Acute myeloblastic leukemic cells acquire cellular cytotoxicity under genotoxic stress: Implication of granzyme B and perforin

Blood

Volumn 96, Issue 5, 2000, Pages 1914-1920

  Bruno, Alain Pierre ^a   Lautier, Dominique ^a   Thonel De D'Orgeix, Aurélie ^a   Laurent, Guy ^a   Quillet Mary, Anne ^a,b  

^a INSERM   (France)

^b INSTITUT CLAUDIUS REGAUD   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; GRANZYME B; PERFORIN;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; CELL MEDIATED CYTOTOXICITY; CONTROLLED STUDY; GENOTOXICITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS;

EID: 0034284472     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.5.1914.h8001914_1914_1920     Document Type: Article

References (47)

1. Cytolytic T cell granules. Isolation, structural, biochemical and functional characterization
2. Identification and characterization of a pore-forming protein of human peripheral blood natural killer cells
3. Isolation of a lytic, pore-forming protein (perforin) from cytolytic T lymphocytes
4. The molecular mechanism of lymphocyte mediated tumor cell lysis
5. New paradigm for lymphocyte granule-mediated cytotoxicity
6. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
7. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
8. - tumor cells
9. Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense
10. Perforin and granzyme B lytic protein expression during chronic viral and autoimmune hepatitis
11. Analysis of major histocompatibility complex class I expression on Reed-Sternberg cells in relation to the cytotoxic T-cell response in Epstein-Barr virus-positive and -negative Hodgkin's disease
12. Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after bone marrow transplantation
13. Expression and down regulation of cytotoxic cell protease 1 or granzyme 'B' transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines
14. - peripheral blood progenitor cells mobilized by chemotherapy and granulocyte colony-stimulating factor
15. Production and characterization of monoclonal antibodies raised against recombinant human granzymes A and B and showing cross reactions with the natural proteins
16. Granzyme B-expressing peripheral T-cell lymphomas: Neoplastic equivalents of activated cytotoxic T cells with preference for mucosa-associated lymphoid tissue localization
17. Localization and identification of granzymes A and B-expressing cells in normal human lymphoid tissue and peripheral blood
18. Constitutive expression of pore-forming protein in peripheral blood gamma/delta T cells: Implication for their cytotoxic role in vivo
19. An enzyme-release assay for natural cytotoxicity
20. A quick and simple method for the quantitation of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
21. Carrier-mediated uptake and presentation of a major histocompatibility complex class I-restricted peptide
22. Human and murine cytotoxic T lymphocyte serine proteases: Subsite mapping with peptide thioester substrate and inhibition of enzyme activity and cytolysis by isocoumarins
23. The function of lymphocytes proteases: Inhibition and restoration of granule-mediated lysis with isocoumarin serine protease inhibitors
24. Cytotoxic T lymphocyte mediated lysis without release of serine esterase
25. - T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer
26. A cytotoxic phenotype does not predict clinical outcome in anaplastic large cell lymphomas
27. Perforin and granzyme B expression is associated with severe acute rejection
28. Perforin, a pore-forming protein detectable by monoclonal antibodies, is a functional marker for killer cells
29. - T cells
30. + T cells are present within a population of intermediate TCR cells
31. Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivo
32. Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody
33. Perforin expression localizing cytotoxic lymphocytes in the intimas of coronary arteries with transplant-related accelerated arteriosclerosis
34. Detection of perforin in human peritoneal fluid T-lymphocytes
35. Large granular lymphocytes in human peripheral blood: Ultrastructure and cytochemical characterization of the granules
36. Granule serine proteases are normal nuclear constituents of natural killer cells
37. Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?
38. Altered intracellular distribution of daunorubicin in immature acute myeloid leukemia cells
39. Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation
40. Activation of the AP-1 transcription factor by arabinofuranosylcytosine in myeloid leukemia cells
41. Activation of the c-jun protooncogene in human myeloid leukemia cells treated by etoposide
42. Irradiation induces WAF1 expression through a p53-independent pathway in KG-1 cells
43. Radiation induction of immediate early genes: Effectors of the radiation-stress response
44. Peripheral blood mononuclear cells induce programmed cell death in human endothelial cells and may prevent repair: Role of cytokines
45. DNA damage signals induction of Fas ligand in tumor cells
46. Tumor necrosis factor: Receptors on hematopoietic cells
47. Functional consequences of Apo-1/Fas (CD95) antigen expression by normal and neoplastic hematopoietic cells