Caspase-mediated degradation of T-cell receptor ζ-chain

Cancer Research

Volumn 59, Issue 7, 1999, Pages 1422-1427

  Gastman, Brian R ^a   Johnson, Daniel E ^a,b   Whiteside, Theresa L ^a,b   Rabinowich, Hannah ^a,b  

^a Department of Pathology ^*  (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CYTOTOXICITY; EFFECTOR CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; KILLER CELL; MACROPHAGE ACTIVATION; MITOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE;

EID: 0033119761     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. lck in T-cell infiltrating human renal cell carcinoma. Cancer Res., 53: 5613-5616, 1993.
2. Gunji, Y., Hori, S., Aoe, T., Asano, T., Ochiai, T., Isono, K., and Saito, T. High frequency of patients with abnormal assembly of T cell receptor-CD3 complex in peripheral blood T lymphocytes. Jpn. J. Cancer Res., 85: 1189-1192, 1994.
3. Healy, C. G., Simons, J. W., Carducci, M. A., DeWeese, T. L., Bartkowski, M., Tong, K. P., and Bolton, W. E. Impaired expression and function of signal-transducing ζ chains in peripheral T cells and natural killer cells in patients with prostate cancer. Cytometry, 32: 109-119, 1998.
4. Lai, P., Rabinowich, H., Crowley-Nowick, P. A., Bell, M. C., Mantovani, G., and Whiteside, T. L. Alteration in expression and function of signal transducing proteins in tumor-associated T and NK cells in patients with ovarian carcinoma. Clin. Cancer Res., 2: 161-173, 1996.
5. Lazarus, A. H., Ellis, J., Blanchette, V., Freedman, J., and Sheng-Tanner, X. Permeabilization and fixation conditions for intracellular flow cytometric detection of the T-cell receptor ζ chain and other intracellular proteins in lymphocyte subpopulations. Cytometry, 32: 206-213, 1998.
6. Matsuda, M., Petersson, M., Lenkei, R., Raupin, J-L., Magnusson, I., Mellstedt, H., Anderson, P., and Kiessling, R. Alterations in the signal-transducing molecules of T cells and NK cells in colorectal tumor-infiltrating gut mucosal and peripheral lymphocytes: correlation with the stage of the disease. Int. J. Cancer, 61: 765-772, 1995.
7. Nakagomi, H., Petersson, M., Magnusson, I., Juhlin, C., Matsuda, M., Mellstedt, H., Taupin, J-L., Vivier, E., Anderson, P., and Kiessling, R. Decreased expression of the signal-transducing ζ chains in tumor-infiltrating T-cell and NK cells of patients with colorectal carcinoma. Cancer Res., 53: 5610-5612, 1993.
8. Rabinowich, H., Banks, M., Reichert, T., Logan, T. F., Kirkwood, J. M., and Whiteside, T. L. Expression and activity of signaling molecules in T lymphocytes obtained from patients with metastatic melanoma before and after IL-2 therapy. Clin. Cancer Res., 2: 1263-1274, 1996.
9. Rabinowich, H., Suminami, K., Reichert, T., Bell, M., Crowley-Nowik, P., Edwards, R. P., and Whiteside, T. L. Expression of cytokine genes or proteins and signaling molecules in lymphocytes associated with human ovarian carcinoma. Int. J. Cancer, 68: 276-284, 1996.
10. Aoe, T., Okamoto, Y., and Saito, T. Activated macrophages induce structural abnormalities of the T cell receptor-CD3 complex. J. Exp. Med., 181: 1881-1886, 1995.
11. Kono, K., Salazar-Onfray, F., Petersson, M., Hansson, J., Masucci, G., Wasserman, K., Nakazawa, T., Anderson, P., and Kiessling, R. Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing ζ molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity. Eur. J. Immunol., 26: 1308-1313, 1996.
12. Rabinowich, H., Reichert, T. E., Kashii, Y., Gastman, B. R., Bell, M. C., and Whiteside, T. L. Lymphocyte apoptosis induced by Fas ligand-expressing ovarian carcinoma cells: implications for altered expression of TcR in tumor-associated lymphocytes. J. Clin. Invest., 101: 2579-2588, 1998.
13. Weissman, A. M., Hou, D., Orloff, D. G., Modi, W. S., Seuanez, H., O'Brien, S. J., and Klausner, R. D. Molecular cloning and chromosomal localization of the human T-cell receptor ζ chain: distinction from the molecular CD3 complex. Proc. Natl. Acad. Sci. USA. 85: 9709-9713, 1988.
14. Nicholson, D. W., and Thomberry, N. A. Caspases: killer proteases. Trends Biochem. Sci., 22: 299-306, 1997.
15. Thomberry, N. A., and Lazebnik, Y. Caspases: enemies within. Science (Washington DC), 281: 1312-1316, 1998.
16. Dou, Q. P., An, B., Antoku, K., and Johnson, D. E. Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE protease family. J. Cell. Biochem., 64: 586-594, 1997.
17. Darzynkiewicz, Z., Juan, G., Li, X., Gorczyca, W., Murakami, T., and Traganos, F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry, 27: 1-20, 1997.
18. Lanier, L. L., Yu, G., and Phillips, J. H. Co-association of CD3 ζ with a receptor (CD16) for IgG Fc on human natural killer cells. Nature (Lond.), 342: 803-805, 1989.
19. Packard, B. Z., Komoriya, A., Toptygin, D. D., and Brand, L. Structural characteristics of fluorophores that form intramolecular H-type dimers in a protease substrate. J. Phys. Chem., 101: 5070-5074, 1997.
20. Cohen, G. M. Caspases: the executioners of apoptosis. Biochem. J., 326: 1-16, 1997.
21. Wange, R. L., and Samelson, L. E. Complex complexes: signaling at the TCR. Immunity, J: 197-205, 1996.
22. Kersh, E. N., Shaw, A. S., and Allen, P. M. Fidelity of T cell activation through multistep T cell receptor ζ phosphorylation. Science (Washington DC), 281: 572-575, 1998.
23. Trimble, L. A., and Lieberman, J. Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 ζ, the signaling chain of the T-cell receptor complex. Blood, 91: 585-594, 1998.
24. Liossis, S. N., Ding, X. Z., Dennis, G. J., and Tsokos, G. C. Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor ζ chain. J. Clin. Invest., 101: 1448-1457, 1998.
25. Whiteside, T. L., and Rabinowich, H. The role of Fas/FasL in immunosuppression induced by human tumors. Cancer Immunol. Immunother., 46: 175-184, 1998.
26. Levey, D. L., and Srivastava, P. K. T cells from late tumor-bearing mice express normal levels of p561ck, p591yn, ZAP-70, and CD3ζ despite suppressed cytolytic activity. J. Exp. Med., 182: 1029-1036, 1995.
27. Cenciarelli, C., Hou, D., Hsu, K. C., Rellahan, B. L., Wiest, D. L., Smith, H. T., Fried, V. A., and Weissman, A. M. Activation-induced ubiquitination of the T cell antigen receptor. Science (Washington DC), 257: 795-797, 1992.
28. Valitutti, S., Muller, S., Salio, M., and Lanzavecchia, A. Degradation of T cell receptor (TCR)-CD3-ζ complexes after antigcnic stimulation. J. Exp. Med., 185: 1859-1864, 1997.
29. Taupin, J-L., and Anderson, P. Activation-induced proteolysis of the cytoplasmic domain of ζ in T cell receptors and Fc receptors. Eur. J. Immunol., 24: 3000-3004, 1994.
30. Mercep, M., Weissman, A. M., Frank, S. J., Klausner, R. D., and Ashwell, J. D. Activation-driven programmed cell death and T cell receptor ζ expression. Science (Washington DC), 246: 1162-1165, 1989.
31. Hicke, L., and Riezman, H. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell. 84: 277-287, 1996.
32. Hurtley, S. M. Lysosomal degradation of ubiquitin-tagged receptors. Science (Washington DC), 271: 617, 1996.
33. Widmann, C., Gibson, S., and Johnson, G. L. Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals. J. Biol. Chem., 273: 7141-7147, 1998.
34. Song, Q., Lees-Miller, S. P., Kumar, S., Zhang, Z., Chan, D. W., Smith, G. C., Jackson, S. P., Alnemri, E. S., Litwack, G., Khanna, K. K., and Lavin, M. F. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J., 15, 3238-3246, 1996.
35. Wen, L. P., Fahmi, J. A., Troie, S., Guan, J. L., Orth, K., and Rosen, G. D. Cleavage of focal adhesion kinase by caspases during apoptosis. J. Biol. Chem., 272: 26056-26061, 1997.
36. Lazebnik, Y. A., Kaufmann, S. H., Desnoyers, S., Poirier, G. G., and Earnshaw, W. C. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (Lond.), 371: 346-347, 1994.
37. Widmann, C., Gerwins, P., Johnson, N. L., Jarpe, M. B., and Johnson, G. L. MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis. Mol. Cell. Biol., 18: 2416-2429, 1998.
38. Rudel, T., and Bokoch, G. M. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science (Washington DC), 276: 1571-1574, 1997.
39. Emoto, Y., Manome, Y., Meinhardt, G., Kisaki, H., Kharbanda, S., Robertson, M., Ghayur, T., Wong, W. W., Kamen, R., Weichselbaum, R., and Kufe, D. Proteolytic activation of protein kinase C δ by an ICE-like protease in apoptotic cells. EMBO J., 14: 6148-6156, 1995.
40. Datta, R., Kojima, H., Yoshida, K., and Kufe, D. Caspase-3-mediated cleavage of protein kinase C θ in induction of apoptosis. J. Biol. Chem., 272: 20317-20320, 1997.
41. Cryns, V. L., Byun, Y., Rana, A., Mellor, H., Lustig, K. D., Ghanem, L., Parker, P. J., Kirschner, M. W., and Yuan, J. Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy. J. Biol. Chem., 272: 29449-29453, 1997.
42. Cheng, E. H-Y., Kirsh, D. G., Clem, R. J., Ravi, R., Kastan, M. B., Bedi, A., Ueno, K., and Hardwick, J. M. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science (Washington DC), 278: 1966-1968, 1997.
43. Thomberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., Miller, D. K., Molineaux, S. M., Weidner, J. R., Aunins, J., et al. A novel heterodimeric cysteine protease is required for interleukin-1β processing in monocytes. Nature (Lond.), 356: 768-774, 1992.
44. Akita, K., Ohtsuki, T., Nukada, Y., Tanimoto, T., Namba, M., Okura, T., Takakura-Yamamoto, R., Torigoe, K., Gu, Y., Su, M. S. S., Fujii, M., Satoh-Itoh, M., Yamamoto, K., Kohno, K., Ikeda, M., and Kurimoto, M. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.I cells. J. Biol. Chem., 272: 26595-26603, 1997.
45. Zhang, Y., Center, D. M., Wu, D. M., Cruikshank, W. W., Yuan, J., Andrews, D. W., and Kornfeld, H. Processing and activation of pro-interleukin-16 by caspase-3. J. Biol. Chem., 273: 1144-1149, 1998.
46. Wilhelm, S., Wagner, H., and Hacker, G. Activation of caspase-3-like enzymes in non-apoptotic T cells. Eur. J. Immunol., 28: 891-900, 1998.
47. Zapata, J. M., Takahashi, R., Salvesen, G. S., and Reed, J. C. Granzyme release and caspase activation in activated human T-lymphocytes. J. Biol. Chem., 273: 6916-6920, 1998.
48. An, B., and Dou, Q. P. Cleavage of retinoblastoma protein during apoptosis: an interleukin 1β-converting enzyme-like protease as candidate. Cancer Res., 56: 438-442, 1996.
49. Ishizaki, Y., Jacobson, M. D., and Raff, M. C. A role for caspases in lens fiber differentiation. J. Cell Biol., 140: 153-158, 1998.