Subcellular distribution and redistribution of Bcl-2 family proteins in human leukemia cells undergoing apoptosis

Blood

Volumn 93, Issue 7, 1999, Pages 2353-2359

  Jia, Li ^a   Macey, Marion G ^a   Yin, Yuzhi ^a   Newland, Adrian C ^a   Kelsey, Stephen M ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME C; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; TUMOR NECROSIS FACTOR ALPHA; VINBLASTINE;

APOPTOSIS; ARTICLE; CELL FREE SYSTEM; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN TARGETING;

EID: 0033120383     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.7.2353     Document Type: Article

References (41)

1. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP, Wang X: Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science 275:1129, 1997
2. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science 275:1132, 1997
3. L regulates the membrane potential and volume homeostasis of mitochondria. Cell 91:627, 1997
4. L inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 57:3115, 1997
5. L can inhibit apoptosis in cells that have undergone Fas-induced protease activation. Proc Natl Acad Sci USA 94:3759, 1997
6. Zhivotosky B, Orrenius S, Brustugun OT, Døskeland SO: Injected cytochrome c induces apoptosis. Nature 391:449, 1998
7. Rossé T, Oliver R, Monney L, Rager M, Conus S, Fellay I, Jansen B, Borner C: Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 391:496, 1998
8. Gajewski TF, Thompson CB: Apoptosis meets signal transduction: Elimination of BAD influence. Cell 87:589, 1996
9. Xiang J, Chao DT, Korsmeryer J: Bax-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc Natl Acad Sci USA 93:14559, 1996
10. L. J Biol Chem 271:6306, 1996
11. L during apoptosis. Proc Natl Acad Sci USA 94:3668, 1997
12. Wolter KG, Hsu Y-T, Smith CL, Nechushtan A, Xi X-G, Youle RJ: Movement of Bax from the cytosol to mitochondria during apoptosis. J Cell Biol 139:1281, 1997
13. Oltvai ZN, Milliman CL, Korsmeyer SJ: Bcl-2 heterodimerizes in-vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609, 1993
14. Reed JC: Double identity for proteins of the Bcl-2 family. Nature 387:773, 1997
15. L antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. Cancer Res 57:62, 1997
16. Banker DE, Groudine M, Norwood T, Appelbaum FR: Measurement of spontaneous and therapeutic agent-induced apoptosis with Bcl-2 protein expression in acute myeloid leukemia. Blood 89:243, 1997
17. Meijerink JPP, Mensink EJBM, Wang K, Sedlak TW, Slöetjes AW, de Witte T, Waksman G, Korsmeyer SJ: Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. Blood 91:2991, 1998
18. Liu X, Kim CN, Yang R, Jemmerson R, Wang X: Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c. Cell 86:147, 1996
19. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X: Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90:405, 1997
20. Li P, Nijhawan D, Budihardjo I, Srinvasula SM, Ahmad ES, Alnemri ES, Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479, 1997
21. Cosulich SC, Worrall V, Hedge PJ, Green S, Clarke PR: Regulation of apoptosis by BH3 domains in a cell-free system. Curr Biol 7:913, 1997
22. Kroemer G: The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3:614, 1997
23. Hockenbery DM, Oltvai ZN, Yin XM, Milliman CL, Korsmeyer SJ: Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75:241, 1993
24. Krajewski SS, Tanaka S, Takayama MJ, Schibler W, Fenton W, Reed JC: Investigation of the subcellular distribution of the Bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum and outer mitochondrial membrane. Cancer Res 53:4701, 1993
25. L is the major Bcl-x mRNA form expressed during development and its product localizes to mitochondria. Development 120:3033, 1994
26. Han J, Sabbatini P, Perez D, Rao L, Modha D, White E: The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein. Genes Dev 10:461, 1996
27. Zha H, Fisk MP, Yaffe N, Mahajan B, Herman B, Reed JC: Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol Cell Biol 16:6494, 1996a
28. L, Cell 87:619, 1996b
29. Franke TF, Cantley LC: A Bad kinase makes good. Nature 390:116, 1997
30. Jia L, Kelsey SM, Grahn MF, Jiang XR, Newland AC: Increased activity and sensitivity of mitochondrial respiratory enzymes to tumor necrosis factor α-mediated inhibition is associated with increased cytotoxicity in drug-resistant leukemic cell lines. Blood 87:2401, 1996
31. Jia L, Dourmashkin RR, Newland AC, Kelsey SM: Mitochondrial ultracondensation, but not swelling, is involved in TNFα-induced apoptosis in human T-lymphoblastic leukaemic cells. Leuk Res 21:973, 1997a
32. Jia L, Dourmashkin RR, Allen PD, Gray AB, Newland AC, Kelsey SM: Inhibition of autophagy abrogates tumor necrosis factor α-induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol 98:673, 1997b
33. Mancini M, Nicholson DW, Roy S, Thornberry NA, Peterson EP, Casciola-Rosen LA, Rosen A: The caspase-3 precursor has a cytosolic and mitochondrial distribution: Implication for apoptotic signaling. J Cell Biol 140:1485, 1998
34. Bossy-Wetzel E, Newmeyer DD, Green DR: Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 17:37, 1998
35. Beck WT, Muller TJ, Tanzer LR: Altered surface membrane glycoproteins in vinca alkaloid resistant human leukemic lymphoblasts. Cancer Res 39:2070, 1979
36. L and Bcl-2, displaces Bax and promotes cell death. Cell 80:285, 1995
37. L as an inhibitor of cytosolic cytochrome c accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA 94:6937, 1997
38. Hus YT, Youle RJ: Nonionic detergents induce dimerzation among members of the Bcl-2 family. J Biol Chem 272:13829, 1997b
39. Cheng EH-T, Kirsch DG, Clem RJ, Ravi R, Kastan MB, Bedi A, Ueno K, Hardwick JM: Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 278:1966, 1997
40. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X: Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 94:481, 1998
41. Li H, Zhu H, Xu C, Yuan J: Cleagave of BID by caspase-9 mediates the mitochondrial damage in the fas pathway of apoptosis. Cell 94:491, 1998