메뉴 건너뛰기




Volumn 32, Issue 12, 2002, Pages 3546-3555

Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice

Author keywords

Glucocorticoid receptor; Homeostasis; T cell development; T cell selection; Thymus

Indexed keywords

GLUCOCORTICOID RECEPTOR; METYRAPONE;

EID: 0036909641     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200212)32:12<3546::AID-IMMU3546>3.0.CO;2-S     Document Type: Article
Times cited : (42)

References (41)
  • 1
    • 0021042619 scopus 로고
    • Thymocyte subpopulations: An experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers
    • Scollay, R. and Shortman, K., Thymocyte subpopulations: an experimental review, including flow cytometric cross-correlations between the major murine thymocyte markers. Thymus 1983. 5: 245-295.
    • (1983) Thymus , vol.5 , pp. 245-295
    • Scollay, R.1    Shortman, K.2
  • 2
    • 0027137599 scopus 로고
    • Chronic elevation of plasma corticosterone causes reductions in the number of cycling cells of the B lineage in murine bone marrow and induces apoptosis
    • Garvy, B. A., King, L. E., Telford, W. G., Morford, L. A. and Fraker, P. J., Chronic elevation of plasma corticosterone causes reductions in the number of cycling cells of the B lineage in murine bone marrow and induces apoptosis. Immunology 1993. 80: 587-592.
    • (1993) Immunology , vol.80 , pp. 587-592
    • Garvy, B.A.1    King, L.E.2    Telford, W.G.3    Morford, L.A.4    Fraker, P.J.5
  • 3
    • 0028233225 scopus 로고
    • Steroid production in the thymus: Implications for thymocyte selection
    • Vacchio, M. S., Papadopoulos, V. and Ashwell, J. D., Steroid production in the thymus: implications for thymocyte selection. J. Exp. Med. 1994. 179: 1835-1846.
    • (1994) J. Exp. Med. , vol.179 , pp. 1835-1846
    • Vacchio, M.S.1    Papadopoulos, V.2    Ashwell, J.D.3
  • 4
    • 0032896835 scopus 로고    scopus 로고
    • Paracrine glucocorticoid activity produced by mouse thymic epithelial cells
    • Pazirandeh, A., Xue, Y., Rafter, I., Sjovall, J., Jondal, M. and Okret, S., Paracrine glucocorticoid activity produced by mouse thymic epithelial cells. FASEB J. 1999. 13: 893-901.
    • (1999) FASEB J. , vol.13 , pp. 893-901
    • Pazirandeh, A.1    Xue, Y.2    Rafter, I.3    Sjovall, J.4    Jondal, M.5    Okret, S.6
  • 7
    • 0025613973 scopus 로고
    • Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic
    • Zacharchuk, C. M., Mercep, M., Chakraborti, P. K., Simons, S. S., Jr. and Ashwell, J. D., Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonistic. J. Immunol. 1990. 145: 4037-4045.
    • (1990) J. Immunol. , vol.145 , pp. 4037-4045
    • Zacharchuk, C.M.1    Mercep, M.2    Chakraborti, P.K.3    Simons S.S., Jr.4    Ashwell, J.D.5
  • 8
    • 0025971637 scopus 로고
    • Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: A possible in vitro model for positive selection of the T cell repertoire
    • Iwata, M., Hanaoka, S. and Sato, K., Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 1991. 21: 643-648.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 643-648
    • Iwata, M.1    Hanaoka, S.2    Sato, K.3
  • 9
    • 0023818566 scopus 로고
    • T cell selection in the thymus
    • Sprent, J., Lo, D., Gao, E. K. and Ron, Y., T cell selection in the thymus. Immunol. Rev. 1988. 101: 173-190.
    • (1988) Immunol. Rev. , vol.101 , pp. 173-190
    • Sprent, J.1    Lo, D.2    Gao, E.K.3    Ron, Y.4
  • 10
    • 0028806218 scopus 로고
    • A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development
    • King, L. B., Vacchio, M. S., Dixon, K., Hunziker, R., Margulies, D. H. and Ashwell, J. D., A targeted glucocorticoid receptor antisense transgene increases thymocyte apoptosis and alters thymocyte development. Immunity 1995. 3: 647-656.
    • (1995) Immunity , vol.3 , pp. 647-656
    • King, L.B.1    Vacchio, M.S.2    Dixon, K.3    Hunziker, R.4    Margulies, D.H.5    Ashwell, J.D.6
  • 11
    • 0031907999 scopus 로고    scopus 로고
    • Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice
    • Tolosa, E., King, L. B. and Ashwell, J. D., Thymocyte glucocorticoid resistance alters positive selection and inhibits autoimmunity and lymphoproliferative disease in MRL-lpr/lpr mice. Immunity 1998. 8: 67-76.
    • (1998) Immunity , vol.8 , pp. 67-76
    • Tolosa, E.1    King, L.B.2    Ashwell, J.D.3
  • 12
  • 13
    • 0029744303 scopus 로고    scopus 로고
    • Cross-talk between the T cell antigen receptor and the glucocorticoid receptor regulates thymocyte development
    • Ashwell, J. D., King, L. B. and Vacchio, M. S., Cross-talk between the T cell antigen receptor and the glucocorticoid receptor regulates thymocyte development. Stem Cells 1996. 14: 490-500.
    • (1996) Stem Cells , vol.14 , pp. 490-500
    • Ashwell, J.D.1    King, L.B.2    Vacchio, M.S.3
  • 14
    • 0031011063 scopus 로고    scopus 로고
    • Thymus-derived glucocorticoids regulate antigen-specific positive selection
    • Vacchio, M. S. and Ashwell, J. D., Thymus-derived glucocorticoids regulate antigen-specific positive selection. J. Exp. Med. 1997. 185: 2033-2038.
    • (1997) J. Exp. Med. , vol.185 , pp. 2033-2038
    • Vacchio, M.S.1    Ashwell, J.D.2
  • 15
    • 0033179257 scopus 로고    scopus 로고
    • Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation
    • Vacchio, M. S., Lee, J. Y. and Ashwell, J. D., Thymus-derived glucocorticoids set the thresholds for thymocyte selection by inhibiting TCR-mediated thymocyte activation. J. Immunol. 1999. 163: 1327-1333.
    • (1999) J. Immunol. , vol.163 , pp. 1327-1333
    • Vacchio, M.S.1    Lee, J.Y.2    Ashwell, J.D.3
  • 16
    • 0034675287 scopus 로고    scopus 로고
    • Glucocorticoid resistance in thymocytes from mice expressing a T cell receptor transgene
    • Pazirandeh, A., Xue, Y., Okret, S. and Jondal, M., Glucocorticoid resistance in thymocytes from mice expressing a T cell receptor transgene. Biochem. Biophys. Res. Commun. 2000. 276: 189-196.
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 189-196
    • Pazirandeh, A.1    Xue, Y.2    Okret, S.3    Jondal, M.4
  • 17
    • 0032979994 scopus 로고    scopus 로고
    • Partial blockade of T cell differentiation during ontogeny and marked alterations of the thymic microenvironment in transgenic mice with impaired glucocorticoid receptor function
    • Sacedon, R., Vicente, A., Varas, A., Morale, M. C., Barden, N., Marchetti, B. and Zapata, A. G., Partial blockade of T cell differentiation during ontogeny and marked alterations of the thymic microenvironment in transgenic mice with impaired glucocorticoid receptor function. J. Neuroimmunol. 1999. 98: 157-167.
    • (1999) J. Neuroimmunol. , vol.98 , pp. 157-167
    • Sacedon, R.1    Vicente, A.2    Varas, A.3    Morale, M.C.4    Barden, N.5    Marchetti, B.6    Zapata, A.G.7
  • 18
    • 0029123504 scopus 로고
    • Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: Effects on T cell trafficking and T cell responsiveness during postnatal development
    • Morale, M. C., Batticane, N., Gallo, F., Barden, N. and Marchetti, B., Disruption of hypothalamic-pituitary-adrenocortical system in transgenic mice expressing type II glucocorticoid receptor antisense ribonucleic acid permanently impairs T cell function: effects on T cell trafficking and T cell responsiveness during postnatal development. Endocrinology 1995. 136: 3949-3960.
    • (1995) Endocrinology , vol.136 , pp. 3949-3960
    • Morale, M.C.1    Batticane, N.2    Gallo, F.3    Barden, N.4    Marchetti, B.5
  • 19
    • 0036581326 scopus 로고    scopus 로고
    • Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis
    • Pazirandeh, A., Xue, Y., Prestegaard, T., Jondal, M. and Okret, S., Effects of altered glucocorticoid sensitivity in the T cell lineage on thymocyte and T cell homeostasis. FASEB J. 2002. 16: 727-729.
    • (2002) FASEB J. , vol.16 , pp. 727-729
    • Pazirandeh, A.1    Xue, Y.2    Prestegaard, T.3    Jondal, M.4    Okret, S.5
  • 20
    • 0028913259 scopus 로고
    • Molecular genetic analysis of glucocorticoid signaling during mouse development
    • Cole, T. J., Blendy, J. A., Monaghan, A. P., Schmid, W., Aguzzi, A. and Schutz, G., Molecular genetic analysis of glucocorticoid signaling during mouse development. Steroids 1995. 60: 93-96.
    • (1995) Steroids , vol.60 , pp. 93-96
    • Cole, T.J.1    Blendy, J.A.2    Monaghan, A.P.3    Schmid, W.4    Aguzzi, A.5    Schutz, G.6
  • 21
  • 22
    • 0032768417 scopus 로고    scopus 로고
    • The glucocorticoid receptor is essential for maintaining basal and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene
    • Cole, T. J., Harris, H. J., Hoong, I., Solomon, N., Smith, R., Krozowski, Z. and Fullerton, M. J., The glucocorticoid receptor is essential for maintaining basal and dexamethasone-induced repression of the murine corticosteroid-binding globulin gene. Mol. Cell. Endocrinol. 1999. 154: 29-36.
    • (1999) Mol. Cell. Endocrinol. , vol.154 , pp. 29-36
    • Cole, T.J.1    Harris, H.J.2    Hoong, I.3    Solomon, N.4    Smith, R.5    Krozowski, Z.6    Fullerton, M.J.7
  • 23
    • 0035931996 scopus 로고    scopus 로고
    • GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant
    • Cole, T. J., Myles, K., Purton, J. F., Brereton, P. S., Solomon, N. M., Godfrey, D. I. and Funder, J. W., GRKO mice express an aberrant dexamethasone-binding glucocorticoid receptor, but are profoundly glucocorticoid resistant. Mol. Cell. Endocrinol. 2001. 173: 193-202.
    • (2001) Mol. Cell. Endocrinol. , vol.173 , pp. 193-202
    • Cole, T.J.1    Myles, K.2    Purton, J.F.3    Brereton, P.S.4    Solomon, N.M.5    Godfrey, D.I.6    Funder, J.W.7
  • 24
    • 0033715726 scopus 로고    scopus 로고
    • Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling
    • Purton, J. F, Boyd, R. L., Cole, T. J. and Godfrey, D. I., Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling. Immunity 2000. 13: 179-186.
    • (2000) Immunity , vol.13 , pp. 179-186
    • Purton, J.F.1    Boyd, R.L.2    Cole, T.J.3    Godfrey, D.I.4
  • 25
    • 0034515723 scopus 로고    scopus 로고
    • Do glucocorticoids participate in thymocyte development?
    • Ashwell, J. D., Vacchio, M. S. and Galon, J., Do glucocorticoids participate in thymocyte development? Immunol. Today. 2000. 21: 644-646.
    • (2000) Immunol. Today , vol.21 , pp. 644-646
    • Ashwell, J.D.1    Vacchio, M.S.2    Galon, J.3
  • 26
    • 0034914405 scopus 로고    scopus 로고
    • A role for glucocorticoids in the thymus?
    • Jondal, M., Pazirandeh, A. and Okret, S., A role for glucocorticoids in the thymus? Trends Immunol. 2001. 22: 185-186.
    • (2001) Trends Immunol. , vol.22 , pp. 185-186
    • Jondal, M.1    Pazirandeh, A.2    Okret, S.3
  • 27
    • 0036681630 scopus 로고    scopus 로고
    • Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development
    • Brewer, J. A., Sleckman, B. P., Swat, W. and Muglia, L. J., Green fluorescent protein-glucocorticoid receptor knockin mice reveal dynamic receptor modulation during thymocyte development. J. Immunol. 2002. 169: 1309-1318.
    • (2002) J. Immunol. , vol.169 , pp. 1309-1318
    • Brewer, J.A.1    Sleckman, B.P.2    Swat, W.3    Muglia, L.J.4
  • 28
    • 0034509630 scopus 로고    scopus 로고
    • Stress-free T cell development: Glucocorticoids are not obligatory
    • Godfrey, D. I., Purton, J. F., Boyd, R. L. and Cole, T. J., Stress-free T cell development: glucocorticoids are not obligatory. Immunol. Today 2000. 21: 606-611.
    • (2000) Immunol. Today , vol.21 , pp. 606-611
    • Godfrey, D.I.1    Purton, J.F.2    Boyd, R.L.3    Cole, T.J.4
  • 29
  • 30
    • 0033526816 scopus 로고    scopus 로고
    • B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    • Loder, F., Mutschler, B., Ray, R. J., Paige, C. J., Sideras, P., Torres, R., Lamers, M. C. and Carsetti, R., B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 1999. 190: 75-89.
    • (1999) J. Exp. Med. , vol.190 , pp. 75-89
    • Loder, F.1    Mutschler, B.2    Ray, R.J.3    Paige, C.J.4    Sideras, P.5    Torres, R.6    Lamers, M.C.7    Carsetti, R.8
  • 31
    • 0031225999 scopus 로고    scopus 로고
    • Developmental pathways of dendritic cells in vivo: Distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice
    • Pulendran, B., Lingappa, J., Kennedy, M. K., Smith, J., Teepe, M., Rudensky, A., Maliszewski, C. R. and Maraskovsky, E., Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice. J. Immunol. 1997. 159: 2222-2231.
    • (1997) J. Immunol. , vol.159 , pp. 2222-2231
    • Pulendran, B.1    Lingappa, J.2    Kennedy, M.K.3    Smith, J.4    Teepe, M.5    Rudensky, A.6    Maliszewski, C.R.7    Maraskovsky, E.8
  • 32
    • 0032078919 scopus 로고    scopus 로고
    • A positive role for thymus-derived steroids in formation of the T cell repertoire
    • Vacchio, M. S., Ashwell, J. D. and King, L. B., A positive role for thymus-derived steroids in formation of the T cell repertoire. Ann. N. Y. Acad. Sci. 1998. 840: 317-327.
    • (1998) Ann. N. Y. Acad. Sci. , vol.840 , pp. 317-327
    • Vacchio, M.S.1    Ashwell, J.D.2    King, L.B.3
  • 33
    • 0034049874 scopus 로고    scopus 로고
    • Glucocorticoids in T cell development and function
    • Ashwell, J. D., Lu, F. W. and Vacchio, M. S., Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 2000. 18: 309-345.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 309-345
    • Ashwell, J.D.1    Lu, F.W.2    Vacchio, M.S.3
  • 34
    • 0029665099 scopus 로고    scopus 로고
    • Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice
    • Xue, Y., Murdjeva, M., Okret, S., McConkey, D., Kiuossis, D. and Jondal, M., Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice. Eur. J. Immunol. 1996. 26: 428-434.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 428-434
    • Xue, Y.1    Murdjeva, M.2    Okret, S.3    McConkey, D.4    Kiuossis, D.5    Jondal, M.6
  • 35
    • 0027548992 scopus 로고
    • Influence of viral superantigens on V beta- and V alpha-specific positive and negative selection
    • Tomonari, K., Fairchild, S. and Rosenwasser, O. A., Influence of viral superantigens on V beta- and V alpha-specific positive and negative selection. Immunol. Rev. 1993. 131: 131-168.
    • (1993) Immunol. Rev. , vol.131 , pp. 131-168
    • Tomonari, K.1    Fairchild, S.2    Rosenwasser, O.A.3
  • 36
    • 0034454682 scopus 로고    scopus 로고
    • How do glucocorticoids; influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
    • Sapolsky, R. M., Romero, L. M. and Munck, A. U., How do glucocorticoids; influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr. Rev. 2000. 21: 55-89.
    • (2000) Endocr. Rev. , vol.21 , pp. 55-89
    • Sapolsky, R.M.1    Romero, L.M.2    Munck, A.U.3
  • 37
    • 0026543152 scopus 로고
    • Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene
    • Pepin, M. C., Pothier, F. and Barden, N., Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature 1992. 355: 725-728.
    • (1992) Nature , vol.355 , pp. 725-728
    • Pepin, M.C.1    Pothier, F.2    Barden, N.3
  • 38
    • 0034691090 scopus 로고    scopus 로고
    • Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling
    • Jamieson, C. A. and Yamamoto, K. R., Crosstalk pathway for inhibition of glucocorticoid-induced apoptosis by T cell receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 2000. 97: 7319-7324.
    • (2000) Proc. Natl. Acad. Sci. U S A , vol.97 , pp. 7319-7324
    • Jamieson, C.A.1    Yamamoto, K.R.2
  • 40
    • 0036272305 scopus 로고    scopus 로고
    • Increased p300 expression inhibits glucocorticoid receptor-T cell receptor antagonism but does not affect thymocyte positive selection
    • Yu, C. T., Fang, M. H., Shih, H. M. and Lai, M. Z., Increased p300 expression inhibits glucocorticoid receptor-T cell receptor antagonism but does not affect thymocyte positive selection. Mol. Cell. Biol. 2002. 22: 4556-4566.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4556-4566
    • Yu, C.T.1    Fang, M.H.2    Shih, H.M.3    Lai, M.Z.4
  • 41
    • 0033526862 scopus 로고    scopus 로고
    • Several different cell surface molecules control negative selection of medullary thymocytes
    • Kishimoto, H. and Sprent, J., Several different cell surface molecules control negative selection of medullary thymocytes. J. Exp. Med. 1999. 190: 65-73.
    • (1999) J. Exp. Med. , vol.190 , pp. 65-73
    • Kishimoto, H.1    Sprent, J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.