. Dianda L, Hanby AM, Wright NA, Sebesteny A, Hayday AC, Owen MJ. T cell receptor-α β-deficient mice fail to develop colitis in the absence of a microbial environment. Am J Pathol 1997;150:91-97.
    • (1997) Am J Pathol , vol.150 , pp. 91-97
    • Dianda, L.1    Hanby, A.M.2    Wright, N.A.3    Sebesteny, A.4    Hayday, A.C.5    Owen, M.J.6
  • 12
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • 12. Sellon RK, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun 1998;66:5224-5231.
    • (1998) Infect Immun , vol.66 , pp. 5224-5231
    • Sellon, R.K.1
  • 13
    • 0030908361 scopus 로고    scopus 로고
    • Role of cytokines in the early stages of chronic colitis in TCRα-mutant mice
    • 13. Mizoguchi E, Mizoguchi A, Bhan AK. Role of cytokines in the early stages of chronic colitis in TCRα-mutant mice. Lab Invest 1997;76:385-397.
    • (1997) Lab Invest , vol.76 , pp. 385-397
    • Mizoguchi, E.1    Mizoguchi, A.2    Bhan, A.K.3
  • 15
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells
    • 15. Simpson SJ, et al. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon γ expression by T cells. J Exp Med 1998;187:1225-1234.
    • (1998) J Exp Med , vol.187 , pp. 1225-1234
    • Simpson, S.J.1
  • 16
    • 0029085294 scopus 로고
    • T cells in inflammatory bowel disease: Protective and pathogenic roles
    • 16. Powrie F. T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 1995;3:171-174.
    • (1995) Immunity , vol.3 , pp. 171-174
    • Powrie, F.1
  • 17
    • 0030666959 scopus 로고    scopus 로고
    • Suppressive role of B cells in chronic colitis of T cell receptor α mutant mice
    • 17. Mizoguchi A, Mizoguchi E, Smith RN, Preffer FI, Bhan AK. Suppressive role of B cells in chronic colitis of T cell receptor α mutant mice. J Exp Med 1997;186:1749-1756.
    • (1997) J Exp Med , vol.186 , pp. 1749-1756
    • Mizoguchi, A.1    Mizoguchi, E.2    Smith, R.N.3    Preffer, F.I.4    Bhan, A.K.5
  • 18
    • 0026728450 scopus 로고
    • Mechanisms of self tolerance
    • 18. Kroemer G, Martinez C. Mechanisms of self tolerance. Immunol Today 1992;13:401-404.
    • (1992) Immunol Today , vol.13 , pp. 401-404
    • Kroemer, G.1    Martinez, C.2
  • 19
    • 0031756746 scopus 로고    scopus 로고
    • Shifting T-cell activation thresholds in autoimmunity and determinant spreading
    • 19. Lehmann PV, Targoni OS, Forsthuber TG. Shifting T-cell activation thresholds in autoimmunity and determinant spreading. Immunol Rev 1998;164:53-61.
    • (1998) Immunol Rev , vol.164 , pp. 53-61
    • Lehmann, P.V.1    Targoni, O.S.2    Forsthuber, T.G.3
  • 20
    • 0032564353 scopus 로고    scopus 로고
    • Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide
    • 20. Levelt CN, Mizoguchi E, Huang X, Zacks R, Bhan AK, Tonegawa S. Inhibition of intrathymic T cell development by expression of a transgenic antagonist peptide. Proc Natl Acad Sci USA 1998;95:14349-14354.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14349-14354
    • Levelt, C.N.1    Mizoguchi, E.2    Huang, X.3    Zacks, R.4    Bhan, A.K.5    Tonegawa, S.6
  • 21
    • 0031726324 scopus 로고    scopus 로고
    • Crucial function of the pre-T-cell receptor (TCR) in tcrβ selection, TCRβ allelic exclusion and α β versus γ-δ lineage commitment
    • 21. Von Boehmer H, et al. Crucial function of the pre-T-cell receptor (TCR) in TCRβ selection, TCRβ allelic exclusion and α β versus γ-δ lineage commitment. Immunol Rev 1998;165:111-119.
    • (1998) Immunol Rev , vol.165 , pp. 111-119
    • Von Boehmer, H.1
  • 22
  • 23
    • 0009650641 scopus 로고    scopus 로고
    • Genomic structure of the human pre-T cell receptor α chain and expression of two mRNA isoforms
    • 23. Saint-Ruf C, Lechner O, Feinberg J, von Boehmer H. Genomic structure of the human pre-T cell receptor α chain and expression of two mRNA isoforms. Immunol Today 1998;14:131-136.
    • (1998) Immunol Today , vol.14 , pp. 131-136
    • Saint-Ruf, C.1    Lechner, O.2    Feinberg, J.3    Von Boehmer, H.4
  • 24
    • 0026485046 scopus 로고
    • Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
    • 24. Mombaerts P, et al. Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature 1992;360:225-231.
    • (1992) Nature , vol.360 , pp. 225-231
    • Mombaerts, P.1
  • 25
    • 0028275142 scopus 로고
    • Peripheral lymphoid development and function in TCR mutant mice
    • 25. Mombaerts P, et al. Peripheral lymphoid development and function in TCR mutant mice. Int Immunol 1994;6:1061-1070.
    • (1994) Int Immunol , vol.6 , pp. 1061-1070
    • Mombaerts, P.1
  • 26
    • 0029975876 scopus 로고    scopus 로고
    • Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease
    • 26. Mizoguchi A, et al. Cytokine imbalance and autoantibody production in T cell receptor-α mutant mice with inflammatory bowel disease. J Exp Med 1996;183:847-856.
    • (1996) J Exp Med , vol.183 , pp. 847-856
    • Mizoguchi, A.1
  • 27
    • 0029832930 scopus 로고    scopus 로고
    • Role of appendix in the development of inflammatory bowel disease in TCR-α mutant mice
    • 27. Mizoguchi A, Mizoguchi E, Chiba C, Bhan AK. Role of appendix in the development of inflammatory bowel disease in TCR-α mutant mice. J Exp Med 1996;184:707-715.
    • (1996) J Exp Med , vol.184 , pp. 707-715
    • Mizoguchi, A.1    Mizoguchi, E.2    Chiba, C.3    Bhan, A.K.4
  • 28
    • 0029102210 scopus 로고
    • Severe colitis in mice with aberrant thymic selection
    • 28. Hollander GA, et al. Severe colitis in mice with aberrant thymic selection. Immunity 1995;3:27-38.
    • (1995) Immunity , vol.3 , pp. 27-38
    • Hollander, G.A.1
  • 29
    • 0030637062 scopus 로고    scopus 로고
    • Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes
    • 29. Ludviksson BR, Gray B, Strober W, Ehrhardt RO. Dysregulated intrathymic development in the IL-2-deficient mouse leads to colitis-inducing thymocytes. J Immunol 1997;158:104-111.
    • (1997) J Immunol , vol.158 , pp. 104-111
    • Ludviksson, B.R.1    Gray, B.2    Strober, W.3    Ehrhardt, R.O.4
  • 30
    • 0030808125 scopus 로고    scopus 로고
    • Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice
    • 30. Clegg CH, et al. Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice. Int Immunol 1997;9:1111-1122.
    • (1997) Int Immunol , vol.9 , pp. 1111-1122
    • Clegg, C.H.1
  • 31
    • 0032055789 scopus 로고    scopus 로고
    • A tale of two T cells
    • 31. Janeway CA Jr. A tale of two T cells. Immunity 1998;8:391-394.
    • (1998) Immunity , vol.8 , pp. 391-394
    • Janeway C.A., Jr.1
  • 32
    • 0030267661 scopus 로고    scopus 로고
    • + lymphocytes in chronic inflammatory bowel disease
    • + lymphocytes in chronic inflammatory bowel disease. J Immunol 1996;157:3183-3191.
    • (1996) J Immunol , vol.157 , pp. 3183-3191
    • Probert, C.S.1
  • 34
    • 0029942841 scopus 로고    scopus 로고
    • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non α/β" T cells
    • 34. Wen L, et al. Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non α/β" T cells. J Exp Med 1996;183:2271-2282.
    • (1996) J Exp Med , vol.183 , pp. 2271-2282
    • Wen, L.1
  • 35
    • 0029119248 scopus 로고
    • Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice
    • 35. Mombaerts P, Terhorst C, Jacks T, Tonegawa S, Sancho J. Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice. Proc Natl Acad Sci USA 1995;92:7420-7424.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 7420-7424
    • Mombaerts, P.1    Terhorst, C.2    Jacks, T.3    Tonegawa, S.4    Sancho, J.5
  • 36
    • 0032110231 scopus 로고    scopus 로고
    • The expression in vivo of a second isoform of pTα: Implications for the mechanism of pTα action
    • 36. Barber DF, Passoni L, Wen L, Geng L, Hayday AC. The expression in vivo of a second isoform of pTα: implications for the mechanism of pTα action. J Immunol 1998;161:11-16.
    • (1998) J Immunol , vol.161 , pp. 11-16
    • Barber, D.F.1    Passoni, L.2    Wen, L.3    Geng, L.4    Hayday, A.C.5
  • 37
    • 4244209673 scopus 로고    scopus 로고
    • The appendix is a priming site for the development of chronic colitis in TCRα-mutant mice
    • 37. Mizoguchi A, Mizoguchi E, Bhan AK. The appendix is a priming site for the development of chronic colitis in TCRα-mutant mice. Gastroenterology 1997;112:A1043.
    • (1997) Gastroenterology , vol.112
    • Mizoguchi, A.1    Mizoguchi, E.2    Bhan, A.K.3
  • 39
    • 0031957145 scopus 로고    scopus 로고
    • The search for pathogenic antigens in ulcerative colitis
    • 39. Targan SR. The search for pathogenic antigens in ulcerative colitis. Gastroenterology 1998;114:1099-1100.
    • (1998) Gastroenterology , vol.114 , pp. 1099-1100
    • Targan, S.R.1
  • 40
    • 0032536827 scopus 로고    scopus 로고
    • + T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: Increased T helper cell type 1 response and ability to transfer disease
    • + T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 1998;187:855-864.
    • (1998) J Exp Med , vol.187 , pp. 855-864
    • Cong, Y.1
  • 41
    • 0029791547 scopus 로고    scopus 로고
    • Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRα mutant mice with inflammatory bowel disease
    • 41. Mizoguchi A, Mizoguchi E, Tonegawa S, Bhan AK. Alteration of a polyclonal to an oligoclonal immune response to cecal aerobic bacterial antigens in TCRα mutant mice with inflammatory bowel disease. Int Immunol 1996;8:1387-1394.
    • (1996) Int Immunol , vol.8 , pp. 1387-1394
    • Mizoguchi, A.1    Mizoguchi, E.2    Tonegawa, S.3    Bhan, A.K.4
  • 42
    • 0031925611 scopus 로고    scopus 로고
    • Give us this day our daily germs
    • 42. Rook GA, Stanford JL. Give us this day our daily germs. Immunol Today 1998;19:113-116.
    • (1998) Immunol Today , vol.19 , pp. 113-116
    • Rook, G.A.1    Stanford, J.L.2
  • 43
    • 0030900764 scopus 로고    scopus 로고
    • The anatomical basis of intestinal immunity
    • 43. Mowat AM, Viney JL. The anatomical basis of intestinal immunity. Immunol Rev 1997;156:145-166.
    • (1997) Immunol Rev , vol.156 , pp. 145-166
    • Mowat, A.M.1    Viney, J.L.2
  • 44
    • 0031404030 scopus 로고    scopus 로고
    • Specific-pathogen-free conditions enhance inflammatory bowel disease in T-cell receptor knockout, but not C3H/HeJBir mice
    • 44. Gaskins HR, Vondrak-Juergens GL, McCracken BA, Woolsey JH. Specific-pathogen-free conditions enhance inflammatory bowel disease in T-cell receptor knockout, but not C3H/HeJBir mice. Lab Anim Sci 1997;47:650-655.
    • (1997) Lab Anim Sci , vol.47 , pp. 650-655
    • Gaskins, H.R.1    Vondrak-Juergens, G.L.2    McCracken, B.A.3    Woolsey, J.H.4
  • 45
    • 0032090186 scopus 로고    scopus 로고
    • Spontaneous inflammatory bowel disease in multiple mutant mouse lines: Association with colonization by Helicobacter hepaticus
    • 45. Foltz CJ, et al. Spontaneous inflammatory bowel disease in multiple mutant mouse lines: association with colonization by Helicobacter hepaticus. Helicobacter 1998;3:69-78.
    • (1998) Helicobacter , vol.3 , pp. 69-78
    • Foltz, C.J.1
  • 46
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specific pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12 and γ interferon-dependent mechanism
    • 46. Kullberg MC, et al. Helicobacter hepaticus triggers colitis in specific pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12 and γ interferon-dependent mechanism. Infect Immun 1998;66:5157-5166.
    • (1998) Infect Immun , vol.66 , pp. 5157-5166
    • Kullberg, M.C.1
  • 47
    • 0028332095 scopus 로고
    • M cells - Entryways of opportunity for enteropathogens
    • 47. Owen RL. M cells - entryways of opportunity for enteropathogens. J Exp Med 1994;180:7-9.
    • (1994) J Exp Med , vol.180 , pp. 7-9
    • Owen, R.L.1
  • 48
    • 0020084531 scopus 로고
    • Cell renewal and migration in lymphoid follicles of Peyer's patches and cecum - an autoradiographic study in mice
    • 48. Bhalla DK, Owen RL. Cell renewal and migration in lymphoid follicles of Peyer's patches and cecum - an autoradiographic study in mice. Gastroenterology 1982;82:232-242.
    • (1982) Gastroenterology , vol.82 , pp. 232-242
    • Bhalla, D.K.1    Owen, R.L.2
  • 51
    • 0029923042 scopus 로고    scopus 로고
    • MALTectomy (appendectomy/tonsillectomy) does not influence the occurrence or mode of presentation of adult celiac disease
    • 51. O'Gorman P, et al. MALTectomy (appendectomy/tonsillectomy) does not influence the occurrence or mode of presentation of adult celiac disease. Am J Gastroenterol 1996;91:723-725.
    • (1996) Am J Gastroenterol , vol.91 , pp. 723-725
    • O'Gorman, P.1
  • 52
    • 0030802981 scopus 로고    scopus 로고
    • Appendectomy and the risk of developing ulcerative colitis or Crohn's disease: Results of a large case-control study. South limburg inflammatory bowel disease study group
    • 52. Russel MG, et al. Appendectomy and the risk of developing ulcerative colitis or Crohn's disease: results of a large case-control study. South Limburg Inflammatory Bowel Disease Study Group. Gastroenterology 1997;113:377-382.
    • (1997) Gastroenterology , vol.113 , pp. 377-382
    • Russel, M.G.1
  • 53
    • 0031689619 scopus 로고    scopus 로고
    • Appendectomy, childhood hygeine, Helicobacter pylori, and risk of inflammatory bowel disease: A case control study
    • 53. Duggan AE, Usmani I, Neal KR, Logan RFA. Appendectomy, childhood hygeine, Helicobacter pylori, and risk of inflammatory bowel disease: a case control study. Gut 1998;43:494-498.
    • (1998) Gut , vol.43 , pp. 494-498
    • Duggan, A.E.1    Usmani, I.2    Neal, K.R.3    Logan, R.F.A.4
  • 55
    • 0032526326 scopus 로고    scopus 로고
    • Mucosal addressin is required for the development of diabetes in nonobese diabetic mice
    • 55. Hanninen A, Jaakkola I, Jalkanen S. Mucosal addressin is required for the development of diabetes in nonobese diabetic mice. J Immunol 1998;160:6018-6025.
    • (1998) J Immunol , vol.160 , pp. 6018-6025
    • Hanninen, A.1    Jaakkola, I.2    Jalkanen, S.3
  • 56
    • 0032521507 scopus 로고    scopus 로고
    • + αβ T cells in lpr mice: The appendix in normal mice
    • + αβ T cells in lpr mice: the appendix in normal mice. J Immunol 1998;160:2665-2674.
    • (1998) J Immunol , vol.160 , pp. 2665-2674
    • Yamagiwa, S.1
  • 57
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • 57. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173.
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 58
    • 0032033419 scopus 로고    scopus 로고
    • Cytokines induce the development of functionally heterogeneous T helper cell subsets
    • 58. O'Garra A: Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 1998;8:275-283.
    • (1998) Immunity , vol.8 , pp. 275-283
    • O'Garra, A.1
  • 59
    • 0029847368 scopus 로고    scopus 로고
    • Functional diversity of helper T lymphocytes
    • 59. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.
    • (1996) Nature , vol.383 , pp. 787-793
    • Abbas, A.K.1    Murphy, K.M.2    Sher, A.3
  • 60
    • 0030739650 scopus 로고    scopus 로고
    • Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease
    • 60. Lafaille JJ, et al. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med 1997;186:307-312.
    • (1997) J Exp Med , vol.186 , pp. 307-312
    • Lafaille, J.J.1
  • 61
    • 0030742237 scopus 로고    scopus 로고
    • T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice
    • 61. Pakala SV, Kurrer MO, Katz JD. T helper 2 (Th2) T cells induce acute pancreatitis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J Exp Med 1997;186:299-306.
    • (1997) J Exp Med , vol.186 , pp. 299-306
    • Pakala, S.V.1    Kurrer, M.O.2    Katz, J.D.3
  • 62
    • 0030209985 scopus 로고    scopus 로고
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
    • + lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol 1996;157:1261-1270.
    • (1996) J Immunol , vol.157 , pp. 1261-1270
    • Fuss, I.J.1
  • 63
    • 0031057872 scopus 로고    scopus 로고
    • Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease
    • 63. Parronchi P, et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am J Pathol 1997;150:823-832.
    • (1997) Am J Pathol , vol.150 , pp. 823-832
    • Parronchi, P.1
  • 64
    • 0031763281 scopus 로고    scopus 로고
    • Mucosal immunoregulation and inflammatory bowel disease: New insights from murine models of inflammation
    • 64. Strober W, Fuss IJ, Ehrhardt RO, Neurath M, Boirivant M, Ludviksson BR. Mucosal immunoregulation and inflammatory bowel disease: new insights from murine models of inflammation. Scand J Immunol 1998;48:453-458.
    • (1998) Scand J Immunol , vol.48 , pp. 453-458
    • Strober, W.1    Fuss, I.J.2    Ehrhardt, R.O.3    Neurath, M.4    Boirivant, M.5    Ludviksson, B.R.6
  • 65
    • 0001454772 scopus 로고    scopus 로고
    • Upregulation of the IL-12/STAT-4 signaling pathway distinguishes Crohn's disease from ulcerative colitis
    • 65. Neurath MF, Fuss I, Schurmann G. Upregulation of the IL-12/STAT-4 signaling pathway distinguishes Crohn's disease from ulcerative colitis. Gastroenterology 1998;114:G4299.
    • (1998) Gastroenterology , vol.114
    • Neurath, M.F.1    Fuss, I.2    Schurmann, G.3
  • 66
    • 0031760741 scopus 로고    scopus 로고
    • Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis
    • 66. Mackay F, et al. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology 1998;115:1464-1475.
    • (1998) Gastroenterology , vol.115 , pp. 1464-1475
    • Mackay, F.1
  • 67
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • 67. Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995;182:1281-1290.
    • (1995) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 68
    • 0031066597 scopus 로고    scopus 로고
    • + T cells and proinflammatory Th1-type cytokines
    • + T cells and proinflammatory Th1-type cytokines. J Immunol 1997;158:1068-1077.
    • (1997) J Immunol , vol.158 , pp. 1068-1077
    • Hornquist, C.E.1
  • 69
    • 0032530697 scopus 로고    scopus 로고
    • IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
    • 69. Davidson NJ, Hudak SA, Lesley RE, Menon S, Leach MW, Rennick DM. IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J Immunol 1998;161:3143-3149.
    • (1998) J Immunol , vol.161 , pp. 3143-3149
    • Davidson, N.J.1    Hudak, S.A.2    Lesley, R.E.3    Menon, S.4    Leach, M.W.5    Rennick, D.M.6
  • 70
    • 0031568001 scopus 로고    scopus 로고
    • Induction and prevention of colonic inflammation in IL-2-deficient mice
    • 70. Ehrhardt RO, Ludviksson BR, Gray B, Neurath M, Strober W. Induction and prevention of colonic inflammation in IL-2-deficient mice. J Immunol 1997;158:566-573.
    • (1997) J Immunol , vol.158 , pp. 566-573
    • Ehrhardt, R.O.1    Ludviksson, B.R.2    Gray, B.3    Neurath, M.4    Strober, W.5
  • 71
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils
    • 71. Takeda K, et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils. Immunity 1999;10:39-49.
    • (1999) Immunity , vol.10 , pp. 39-49
    • Takeda, K.1
  • 72
    • 0029995799 scopus 로고    scopus 로고
    • Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance
    • 72. Neurath MF, Fuss I, Kelsall BL, Presky DH, Waegell W, Strober W. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance. J Exp Med 1996;183:2605-2616.
    • (1996) J Exp Med , vol.183 , pp. 2605-2616
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Presky, D.H.4    Waegell, W.5    Strober, W.6
  • 74
    • 7144227303 scopus 로고    scopus 로고
    • Effects of murine recombinant interleukin-10 on the inflammatory disease of rats transgenic for HLA-B27 and human β 2-microglobulin
    • 74. Bertrand V, et al. Effects of murine recombinant interleukin-10 on the inflammatory disease of rats transgenic for HLA-B27 and human β 2-microglobulin. Eur Cytokine Netw 1998;9:161-170.
    • (1998) Eur Cytokine Netw , vol.9 , pp. 161-170
    • Bertrand, V.1
  • 75
    • 0030781954 scopus 로고    scopus 로고
    • Antineutrophil cytoplasmic antibodies in T-cell receptor α deficient mice with chronic colitis
    • 75. Mizoguchi E, Mizoguchi A, Chiba C, Niles JL, Bhan AK. Antineutrophil cytoplasmic antibodies in T-cell receptor α deficient mice with chronic colitis. Gastroenterology 1997;113:1828-1835.
    • (1997) Gastroenterology , vol.113 , pp. 1828-1835
    • Mizoguchi, E.1    Mizoguchi, A.2    Chiba, C.3    Niles, J.L.4    Bhan, A.K.5
  • 76
    • 0031004877 scopus 로고    scopus 로고
    • + T-cell population mediates development of inflammatory bowel disease in T-cell receptor a chain-deficient mice
    • + T-cell population mediates development of inflammatory bowel disease in T-cell receptor a chain-deficient mice. Gastroenterology 1997;112:1876-1886.
    • (1997) Gastroenterology , vol.112 , pp. 1876-1886
    • Takahashi, I.1    Kiyono, H.2    Hamada, S.3
  • 77
    • 0031570453 scopus 로고    scopus 로고
    • IL-6 rescues resting mouse T cells from apoptosis
    • 77. Teague TK, Marrack P, Kappler JW, Vella AT. IL-6 rescues resting mouse T cells from apoptosis. J Immunol 1997;158:5791-5796.
    • (1997) J Immunol , vol.158 , pp. 5791-5796
    • Teague, T.K.1    Marrack, P.2    Kappler, J.W.3    Vella, A.T.4
  • 79
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Role of IL-6 in the activation and differentiation of autoreactive T cells
    • 79. Samoilova EB, Horton JL, Hilliard B, Lin TST, Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: role of IL-6 in the activation and differentiation of autoreactive T cells. J Immunol 1998;161:6480-6486.
    • (1998) J Immunol , vol.161 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Lin, T.S.T.4    Chen, Y.5
  • 80
    • 0032410575 scopus 로고    scopus 로고
    • In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen
    • 80. Drakesmith H. In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen. Proc Natl Acad Sci USA 1998;95:14903-14908.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14903-14908
    • Drakesmith, H.1
  • 81
    • 0030954732 scopus 로고    scopus 로고
    • A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. Crohn's disease cA2 study group
    • 81. Targan SR, et al. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease. Crohn's Disease cA2 Study Group. N Engl J Med 1997;337:1029-1035.
    • (1997) N Engl J Med , vol.337 , pp. 1029-1035
    • Targan, S.R.1
  • 83
    • 0028906467 scopus 로고
    • Impaired mucosal immune responses in interleukin 4-targeted mice
    • 83. Vajdy M, Kosco-Vilbois MH, Kopf M, Kohler G, Lycke N. Impaired mucosal immune responses in interleukin 4-targeted mice. J Exp Med 1995;181:41-53.
    • (1995) J Exp Med , vol.181 , pp. 41-53
    • Vajdy, M.1    Kosco-Vilbois, M.H.2    Kopf, M.3    Kohler, G.4    Lycke, N.5
  • 84
    • 0031759373 scopus 로고    scopus 로고
    • T-cell survival
    • 84. Marrack P, et al. T-cell survival. Immunol Rev 1998;165:279-285.
    • (1998) Immunol Rev , vol.165 , pp. 279-285
    • Marrack, P.1
  • 85
    • 0032472838 scopus 로고    scopus 로고
    • Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa
    • 85. Watanabe M, et al. Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 1998;187:389-402.
    • (1998) J Exp Med , vol.187 , pp. 389-402
    • Watanabe, M.1
  • 86
    • 0028179230 scopus 로고
    • + T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • + T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994;179:589-600.
    • (1994) J Exp Med , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 87
    • 0030704726 scopus 로고    scopus 로고
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997;389:737-742.
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1
  • 88
    • 0030942666 scopus 로고    scopus 로고
    • Altered immune responses in interleukin 10 transgenic mice
    • 88. Hagenbaugh A, et al. Altered immune responses in interleukin 10 transgenic mice. J Exp Med 1997;185:2101-2110.
    • (1997) J Exp Med , vol.185 , pp. 2101-2110
    • Hagenbaugh, A.1
  • 89
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • 89. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994;265:1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 90
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: A murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
    • 90. Boirivant M, Fuss IJ, Chu A, Strober W. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 1998;188:1929-1939.
    • (1998) J Exp Med , vol.188 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3    Strober, W.4
  • 91
    • 0031716664 scopus 로고    scopus 로고
    • IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis
    • 91. Inobe J, Slavin AJ, Komagata Y, Chen Y, Liu L, Weiner HL. IL-4 is a differentiation factor for transforming growth factor-β secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur J Immunol 1998;28:2780-2790.
    • (1998) Eur J Immunol , vol.28 , pp. 2780-2790
    • Inobe, J.1    Slavin, A.J.2    Komagata, Y.3    Chen, Y.4    Liu, L.5    Weiner, H.L.6
  • 92
    • 0032538918 scopus 로고    scopus 로고
    • + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis
    • + T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitis. J Exp Med 1998;188:1883-1894.
    • (1998) J Exp Med , vol.188 , pp. 1883-1894
    • Olivares-Villagomez, D.1    Wang, Y.2    Lafaille, J.J.3
  • 93
    • 0032538820 scopus 로고    scopus 로고
    • + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice
    • + T cells prevent spontaneous experimental autoimmune encephalomyelitis in anti-myelin basic protein T cell receptor transgenic mice. J Exp Med 1998;188:1875-1882.
    • (1998) J Exp Med , vol.188 , pp. 1875-1882
    • Van De Keere, F.1    Tonegawa, S.2
  • 94
    • 0032538904 scopus 로고    scopus 로고
    • Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes
    • 94. Lehuen A, et al. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J Exp Med 1998;188:1831-1839.
    • (1998) J Exp Med , vol.188 , pp. 1831-1839
    • Lehuen, A.1
  • 95
    • 16044374633 scopus 로고    scopus 로고
    • Essential requirement of an invariant V α 14 T cell antigen receptor expression in the development of natural killer T cells
    • 95. Taniguchi M, et al. Essential requirement of an invariant V α 14 T cell antigen receptor expression in the development of natural killer T cells. Proc Natl Acad Sci USA 1996;93:11015-11018.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11015-11018
    • Taniguchi, M.1
  • 98
    • 0028877061 scopus 로고
    • T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice
    • 98. Ma A, Datta M, Margosian E, Chen J, Horak I. T cells, but not B cells, are required for bowel inflammation in interleukin 2-deficient mice. J Exp Med 1995;182:1567-1572.
    • (1995) J Exp Med , vol.182 , pp. 1567-1572
    • Ma, A.1    Datta, M.2    Margosian, E.3    Chen, J.4    Horak, I.5
  • 99
    • 0030018186 scopus 로고    scopus 로고
    • + T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    • + T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 1996;184:241-251.
    • (1996) J Exp Med , vol.184 , pp. 241-251
    • Davidson, N.J.1
  • 100
    • 0029073633 scopus 로고
    • Perinuclear antineutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients
    • 100. Targan SR, Landers CJ, Cobb L, MacDermott RP, Vidrich A. Perinuclear antineutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients. J Immunol 1995;155:3262-3267.
    • (1995) J Immunol , vol.155 , pp. 3262-3267
    • Targan, S.R.1    Landers, C.J.2    Cobb, L.3    MacDermott, R.P.4    Vidrich, A.5
  • 101
    • 0031958070 scopus 로고    scopus 로고
    • Tropomyosin isoforms in intestinal mucosa: Production of autoantibodies to tropomyosin isoforms in ulcerative colitis
    • 101. Geng X, et al. Tropomyosin isoforms in intestinal mucosa: production of autoantibodies to tropomyosin isoforms in ulcerative colitis. Gastroenterology 1998;114:912-922.
    • (1998) Gastroenterology , vol.114 , pp. 912-922
    • Geng, X.1
  • 102
    • 0028457164 scopus 로고
    • + T cells
    • + T cells. Nature 1994;369:654-658.
    • (1994) Nature , vol.369 , pp. 654-658
    • Wen, L.1
  • 103
    • 0030456897 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice
    • 103. Wolf SD, Dittel BN, Hardardottir F, Janeway CA Jr. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med 1996;184:2271-2278.
    • (1996) J Exp Med , vol.184 , pp. 2271-2278
    • Wolf, S.D.1    Dittel, B.N.2    Hardardottir, F.3    Janeway C.A., Jr.4
  • 104
    • 43949172708 scopus 로고
    • Phagocyte recognition of cells undergoing apoptosis
    • 104. Savill J, Fadok V, Henson P, Haslett C. Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993;14:131-136.
    • (1993) Immunol Today , vol.14 , pp. 131-136
    • Savill, J.1    Fadok, V.2    Henson, P.3    Haslett, C.4
  • 105
    • 0031825552 scopus 로고    scopus 로고
    • Systemic exposure to irradiated apoptotic cells induces autoantibody production
    • 105. Mevorach D, Zhou JL, Song X, Elkon KB. Systemic exposure to irradiated apoptotic cells induces autoantibody production. J Exp Med 1998;188:387-392.
    • (1998) J Exp Med , vol.188 , pp. 387-392
    • Mevorach, D.1    Zhou, J.L.2    Song, X.3    Elkon, K.B.4
  • 107
    • 0023612719 scopus 로고
    • Evidence for function of 1a molecules on gut epithelial cells in man
    • 107. Mayer L, Shlien R. Evidence for function of 1a molecules on gut epithelial cells in man. J Exp Med 1987;166:1471-1483.
    • (1987) J Exp Med , vol.166 , pp. 1471-1483
    • Mayer, L.1    Shlien, R.2
  • 108
    • 0028069666 scopus 로고
    • Stimulation of lamina propria lymphocytes by intestinal epithelial cells: Evidence for recognition of nonclassical restriction elements
    • 108. Panja A, Barone A, Mayer L. Stimulation of lamina propria lymphocytes by intestinal epithelial cells: evidence for recognition of nonclassical restriction elements. J Exp Med 1994;179:943-950.
    • (1994) J Exp Med , vol.179 , pp. 943-950
    • Panja, A.1    Barone, A.2    Mayer, L.3
  • 109
    • 1842373829 scopus 로고    scopus 로고
    • Defective expression of gp180, a novel CD8 ligand on intestinal epithelial cells, in inflammatory bowel disease
    • 109. Toy LS, Yio XY, Lin A, Honig S, Mayer L. Defective expression of gp180, a novel CD8 ligand on intestinal epithelial cells, in inflammatory bowel disease. J Clin Invest 1997;100:2062-2071.
    • (1997) J Clin Invest , vol.100 , pp. 2062-2071
    • Toy, L.S.1    Yio, X.Y.2    Lin, A.3    Honig, S.4    Mayer, L.5
  • 110
    • 0028972499 scopus 로고
    • Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin
    • 110. Hermiston ML, Gordon JI. Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherin. Science 1995;270:1203-1207.
    • (1995) Science , vol.270 , pp. 1203-1207
    • Hermiston, M.L.1    Gordon, J.I.2
  • 111
    • 0028607055 scopus 로고
    • Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice
    • 111. Baribault H, Penner J, Jozzo RV, Wilson-Heiner M. Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice. Genes Dev 1994;8:2964-2973.
    • (1994) Genes Dev , vol.8 , pp. 2964-2973
    • Baribault, H.1    Penner, J.2    Jozzo, R.V.3    Wilson-Heiner, M.4
  • 112
    • 0032534043 scopus 로고    scopus 로고
    • A novel model of inflammatory bowel disease: Mice deficient for the multiple drug resistance, mdr1a, spontaneously develop colitis
    • 112. Panwala CM, Jones JC, Viney JL. A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance, mdr1a, spontaneously develop colitis. J Immunol 1998;161:5733-5744.
    • (1998) J Immunol , vol.161 , pp. 5733-5744
    • Panwala, C.M.1    Jones, J.C.2    Viney, J.L.3
  • 113
    • 0028231686 scopus 로고
    • Fibroblast growth factors modulate intestinal epithelial cell growth and migration
    • 113. Dignass AU, Tsunekawa S, Podolsky DK. Fibroblast growth factors modulate intestinal epithelial cell growth and migration. Gastroenterology 1994;106:1254-1262.
    • (1994) Gastroenterology , vol.106 , pp. 1254-1262
    • Dignass, A.U.1    Tsunekawa, S.2    Podolsky, D.K.3
  • 114
    • 0030848520 scopus 로고    scopus 로고
    • Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice
    • 114. Koh TJ, et al. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology 1997;113:1015-1025.
    • (1997) Gastroenterology , vol.113 , pp. 1015-1025
    • Koh, T.J.1
  • 115
    • 0029828745 scopus 로고    scopus 로고
    • Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
    • 115. Mashimo H, Wu DC, Podolsky DK, Fishman MC. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996;274:262-265.
    • (1996) Science , vol.274 , pp. 262-265
    • Mashimo, H.1    Wu, D.C.2    Podolsky, D.K.3    Fishman, M.C.4
  • 116
    • 0031987359 scopus 로고    scopus 로고
    • γδ T cells in host defense and epithelial cell biology
    • 116. Boismenu R, Havran WL. γδ T cells in host defense and epithelial cell biology. Clin Immunol Immunopathol 1998;86:121-133.
    • (1998) Clin Immunol Immunopathol , vol.86 , pp. 121-133
    • Boismenu, R.1    Havran, W.L.2
  • 117
    • 0030752587 scopus 로고    scopus 로고
    • Mice lacking transforming growth factor α have an increased susceptibility to dextran sulfate-induced colitis
    • 117. Egger B, et al. Mice lacking transforming growth factor α have an increased susceptibility to dextran sulfate-induced colitis. Gastroenterology 1997;113:825-832.
    • (1997) Gastroenterology , vol.113 , pp. 825-832
    • Egger, B.1
  • 118
    • 0032030636 scopus 로고    scopus 로고
    • A mucosal intranet: Intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes
    • 118. Yamamoto M, Fujihashi K, Kawabata K, McGhee JR, Kiyono H. A mucosal intranet: intestinal epithelial cells down-regulate intraepithelial, but not peripheral, T lymphocytes. J Immunol 1998;160:2188-2196.
    • (1998) J Immunol , vol.160 , pp. 2188-2196
    • Yamamoto, M.1    Fujihashi, K.2    Kawabata, K.3    McGhee, J.R.4    Kiyono, H.5
  • 119
    • 0029016752 scopus 로고
    • Homeostatic regulation of intestinal epithelia by intraepithelial γδ T cells
    • 119. Komano H, et al. Homeostatic regulation of intestinal epithelia by intraepithelial γδ T cells. Proc Natl Acad Sci USA 1995;92:6147-6151.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 6147-6151
    • Komano, H.1
  • 120
    • 0028117098 scopus 로고
    • Modulation of epithelial cell growth by intraepithelial γδ T cells
    • 120. Boismenu R, Havran WL. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 1994;266:1253-1255.
    • (1994) Science , vol.266 , pp. 1253-1255
    • Boismenu, R.1    Havran, W.L.2
  • 121
    • 0030210745 scopus 로고    scopus 로고
    • Chemokine expression by intraepithelial γδ T cells. Implications for the recruitment of inflammatory cells to damaged epithelia
    • 121. Boismenu R, Feng L, Xia YY, Chang JC, Havran WL. Chemokine expression by intraepithelial γδ T cells. Implications for the recruitment of inflammatory cells to damaged epithelia. J Immunol 1996;157:985-992.
    • (1996) J Immunol , vol.157 , pp. 985-992
    • Boismenu, R.1    Feng, L.2    Xia, Y.Y.3    Chang, J.C.4    Havran, W.L.5
  • 122
    • 0031446766 scopus 로고    scopus 로고
    • γδ cells regulate autoimmunity
    • 122. Hayday A, Geng L. γδ cells regulate autoimmunity. Curr Opin Immunol 1997;9:884-889.
    • (1997) Curr Opin Immunol , vol.9 , pp. 884-889
    • Hayday, A.1    Geng, L.2
  • 123
    • 0029813545 scopus 로고    scopus 로고
    • + TH1-like responses
    • + TH1-like responses. J Clin Invest 1996;98:1010-1020.
    • (1996) J Clin Invest , vol.98 , pp. 1010-1020
    • Berg, D.J.1
  • 124
    • 0031954425 scopus 로고    scopus 로고
    • Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice
    • 124. Meijssen MA, Brandwein SL, Reinecker HC, Bhan AK, Podolsky DK. Alteration of gene expression by intestinal epithelial cells precedes colitis in interleukin-2-deficient mice. Am J Physiol 1998;274: G472-G479.
    • (1998) Am J Physiol , vol.274
    • Meijssen, M.A.1    Brandwein, S.L.2    Reinecker, H.C.3    Bhan, A.K.4    Podolsky, D.K.5
  • 125
    • 0027436376 scopus 로고
    • Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β
    • 125. Dignass AU, Podolsky DK. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor β. Gastroenterology 1993;105:1323-1332.
    • (1993) Gastroenterology , vol.105 , pp. 1323-1332
    • Dignass, A.U.1    Podolsky, D.K.2
  • 126
    • 0027146545 scopus 로고
    • Differential cytokine expression by human intestinal epithelial cell lines: Regulated expressions of interleukin-8
    • 126. Eckmann L, Jung HC, Schurer-Maly C, Panja A, Morzycka Wroblewska E, Kagnoff MF. Differential cytokine expression by human intestinal epithelial cell lines: regulated expressions of interleukin-8. Gastroenterology 1993;105:1689-1697.
    • (1993) Gastroenterology , vol.105 , pp. 1689-1697
    • Eckmann, L.1    Jung, H.C.2    Schurer-Maly, C.3    Panja, A.4    Morzycka Wroblewska, E.5    Kagnoff, M.F.6
  • 127
    • 0029114643 scopus 로고
    • Human intestinal epithelial cells express functional cytokine receptors sharing the common γc chain of interleukin 2 receptor
    • 127. Reinecker HC, Podolsky DK. Human intestinal epithelial cells express functional cytokine receptors sharing the common γc chain of interleukin 2 receptor. Proc Natl Acad Sci USA 1995;92:8353-8357.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 8353-8357
    • Reinecker, H.C.1    Podolsky, D.K.2
  • 129
    • 0025219434 scopus 로고
    • Interleukin-6 and its receptor are expressed in human intestinal epithelial cells
    • 129. Shirato K, LeDuy L, Yuan SY, Jothy S. Interleukin-6 and its receptor are expressed in human intestinal epithelial cells. Virchows Arch 1990;58:303-308.
    • (1990) Virchows Arch , vol.58 , pp. 303-308
    • Shirato, K.1    LeDuy, L.2    Yuan, S.Y.3    Jothy, S.4
  • 130
    • 0030860713 scopus 로고    scopus 로고
    • Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis
    • 130. Keates S, Keates AC, Mizoguchi E, Bhan AK, Kelly CP. Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis. Am J Physiol 1997;273:G75-G82.
    • (1997) Am J Physiol , vol.273
    • Keates, S.1    Keates, A.C.2    Mizoguchi, E.3    Bhan, A.K.4    Kelly, C.P.5
  • 131
    • 0031467628 scopus 로고    scopus 로고
    • Therapeutic effects of interleukin 4 gene transfer in experimental inflammatory bowel disease
    • 131. Hogaboam CM, et al. Therapeutic effects of interleukin 4 gene transfer in experimental inflammatory bowel disease. J Clin Invest 1997;100:2766-2776.
    • (1997) J Clin Invest , vol.100 , pp. 2766-2776
    • Hogaboam, C.M.1
  • 132
    • 0026799402 scopus 로고
    • Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammation
    • 132. Shull MM, et al. Targeted disruption of the mouse transforming growth factor-β 1 gene results in multifocal inflammation. Nature 1992;359:693-699.
    • (1992) Nature , vol.359 , pp. 693-699
    • Shull, M.M.1
  • 133
    • 0029061801 scopus 로고
    • Ulcerative colitis and adenocarcinoma of the colon in Gα12-deficient mice
    • 133. Rudolph U, et al. Ulcerative colitis and adenocarcinoma of the colon in Gα12-deficient mice. Nat Genet 1995;10:143-150.
    • (1995) Nat Genet , vol.10 , pp. 143-150
    • Rudolph, U.1
  • 134
    • 0032118427 scopus 로고    scopus 로고
    • Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
    • 134. Snapper SB, et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 1998;9:81-91.
    • (1998) Immunity , vol.9 , pp. 81-91
    • Snapper, S.B.1
  • 135
    • 0032540266 scopus 로고    scopus 로고
    • Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice
    • 135. Bush TG, et al. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 1998;93:189-201.
    • (1998) Cell , vol.93 , pp. 189-201
    • Bush, T.G.1


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