Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus

Arthritis and Rheumatism

Volumn 52, Issue 6, 2005, Pages 1684-1693

  Graham, Kareem L ^a   Thibault, Donna L ^a   Steinman, Jonathan B ^a   Okeke, Lance ^a   Kao, Peter N ^a   Utz, Paul J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; AUTOANTIBODY; AUTOANTIGEN; CASPASE; COMPLEMENTARY DNA; DOUBLE STRANDED RNA; GRANZYME B; INTERLEUKIN ENHANCER BINDING FACTOR 2; INTERLEUKIN ENHANCER BINDING FACTOR 3; METHIONINE; MINERAL OIL; NUCLEAR FACTOR; PRISTANE; RNA BINDING PROTEIN; SERINE PROTEINASE; SULFUR 35; U1 70 KD ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; APOPTOSIS; ARTICLE; AUTOIMMUNE DISEASE; AUTORADIOGRAPHY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SUBSTRATE; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOPRECIPITATION; ISOTOPE LABELING; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; RNA TRANSLATION; SYSTEMIC LUPUS ERYTHEMATOSUS; WESTERN BLOTTING;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; AUTOIMMUNITY; FEMALE; GRANZYMES; IMMUNE TOLERANCE; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MODELS, ANIMAL; SERINE ENDOPEPTIDASES;

EID: 20744451720     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21092     Document Type: Article

References (40)

1. White S, Rosen A. Apoptosis in systemic lupus erythematosus. Curr Opin Rheumatol 2003;15:557-62.
2. Rosen A, Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ 1999;6:6-12.
3. Andrade F, Roy S, Nicholson D. Thornberry N, Rosen A, Casciola-Rosen L. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity 1998;8:451-60.
4. Casciola-Rosen L, Andrade F, Ulanet D, Wong WB, Rosen A, Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. J Exp Med 1999;190:815-26.
5. Satoh M, Richards HB, Shaheen VM, Yoshida H, Shaw M, Naim JO, et al. Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane. Clin Exp Immunol 2000;121:399-405.
6. Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, et al. Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity. J Biol Chem 1999;274:34598-604.
7. Satoh M, Weintraub J, Yoshida H, Shaheen V, Richards H, Shaw M, et al. Fas and Fas ligand mutations inhibit autoantibody production in pristane-induced lupus. J Immunol 2000;165: 1036-43.
8. Reichman T, Muniz L, Matthews M. The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells. Mol Cell Biol 2002;22:343-56.
9. Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, et al. Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90. J Biol Chem 1994; 269:20691-9.
10. Karwan R, Bennett JL, Clayton DA. Nuclear RNase MRP processes RNA at multiple discrete sites: interaction with an upstream G box is required for subsequent downstream cleavages. Genes Dev 1991;5:1264-76.
11. Li H, Bergeron L, Cryns V, Pasternack M, Zhu H, Shi L, et al. Activation of caspase-2 in apoptosis. J Biol Chem 1997;272: 21010-7.
12. Utz PJ, Hottelet M, van Venrooij WJ, Anderson P. The 72-kDa component of signal recognition particle is cleaved during apoptosis. J Biol Chem 1998;273:35362-70.
13. Fisher D, Reeves W, Conner G, Blobel G, Kunkel H. Pulse labeling of small nuclear ribonucleoproteins in vivo reveals distinct patterns of antigen recognition by human autoimmune antibodies. Proc Natl Acad Sci U S A 1984;81:3185-9.
14. Satoh M, Reeves WH. Induction of lupus-associated autoantibodies in BALB/c mice by intraperitoneal injection of pristane. J Exp Med 1994;180:2341-6.
15. Utz PJ, Hottelet M, Schur PH, Anderson P. Proteins phosphorylated during stress-induced apoptosis are common targets for autoantibody production in patients with systemic lupus erythematosus. J Exp Med 1997;185:843-54.
16. Harris J, Peterson E, Hudig D, Thornberry N, Craik C. Definition and redesign of the extended substrate specificity of granzyme B. J Biol Chem 1998;273:27364-73.
17. Casiano CA, Martin SJ, Green DR, Tan EM. Selective cleavage of nuclear autoantigens during CD95 (Fas/Apo-1)-mediated T cell apoptosis. J Exp Med 1996;184:765-70.
18. Kotzin BL. Systemic lupus erythematosus. Cell 1996;85:303-6.
19. Van Parijs L, Abbas AK. Role of Fas-mediated cell death in the regulation of immune responses. Curr Opin Immunol 1996;8: 355-61.
20. Balkow S, Kersten A, Tran T, Stehle T, Grosse P, Museteanu C, et al. Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol 2001; 75:8781-91.
21. Lieberman J. The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 2003;3:361-70.
22. Chu J, Drappa J, Parnassa A, Elkon KB. The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn. J Exp Med 1993;178:723-30.
23. Andrews B, Eisenberg R, Theofilopoulos A, Izui S, Wilson C, McConahey P, et al. Spontaneous murine lupus-like syndromes: clinical and immunopathological manifestations in several strains. J Exp Med 1978;148:1198-215.
24. Peng SL, Moslehi J, Robert ME, Craft J. Perform protects against autoimmunity in lupus-prone mice. J Immunol 1998;160:652-60.
25. Benoist C, Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat Immunol 2001;2:797-801.
26. Morgan BP, Walport MJ. Complement deficiency and disease. Immunol Today 1991;12:301-6.
27. Fisher GH, Rosenberg FJ, Straus SE, Dale JK, Middleton LA, Lin AJ, et al. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 1995;81:935-46.
28. Drappa J, Vaishnaw AK, Sullivan KE, Chu J, Elkon KB. Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. N Engl J Med 1996;335:1643-9.
29. Alam A, Cohen LY, Aouad S, Sekaly RP. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J Exp Med 1999;190: 1879-90.
30. Kennedy NJ, Kataoka T, Tschopp J, Budd RC. Caspase activation is required for T cell proliferation. J Exp Med 1999;190:1891-5.
31. Chun HJ, Zheng L, Ahmad M, Wang J, Speirs CK, Siegel RM, et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 2002;419:395-9.
32. Van Parijs L, Abbas AK. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science 1998;280:243-8.
33. Schachna L, Wigley FM, Morris S, Gelber AC, Rosen A, Casciola-Rosen LA. Recognition of granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss. Arthritis Rheum 2002;46:1873-84.
34. Ebnet K, Levelt CN, Tran TT, Eichmann K, Simon MM. Transcription of granzyme A and B genes is differentially regulated during lymphoid ontogeny. J Exp Med 1995;181:755-63.
35. Trapani JA. Granzymes: a family of lymphocyte granule serine proteases [review]. Genome Biol 2001;2:30141-7.
36. Utz PJ, Gensler TJ, Anderson P. Death, autoantigen modifications, and tolerance. Arthritis Res 2000;2:101-14.
37. Reichlin M, Rader M, Harley JB. Autoimmune response to the Ro/SSA particle is directed to the human antigen. Clin Exp Immunol 1989;76:373-7.
38. Pasternack MS, Bleier KJ, McInerney TN. Granzyme A binding to target cell proteins: granzyme A binds to and cleaves nucleolin in vitro. J Biol Chem 1991;266:14703-8.
39. Zhang D, Beresford PJ, Greenberg AH, Lieberman J. Granzymes A and B directly cleave lamins and disrupt the nuclear lamina during granule-mediated cytolysis. Proc Natl Acad Sci U S A 2001;98:5746-51.
40. Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 2004;104:2840-8.