메뉴 건너뛰기




Volumn 15, Issue 5, 2005, Pages 315-322

Granzyme B and natural killer (NK) cell death

Author keywords

Apoptosis; Autoantibody; Granzyme B; Natural killer (NK) cell

Indexed keywords

ALANINE TRANSFER RNA LIGASE; AUTOANTIBODY; AUTOANTIGEN; CASPASE; CASPASE 10; CASPASE 3; CASPASE 7; CHOLINERGIC RECEPTOR; DNA DIRECTED RNA POLYMERASE; DNA TOPOISOMERASE; FIBRILLARIN; FILAMIN; FODRIN; GRANZYME B; HISTIDINE TRANSFER RNA LIGASE; ISOLEUCINE TRANSFER RNA LIGASE; KI 67 ANTIGEN; LA ANTIGEN; LAMIN B; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 3; NUCLEOPHOSMIN; PROTEIN BID; RNA POLYMERASE II; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR;

EID: 27744545340     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-005-0426-6     Document Type: Review
Times cited : (22)

References (100)
  • 1
    • 0034104585 scopus 로고    scopus 로고
    • Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo
    • 10.1016/S0952-7915(00)00094-7 10781403
    • JA Trapani J Davis VR Sutton MJ Smyth 2000 Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo Curr Opin Immunol 12 323-9 10.1016/S0952-7915(00)00094-7 10781403
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 323-329
    • Trapani, J.A.1    Davis, J.2    Sutton, V.R.3    Smyth, M.J.4
  • 2
    • 0037833737 scopus 로고    scopus 로고
    • Granzyme B: A natural born killer
    • 10.1034/j.1600-065X.2003.00044.x 12752668
    • SJ Lord RV Rajotte GS Korbutt RC Bleackley 2003 Granzyme B: A natural born killer Immunol Rev 193 31-8 10.1034/j.1600-065X.2003.00044.x 12752668
    • (2003) Immunol. Rev. , vol.193 , pp. 31-38
    • Lord, S.J.1    Rajotte, R.V.2    Korbutt, G.S.3    Bleackley, R.C.4
  • 3
    • 0033588955 scopus 로고    scopus 로고
    • Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
    • 10.1084/jem.190.6.815 10499920
    • L Casciola-Rosen F Andrade D Ulanet WB Wong A Rosen 1999 Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity J Exp Med 190 815-26 10.1084/ jem.190.6.815 10499920
    • (1999) J. Exp. Med. , vol.190 , pp. 815-826
    • Casciola-Rosen, L.1    Andrade, F.2    Ulanet, D.3    Wong, W.B.4    Rosen, A.5
  • 4
    • 0029874672 scopus 로고    scopus 로고
    • Receptors for HLA class-I molecules in human natural killer cells
    • 10.1146/annurev.immunol.14.1.619 8717527
    • A Moretta C Bottino M Vitale D Pende R Biassoni MC Mingari 1996 Receptors for HLA class-I molecules in human natural killer cells Annu Rev Immunol 14 619-48 10.1146/annurev.immunol.14.1.619 8717527
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 619-648
    • Moretta, A.1    Bottino, C.2    Vitale, M.3    Pende, D.4    Biassoni, R.5    Mingari, M.C.6
  • 5
    • 0031944075 scopus 로고    scopus 로고
    • NK cell receptors
    • 10.1146/annurev.immunol.16.1.359 9597134
    • LL Lanier 1998 NK cell receptors Annu Rev Immunol 16 359-93 10.1146/ annurev.immunol.16.1.359 9597134
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 359-393
    • Lanier, L.L.1
  • 6
    • 0027514685 scopus 로고
    • The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: Evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms
    • 10.1084/jem.177.1.155 8418197
    • K Takeda G Dennert 1993 The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: Evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms J Exp Med 177 155-64 10.1084/jem.177.1.155 8418197
    • (1993) J. Exp. Med. , vol.177 , pp. 155-164
    • Takeda, K.1    Dennert, G.2
  • 7
    • 0030712367 scopus 로고    scopus 로고
    • Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells
    • 10.1084/jem.186.10.1677 9362528
    • B Zhang T Yamamura T Kondo M Fujiwara T Tabira 1997 Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells J Exp Med 186 1677-87 10.1084/jem.186.10.1677 9362528
    • (1997) J. Exp. Med. , vol.186 , pp. 1677-1687
    • Zhang, B.1    Yamamura, T.2    Kondo, T.3    Fujiwara, M.4    Tabira, T.5
  • 8
    • 0032193206 scopus 로고    scopus 로고
    • A role for NK cells as regulators of CD4+ T cells in a transfer model of colitis
    • 9759840
    • MM Fort MW Leach DM Rennick 1998 A role for NK cells as regulators of CD4+ T cells in a transfer model of colitis J Immunol 161 3256-61 9759840
    • (1998) J. Immunol. , vol.161 , pp. 3256-3261
    • Fort, M.M.1    Leach, M.W.2    Rennick, D.M.3
  • 9
    • 0023645045 scopus 로고
    • A family of serine esterases in lytic granules of cytolytic T lymphocytes
    • 10.1016/0092-8674(87)90544-7 3555842
    • D Masson J Tschopp 1987 A family of serine esterases in lytic granules of cytolytic T lymphocytes Cell 49 679-85 10.1016/0092-8674(87)90544-7 3555842
    • (1987) Cell , vol.49 , pp. 679-685
    • Masson, D.1    Tschopp, J.2
  • 11
    • 1642541145 scopus 로고    scopus 로고
    • Granzyme B and perforin: Constitutive expression in human polymorphonuclear neutrophils
    • 10.1182/blood-2003-04-1069 14512315
    • C Wagner C Iking-Konert B Denefleh S Stegmaier F Hug GM Hansch 2004 Granzyme B and perforin: Constitutive expression in human polymorphonuclear neutrophils Blood 103 1099-104 10.1182/ blood-2003-04-1069 14512315
    • (2004) Blood , vol.103 , pp. 1099-1104
    • Wagner, C.1    Iking-Konert, C.2    Denefleh, B.3    Stegmaier, S.4    Hug, F.5    Hansch, G.M.6
  • 12
    • 0034284472 scopus 로고    scopus 로고
    • Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: Implication of granzyme B and perforin
    • 10961894
    • AP Bruno D Lautier AT d'Orgeix G Laurent A Quillet-Mary 2000 Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: Implication of granzyme B and perforin Blood 96 1914-20 10961894
    • (2000) Blood , vol.96 , pp. 1914-1920
    • Bruno, A.P.1    Lautier, D.2    d'Orgeix, A.T.3    Laurent, G.4    Quillet-Mary, A.5
  • 13
    • 0042845990 scopus 로고    scopus 로고
    • Expression of endogenous granzyme B in a subset of human primary breast carcinomas
    • 10.1038/sj.bjc.6601051 12838314
    • SX Hu S Wang JP Wang GB Mills Y Zhou HJ Xu 2003 Expression of endogenous granzyme B in a subset of human primary breast carcinomas Br J Cancer 89 135-9 10.1038/sj.bjc.6601051 12838314
    • (2003) Br. J. Cancer , vol.89 , pp. 135-139
    • Hu, S.X.1    Wang, S.2    Wang, J.P.3    Mills, G.B.4    Zhou, Y.5    Xu, H.J.6
  • 14
    • 0008957831 scopus 로고    scopus 로고
    • Apoptotic chondrocyte death in rheumatoid arthritis
    • 10.1002/1529-0131(199907)42:7<1528::AID-ANR28>3.0.CO;2-9 10403282
    • HA Kim YW Song 1999 Apoptotic chondrocyte death in rheumatoid arthritis Arthritis Rheum 42 1528-37 10.1002/ 1529-0131(199907)42:7<1528::AID-ANR28>3.0.CO;2-9 10403282
    • (1999) Arthritis Rheum. , vol.42 , pp. 1528-1537
    • Kim, H.A.1    Song, Y.W.2
  • 15
    • 0033652796 scopus 로고    scopus 로고
    • Leukocyte granule proteins mobilize innate host defenses and adaptive immune responses
    • 10.1034/j.1600-065X.2000.17702.x 11138786
    • O Chertov D Yang OM Howard JJ Oppenheim 2000 Leukocyte granule proteins mobilize innate host defenses and adaptive immune responses Immunol Rev 177 68-78 10.1034/j.1600-065X.2000.17702.x 11138786
    • (2000) Immunol. Rev. , vol.177 , pp. 68-78
    • Chertov, O.1    Yang, D.2    Howard, O.M.3    Oppenheim, J.J.4
  • 16
    • 3242761502 scopus 로고    scopus 로고
    • Human neutrophils lack granzyme A, granzyme B, and perforin
    • 10.1182/blood-2004-03-0888 15265799
    • SS Metkar CJ Froelich 2004 Human neutrophils lack granzyme A, granzyme B, and perforin Blood 104 905-6 10.1182/blood-2004-03-0888 15265799
    • (2004) Blood , vol.104 , pp. 905-906
    • Metkar, S.S.1    Froelich, C.J.2
  • 17
    • 3242790966 scopus 로고    scopus 로고
    • Granzymes A and B are not expressed in human neutrophils
    • 10.1182/blood-2004-03-0858 15265800
    • WJ Grossman TJ Ley 2004 Granzymes A and B are not expressed in human neutrophils Blood 104 906-7 10.1182/blood-2004-03-0858 15265800
    • (2004) Blood , vol.104 , pp. 906-907
    • Grossman, W.J.1    Ley, T.J.2
  • 18
    • 0036779576 scopus 로고    scopus 로고
    • Functional significance of the perforin/granzyme cell death pathway
    • 10.1038/nri911 12360212
    • JA Trapani MJ Smyth 2002 Functional significance of the perforin/ granzyme cell death pathway Nat Rev Immunol 2 735-47 10.1038/nri911 12360212
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 735-747
    • Trapani, J.A.1    Smyth, M.J.2
  • 19
    • 0034721646 scopus 로고    scopus 로고
    • Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
    • 10.1016/S0092-8674(00)00140-9 11081635
    • B Motyka G Korbutt MJ Pinkoski JA Heibein A Caputo M Hobman 2000 Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis Cell 103 491-500 10.1016/S0092-8674(00)00140-9 11081635
    • (2000) Cell , vol.103 , pp. 491-500
    • Motyka, B.1    Korbutt, G.2    Pinkoski, M.J.3    Heibein, J.A.4    Caputo, A.5    Hobman, M.6
  • 20
    • 0036195424 scopus 로고    scopus 로고
    • Cytotoxic cell granule-mediated apoptosis: Perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation
    • 10.1016/S1074-7613(02)00286-8 11911826
    • SS Metkar B Wang M Aguilar-Santelises SM Raja L Uhlin-Hansen E Podack 2002 Cytotoxic cell granule-mediated apoptosis: Perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation Immunity 16 417-28 10.1016/S1074-7613(02)00286-8 11911826
    • (2002) Immunity , vol.16 , pp. 417-428
    • Metkar, S.S.1    Wang, B.2    Aguilar-Santelises, M.3    Raja, S.M.4    Uhlin-Hansen, L.5    Podack, E.6
  • 21
    • 2342514099 scopus 로고    scopus 로고
    • The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis
    • 10.1182/blood-2003-06-2156 14739229
    • K Veugelers B Motyka C Frantz I Shostak T Sawchuk RC Bleackley 2004 The granzyme B-serglycin complex from cytotoxic granules requires dynamin for endocytosis Blood 103 3845-53 10.1182/blood-2003-06-2156 14739229
    • (2004) Blood , vol.103 , pp. 3845-3853
    • Veugelers, K.1    Motyka, B.2    Frantz, C.3    Shostak, I.4    Sawchuk, T.5    Bleackley, R.C.6
  • 22
    • 17844380811 scopus 로고    scopus 로고
    • Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis
    • 15843543
    • L Shi D Keefe E Durand H Feng D Zhang J Lieberman 2005 Granzyme B binds to target cells mostly by charge and must be added at the same time as perforin to trigger apoptosis J Immunol 174 5456-61 15843543
    • (2005) J. Immunol. , vol.174 , pp. 5456-5461
    • Shi, L.1    Keefe, D.2    Durand, E.3    Feng, H.4    Zhang, D.5    Lieberman, J.6
  • 23
    • 20144380101 scopus 로고    scopus 로고
    • A novel mechanism for protein delivery: Granzyme B undergoes electrostatic exchange from serglycin to target cells
    • 10.1074/jbc.M501181200 15788411
    • SM Raja SS Metkar S Honing B Wang WA Russin NH Pipalia 2005 A novel mechanism for protein delivery: Granzyme B undergoes electrostatic exchange from serglycin to target cells J Biol Chem 280 20752-61 10.1074/ jbc.M501181200 15788411
    • (2005) J. Biol. Chem. , vol.280 , pp. 20752-20761
    • Raja, S.M.1    Metkar, S.S.2    Honing, S.3    Wang, B.4    Russin, W.A.5    Pipalia, N.H.6
  • 24
    • 13644252220 scopus 로고    scopus 로고
    • Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner
    • 10.1084/jem.20031877 15699075
    • M Sebbagh J Hamelin J Bertoglio E Solary J Breard 2005 Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner J Exp Med 201 465-71 10.1084/jem.20031877 15699075
    • (2005) J. Exp. Med. , vol.201 , pp. 465-471
    • Sebbagh, M.1    Hamelin, J.2    Bertoglio, J.3    Solary, E.4    Breard, J.5
  • 25
    • 0142103373 scopus 로고    scopus 로고
    • Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B
    • 10.1074/jbc.M302644200 12874291
    • C Gross W Koelch A DeMaio N Arispe G Multhoff 2003 Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B J Biol Chem 278 41173-81 10.1074/jbc.M302644200 12874291
    • (2003) J. Biol. Chem. , vol.278 , pp. 41173-47181
    • Gross, C.1    Koelch, W.2    DeMaio, A.3    Arispe, N.4    Multhoff, G.5
  • 26
    • 0035890085 scopus 로고    scopus 로고
    • The expanding role of mitochondria in apoptosis
    • 11711427
    • X Wang 2001 The expanding role of mitochondria in apoptosis Genes Dev 15 2922-33 11711427
    • (2001) Genes Dev. , vol.15 , pp. 2922-2933
    • Wang, X.1
  • 27
  • 29
    • 0029914132 scopus 로고    scopus 로고
    • A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
    • 10.1074/jbc.271.44.27802 8910377
    • J Sun CH Bird V Sutton L McDonald PB Coughlin TA De Jong 1996 A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes J Biol Chem 271 27802-9 10.1074/jbc.271.44.27802 8910377
    • (1996) J. Biol. Chem. , vol.271 , pp. 27802-27809
    • Sun, J.1    Bird, C.H.2    Sutton, V.3    McDonald, L.4    Coughlin, P.B.5    De Jong, T.A.6
  • 30
    • 0031792776 scopus 로고    scopus 로고
    • Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway
    • 9774654
    • CH Bird VR Sutton J Sun CE Hirst A Novak S Kumar 1998 Selective regulation of apoptosis: The cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death pathway Mol Cell Biol 18 6387-98 9774654
    • (1998) Mol. Cell Biol. , vol.18 , pp. 6387-6398
    • Bird, C.H.1    Sutton, V.R.2    Sun, J.3    Hirst, C.E.4    Novak, A.5    Kumar, S.6
  • 31
    • 0033026169 scopus 로고    scopus 로고
    • Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins
    • 10.1046/j.1440-1711.1999.00787.x 10101686
    • PI Bird 1999 Regulation of pro-apoptotic leucocyte granule serine proteinases by intracellular serpins Immunol Cell Biol 77 47-57 10.1046/ j.1440-1711.1999.00787.x 10101686
    • (1999) Immunol. Cell Biol. , vol.77 , pp. 47-57
    • Bird, P.I.1
  • 32
    • 0035284891 scopus 로고    scopus 로고
    • The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites
    • 11207275
    • BA Bladergroen MC Strik N Bovenschen O van Berkum GL Scheffer CJ Meijer 2001 The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites J Immunol 166 3218-25 11207275
    • (2001) J. Immunol. , vol.166 , pp. 3218-3225
    • Bladergroen, B.A.1    Strik, M.C.2    van Bovenschen, N.3    Berkum, O.4    Scheffer, G.L.5    Meijer, C.J.6
  • 33
    • 17444408171 scopus 로고    scopus 로고
    • The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells
    • 10.1002/eji.200425949 15739160
    • BA Bladergroen MC Strik AM Wolbink D Wouters R Broekhuizen JA Kummer 2005 The granzyme B inhibitor proteinase inhibitor 9 (PI9) is expressed by human mast cells Eur J Immunol 35 1175-83 10.1002/eji.200425949 15739160
    • (2005) Eur. J. Immunol. , vol.35 , pp. 1175-1183
    • Bladergroen, B.A.1    Strik, M.C.2    Wolbink, A.M.3    Wouters, D.4    Broekhuizen, R.5    Kummer, J.A.6
  • 34
    • 0035949570 scopus 로고    scopus 로고
    • Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
    • 10.1073/pnas.201398198 11562487
    • JP Medema J de Jong LT Peltenburg EM Verdegaal A Gorter SA Bres 2001 Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors Proc Natl Acad Sci USA 98 11515-20 10.1073/ pnas.201398198 11562487
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11515-11520
    • Medema, J.P.1    de Jong, J.2    Peltenburg, L.T.3    Verdegaal, E.M.4    Gorter, A.5    Bres, S.A.6
  • 35
    • 0036095702 scopus 로고    scopus 로고
    • Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: A novel protective mechanism for tumor cells to circumvent the immune system?
    • 10.1182/blood.V99.1.232 11756176
    • BA Bladergroen CJ Meijer RL ten Berge CE Hack JJ Muris DF Dukers 2002 Expression of the granzyme B inhibitor, protease inhibitor 9, by tumor cells in patients with non-Hodgkin and Hodgkin lymphoma: A novel protective mechanism for tumor cells to circumvent the immune system? Blood 99 232-7 10.1182/blood.V99.1.232 11756176
    • (2002) Blood , vol.99 , pp. 232-237
    • Bladergroen, B.A.1    Meijer, C.J.2    ten Berge, R.L.3    Hack, C.E.4    Muris, J.J.5    Dukers, D.F.6
  • 36
    • 17944376032 scopus 로고    scopus 로고
    • Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: Differential modulation by T helper type 1 and type 2 cells
    • 10.1084/jem.194.5.657 11535633
    • JP Medema DH Schuurhuis D Rea J van Tongeren J de Jong SA Bres 2001 Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: Differential modulation by T helper type 1 and type 2 cells J Exp Med 194 657-67 10.1084/jem.194.5.657 11535633
    • (2001) J. Exp. Med. , vol.194 , pp. 657-667
    • Medema, J.P.1    Schuurhuis, D.H.2    Rea, D.3    van Tongeren, J.4    de Jong, J.5    Bres, S.A.6
  • 37
    • 0034194055 scopus 로고    scopus 로고
    • The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
    • 10.1084/jem.191.9.1535 10790428
    • JL Young GK Sukhova D Foster W Kisiel P Libby U Schonbeck 2000 The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells J Exp Med 191 1535-44 10.1084/jem.191.9.1535 10790428
    • (2000) J. Exp. Med. , vol.191 , pp. 1535-1544
    • Young, J.L.1    Sukhova, G.K.2    Foster, D.3    Kisiel, W.4    Libby, P.5    Schonbeck, U.6
  • 38
    • 0031863698 scopus 로고    scopus 로고
    • Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens
    • 10.1002/1529-0131(199807)41:7<1152::AID-ART3>3.0.CO;2-L 9663470
    • PJ Utz P Anderson 1998 Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens Arthritis Rheum 41 1152-60 10.1002/1529-0131(199807)41:7<1152::AID-ART3>3.0.CO;2-L 9663470
    • (1998) Arthritis Rheum. , vol.41 , pp. 1152-1160
    • Utz, P.J.1    Anderson, P.2
  • 39
    • 0034469907 scopus 로고    scopus 로고
    • Death, autoantigen modifications, and tolerance
    • 10.1186/ar75 11094420
    • PJ Utz TJ Gensler P Anderson 2000 Death, autoantigen modifications, and tolerance Arthritis Res 2 101-14 10.1186/ar75 11094420
    • (2000) Arthritis Res. , vol.2 , pp. 101-114
    • Utz, P.J.1    Gensler, T.J.2    Anderson, P.3
  • 40
    • 0032917731 scopus 로고    scopus 로고
    • Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease
    • 10.1038/sj.cdd.4400460 10200542
    • A Rosen L Casciola-Rosen 1999 Autoantigens as substrates for apoptotic proteases: Implications for the pathogenesis of systemic autoimmune disease Cell Death Differ 6 6-12 10.1038/sj.cdd.4400460 10200542
    • (1999) Cell Death Differ , vol.6 , pp. 6-12
    • Rosen, A.1    Casciola-Rosen, L.2
  • 41
    • 25444518452 scopus 로고    scopus 로고
    • Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sögren's syndrome
    • 10.1111/j.1365-2249.2005.02888.x 16178869
    • M Huang H Ida M Kamachi N Iwanaga Y Izumi F Tanaka 2005 Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome Clin Exp Immunol 142 148-54 10.1111/ j.1365-2249.2005.02888.x 16178869
    • (2005) Clin. Exp. Immunol. , vol.142 , pp. 148-154
    • Huang, M.1    Ida, H.2    Kamachi, M.3    Iwanaga, N.4    Izumi, Y.5    Tanaka, F.6
  • 42
    • 0036090284 scopus 로고    scopus 로고
    • Apoptotic U1-70kd is antigenically distinct from the intact form of the U1-70-kd molecule
    • 10.1002/art.10211 12115232
    • EL Greidinger MF Foecking S Ranatunga RW Hoffman 2002 Apoptotic U1-70kd is antigenically distinct from the intact form of the U1-70-kd molecule Arthritis Rheum 46 1264-9 10.1002/art.10211 12115232
    • (2002) Arthritis Rheum. , vol.46 , pp. 1264-1269
    • Greidinger, E.L.1    Foecking, M.F.2    Ranatunga, S.3    Hoffman, R.W.4
  • 43
    • 0036064139 scopus 로고    scopus 로고
    • Recognition of granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss
    • 10.1002/art.10407 12124872
    • L Schachna FM Wigley S Morris AC Gelber A Rosen L Casciola-Rosen 2002 Recognition of granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss Arthritis Rheum 46 1873-84 10.1002/ art.10407 12124872
    • (2002) Arthritis Rheum. , vol.46 , pp. 1873-1884
    • Schachna, L.1    Wigley, F.M.2    Morris, S.3    Gelber, A.C.4    Rosen, A.5    Casciola-Rosen, L.6
  • 44
    • 0027997472 scopus 로고
    • Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue
    • 7986219
    • PP Tak JA Kummer CE Hack MR Daha TJ Smeets GW Erkelens 1994 Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue Arthritis Rheum 37 1735-43 7986219
    • (1994) Arthritis Rheum. , vol.37 , pp. 1735-1743
    • Tak, P.P.1    Kummer, J.A.2    Hack, C.E.3    Daha, M.R.4    Smeets, T.J.5    Erkelens, G.W.6
  • 45
    • 1942532230 scopus 로고    scopus 로고
    • T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis
    • 10.1136/ard.2003.009225 15082476
    • MC Kraan JJ Haringman H Weedon EC Barg MD Smith MJ Ahern et al, 2004 T cells, fibroblast-like synoviocytes, and granzyme B+ cytotoxic cells are associated with joint damage in patients with recent onset rheumatoid arthritis Ann Rheum Dis 63 483-8 10.1136/ard.2003.009225 15082476
    • (2004) Ann. Rheum. Dis. , vol.63 , pp. 483-488
    • Kraan, M.C.1    Haringman, J.J.2    Weedon, H.3    Barg, E.C.4    Smith, M.D.5    Ahern, M.J.6
  • 46
    • 0032895417 scopus 로고    scopus 로고
    • The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)
    • 10.1046/j.1365-2249.1999.00881.x 10337032
    • PP Tak L Spaeny-Dekking MC Kraan FC Breedveld CJ Froelich CE Hack 1999 The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA) Clin Exp Immunol 116 366-70 10.1046/j.1365-2249.1999.00881.x 10337032
    • (1999) Clin. Exp. Immunol. , vol.116 , pp. 366-370
    • Tak, P.P.1    Spaeny-Dekking, L.2    Kraan, M.C.3    Breedveld, F.C.4    Froelich, C.J.5    Hack, C.E.6
  • 47
    • 0036067610 scopus 로고    scopus 로고
    • A subset of natural killer cells is greatly expanded within inflamed joints
    • 10.1002/art.10410 12124859
    • N Dalbeth MF Callan 2002 A subset of natural killer cells is greatly expanded within inflamed joints Arthritis Rheum 46 1763-72 10.1002/ art.10410 12124859
    • (2002) Arthritis Rheum. , vol.46 , pp. 1763-1772
    • Dalbeth, N.1    Callan, M.F.2
  • 48
    • 0141615899 scopus 로고    scopus 로고
    • Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype
    • 10.1093/rheumatology/keg240
    • C Pridgeon GP Lennon L Pazmany RN Thompson SE Christmas RJ Moots 2003 Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype Rheumatology (Oxford) 42 870-8 10.1093/rheumatology/keg240
    • (2003) Rheumatology (Oxford) , vol.42 , pp. 870-878
    • Pridgeon, C.1    Lennon, G.P.2    Pazmany, L.3    Thompson, R.N.4    Christmas, S.E.5    Moots, R.J.6
  • 49
    • 17644427742 scopus 로고    scopus 로고
    • Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis
    • 10.1136/ard.2003.007039 15471892
    • R Goldbach-Mansky S Suson R Wesley CE Hack HS El-Gabalawy PP Tak 2005 Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis Ann Rheum Dis 64 715-21 10.1136/ard.2003.007039 15471892
    • (2005) Ann. Rheum. Dis. , vol.64 , pp. 715-721
    • Goldbach-Mansky, R.1    Suson, S.2    Wesley, R.3    Hack, C.E.4    El-Gabalawy, H.S.5    Tak, P.P.6
  • 50
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • 7636184
    • S Sakaguchi N Sakaguchi M Asano M Itoh M Toda 1995 Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 1151-64 7636184
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 51
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • 10.1126/science.1079490 12522256
    • S Hori T Nomura S Sakaguchi 2003 Control of regulatory T cell development by the transcription factor Foxp3 Science 299 1057-61 10.1126/science.1079490 12522256
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 52
    • 0035198252 scopus 로고    scopus 로고
    • B cells and professional APCs recruit regulatory T cells via CCL4
    • 10.1038/ni735 11702067
    • RS Bystry V Aluvihare KA Welch M Kallikourdis AG Betz 2001 B cells and professional APCs recruit regulatory T cells via CCL4 Nat Immunol 2 1126-32 10.1038/ni735 11702067
    • (2001) Nat. Immunol. , vol.2 , pp. 1126-1132
    • Bystry, R.S.1    Aluvihare, V.2    Welch, K.A.3    Kallikourdis, M.4    Betz, A.G.5
  • 53
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • 10.1038/ni1180 15785759
    • H von Boehmer 2005 Mechanisms of suppression by suppressor T cells Nat Immunol 6 338-44 10.1038/ni1180 15785759
    • (2005) Nat. Immunol. , vol.6 , pp. 338-3344
    • von Boehmer, H.1
  • 54
    • 0036597371 scopus 로고    scopus 로고
    • CD4+ CD25+ suppressor T cells: More questions than answers
    • 12093005
    • EM Shevach 2002 CD4+ CD25+ suppressor T cells: More questions than answers Nat Rev Immunol 2 389-400 12093005
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 55
    • 13544271161 scopus 로고    scopus 로고
    • Cutting edge: Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
    • 15699103
    • DC Gondek LF Lu SA Quezada S Sakaguchi RJ Noelle 2005 Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism J Immunol 174 1783-6 15699103
    • (2005) J. Immunol. , vol.174 , pp. 1783-1786
    • Gondek, D.C.1    Lu, S.A.2    Quezada, L.F.3    Sakaguchi, S.4    Noelle, R.J.5
  • 56
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • 10.1016/j.immuni.2004.09.002 15485635
    • WJ Grossman JW Verbsky W Barchet M Colonna JP Atkinson TJ Ley 2004 Human T regulatory cells can use the perforin pathway to cause autologous target cell death Immunity 21 589-601 10.1016/j.immuni.2004.09.002 15485635
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 57
    • 27744496855 scopus 로고    scopus 로고
    • CD94 workshop: Induction of apoptosis in interleukin 2-activated natural killer cells by cross-linking of workshop natural killer cell monoclonal antibodies
    • Proceedings of the sixth international CD workshop and conference
    • Ida H, Anderson P. CD94 workshop: Induction of apoptosis in interleukin 2-activated natural killer cells by cross-linking of workshop natural killer cell monoclonal antibodies. Proceedings of the sixth international CD workshop and conference. Leucocyte typing VI. 1997; p. 282-5.
    • (1997) Leucocyte Typing VI , pp. 282-285
    • Ida, H.1    Anderson, P.2
  • 58
    • 0031229824 scopus 로고    scopus 로고
    • CD94 ligation induces apoptosis in a subset of IL-2-stimulated NK cells
    • 9278302
    • H Ida MJ Robertson S Voss J Ritz P Anderson 1997 CD94 ligation induces apoptosis in a subset of IL-2-stimulated NK cells J Immunol 159 2154-60 9278302
    • (1997) J. Immunol. , vol.159 , pp. 2154-2160
    • Ida, H.1    Robertson, M.J.2    Voss, S.3    Ritz, J.4    Anderson, P.5
  • 59
    • 0036214286 scopus 로고    scopus 로고
    • Structure and function of natural killer cell receptors: Multiple molecular solutions to self, nonself discrimination
    • 10.1146/annurev.immunol.20.100301.064812 11861620
    • K Natarajan N Dimasi J Wang RA Mariuzza DH Margulies 2002 Structure and function of natural killer cell receptors: Multiple molecular solutions to self, nonself discrimination Annu Rev Immunol 20 853-85 10.1146/ annurev.immunol.20.100301.064812 11861620
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 853-885
    • Natarajan, K.1    Dimasi, N.2    Wang, J.3    Mariuzza, R.A.4    Margulies, D.H.5
  • 60
    • 0031717783 scopus 로고    scopus 로고
    • HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors
    • 10.1159/000025346 9758906
    • PE Posch F Borrego AG Brooks JE Coligan 1998 HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors J Biomed Sci 5 321-31 10.1159/ 000025346 9758906
    • (1998) J. Biomed. Sci. , vol.5 , pp. 321-331
    • Posch, P.E.1    Borrego, F.2    Brooks, A.G.3    Coligan, J.E.4
  • 61
    • 0031980631 scopus 로고    scopus 로고
    • Activation-induced NK cell death triggered by CD2 stimulation
    • 9565369
    • H Ida P Anderson 1998 Activation-induced NK cell death triggered by CD2 stimulation Eur J Immunol 28 1292-300 9565369
    • (1998) Eur. J. Immunol. , vol.28 , pp. 1292-1300
    • Ida, H.1    Anderson, P.2
  • 62
    • 0028899622 scopus 로고
    • Receptor-induced death in human natural killer cells: Involvement of CD16
    • 10.1084/jem.181.1.339 7528771
    • JR Ortaldo AT Mason JJ O'Shea 1995 Receptor-induced death in human natural killer cells: Involvement of CD16 J Exp Med 181 339-44 10.1084/ jem.181.1.339 7528771
    • (1995) J. Exp. Med. , vol.181 , pp. 339-344
    • Ortaldo, J.R.1    Mason, A.T.2    O'Shea, J.J.3
  • 63
    • 10744233370 scopus 로고    scopus 로고
    • Granzyme B leakage-induced cell death: A new type of activation-induced natural killer cell death
    • 10.1002/eji.200324376 14635036
    • H Ida T Nakashima NL Kedersha S Yamasaki M Huang Y Izumi 2003 Granzyme B leakage-induced cell death: A new type of activation-induced natural killer cell death Eur J Immunol 33 3284-92 10.1002/eji.200324376 14635036
    • (2003) Eur. J. Immunol. , vol.33 , pp. 3284-3292
    • Ida, H.1    Nakashima, T.2    Kedersha, N.L.3    Yamasaki, S.4    Huang, M.5    Izumi, Y.6
  • 64
    • 0032168394 scopus 로고    scopus 로고
    • Natural killer cell lysis of cytomegalovirus (CMV)-infected cells correlates with virally induced changes in cell surface lymphocyte function-associated antigen-3 (LFA-3) expression and not with the CMV-induced down-regulation of cell surface class I HLA
    • 9725232
    • JM Fletcher HG Prentice JE Grundy 1998 Natural killer cell lysis of cytomegalovirus (CMV)-infected cells correlates with virally induced changes in cell surface lymphocyte function-associated antigen-3 (LFA-3) expression and not with the CMV-induced down-regulation of cell surface class I HLA J Immunol 161 2365-74 9725232
    • (1998) J. Immunol. , vol.161 , pp. 2365-2374
    • Fletcher, J.M.1    Prentice, H.G.2    Grundy, J.E.3
  • 65
    • 0027504213 scopus 로고
    • Enhanced expression of LFA-3 on human T-cell lines and leukemic cells carrying human T-cell-leukemia virus type 1
    • 7503960
    • T Imai Y Tanaka K Fukudome S Takagi K Araki O Yoshie 1993 Enhanced expression of LFA-3 on human T-cell lines and leukemic cells carrying human T-cell-leukemia virus type 1 Int J Cancer 55 811-6 7503960
    • (1993) Int. J. Cancer , vol.55 , pp. 811-816
    • Imai, T.1    Tanaka, Y.2    Fukudome, K.3    Takagi, S.4    Araki, K.5    Yoshie, O.6
  • 66
    • 0028909049 scopus 로고
    • Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines
    • 7530239
    • Y Tanaka K Fukudome M Hayashi S Takagi O Yoshie 1995 Induction of ICAM-1 and LFA-3 by Tax1 of human T-cell leukemia virus type 1 and mechanism of down-regulation of ICAM-1 or LFA-1 in adult-T-cell-leukemia cell lines Int J Cancer 60 554-61 7530239
    • (1995) Int. J. Cancer , vol.60 , pp. 554-561
    • Tanaka, Y.1    Fukudome, K.2    Hayashi, M.3    Takagi, S.4    Yoshie, O.5
  • 69
    • 0029099845 scopus 로고
    • Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
    • 10.1038/377446a0 7566124
    • AJ Darmon DW Nicholson RC Bleackley 1995 Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B Nature 377 446-8 10.1038/377446a0 7566124
    • (1995) Nature , vol.377 , pp. 446-448
    • Darmon, A.J.1    Nicholson, D.W.2    Bleackley, R.C.3
  • 70
    • 0027453988 scopus 로고
    • Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma
    • 8242612
    • H Nakagomi M Petersson I Magnusson C Juhlin M Matsuda H Mellstedt 1993 Decreased expression of the signal-transducing zeta chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma Cancer Res 53 5610-2 8242612
    • (1993) Cancer Res. , vol.53 , pp. 5610-5612
    • Nakagomi, H.1    Petersson, M.2    Magnusson, I.3    Juhlin, C.4    Matsuda, M.5    Mellstedt, H.6
  • 71
    • 0018909381 scopus 로고
    • Natural killer function in systemic lupus erythematosus
    • 7352941
    • T Hoffman 1980 Natural killer function in systemic lupus erythematosus Arthritis Rheum 23 30-5 7352941
    • (1980) Arthritis Rheum. , vol.23 , pp. 30-35
    • Hoffman, T.1
  • 72
    • 0019781157 scopus 로고
    • Natural cell-mediated cytotoxicity in Sjögren's syndrome and rheumatoid arthritis
    • 7317114
    • M Goto K Tanimoto T Chihara Y Horiuchi 1981 Natural cell-mediated cytotoxicity in Sjögren's syndrome and rheumatoid arthritis Arthritis Rheum 24 1377-82 7317114
    • (1981) Arthritis Rheum. , vol.24 , pp. 1377-1382
    • Goto, M.1    Tanimoto, K.2    Chihara, T.3    Horiuchi, Y.4
  • 73
    • 0020506289 scopus 로고
    • Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms
    • 6882489
    • N Miyasaka W Seaman A Bakshi B Sauvezie V Strand R Pope 1983 Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms Arthritis Rheum 26 954-60 6882489
    • (1983) Arthritis Rheum. , vol.26 , pp. 954-960
    • Miyasaka, N.1    Seaman, W.2    Bakshi, A.3    Sauvezie, B.4    Strand, V.5    Pope, R.6
  • 74
    • 0021178460 scopus 로고
    • Impaired release of a soluble natural killer cytotoxic factor in systemic lupus erythematosus
    • 6487394
    • WL Sibbitt Jr PM Mathews AD Bankhurst 1984 Impaired release of a soluble natural killer cytotoxic factor in systemic lupus erythematosus Arthritis Rheum 27 1095-100 6487394
    • (1984) Arthritis Rheum. , vol.27 , pp. 1095-1100
    • Sibbitt Jr., W.L.1    Mathews, P.M.2    Bankhurst, A.D.3
  • 75
    • 0022559751 scopus 로고
    • Interleukin 2 augmentation of the defective natural killer cell activity in patients with primary Sjögren's syndrome
    • 3485480
    • BK Pedersen P Oxholm R Manthorpe V Andersen 1986 Interleukin 2 augmentation of the defective natural killer cell activity in patients with primary Sjögren's syndrome Clin Exp Immunol 63 1-7 3485480
    • (1986) Clin. Exp. Immunol. , vol.63 , pp. 1-7
    • Pedersen, B.K.1    Oxholm, P.2    Manthorpe, R.3    Andersen, V.4
  • 76
    • 0023952012 scopus 로고
    • Natural killer and natural killer-like cell activity of peripheral blood and intrathyroidal mononuclear cells from patients with Graves' disease
    • 3257969
    • H Tezuka K Eguchi T Fukuda T Otsubo Y Kawabe Y Ueki 1988 Natural killer and natural killer-like cell activity of peripheral blood and intrathyroidal mononuclear cells from patients with Graves' disease J Clin Endocrinol Metab 66 702-7 3257969
    • (1988) J. Clin. Endocrinol. Metab. , vol.66 , pp. 702-707
    • Tezuka, H.1    Eguchi, K.2    Fukuda, T.3    Otsubo, T.4    Kawabe, Y.5    Ueki, Y.6
  • 77
    • 0023814932 scopus 로고
    • Natural killer cell activity in the systemic connective tissue diseases
    • 3263500
    • R Gonzalez-Amaro J Alcocer-Varela D Alarcon-Segovia 1988 Natural killer cell activity in the systemic connective tissue diseases J Rheumatol 15 1223-8 3263500
    • (1988) J. Rheumatol. , vol.15 , pp. 1223-1228
    • Gonzalez-Amaro, R.1    Alcocer-Varela, J.2    Alarcon-Segovia, D.3
  • 79
    • 0033009888 scopus 로고    scopus 로고
    • Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    • 10.1146/annurev.immunol.17.1.189 10358757
    • CA Biron KB Nguyen GC Pien LP Cousens TP Salazar-Mather 1999 Natural killer cells in antiviral defense: Function and regulation by innate cytokines Annu Rev Immunol 17 189-220 10.1146/annurev.immunol.17.1.189 10358757
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 189-220
    • Biron, C.A.1    Nguyen, K.B.2    Pien, G.C.3    Cousens, L.P.4    Salazar-Mather, T.P.5
  • 80
    • 0035046451 scopus 로고    scopus 로고
    • A novel role for interleukin-18 in human natural killer cell death: High serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases
    • 10.1002/1529-0131(200104)44:4<884::AID-ANR145>3.0.CO;2-4 11315928
    • K Shibatomi H Ida S Yamasaki T Nakashima T Origuchi A Kawakami 2001 A novel role for interleukin-18 in human natural killer cell death: High serum levels and low natural killer cell numbers in patients with systemic autoimmune diseases Arthritis Rheum 44 884-92 10.1002/ 1529-0131(200104)44:4<884::AID-ANR145>3.0.CO;2-4 11315928
    • (2001) Arthritis Rheum. , vol.44 , pp. 884-892
    • Shibatomi, K.1    Ida, H.2    Yamasaki, S.3    Nakashima, T.4    Origuchi, T.5    Kawakami, A.6
  • 81
    • 0034694091 scopus 로고    scopus 로고
    • Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation
    • 10.1084/jem.192.10.1403 11085743
    • VR Sutton JE Davis M Cancilla RW Johnstone AA Ruefli K Sedelies 2000 Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation J Exp Med 192 1403-14 10.1084/jem.192.10.1403 11085743
    • (2000) J. Exp. Med. , vol.192 , pp. 1403-1414
    • Sutton, V.R.1    Davis, J.E.2    Cancilla, M.3    Johnstone, R.W.4    Ruefli, A.A.5    Sedelies, K.6
  • 82
    • 0346458560 scopus 로고    scopus 로고
    • Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: Insights into the association of specific autoantibodies with distinct disease phenotypes
    • 10.1002/art.11485 14730621
    • DB Ulanet NA Flavahan L Casciola-Rosen A Rosen 2004 Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: Insights into the association of specific autoantibodies with distinct disease phenotypes Arthritis Rheum 50 233-41 10.1002/art.11485 14730621
    • (2004) Arthritis Rheum. , vol.50 , pp. 233-241
    • Ulanet, D.B.1    Flavahan, N.A.2    Casciola-Rosen, L.3    Rosen, A.4
  • 83
    • 0032055097 scopus 로고    scopus 로고
    • Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis
    • 10.1016/S1074-7613(00)80550-6 9586635
    • F Andrade S Roy D Nicholson N Thornberry A Rosen L Casciola-Rosen 1998 Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis Immunity 8 451-60 10.1016/S1074-7613(00)80550-6 9586635
    • (1998) Immunity , vol.8 , pp. 451-460
    • Andrade, F.1    Roy, S.2    Nicholson, D.3    Thornberry, N.4    Rosen, A.5    Casciola-Rosen, L.6
  • 84
    • 0035805613 scopus 로고    scopus 로고
    • Importance of the P4S61602 residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop
    • 10.1074/jbc.M006645200 11278311
    • J Sun JC Whisstock P Harriott B Walker A Novak PE Thompson 2001 Importance of the P4S61602 residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop J Biol Chem 276 15177-84 10.1074/jbc.M006645200 11278311
    • (2001) J. Biol. Chem. , vol.276 , pp. 15177-15184
    • Sun, J.1    Whisstock, J.C.2    Harriott, P.3    Walker, B.4    Novak, A.5    Thompson, P.E.6
  • 85
    • 0034671856 scopus 로고    scopus 로고
    • Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis
    • 10.1074/jbc.C000622200 11050075
    • KA Browne RW Johnstone DA Jans JA Trapani 2000 Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis J Biol Chem 275 39262-6 10.1074/jbc.C000622200 11050075
    • (2000) J. Biol. Chem. , vol.275 , pp. 39262-39266
    • Browne, K.A.1    Johnstone, R.W.2    Jans, D.A.3    Trapani, J.A.4
  • 86
    • 0034762759 scopus 로고    scopus 로고
    • Novel fragments of the Sjögren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death
    • 10.1002/1529-0131(200110)44:10<2376::AID-ART402>3.0.CO;2-E 11665980
    • K Nagaraju A Cox L Casciola-Rosen A Rosen 2001 Novel fragments of the Sjögren's syndrome autoantigens alpha-fodrin and type 3 muscarinic acetylcholine receptor generated during cytotoxic lymphocyte granule-induced cell death Arthritis Rheum 44 2376-86 10.1002/ 1529-0131(200110)44:10<2376::AID-ART402>3.0.CO;2-E 11665980
    • (2001) Arthritis Rheum. , vol.44 , pp. 2376-2386
    • Nagaraju, K.1    Cox, A.2    Casciola-Rosen, L.3    Rosen, A.4
  • 87
    • 0035500928 scopus 로고    scopus 로고
    • Autoantibodies to the amino-terminal fragment of beta-fodrin expressed in glandular epithelial cells in patients with Sjögren's syndrome
    • 11673564
    • M Kuwana T Okano Y Ogawa J Kaburaki Y Kawakami 2001 Autoantibodies to the amino-terminal fragment of beta-fodrin expressed in glandular epithelial cells in patients with Sjögren's syndrome J Immunol 167 5449-56 11673564
    • (2001) J. Immunol. , vol.167 , pp. 5449-5456
    • Kuwana, M.1    Okano, T.2    Ogawa, Y.3    Kaburaki, J.4    Kawakami, Y.5
  • 88
    • 0033673428 scopus 로고    scopus 로고
    • DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis
    • 10.1016/S1074-7613(00)80213-7 10894162
    • DA Thomas C Du M Xu X Wang TJ Ley 2000 DFF45/ICAD can be directly processed by granzyme B during the induction of apoptosis Immunity 12 621-32 10.1016/S1074-7613(00)80213-7 10894162
    • (2000) Immunity , vol.12 , pp. 621-632
    • Thomas, D.A.1    Du, C.2    Xu, M.3    Wang, X.4    Ley, T.J.5
  • 89
    • 17844365555 scopus 로고    scopus 로고
    • Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation
    • 10.1093/emboj/20.12.3101 11406587
    • E Sharif-Askari A Alam E Rheaume PJ Beresford C Scotto K Sharma 2001 Direct cleavage of the human DNA fragmentation factor-45 by granzyme B induces caspase-activated DNase release and DNA fragmentation EMBO J 20 3101-13 10.1093/emboj/20.12.3101 11406587
    • (2001) EMBO J. , vol.20 , pp. 3101-3113
    • Sharif-Askari, E.1    Alam, A.2    Rheaume, E.3    Beresford, P.J.4    Scotto, C.5    Sharma, K.6
  • 90
    • 0035826778 scopus 로고    scopus 로고
    • Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis
    • 10.1073/pnas.101329598 11331782
    • D Zhang PJ Beresford AH Greenberg J Lieberman 2001 Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis Proc Natl Acad Sci USA 98 5746-51 10.1073/ pnas.101329598 11331782
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 5746-5751
    • Zhang, D.1    Beresford, P.J.2    Greenberg, A.H.3    Lieberman, J.4
  • 91
    • 0035253348 scopus 로고    scopus 로고
    • Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation
    • 11160179
    • L Gahring NG Carlson EL Meyer SW Rogers 2001 Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation J Immunol 166 1433-8 11160179
    • (2001) J. Immunol. , vol.166 , pp. 1433-1438
    • Gahring, L.1    Carlson, N.G.2    Meyer, E.L.3    Rogers, S.W.4
  • 92
    • 20744451720 scopus 로고    scopus 로고
    • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus
    • 10.1002/art.21092 15934098
    • KL Graham DL Thibault JB Steinman L Okeke PN Kao PJ Utz 2005 Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus Arthritis Rheum 52 1684-93 10.1002/ art.21092 15934098
    • (2005) Arthritis Rheum. , vol.52 , pp. 1684-1693
    • Graham, K.L.1    Thibault, D.L.2    Steinman, J.B.3    Okeke, L.4    Kao, P.N.5    Utz, P.J.6
  • 93
    • 0031049720 scopus 로고    scopus 로고
    • Fas involvement in human NK cell apoptosis: Lack of a requirement for CD16-mediated events
    • 9021927
    • JR Ortaldo RT Winkler-Pickett S Nagata CF Ware 1997 Fas involvement in human NK cell apoptosis: Lack of a requirement for CD16-mediated events J Leukocyte Biol 61 209-15 9021927
    • (1997) J. Leukocyte Biol. , vol.61 , pp. 209-215
    • Ortaldo, J.R.1    Winkler-Pickett, R.T.2    Nagata, S.3    Ware, C.F.4
  • 94
    • 0028927607 scopus 로고
    • The Fas death factor
    • 7533326
    • S Nagata P Golstein 1995 The Fas death factor Science 267 1449-56 7533326
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 95
    • 0028795758 scopus 로고
    • Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
    • 10.1038/373438a0 7530335
    • J Dhein H Walczak C Baumler KM Debatin PH Krammer 1995 Autocrine T-cell suicide mediated by APO-1/(Fas/CD95) Nature 373 438-41 10.1038/373438a0 7530335
    • (1995) Nature , vol.373 , pp. 438-441
    • Dhein, J.1    Walczak, H.2    Baumler, C.3    Debatin, K.M.4    Krammer, P.H.5
  • 96
    • 0028983657 scopus 로고
    • Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
    • 10.1038/373441a0 7530336
    • T Brunner RJ Mogil D LaFace NJ Yoo A Mahboubi F Echeverri 1995 Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas Nature 373 441-4 10.1038/373441a0 7530336
    • (1995) Nature , vol.373 , pp. 441-444
    • Brunner, T.1    Mogil, R.J.2    LaFace, D.3    Yoo, N.J.4    Mahboubi, A.5    Echeverri, F.6
  • 97
    • 0028893078 scopus 로고
    • Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
    • 10.1038/373444a0 7530337
    • ST Ju DJ Panka H Cui R Ettinger M el-Khatib DH Sherr 1995 Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation Nature 373 444-8 10.1038/373444a0 7530337
    • (1995) Nature , vol.373 , pp. 444-448
    • Ju, S.T.1    Panka, D.J.2    Cui, H.3    Ettinger, R.4    el-Khatib, M.5    Sherr, D.H.6
  • 98
    • 0027176644 scopus 로고
    • Apoptosis of activated CD8+/CD57+ T cells is induced by some combinations of anti-CD2 mAb
    • 7690806
    • M Rouleau A Bernard O Lantz JP Vernant B Charpentier A Senik 1993 Apoptosis of activated CD8+/CD57+ T cells is induced by some combinations of anti-CD2 mAb J Immunol 151 3547-56 7690806
    • (1993) J. Immunol. , vol.151 , pp. 3547-3556
    • Rouleau, M.1    Bernard, A.2    Lantz, O.3    Vernant, J.P.4    Charpentier, B.5    Senik, A.6
  • 99
    • 0025126816 scopus 로고
    • Anti-immunoglobulin antibodies induce apoptosis in immature B cell lymphomas
    • 2209683
    • J Hasbold GG Klaus 1990 Anti-immunoglobulin antibodies induce apoptosis in immature B cell lymphomas Eur J Immunol 20 1685-90 2209683
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1685-1690
    • Hasbold, J.1    Klaus, G.G.2
  • 100
    • 0026558821 scopus 로고
    • Anti-IgM antibody-induced cell death in a human B lymphoma cell line, B104, represents a novel programmed cell death
    • 1729359
    • T Ishigami KM Kim Y Horiguchi Y Higaki D Hata T Heike 1992 Anti-IgM antibody-induced cell death in a human B lymphoma cell line, B104, represents a novel programmed cell death J Immunol 148 360-8 1729359
    • (1992) J. Immunol. , vol.148 , pp. 360-368
    • Ishigami, T.1    Kim, K.M.2    Horiguchi, Y.3    Higaki, Y.4    Hata, D.5    Heike, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.