Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

Cell Death and Differentiation

Volumn 9, Issue 8, 2002, Pages 832-841

  O'Reilly L A ^a   Ekert, P ^a,c   Harvey, N ^b   Marsden, V ^a   Cullen, L ^a   Vaux, D L ^a   Hacker, G ^a,f   Magnusson, C ^a,g   Pakusch, M ^a   Cecconi, F ^d   Kuida, K ^e   Strasser, A ^a   Huang, D C S ^a   Kumar, S ^b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e VERTEX PHARMACEUTICALS   (United States)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g NONE   (Sweden)

Author keywords

Apaf 1; Apoptosis; Caspase 2; Caspase 9; Monoclonal antibody; Subcellular localisation

Indexed keywords

APAF1 PROTEIN, HUMAN; APAF1 PROTEIN, MOUSE; APAF1 PROTEIN, RAT; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASP9 PROTEIN, HUMAN; CASP9 PROTEIN, MOUSE; CASP9 PROTEIN, RAT; CASPASE; CASPASE 2; CASPASE 9; DIAGNOSTIC AGENT; MONOCLONAL ANTIBODY; PROTEIN;

ANIMAL; ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; C57BL MOUSE; CELL NUCLEUS; CYTOLOGY; ENZYMOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GOLGI COMPLEX; HELA CELL; HUMAN; IMMUNOLOGY; MALE; METABOLISM; MOUSE; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; SPINAL GANGLION; T LYMPHOCYTE; ULTRASTRUCTURE; WISTAR RAT; ANIMAL CELL; CELL FRACTIONATION; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOLIC FRACTION; CYTOTOXICITY; EMBRYO; ENZYME ACTIVATION; ENZYME DEGRADATION; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 2; CASPASE 9; CASPASES; CELL NUCLEUS; FEMALE; GANGLIA, SPINAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GOLGI APPARATUS; HELA CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; PROTEINS; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; ANIMAL; HUMAN; SUPPORT, NON-U.S. GOV'T;

EID: 0036024020     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401033     Document Type: Article

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