Glucocorticoid production in the murine thymus

European Journal of Immunology

Volumn 30, Issue 2, 2000, Pages 337-346

  Lechner, Oskar ^a   Jan Wiegers, G ^a   Oliveira dos Santos, Antonio J ^a   Dietrich, Hermann ^a   Recheis, Heidrun ^a   Waterman, Michael ^b   Boyd, Richard ^c   Wick, Georg ^a,d  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ALFRED HOSPITAL   (Australia)

^d Institute of General and Experimental Pathology   (Austria)

Author keywords

Autoimmunity; T cell selection; Thymic epithelial cell; Thymus glucocorticoid

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CYTOCHROME P450 ISOENZYME; GLUCOCORTICOID; STEROID 11BETA MONOOXYGENASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ORGANELLE; ENZYME ACTIVITY; EPITHELIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEROIDOGENESIS; THIN LAYER CHROMATOGRAPHY; THYMUS;

ANIMALS; APOPTOSIS; GLUCOCORTICOIDS; MICE; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0343550300     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200002)30:2<337::AID-IMMU337>3.0.CO;2-L     Document Type: Article

References (36)

1. Smith, C. A., Williams, G. T., Kingston, R., Jenkinson, E. J. and Owen, J. J. T., Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature 1989. 337: 181-184.
2. Von Boehmer, H., Positive selection of lymphocytes. Cell 1994. 76: 219-226.
3. Selye, H., Thymus and adrenals in the response of the organism to injuries and ontoxications. Br. J. Exp. Pathol. 1936. 17: 234-248.
4. Ingle, D. J., Effect of two steroid components on weigth of thymus of adrenalectomized rats. Proc. Soc. Exp. Bio. Med. 1940. 44: 174-175.
5. Spangelo, B. L., The thymic-endocrine connection. J. Endocrinol. 1995. 147: 5-10.
6. Wyllie, A. H., Glucocorticoid-induced thymocyte apoptosis is associated with endogenous enonuclease activation. Nature 1980. 284: 555-556.
7. Zacharuk, C. M., Mercep, M., Chakraborti, P., Simons, S. S. and Ashwell, J. D., Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic. J. Immunol. 1990. 145: 4037-4045.
8. King, L. B., Vacchio, M. S., Dixon, K., Hunziker, R., Margulies, D. H. and Ashwell, J. D., A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 1995. 3: 647-656.
9. Wiegers, G. J. and Reul, J. M. H. M., Holsboer, F. and de Kloet, E. R., Enhancement of rat splenic lymphocyte mitogenesis after short-term preexposure to corticosteroids in vitro. Endocrinology 1994. 135: 2351-2357.
10. Vacchio, M. S., Papadopoulos, V. and Ashwell, J. D., Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 1994. 179: 1835-1846.
11. Vacchio, M. S. and Ashwell, J. D., Thymus-derived glucocorticoids regulate antigen-specific positive selection. J. Exp. Med. 1997. 185: 2033-2038.
12. King, L. B., Vacchio, M. S. and Ashwell, J. D., To be or not to be: mutually antagonistic death signals regulate thymocyte apoptosis. Int. Arch. Allergy. Immunol. 1994. 105: 355-358.
13. d-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice. Eur. J. Immunol. 1996. 26: 428-434.
14. Penninger, J., Hala, K. and Wick, G., Intrathymic nurse cell lymphocytes can induce a specific graft-versus-host reaction. J. Exp. Med. 1990. 172: 521-529.
15. Aird, F., Clevenger, C. V., Prystowsky, M. B. and Redei, E., Corticotropin-releasing factor mRNA in rat thymus and spleen. Proc. Natl. Acad. Sci. USA 1993. 90: 7104.
16. Grazzini, E., Guillon, G., Mouillac, B. and Zing, H. H., Inhibition of oxytocin receptor function by direct binding of progesterone. Nature 1998. 392: 592-512.
17. Elands, J., Resink, A. and de Kloet, E. R., Neurohypophyseal hormone receptors in the rat thymus, spleen, and lymphocytes. Endocrinology 1990. 126: 2703-2710.
18. Geenen, V., Defresne, M. P., Robert, F., Legros, J. J., Franchimont, P. and Boniver, J., The neurohormonal thymic microenvironment: immunocytochemical evidence that thymic nurse cells are neuroendocrine cells. Neuroendocrinology 1988. 47: 365-368.
19. Lechner, O., Hu, Y., Jafarian-Tehrani, M. J., Dietrich, H., Schwarz, S., Herold, M., Haour, F. and Wick, G., Disturbed immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in murine lupus. Brain Behav. Immun. 1996. 10: 337-350.
20. Hu, Y., Dietrich, H., Herold, M., Heinrich, P. C. and Wick, G., Disturbed immunoendocrine communication via the hypothalamo-pituitary-adrenal axis in autoimmune disease. Int. Arch. All. Immunol. 1993. 102: 232-241.
21. Wick, G., Hu, Y., Schwarz, S. and Kroemer, G., Immunoendocrine communication via the hypothalamo- pituitary-adrenal axis in autoimmune diseases. Endocr. Rev. 1993. 14: 539-563.
22. Tolosa, E., King, L. B. and Ashwell, J. D., Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice. Immunity 1998. 8: 67-76.
23. Zilberman, Y., Yefenof, E., Oron, E., Dorogin, A. and Guy, R., T cell receptor-independent apoptosis of thymocyte clones induced by a thymic epithelial cell line is mediated by steroids. Cell Immunol. 1996. 170: 78-84.
24. Dallman, M. F., Akana, S. F., Cascio, C. S., Darlington, D. N., Jacobson, L. and Levin, N., Regulation of ACTH secretion: variations on a therme of B. Recent Prog. Harm. Res. 1987. 43: 113-173.
25. de Kloet, E. R., Brain corticosteroid receptor balance and homeostatic control. Front Neuroendocrinol. 1991. 12: 95-164.
26. Anderson, G., Jenkinson, E. J., Moore, N. C. and Owen, J. J. T., MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature 1993. 362: 70.
27. Ritter, M. A. and Boyd, R L., Development in the thymus: it takes two to tango. Immunol. Today 1993. 14: 462-468.
28. Hollander, G. A., Wang, B. P., Nicogiannopoupolou, A., Platenburg, P. P., Van Ewijk, W., Burakoff, S. J., Guttierez-Ramos, J. C. and Terhorst, C., Developmental control point in the induction of thymic cortex regulated by a subpopulation of prothymocytes. Nature 1995. 373: 350-353.
29. Huiskamp, R., Davis, J. A. G. and Vos, O., Short- and long-term effects of whole body irradiation with fission neutrons or X-rays on the thymus in CB mice. Rad. Res. 1983. 95: 370-381.
30. Huiskamp, R. and Van Ewijk, W., Repopulation of the mouse thymus after sublethal fission neutron irradiation: I. Sequential appearance of thymocyte subpopulations. J. Immunol. 1985. 134: 2170-2178.
31. Villa-Verde, D. M. S., Mello, Coelho, V., Farias-De-Oliveira, D. A., Dardenne, M. and Savino, W., Pleiotropic influence of triiodothyronine on thymus physiology. Endocrinology 1993. 133: 867-875.
32. Kroemer, G., Brezinschek, H. P., Faessler, K., Schauenstein, K. and Wick, G., Physiology and pathology of an immunoendocrine feedback loop. Immunol. Today 1988. 9: 163-165.
33. Storrie, B. and Madden, E. A., Isolation of subcellular organelles. Methods Enzymol. 1999. 182: 203-225.
34. Boyd, R. L., Tucek, C. L., Godfrey, D. I., Izon, D. J., Wilson, T. J., Davidson, N. J., Bean, A. G. D., Ladyman, H. M., Ritter, M. A. and Hugo, P., The thymic microenvironment. Immunol. Today 1993. 14: 445-459.
35. Oliveira dos Santos, A. J., Rieker-Geley, T. and Recheis, H. and Wick, G., Murine thymic nurse cells and rosettes: Analysis of adhesion molecule expression using confocal microscopy and a simplified enrichment method. J. Histochem. Cytochem. 1997. 45: 1293-1297.
36. Rupprecht, R., Reul, J. M. H. M., van Steensel, B., Spengler, C., Soeder, M., Berning, B., Holsboer, F. and Damm, K., Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. Eur. J. Pharmacol. 1993. 247: 145-154.