Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice

Immunity

Volumn 8, Issue 1, 1998, Pages 67-76

  Tolosa, Eva ^b   King, Leslie B ^a,b   Ashwell, Jonathan D ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; GROWTH REGULATION; HORMONE RESISTANCE; LYMPHOCYTE DIFFERENTIATION; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; THYMOCYTE;

EID: 0031907999     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80459-8     Document Type: Article

References (60)

1. Alberola-Ila, J., Hogquist, K.A., Swan, K.A., Bevan, M.J., and Perlmutter, R.M. (1996). Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184, 9-18.
2. Altman, A. (1994). Abnormal antigen receptor-initiated signal transduction in lpr T lymphocytes. Semin. Immunol. 6, 9-17.
3. Amakawa, R., Hakem, A., Kundig, T.M., Matsuyama, T., Simard, J.J., Timms, E., Wakeham, A., Mittruecker, H.W., Griesser, H., Takimoto, H., et al. (1996). Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell 84, 551-562.
4. Balomenos, D., Rumold, R., and Theofilopoulos, A.N. (1997). The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansion. J. Immunol. 159, 2265-2273.
5. Benoist, C., and Mathis, D. (1989). Positive selection of the T cell repertoire: where and when does it occur? Cell 58, 1027-1033.
6. + T cells mediated by MHC class II-bearing stromal cell in the thymic cortex. Nature 341, 649-651.
7. + T lymphocytes from MRL/ lpr mice are resistant to receptor-mediated tolerance and apoptosis. J. Immunol. 151, 7233-7239.
8. + thymocytes: a model based on T-cell receptor avidity. Immunol. Today 16, 428-431.
9. Cohen, J.J., and Duke, R.C. (1984). Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol. 132, 38-42.
10. Cohen, P.L., and Eisenberg, R.A. (1991). Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9, 243-269.
11. Cohen, P.L., Rapoport, R., and Eisenberg, R.A. (1986). Characterization of functional T-cell lines derived from MRL mice. Clin. Immunol. Immunopathol. 40, 485-496.
12. Crispe, I.N. (1994). CD4/CD8-negative T cells with αβ antigen receptors. Curr. Opin. Immunol. 6, 438-441.
13. Davidson, W.F., Dumont, F.J., Bedigian, H.G., Fowlkes, B.J., and Morse, H.C.d. (1986). Phenotypic, functional, and molecular genetic comparisons of the abnormal lymphoid cells of C3H-lpr/lpr and C3H-gld/gld mice. J. Immunol. 136, 4075-4084.
14. Foy, T.M., Page, D.M., Waldschmidt, T.J., Schoneveld, A., Laman, J.D., Masters, S.R., Tygrett, L., Ledbetter, J.A., Aruffo, A., Claassen, E., et al. (1995). An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 182, 1377-1388.
15. Garvin, A.M., Abraham, K.M., Forbush, K.A., Farr, A.G., Davison, B.L., and Perlmutter, R.M. (1990). Disruption of thymocyte development and lymphomagenesis induced by SV40 T-antigen. Int. Immunol. 2, 173-180.
16. Herron, L.R., Eisenberg, R.A., Roper, E., Kakkanaiah, V.N., Cohen, P.L., and Lotzin, B.L. (1993). Selection of the T cell receptor repertoire in Lpr mice. J. Immunol. 151, 3450-3459.
17. + T cells. Immunity 3, 79-86.
18. Isenberg, D.A., Dudeney, C., Williams, W., Addison, I., Charles, S., Clarke, J., and Todd-Pokropek, A. (1987). Measurement of anti-DNA antibodies: a reappraisal using five different methods. Ann. Rheum. Dis. 46, 448-456.
19. Iwata, M., Hanaoka, S., and Sato, K. (1991). Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 21, 643-648.
20. Izui, S., Berney, T., Shibata, T., and Fulpius, T. (1993). IgG3 cryoglobulins in autoimmune MRL-lpr/lpr mice: immunopathogenesis, therapeutic approaches and relevance to similar human diseases. Ann. Rheum. Dis. 52, S48-S54.
21. Kelly, K.A., Pircher, H., von Boehmer, H., Davis, M.M., and Scollay, R. (1993). Regulation of T cell production in T cell receptortransgenic mice. Eur. J. Immunol. 23, 1922-1928.
22. Kelley, V.E., and Roths, J.B. (1985). Interaction of mutant lpr gene with background strain influences renal disease. Clin. Immunol. Immunopathol. 37, 220-229.
23. King, L.B., Vacchio, M.S., Dixon, K., Hunziker, R., Margulies, D.H., and Ashwell, J.D. (1995). A targeted glucocorticoid receptor anti-sense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 3, 647-656.
24. Kishimoto, H., Cai, Z., Brunmark, A., Jackson, M.R., Peterson, P.A., and Sprent, J. (1996). Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J. Exp. Med. 184, 531-537.
25. - T cells of lpr mice. J. Exp. Med. 168, 2221-2229.
26. Leo, O., Foo, M., Sachs, D.H., Samelson, L.E., and Bluestone, J.A. (1987). Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl. Acad. Sci. USA 84, 1374-1378.
27. + T cells. J. Exp. Med. 170, 135-143.
28. + thymocytes controlled by MHC class II gene products. Nature 336, 471-473.
29. + T cells in lpr/lpr mice. J. Exp. Med. 172, 1805-1817.
30. Nagata, S., and Suda, T. (1995). Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16, 39-43.
31. Peng, S.L., Fatenejad, S., and Craft, J. (1996). Induction of nonpathologic, humoral autoimmunity in lupus-prone mice by a class II-restricted, transgenic alpha beta T cell: separation of autoantigen-specific and -nonspecific help. J. Immunol. 157, 5225-5230.
32. Perkins, D.L., Listman, J.A., Marshak-Rothstein, A., Kozlow, W., Kelley, V.R., Finn, P.W., and Rimm, I.J. (1996). Restriction of the TCR repertoire inhibits the development of memory T cells and prevents autoimmunity in lpr mice. J. Immunol. 156, 4961-4968.
33. Punt, J.A., Osborne, B.A., Takahama, Y., Sharrow, S.O., and Singer, A. (1994). Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179, 709-713.
34. Raveche, E.S., Steinberg, A.D., DeFranco, A.L., and Tjio, J.H. (1982). Cell cycle analysis of lymphocyte activation in normal and autoimmune strains of mice. J. Immunol. 129, 1219-1226.
35. Rocha, B., Dautigny, N., and Pereira, P. (1989). Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo. Eur. J. Immunol. 19, 905-911.
36. Russell, J.H., Rush, B., Weaver, C., and Wang, R. (1993). Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. USA 90, 4409-4413.
37. Sebzda, E., Wallace, V.A., Mayer, J., Yeung, R.S., Mak, T.W., and Ohashi, P.S. (1994). Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science 263, 1615-1618.
38. + T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis. J. Immunol. 143, 103-112.
39. Sidman, C.L., Marshall, J.D., and Von Boehmer, H. (1992). Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice. Eur. J. Immunol. 22, 499-504.
40. Singer, G.G., and Abbas, A.K. (1994). The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1, 365-371.
41. + and abnormal lpr and gld cell populations. J. Exp. Med. 170, 1869-1877.
42. Sprent, J., Lo, D., Gao, E.-K., and Ron, Y. (1988). T cell selection in the thymus. Immunol. Rev. 101, 172-190.
43. Swiger, R.R. (1995). Detection of transgenic animals without cell culture using fluorescence in situ hybridization. Biotechniques 18, 952-956.
44. Sy, M.S., Wang, P.T., Ju, S.T., Weston, K.M., Alarcon, B., Terhorst, C., and Yeh, E.T. (1988). Abnormal T cells from MRL/Mp-lpr/lpr mice do not respond to anti-T-cell-receptor antibody or tumor promoter and calcium ionophore A23187 despite the presence of the T-cell-receptor complex and protein kinase c. Cell. Immunol. 113, 82-94.
45. Theofilopoulos, A.N., and Dixon, F.J. (1985). Murine models of systemic lupus erythematosus. Adv. Immunol. 37, 269-390.
46. + T cells. Int. Immunol. 4, 1195-1198.
47. + T cells. Immunogenetics 36, 230-237.
48. Tomonari, K., Hederer, R., and Hengartner, H. (1992). Positive selection of Tcrb-V10b+ T cells. Immunogenetics 35, 9-15.
49. Tomonari, K., Fairchild, S., and Rosenwasser, O.A. (1993). Influence of viral superantigens on Vβ- and Vα-specific positive and negative selection. Immunol. Rev. 131, 131-168.
50. Tucker, J.D., Breneman, J.W., Lee, D.A., Ramsey, M.J., and Swiger, R.R. (1994). Fluorescence in situ hybridization of human and mouse DNA probes to determine the chromosomal contents of cell lines and tumors. In Cell Biology: A Laboratory Handbook (Academic Press), pp. 450-458.
51. Vacchio, M.S., and Ashwell, J.D. (1997). Thymus-derived glucocorticoids regulate antigen-specific positive selection. J. Exp. Med. 185, 2033-2038.
52. Vacchio, M.S., Papadopoulos, V., and Ashwell, J.D. (1994). Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 179, 1835-1846.
53. Warren, R.W., Caster, S.A., Roths, J.B., Murphy, E.D., and Pisetsky, D.S. (1984). The influence of the lpr gene on B cell activation: differential antibody expression in lpr congenic mouse strains. Clin. Immunol. Immunopathol. 31, 65-77.
54. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A., and Nagata, S. (1992). Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356, 314-317.
55. Weber, S., Traunecker, A., Oliveri, F., Gerhard, W., and Karjalainen, K. (1992). Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor. Nature 356, 793-796.
56. Weston, K.M., Ju, S.T., Lu, C.Y., and Sy, M.S. (1988). Autoreactive T cells in MRL/Mpr-lpr/lpr mice: characterization of the lymphokines produced and analysis of antigen-presenting cells required. J. Immunol. 141, 1941-1948.
57. Woodland, D., Happ, M.P., Bill, J., and Palmer, E. (1990). Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells. Science 247, 964-967.
58. Zacharchuk, C.M., and Ashwell, J.D. (1992). Fruitful outcomes of intracellular cross-talk. Curr. Biol. 2, 246-248.
59. Zacharchuk, C.M., Mercep, M., Chakraborti, P., Simons, S.S., Jr., and Ashwell, J.D. (1990). Programmed T lymphocyte death: cell activation- and steroid-induced pathways are mutually antagonistic. J. Immunol. 145, 4037-4045.
60. + T cells in MRL-lpr/lpr mice: clues from a T cell receptor β transgenic mouse. J. Immunol. 150, 3651-3667.