Characterization of mice deficient in interleukin-1β converting enzyme

Journal of Cellular Biochemistry

Volumn 64, Issue 1, 1997, Pages 27-32

  Li, Ping ^a   Allen, Hamish ^a   Banerjee, Subhashis ^a   Seshadri, Tara ^a  

^a BASF Bioresearch Corporation   (United States)

Author keywords

apoptosis; gene targeting; IL 1 ; IL 1 ; inflammation; interleukin 1 converting enzyme

Indexed keywords

INTERLEUKIN 1BETA CONVERTING ENZYME;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME SUBSTRATE; GENE TARGETING; INFLAMMATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; STEM CELL;

ADENOSINE TRIPHOSPHATE; AGE FACTORS; ANIMALS; APOPTOSIS; CASPASE 1; CYSTEINE ENDOPEPTIDASES; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GALACTOSAMINE; GAMMA RAYS; HETEROZYGOTE; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PHENOTYPE; RECOMBINATION, GENETIC; SHOCK, SEPTIC; THYMUS GLAND;

ANIMALIA;

EID: 0031044777     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(199701)64:1<27::AID-JCB5>3.0.CO;2-1     Document Type: Article

References (41)

1. Alexander HR, Doherty GM, Buresh CM, Venzon DJ, Norton JA (1991): A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice. J Exp Med 173:1029-1032.
2. Black RA, Kronheim SR, Cantrell M, Deeley MC, March CJ, Prickett KS, Wignall J, Conlon PJ, Cosman D, Hopp TP, Mochizuki DY (1988): Generation of biologically active interleukin-1 beta by proteolytic cleavage of the inactive precursor. J Biol Chem 263:9437-9442.
3. Capecchi MR (1989): Altering the genome by homologous recombination. Science 244:1288-1292.
4. Car BD, Eng VM, Schnyder B, Ozmen L, Huang S, Gallay P, Heumann D, Aguet M, Ryffel B (1994): Interferon gamma receptor deficient mice are resistant to endotoxic shock. J Exp Med 179:1437-1444.
5. Carruth LM, Demczuk S, Mizel SB (1991): Involvement of a calpain-like protease in the processing of the murine interleukin 1 alpha precursor. J Biol Chem 266:12162-12167.
6. Casano FJ, Rolando AM, Mudgett JS, Molineaux SM (1994): The structure and complete nucleotide sequence of the murine gene encoding interleukin-1 beta converting enzyme (ICE). Genomics 20:474-481.
7. Cerretti DP, Kozlosky CJ, Mosley B, Nelson N, Ness KV, Greenstreet TA, March CJ, Kronheim SR, Druck T, Cannizzaro LA, Huebner K, Black RA (1992): Molecular cloning of the interleukin-1β converting enzyme. Science 256:97-100.
8. Dinarello CA, Gelfand JA, Wolff SM (1993): Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA 269:1829-1835.
9. Dinarello CA, Wolff SM (1993): The role of interleukin-1 in disease [published erratum appears in N Engl J Med 1993 Mar 11; 328(10):744]. N Engl J Med 328:106-113.
10. Enari M, Hug H, Nagata S (1995): Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 375: 78-81.
11. Faucheu C, Diu A, Chan AWE, Blanchet A-M, Miossec C, Herve F, Collard-Dutilleul V, Gu Y, Aldape RA, Lippke JA, Rocher C, Su MSS, Livingston DJ, Hercend T, Lalanne J-L (1995): A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. EMBO J 14:1914-1922.
12. Fernandes-Alnemri T, Litwack G, Alnemri ES (1994): CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269:30761-30764.
13. Fernandes-Alnemri T, Takahashi A, Armstrong R, Krebs J, Fritz L, Tomaselli KJ, Wang L, Yu Z, Croce CM, Salveson G, Earnshaw WC, Litwack G, Alnemri ES (1995): Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res 55:6045-6052.
14. Griffiths RJ, Stam EJ, Downs JT, Otterness IG (1995): ATP induces the release of IL-1 from LPS-primed cells in vivo. J Immunol 154:2821-2828.
15. Hogquist KA, Nett MA, Unanue ER, Chaplin DD (1991): Interleukin 1 is processed and released during apoptosis. Proc Natl Acad Sci U S A 88:8485-8489.
16. Howard AD, Kostura MJ, Thornberry N, Ding GJ, Limjuco G, Weidner J, Salley JP, Hogquist KA, Chaplin DD, Mumford RA, Schmidt JA, Tocci MJ (1991): IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha. J Immunol 147:2964-2969.
17. Kamens J, Paskind M, Hugunin M, Talanian RV, Allen H, Banach D, Bump N, Hackett M, Johnston CG, Li P, Mankovich JA, Terranova M, Ghayur T (1995): Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases. J Biol Chem 270:15250-15256.
18. Kobayashi Y, Yamamoto K, Saido T, Kawasaki H, Oppenheim JJ, Matsushima K (1990): Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha. Proc Natl Acad Sci U S A 87:5548-5552.
19. Kostura MJ, Tocci MJ, Limjuco G, Chin J, Cameron P, Hillman AG, Chartrain NA, Schmidt JA (1989): Identification of a monocyte specific pre-interleukin 1 beta convertase activity. Proc Natl Acad Sci U S A 86:5227-5231.
20. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, Flavell RA (1995): Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 267:2000-2003.
21. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA (1994): Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Gene Dev 8:1613-1626.
22. Leist M, Gantner F, Bohlinger I, Tiegs G, Germann PG, Wendel A (1995): Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Amer J Pathol 146:1220-1234.
23. Li P, Allen H, Banerjee S, Franklin S, Herzog L, Johnston C, McDowell J, Paskind M, Rodman L, Salfeld J, Towne E, Tracey D, Wardwell S, Wei FY, Wong W, Kamen R, Seshadri T (1995): Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 80:401-411.
24. Los M, Van dCM, Penning LC, Schenk H, Westendorp M, Baeuerle PA, Droge W, Krammer PH, Fiers W, Schulze OK (1995): Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature 375:81-83.
25. Miller DK, Ayala JM, Egger LA, Raju SM, Yamin TT, Ding GJ, Gaffney EP, Howard AD, Palyha OG, Rolando AM, Salley JP, Thornberry NA, Weidner JR, Williams JH, Chapman KT, Jackson J, Kostura MJ, Limjuco G, Molineaux SM, Mumford RA, Calaycay JR (1993): Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells. J Biol Chem 268:18062-18069.
26. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J (1993): Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 75:653-660.
27. Nagata S, Suda T (1995) Fas and Fas ligand: lpr and gld mutations. Immunol Today 16:39-43.
28. Perregaux D, Gabel CA (1994) Interleukin-1 beta maturation and release in response to ATP and nigericin -Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 269:15195-15203.
29. Rothe J, Lesslauer W, Lotscher H, Lang Y, Koebel P, Kontgen F, Althage A, Zinkernagel R, Steinmetz M, Bluethmann H (1993): Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes. Nature 364:798-802.
30. Shornick LP, de Togni P, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Ferguson TA, Chaplin DD (1996): Mice deficient in IL-1b manifest impaired contact hypersensitivity to trinitrochlorobenzene. J Exp Med 183: 1427-1436.
31. Sleath PR, Hendrickson RC, Kronheim SR, March CJ, Black RA (1990): Substrate specificity of the protease that processes human interleukin-1 beta. J Biol Chem 265:14526-14528.
32. Tewari M, Dixit VM (1995): Fas- and tumor necrosis factor-induced apoptosis is inhibited by the poxvirus crmA gene product. J Biol Chem 270:3255-3260.
33. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM (1995): Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801-809.
34. Thornberry NA, Bull HG, Calaycay JR, Chapman KT, Howard AD, Kostura MJ, Miller DK, Molineaux SM, Weidner JR, Aunins J, Elliston KO, Ayala JM, Casano FJ, Chin J, Ding gJF, Egger LA, Gaffney EP, Limjuco G, Paylha OC, Raju SM, Rolando AM, Salley JP, Yamin TT, Lee TD, Shively JE, MacCross M, Mumford RA, Schmidt JA, Tocci MJ (1992): A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356:768-774.
35. Vaux DL, Haecker G, Strasser A (1994): An Evolutionary Perspective on Apoptosis. Cell 76:777-779.
36. Walker NPC, Talanian RV, Brady KD, Dang LC, Bump NJ, Ferenz CR, Franklin S, Ghayur T, Hackett MC, Hammill LD, Herzog L, Hugunin M, Houy W, Mankovich JA, Mcguiness L, Orlewicz E, Paskind M, Pratt CA, Reis P, Summani A, Terranova M, Welch JP, Xiong L, Moller A, Tracey DE, Kamen R, Wong WW (1994): Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: A (p20/p10)(2) homodimer. Cell 78:343-352.
37. Wang XM, Helaszek CT, Winter LA, Lirette RP, Dixon DC, Ciccarelli RB, Kelley MM, Malinowski JJ, Simmons SJ, Huston EE, Koehn JA, Kratz D, Bruckner RC, Graybill T, Ator MA, Lehr RV, Stevis PE (1994): Production of active human interleukin-1 betaconverting enzyme in a baculovirus expression system. Gene 145:273-277.
38. Wilson KP, Black JAF, Thomson JA, Kim EE, Griffith JP, Navia MA, Murcko MA, Chambers SP, Aldape RA, Raybuck SA, Livingston DJ (1994): Structure and mechanism of interleukin-1 beta converting enzyme. Nature 370:270-275.
39. Young PR, Hazuda DJ, Simon PL (1988): Human interleukin 1 beta is not secreted from hamster fibroblasts when expressed constitutively from a transfected cDNA. J Cell Biol 107:447-456.
40. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993): The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1b-converting enzyme. Cell 75:641-652.
41. Zheng H, Fletcher D, Kozak W, Jiang M, Hofmann KJ, Conn CA, Soszynski D, Grabiec C, Trumbauer ME, Shaw A, Kostura MJ, Stevens K, Rosen H, North RJ, Chen HY, Tocci MJ, Kluger MJ, Van der Ploeg LHT (1995): Resistance to fever induction and impaired acute-phase response in interleukin-1 beta-deficient mice. Immunity 3:9-19.