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Volumn 12, Issue 3, 2000, Pages 323-329

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; GRANZYME A; GRANZYME B; PERFORIN; SERINE PROTEINASE INHIBITOR;

EID: 0034104585     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00094-7     Document Type: Review
Times cited : (118)

References (49)
  • 2
    • 0031899584 scopus 로고    scopus 로고
    • Dual mechanisms of apoptosis induction by cytolytic lymphocytes
    • Trapani J.A. Dual mechanisms of apoptosis induction by cytolytic lymphocytes. Int Rev Cytol. 182:1997;111-192.
    • (1997) Int Rev Cytol , vol.182 , pp. 111-192
    • Trapani, J.A.1
  • 3
    • 0031975821 scopus 로고    scopus 로고
    • The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology
    • Smyth M.J., Trapani J.A. The relative role of lymphocyte granule exocytosis versus death receptor-mediated cytotoxicity in viral pathophysiology. J Virol. 72:1998;1-9.
    • (1998) J Virol , vol.72 , pp. 1-9
    • Smyth, M.J.1    Trapani, J.A.2
  • 5
    • 0028258577 scopus 로고
    • Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation, apoptosis in allogeneic target cells
    • Heusel J.W., Wesselschmidt R.L., Shresta S., Russell J.H., Ley T.J. Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation, apoptosis in allogeneic target cells. Cell. 76:1994;977-987.
    • (1994) Cell , vol.76 , pp. 977-987
    • Heusel, J.W.1    Wesselschmidt, R.L.2    Shresta, S.3    Russell, J.H.4    Ley, T.J.5
  • 6
    • 0024567523 scopus 로고
    • Granule-mediated cytolysis of target cells
    • Podack E.R. Granule-mediated cytolysis of target cells. Curr Top Microbiol Immunol. 140:1989;1-9.
    • (1989) Curr Top Microbiol Immunol , vol.140 , pp. 1-9
    • Podack, E.R.1
  • 8
    • 0026532606 scopus 로고
    • A natural killer cell granule protein that induces DNA fragmentation and apoptosis
    • Shi L., Kraut R.P., Aebersold R., Greenberg A.H. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J Exp Med. 175:1992;553-566.
    • (1992) J Exp Med , vol.175 , pp. 553-566
    • Shi, L.1    Kraut, R.P.2    Aebersold, R.3    Greenberg, A.H.4
  • 9
    • 0026474805 scopus 로고
    • Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
    • Shi L., Kam C.M., Powers J.C., Aebersold R., Greenberg A.H. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med. 176:1992;1521-1529.
    • (1992) J Exp Med , vol.176 , pp. 1521-1529
    • Shi, L.1    Kam, C.M.2    Powers, J.C.3    Aebersold, R.4    Greenberg, A.H.5
  • 10
    • 0030892138 scopus 로고    scopus 로고
    • Granzyme B (GraB) autonomously crosses the cell membrane, perforin initiates apoptosis and GraB nuclear localization
    • Shi L., Mai S., Israels S., Browne K., Trapani J.A., Greenberg A.H. Granzyme B (GraB) autonomously crosses the cell membrane, perforin initiates apoptosis and GraB nuclear localization. J Exp Med. 185:1997;855-866.
    • (1997) J Exp Med , vol.185 , pp. 855-866
    • Shi, L.1    Mai, S.2    Israels, S.3    Browne, K.4    Trapani, J.A.5    Greenberg, A.H.6
  • 11
    • 10544252275 scopus 로고    scopus 로고
    • New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind, internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis
    • Froelich C.J., Orth K., Turbov J., Seth P., Gottlieb R., Babior B., Shah G.M., Bleackley R.C., Dixit V.M., Hanna W. New paradigm for lymphocyte granule-mediated cytotoxicity. Target cells bind, internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis. J Biol Chem. 271:1996;29073-29079.
    • (1996) J Biol Chem , vol.271 , pp. 29073-29079
    • Froelich, C.J.1    Orth, K.2    Turbov, J.3    Seth, P.4    Gottlieb, R.5    Babior, B.6    Shah, G.M.7    Bleackley, R.C.8    Dixit, V.M.9    Hanna, W.10
  • 13
    • 0033499729 scopus 로고    scopus 로고
    • Bacterial toxins facilitate intracellular delivery of granzyme B: Evidence that endosomal disruption is an important function of perforin, in addition to transmembrane pore-formation
    • The first study providing quantitative and kinetic data challenging the notion that perforin functions through simple transmembrane pore formation. The role of perforin in facilitating apoptosis can be replicated by endosomolytic agents and, in the apparent absence of sizeable transmembrane lesions, even in the presence of 'high' perforin concentrations.
    • Browne K.A., Blink E., Sutton V.R., Froelich C.J., Jans D.A., Trapani J.A. Bacterial toxins facilitate intracellular delivery of granzyme B: evidence that endosomal disruption is an important function of perforin, in addition to transmembrane pore-formation. Mol Cell Biol. 19:1999;8604-8615. The first study providing quantitative and kinetic data challenging the notion that perforin functions through simple transmembrane pore formation. The role of perforin in facilitating apoptosis can be replicated by endosomolytic agents and, in the apparent absence of sizeable transmembrane lesions, even in the presence of 'high' perforin concentrations.
    • (1999) Mol Cell Biol , vol.19 , pp. 8604-8615
    • Browne, K.A.1    Blink, E.2    Sutton, V.R.3    Froelich, C.J.4    Jans, D.A.5    Trapani, J.A.6
  • 14
    • 0032475823 scopus 로고    scopus 로고
    • An antimicrobial activity of cytolytic T cells mediated by granulysin
    • The first instance of perforin-dependent killing, of an intracellular microbial pathogen, that does not appear to utilize granzymes.
    • Stenger S., Hanson D., Teitelbaum R., Dewan P., Niazi K., Froelich C.J., Ganz T., Thoma-Uszynski S., Melian A., Bogdan C.et al. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science. 282:1998;121-125. The first instance of perforin-dependent killing, of an intracellular microbial pathogen, that does not appear to utilize granzymes.
    • (1998) Science , vol.282 , pp. 121-125
    • Stenger, S.1    Hanson, D.2    Teitelbaum, R.3    Dewan, P.4    Niazi, K.5    Froelich, C.J.6    Ganz, T.7    Thoma-Uszynski, S.8    Melian, A.9    Bogdan, C.10
  • 15
    • 0033136316 scopus 로고    scopus 로고
    • Apoptosis induced by granzyme B-glycosaminoglycan complexes: Implications for granule-mediated apoptosis in vivo
    • The first paper to point out that the co-delivery of proapoptotic agents to the target cell is probably achieved in the context of macromolecular complexes containing chondroitin sulfate proteoglycans.
    • Galvin J.P., Spaeny-Dekking L.H., Wang B., Seth P., Hack C.E., Froelich C.J. Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo. J Immunol. 162:1999;5345-5350. The first paper to point out that the co-delivery of proapoptotic agents to the target cell is probably achieved in the context of macromolecular complexes containing chondroitin sulfate proteoglycans.
    • (1999) J Immunol , vol.162 , pp. 5345-5350
    • Galvin, J.P.1    Spaeny-Dekking, L.H.2    Wang, B.3    Seth, P.4    Hack, C.E.5    Froelich, C.J.6
  • 16
    • 0033178379 scopus 로고    scopus 로고
    • Cytotoxic lymphocyte granules: Evolution of vesicles essential for combating virus infections
    • Trapani J.A., Sutton V.R., Smyth M.J. Cytotoxic lymphocyte granules: evolution of vesicles essential for combating virus infections. Immunol Today. 20:1999;351-356.
    • (1999) Immunol Today , vol.20 , pp. 351-356
    • Trapani, J.A.1    Sutton, V.R.2    Smyth, M.J.3
  • 18
    • 0032530361 scopus 로고    scopus 로고
    • Caspase dependence of target cell damage induced by cytotoxic lymphocytes
    • The first paper to point out that nuclear damage, particularly DNA release, inflicted by cytotoxic lymphocytes requires caspase activation whereas non-nuclear parameters of cell death are largely independent of caspases.
    • Sarin A., Haddad E.K., Henkart P.A. Caspase dependence of target cell damage induced by cytotoxic lymphocytes. J Immunol. 161:1998;2810-2816. The first paper to point out that nuclear damage, particularly DNA release, inflicted by cytotoxic lymphocytes requires caspase activation whereas non-nuclear parameters of cell death are largely independent of caspases.
    • (1998) J Immunol , vol.161 , pp. 2810-2816
    • Sarin, A.1    Haddad, E.K.2    Henkart, P.A.3
  • 19
    • 0032561352 scopus 로고    scopus 로고
    • Efficient nuclear targeting of granzyme B, the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent
    • This paper first localised the essential proapoptotic effect of granzyme B as residing outside the nucleus. Cell death in response to granzyme B and perforin occurs irrespective of the apparent inhibition of nuclear damage by caspase inhibitors.
    • Trapani J.A., Jans D.A., Browne K.A., Smyth M.J., Jans P.J., Sutton V.R. Efficient nuclear targeting of granzyme B, the nuclear consequences of apoptosis induced by granzyme B and perforin are caspase-dependent, but cell death is caspase-independent. J Biol Chem. 273:1998;27934-27938. This paper first localised the essential proapoptotic effect of granzyme B as residing outside the nucleus. Cell death in response to granzyme B and perforin occurs irrespective of the apparent inhibition of nuclear damage by caspase inhibitors.
    • (1998) J Biol Chem , vol.273 , pp. 27934-27938
    • Trapani, J.A.1    Jans, D.A.2    Browne, K.A.3    Smyth, M.J.4    Jans, P.J.5    Sutton, V.R.6
  • 20
    • 0032055097 scopus 로고    scopus 로고
    • Granzyme B directly and efficiently cleaves several downstream caspase substrates: Implications for CTL-induced apoptosis
    • This elegant and comprehensive paper shows that downstream caspase substrates can be targeted directly by granzyme B when caspases are inhibited.
    • Andrade F., Roy S., Thornberry N., Rosen A., Casciola-Rosen L. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity. 8:1998;451-460. This elegant and comprehensive paper shows that downstream caspase substrates can be targeted directly by granzyme B when caspases are inhibited.
    • (1998) Immunity , vol.8 , pp. 451-460
    • Andrade, F.1    Roy, S.2    Thornberry, N.3    Rosen, A.4    Casciola-Rosen, L.5
  • 21
    • 0033137079 scopus 로고    scopus 로고
    • Granzyme A induces rapid cytolysis, a novel form of DNA damage independently of caspases
    • Granzyme A loading into target cells was used to demonstrate for the first time that granzyme A can induce single-stranded DNA breaks in a caspase-independent manner. The significance of this finding is yet to be reported when using granzyme A deficient effector cells.
    • Beresford P.J., Xia Z., Greenberg A.H., Lieberman J. Granzyme A induces rapid cytolysis, a novel form of DNA damage independently of caspases. Immunity. 10:1999;585-594. Granzyme A loading into target cells was used to demonstrate for the first time that granzyme A can induce single-stranded DNA breaks in a caspase-independent manner. The significance of this finding is yet to be reported when using granzyme A deficient effector cells.
    • (1999) Immunity , vol.10 , pp. 585-594
    • Beresford, P.J.1    Xia, Z.2    Greenberg, A.H.3    Lieberman, J.4
  • 22
    • 0028938366 scopus 로고
    • The target cell nucleus is not required for cell-mediated granzyme- Or Fas-based cytotoxicity
    • Nakajima H., Golstein P., Henkart P.A. The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity. J Exp Med. 181:1995;1905-1909.
    • (1995) J Exp Med , vol.181 , pp. 1905-1909
    • Nakajima, H.1    Golstein, P.2    Henkart, P.A.3
  • 23
    • 0033521626 scopus 로고    scopus 로고
    • Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis
    • MacDonald G., Shi L., Vande Velde C., Lieberman J., Greenberg A. Mitochondria-dependent and -independent regulation of granzyme B-induced apoptosis. J Exp Med. 189:1999;131-144.
    • (1999) J Exp Med , vol.189 , pp. 131-144
    • MacDonald, G.1    Shi, L.2    Vande Velde, C.3    Lieberman, J.4    Greenberg, A.5
  • 24
    • 0032752882 scopus 로고    scopus 로고
    • Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent
    • This elegant study documented non-nuclear events that occur independently of caspases and that may influence cell survival.
    • Helbein J.A., Barry M., Motyka B., Bleackley R.C. Granzyme B-induced loss of mitochondrial inner membrane potential (Delta Psi m) and cytochrome c release are caspase independent. J Immunol. 163:1999;4683-4693. This elegant study documented non-nuclear events that occur independently of caspases and that may influence cell survival.
    • (1999) J Immunol , vol.163 , pp. 4683-4693
    • Helbein, J.A.1    Barry, M.2    Motyka, B.3    Bleackley, R.C.4
  • 25
    • 0031570536 scopus 로고    scopus 로고
    • Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes
    • Sutton V.R., Vaux D.A., Trapani J.A. Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes. J Immunol. 158:1997;5783-5790.
    • (1997) J Immunol , vol.158 , pp. 5783-5790
    • Sutton, V.R.1    Vaux, D.A.2    Trapani, J.A.3
  • 26
    • 0033548065 scopus 로고    scopus 로고
    • BCL-2 blocks perforin-induced nuclear translocation of granzymes, concomitant with protection against the nuclear events of apoptosis
    • Jans D.J., Sutton V.R., Jans P.J., Froelich C.J., Trapani J.A. BCL-2 blocks perforin-induced nuclear translocation of granzymes, concomitant with protection against the nuclear events of apoptosis. J Biol Chem. 274:1999;3953-3961.
    • (1999) J Biol Chem , vol.274 , pp. 3953-3961
    • Jans, D.J.1    Sutton, V.R.2    Jans, P.J.3    Froelich, C.J.4    Trapani, J.A.5
  • 27
    • 0042377711 scopus 로고    scopus 로고
    • The human cytotoxic T cell granule protease granzyme H has chymotrypsin-like (chymase) activity, is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes
    • The first characterization of a chymase granzyme in human CTLs. This study utilized recombinant granzyme H expressed in insect Sf9 cells.
    • Edwards K.M., Kam C-M., Powers J., Trapani J.A. The human cytotoxic T cell granule protease granzyme H has chymotrypsin-like (chymase) activity, is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes. J Biol Chem. 274:1999;30468-30473. The first characterization of a chymase granzyme in human CTLs. This study utilized recombinant granzyme H expressed in insect Sf9 cells.
    • (1999) J Biol Chem , vol.274 , pp. 30468-30473
    • Edwards, K.M.1    Kam, C.-M.2    Powers, J.3    Trapani, J.A.4
  • 28
    • 0030014911 scopus 로고    scopus 로고
    • Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia
    • Mullbacher A., Ebnet K., Blanden R.V., Hla R.T., Stehle T., Museteanu C., Simon M.M. Granzyme A is critical for recovery of mice from infection with the natural cytopathic viral pathogen, ectromelia. Proc Natl Acad Sci USA. 93:1996;5783-5787.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5783-5787
    • Mullbacher, A.1    Ebnet, K.2    Blanden, R.V.3    Hla, R.T.4    Stehle, T.5    Museteanu, C.6    Simon, M.M.7
  • 29
    • 0033598718 scopus 로고    scopus 로고
    • Granzymes are essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes
    • This is the first reported instance of a pathophysiological consequence of a granzyme deficiency. The investigators make the observation that CTLs equipped with normal levels of perforin but lacking granzymes A and B are specifically deficient in protecting the host from a natural mouse pathogen, the poxvirus ectromelia. Despite this, mice lacking granzymes A and B have no intrinsic problem with raising CTL responses. The defective response to ectromelia is virtually as profound as perforin-deficiency per se.
    • Mullbacher A., Waring P., Tha Hla R., Tran T., Chin S., Stehle T., Museteanu C., Simon M.M. Granzymes are essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc Natl Acad Sci USA. 96:1999;13950-13955. This is the first reported instance of a pathophysiological consequence of a granzyme deficiency. The investigators make the observation that CTLs equipped with normal levels of perforin but lacking granzymes A and B are specifically deficient in protecting the host from a natural mouse pathogen, the poxvirus ectromelia. Despite this, mice lacking granzymes A and B have no intrinsic problem with raising CTL responses. The defective response to ectromelia is virtually as profound as perforin-deficiency per se.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13950-13955
    • Mullbacher, A.1    Waring, P.2    Tha Hla, R.3    Tran, T.4    Chin, S.5    Stehle, T.6    Museteanu, C.7    Simon, M.M.8
  • 30
    • 0344097497 scopus 로고    scopus 로고
    • Perforin is essential for control of ectromelia virus but not related poxviruses in mice
    • Mullbacher A., Hla R.T., Museteanu C., Simon M.M. Perforin is essential for control of ectromelia virus but not related poxviruses in mice. J Virol. 73:1999;1665-1667.
    • (1999) J Virol , vol.73 , pp. 1665-1667
    • Mullbacher, A.1    Hla, R.T.2    Museteanu, C.3    Simon, M.M.4
  • 31
    • 0345517173 scopus 로고    scopus 로고
    • Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections
    • This elegant in vivo study reinforces the notion that CTLs recruited in the context of most antiviral responses can bypass antiapoptotic mechanisms erected by the pathogen.
    • Mullbacher A., Wallich R., Moyer R.W., Simon M.M. Poxvirus-encoded serpins do not prevent cytolytic T cell-mediated recovery from primary infections. J Immunol. 162:1999;7315-7321. This elegant in vivo study reinforces the notion that CTLs recruited in the context of most antiviral responses can bypass antiapoptotic mechanisms erected by the pathogen.
    • (1999) J Immunol , vol.162 , pp. 7315-7321
    • Mullbacher, A.1    Wallich, R.2    Moyer, R.W.3    Simon, M.M.4
  • 32
    • 0033136315 scopus 로고    scopus 로고
    • Granzyme A initiates an alternative pathway for granule-mediated apoptosis
    • + CTLs mediating graft-versus-host disease inflict less potent tissue damage in the recipient if they are deficient in granzyme expression, especially granzyme A.
    • + CTLs mediating graft-versus-host disease inflict less potent tissue damage in the recipient if they are deficient in granzyme expression, especially granzyme A.
    • (1999) Immunity , vol.10 , pp. 595-605
    • Shresta, S.1    Graubert, T.A.2    Thomas, D.A.3    Raptis, S.Z.4    Ley, T.J.5
  • 33
    • 0032895417 scopus 로고    scopus 로고
    • The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis
    • Tak P.P., Spaeny-Dekking L., Kraan M.C., Breedveld F.C., Froelich C.J., Hack C.E. The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol. 116:1999;366-370.
    • (1999) Clin Exp Immunol , vol.116 , pp. 366-370
    • Tak, P.P.1    Spaeny-Dekking, L.2    Kraan, M.C.3    Breedveld, F.C.4    Froelich, C.J.5    Hack, C.E.6
  • 34
    • 0029914132 scopus 로고    scopus 로고
    • A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes
    • Sun J., Bird C.H., Sutton V., McDonald L., Coughlin P.B., De Jong T.A., Trapani J.A., Bird P.I. A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes. J Biol Chem. 271:1996;27802-27809.
    • (1996) J Biol Chem , vol.271 , pp. 27802-27809
    • Sun, J.1    Bird, C.H.2    Sutton, V.3    McDonald, L.4    Coughlin, P.B.5    De Jong, T.A.6    Trapani, J.A.7    Bird, P.I.8
  • 35
    • 0029582926 scopus 로고
    • The roles of perforin- And Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses
    • Kagi D., Seiler P., Pavlovic J., Ledermann B., Burki K., Zinkernagel R.M., Hengartner H. The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses. Eur J Immunol. 25:1995;3256-3262.
    • (1995) Eur J Immunol , vol.25 , pp. 3256-3262
    • Kagi, D.1    Seiler, P.2    Pavlovic, J.3    Ledermann, B.4    Burki, K.5    Zinkernagel, R.M.6    Hengartner, H.7
  • 36
    • 0033485408 scopus 로고    scopus 로고
    • Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus
    • Increased immunopathology mediated by perforin is observed when IFN-γ-deficient mice are infected with LCMV, indicating for the first time a role for both cytokine secretion and direct cytotoxicity in the control of this pathogen.
    • Nansen A., Jensen T., Christensen J.P., Andreasen S.O., Ropke C., Marker O., Thomsen A.R. Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus. J Immunol. 163:1999;6114-6122. Increased immunopathology mediated by perforin is observed when IFN-γ-deficient mice are infected with LCMV, indicating for the first time a role for both cytokine secretion and direct cytotoxicity in the control of this pathogen.
    • (1999) J Immunol , vol.163 , pp. 6114-6122
    • Nansen, A.1    Jensen, T.2    Christensen, J.P.3    Andreasen, S.O.4    Ropke, C.5    Marker, O.6    Thomsen, A.R.7
  • 37
    • 0033517288 scopus 로고    scopus 로고
    • Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells
    • This elegant and comprehensive paper points out that the balance between direct cytotoxicity and release of inflammatory cytokines can be regulated at the single-cell level.
    • Slifka M.K., Rodriguez F., Whitton J.L. Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells. Nature. 401:1999;76-79. This elegant and comprehensive paper points out that the balance between direct cytotoxicity and release of inflammatory cytokines can be regulated at the single-cell level.
    • (1999) Nature , vol.401 , pp. 76-79
    • Slifka, M.K.1    Rodriguez, F.2    Whitton, J.L.3
  • 38
    • 0032534572 scopus 로고    scopus 로고
    • Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis
    • The first paper that pointed out a role for perforin other than in direct cytotoxicity and indicated a role in modulating the immune response
    • Spielman J., Lee R.K., Podack E.R. Perforin/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis. J Immunol. 161:1998;7063-7070. The first paper that pointed out a role for perforin other than in direct cytotoxicity and indicated a role in modulating the immune response.
    • (1998) J Immunol , vol.161 , pp. 7063-7070
    • Spielman, J.1    Lee, R.K.2    Podack, E.R.3
  • 39
  • 41
    • 0032101604 scopus 로고    scopus 로고
    • + T cells in persistent infection with lymphocytic choriomeningitis virus
    • Perturbation of the normal immune response to LCMV due to perforin deficiency results in bone marrow hypoplasia secondary to excessive secretion of cytokines.
    • + T cells in persistent infection with lymphocytic choriomeningitis virus. J Exp Med. 187:1998;1903-1920. Perturbation of the normal immune response to LCMV due to perforin deficiency results in bone marrow hypoplasia secondary to excessive secretion of cytokines.
    • (1998) J Exp Med , vol.187 , pp. 1903-1920
    • Binder, D.1    Van Den Broek, M.F.2    Kagi, D.3    Bluethmann, H.4    Fehr, J.5    Hengartner, H.6    Zinkernagel, R.M.7
  • 43
    • 0033520970 scopus 로고    scopus 로고
    • Perforin gene defects in familial hemophagocytic lymphohistiocytosis
    • The first description of the clinical consequences of perforin deficiency in humans. FHL patients present with a syndrome that is highly reminiscent of perforin-deficient mice chronically infected with a viral pathogen that cannot be cleared, for example LCMV.
    • Stepp S.E., Dufourcq-Lagelouse R., Le Deist F., Bhawan S., Certain S., Mathew P.A., Henter J.I., Bennett M., Fischer A., de Saint Basile G., Kumar V. Perforin gene defects in familial hemophagocytic lymphohistiocytosis. Science. 286:1999;1957-1959. The first description of the clinical consequences of perforin deficiency in humans. FHL patients present with a syndrome that is highly reminiscent of perforin-deficient mice chronically infected with a viral pathogen that cannot be cleared, for example LCMV.
    • (1999) Science , vol.286 , pp. 1957-1959
    • Stepp, S.E.1    Dufourcq-Lagelouse, R.2    Le Deist, F.3    Bhawan, S.4    Certain, S.5    Mathew, P.A.6    Henter, J.I.7    Bennett, M.8    Fischer, A.9    De Saint Basile, G.10    Kumar, V.11
  • 45
    • 0033152840 scopus 로고    scopus 로고
    • Perforin is a major contributor to NK cell control of tumor metastasis
    • The first demonstration that innate immune mechanisms can control tumor metastasis in a perforin-dependent manner.
    • Smyth M.J., Thia K.Y., Cretney E., Kelly J.M., Snook M.B., Forbes C.A., Scalzo A.A. Perforin is a major contributor to NK cell control of tumor metastasis. J Immunol. 162:1999;6658-6662. The first demonstration that innate immune mechanisms can control tumor metastasis in a perforin-dependent manner.
    • (1999) J Immunol , vol.162 , pp. 6658-6662
    • Smyth, M.J.1    Thia, K.Y.2    Cretney, E.3    Kelly, J.M.4    Snook, M.B.5    Forbes, C.A.6    Scalzo, A.A.7
  • 47
    • 0033523670 scopus 로고    scopus 로고
    • Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
    • Medema J.P., de Jong J., van Hall T., Melief C.J., Offringa R. Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein. J Exp Med. 190:1999;1033-1038.
    • (1999) J Exp Med , vol.190 , pp. 1033-1038
    • Medema, J.P.1    De Jong, J.2    Van Hall, T.3    Melief, C.J.4    Offringa, R.5
  • 48
    • 0032853311 scopus 로고    scopus 로고
    • Tumor regression after adoptive transfer of effector T cells is independent of perforin or Fas ligand (APO-1L/CD95L)
    • Winter H., Hu H.M., Urba W.J., Fox B.A. Tumor regression after adoptive transfer of effector T cells is independent of perforin or Fas ligand (APO-1L/CD95L). J Immunol. 163:1999;4462-4472.
    • (1999) J Immunol , vol.163 , pp. 4462-4472
    • Winter, H.1    Hu, H.M.2    Urba, W.J.3    Fox, B.A.4
  • 49
    • 0033529581 scopus 로고    scopus 로고
    • Fas ligand: A sensor for DNA damage critical in skin cancer etiology
    • Immune surveillance of cellular transformation in the skin involves local expression of FasL and deletion of cells with DNA damage through a Fas-dependent mechanism.
    • Hill L.L., Ouhtit A., Loughlin S.M., Kripke M.L., Ananthaswamy H.N., Owen Schaub L.B. Fas ligand: a sensor for DNA damage critical in skin cancer etiology. Science. 285:1999;898-900. Immune surveillance of cellular transformation in the skin involves local expression of FasL and deletion of cells with DNA damage through a Fas-dependent mechanism.
    • (1999) Science , vol.285 , pp. 898-900
    • Hill, L.L.1    Ouhtit, A.2    Loughlin, S.M.3    Kripke, M.L.4    Ananthaswamy, H.N.5    Owen Schaub, L.B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.