Glucocorticoid-induced thymocyte apoptosis: Protease-dependent activation of cell shrinkage and DNA degradation

Journal of Steroid Biochemistry and Molecular Biology

Volumn 65, Issue 1-6, 1998, Pages 207-217

  Hughes Jr , Francis M ^a   Cidlowski, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; DNA; DNA FRAGMENT; GLUCOCORTICOID; PROTEINASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; CELL VOLUME; CHROMATIN CONDENSATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA DEGRADATION; ENZYME MECHANISM; NONHUMAN; RAT; REGULATORY MECHANISM; THYMOCYTE;

ANIMALIA;

EID: 0032052315     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00188-X     Document Type: Conference Paper

References (50)

1. Häcker G., Vaux D. L. The medical significance of physiological cell death. Med. Res. Rev. 15:1995;299-311.
2. Kerr J. F. R. Shrinkage necrosis: a distinct mode of cellular death. J. Pathol. 105:1971;13-20.
3. Kerr J. F. R., Wyllie A. H., Currie A. R. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
4. Searle J., Kerr J.F.R., Bishop C.J. Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance. Pathol. Annu. 17:1982;229-259.
5. Bortner, C. D., Hughes, F. M., Jr. and Cidlowski, J. A., Cell volume regulation, ions, and apoptosis. In Programmed Cell Death, ed. Y.-B. Shi, et al. Plenum, New York, 1997, 63-70.
6. Bortner C. D., Cidlowski J. A. The absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. Am. J. Physiol. 271:1996;C950-C961.
7. Beauvais F., Michel L., Dubertret L. Human eosinophils in culture undergo a striking and rapid shrinkage during apoptosis. Role of K+ channels. J. Leuk. Biol. 57:1995;851-855.
8. Barbiero G., Duranti F., Bonelli G., Amenta J. S., Baccino F. M. Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression. Exp. Cell. Res. 217:1995;410-418.
9. Hughes F. M. Jr., Cidlowski J. A. Apoptotic DNA degradation: evidence for novel enzymes. Cell Death Differen. 1:1994;11-17.
10. Bortner C. D., Oldenburg N. B. E., Cidlowski J. A. The role of DNA fragmentation in apoptosis. Trends Cell Biol. 5:1995;21-26.
11. Schwartzman R. A., Cidlowski J. A. Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocrine Rev. 14:1993;133-151.
12. Skalka M., Matyásová J., Cejková M. DNA in chromatin of irradiated lymphoid tissues degrades in vivo into regular fragments. FEBS Lett. 72:1976;271-274.
13. Wyllie A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
14. Cohen G. M., Sun X.-M., Fearnhead H., MacFarlane M., Brown D. G., Snowden R. T., Dinsdale D. Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes. J. Immunol. 153:1994;507-516.
15. Oberhammer F., Wilson J. W., Dive C., Morris I. D., Hickman J. A., Wakeling A. E., Walker P. R., Sikorska M. Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12:1993;3679-3684.
16. Walker P. R., Kokileva L., LeBlanc J., Sikorska M. Detection of the initial stages of DNA fragmentation in apoptosis. BioTechniques. 15:1993;1032-1040.
17. Filipski J., Leblanc J., Youdale T., Sikorska M., Walker P. R. Periodicity of DNA folding in higher order chromatin structures. EMBO J. 9:1990;1319-1327.
18. Kokileva L. Multi-step chromatin degradation in apoptosis. Int. Arch. Allergy Immunol. 105:1994;339-343.
19. Walker P. R., Pandey S., Sikorska M. Degradation of chromatin in apoptotic cells. Cell Death Differen. 2:1995;97-104.
20. Montague J. W., Gaido M. L., Frye C., Cidlowski J. A. A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin: recombinant cyclophilins A and B exhibit nuclease activity. J. Biol. Chem. 269:1994;18877-18880.
21. Montague, J. W., Hughes, F. M., Jr. and Cidlowski J. A., Native recombinant cyclophilins A, B, and C degrade DNA independently of peptidylprolyl cis-trans isomerase activity: potential roles of cyclophilins in apoptosis. J. Biol. Chem. 272 (1997) 6677-6684.
22. Peitsch M. C., Polzar B., Stephan H., Crompton T., MacDonald H. R., Mannherz H. G., Tschopp J. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). EMBO J. 12:1993;371-377.
23. Peitsch M. C., Polzar B., Tschopp J., Mannherz H. G. About the involvement of deoxyribonuclease I in apoptosis. Cell Death Differen. 1:1994;1-6.
24. Barry M. A., Eastman A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch. Biochem. Biophys. 300:1993;440-450.
25. Eastman A. Deoxyribonuclease II in apoptosis and the significance of intracellular acidification. Cell Death Differen. 1:1994;7-10.
26. Hughes F. M. Jr., Cidlowski J. A. Utilization of an in vitro apoptosis assay to evaluate chromatin degradation by candidate apoptotic nucleases. Cell Death Differen. 4:1997;200-208.
27. Nagata S. Apoptosis by death factor. Cell. 88:1997;355-365.
28. Henkart P. A. ICE family proteases: mediators of all apoptotic cell death? Immunity. 4:1996;195-201.
29. Patel T., Gores G. J., Kaufmann S. H. The role of proteases during apoptosis. FASEB J. 10:1996;587-597.
30. Whyte M. ICE/Ced-3 proteases in apoptosis. Trends Cell. Biol. 6:1996;245-248.
31. Kumar S. ICE-like proteases in apoptosis. Trends Biochem. Sci. 20:1995;198-202.
32. Martin S. J., Green D. R. Protease activation during apoptosis, death by a thousand cuts? Cell. 82:1995;349-352.
33. Ellis R. E., Yuan J., Horvitz H. R. Mechanisms and functions cell death. Annu. Rev. Cell. Biol. 7:1991;663-698.
34. Yuan J.-Y., Shaham S., Ledoux S., Ellis H. M., Horvitz H. R. The C. elegans cell death gene Ced-3 encodes a protein similar to mammalian interleukin-1beta converting enzyme. Cell. 75:1993;641-652.
35. Enari M., Talanian R. V., Wong W. W., Nagata S. Sequential activation of ICE-like and CPP32-like proteases during fas-mediated apoptosis. Nature. 380:1996;723-726.
36. Fernandes-Alnemri T., Litwack G., Alnemri E. S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem. 269:1994;30761-30764.
37. Tewari M., Quan L. T., O'Rourke K., Desnoyers S., Zeng Z., Beidler D. R., Poirier G. G., Salvesen G. S., Dixit V. M. Yama/CPP32 beta, a mammalian homolog of Ced-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81:1995;801-809.
38. Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gallant M., Gareau Y., Griffin P. R., Labelle M., Lazebnik Y. A., Munday N. A., Raju S. M., Smulson M. E., Yamin T.-T., Yu V. L., Miller D. K. Identification and inhibition of the ICE/Ced-3 protease necessary for mammalian apoptosis. Nature. 376:1995;37-43.
39. Compton M. M., Haskil J. S., Cidlowski J. A. Analysis of glucocorticoid actions on rat thymocyte deoxyribonucleic acid by fluorescence-activated flow cytometry. Endocrinology. 122:1988;2158-2164.
40. Hughes, F. M., Jr., Bortner, C. D., Purdy, G. P. and Cidlowski, J. A., Intracellular potassium suppresses the activation of apoptosis in lymphocytes. J. Biol. Chem. 272 (1997) 30567-30576.
41. + efflux in the activation of apoptosis. J. Biol. Chem. 272 (1997) 32436-32442.
42. Cidlowski J. A. Glucocorticoids stimulate ribonucleic acid degradation in isolated rat thymic lymphocytes in vitro. Endocrinology. 111:1982;184-190.
43. Schwartzman R. A., Cidlowski J. A. Internucleosomal deoxyribonucleic acid cleavage activity in apoptotic thymocytes: detection and endocrine regulation. Endocrinology. 128:1991;1190-1197.
44. Compton M. M., Cidlowski J. A. Identification of a glucocorticoid-induced nuclease in thymocytes: a potential "lysis gene" product. J. Biol. Chem. 262:1987;8288-8292.
45. Norman M. R., Thompson E. B. Characterization of a glucocorticoid-sensitive human lymphoid cell line. Cancer Res. 37:1977;3785-3791.
46. Thomas N., Bell P. A. Glucocorticoid-induced cell size changes and nuclear fragility in rat thymocytes. Mol. Cell. Endocrinol. 22:1981;71-84.
47. Cohen J. J., Duke R. C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132:1984;38-42.
48. Wyllie A. H., Morris R. G., Smith A. L., Dunlop D. Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis. J. Pathol. 142:1984;67-77.
49. Compton M. M., Caron L.-A. M., Cidlowski J. A. Glucocorticoid action on the immune system. J. Steroid Biochem. 27:1987;201-208.
50. Jacobson M. D., Weil M., Raff M. C. Programmed cell death in animal development. Cell. 88:1997;347-354.