Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype

Rheumatology

Volumn 42, Issue 7, 2003, Pages 870-878

  Pridgeon, C ^a   Lennon, G P ^a   Pazmany, L ^a   Thompson, R N ^a   Christmas, S E ^a   Moots, R J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

CD158; CD94; Killer immunoglobulin like receptors; NK cells; Rheumatoid arthritis; Synovial fluid

Indexed keywords

ANTIGEN; CD158 ANTIGEN; CD56 ANTIGEN; CD94 ANTIGEN; MESSENGER RNA; PERFORIN; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; INTERLEUKIN 2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR; KLRD1 PROTEIN, HUMAN; LECTIN; LEUKOCYTE ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CELL ACTIVITY; CELL COUNT; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; GENE LOCATION; HUMAN; HUMAN CELL; MALE; NATURAL KILLER CELL; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; T LYMPHOCYTE; IMMUNOLOGY; IMMUNOPHENOTYPING; MIDDLE AGED; NONPARAMETRIC TEST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ANTIGENS, CD56; ANTIGENS, CD94; ARTHRITIS, RHEUMATOID; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INTERLEUKIN-2; KILLER CELLS, NATURAL; LECTINS, C-TYPE; MALE; MIDDLE AGED; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS, NONPARAMETRIC; SYNOVIAL FLUID;

EID: 0141615899     PISSN: 14620324     EISSN: None     Source Type: Journal    
DOI: 10.1093/rheumatology/keg240     Document Type: Article

References (42)

1. Fox DA. The role of T cells in the immunopathogenesis of rheumatoid arthritis. Arthritis Rheum 1997;40:598-609.
2. dim, CD27- memory T cells in the peripheral blood, synovial fluid and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 1996; 39:844-54.
3. Matthews N, Emery P, Pilling D, Akbar A, Salmon M. Subpopulations of primed T helper cells in rheumatoid arthritis. Arthritis Rheum 1993;36:603-7.
4. Zhang B, Yamamura T, Kondo T, Fujiwara M, Tabira T. Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J Exp Med 1997; 186:1677-87.
5. + cells in experimental Staphylococcus aureus arthritis. Clin Exp Immunol 1999; 117:63-9.
6. Smeltz RB, Wolf NA, Swanborg RH. Inhibition of autoimmune T cell responses in the DA rat by bone marrow-derived NK cells in vitro: implications for autoimmunity. J Immunol 1999;163:1390-7.
7. Silver RM. Studies of rheumatoid synovial fluid lymphocytes. III. Phenotypic and functional analysis of natural killer-like cells. Clin Immunol Immunopathol 1986; 39:159-67.
8. Dobloug JH, Førre Ø, Kvien TK, Egeland T, Degré M. Natural killer (NK) cell activity of peripheral blood, synovial fluid, and synovial tissue lymphocytes from patients with rheumatoid arthritis and juvenile rheumatoid arthritis. Ann Rheum Dis 1982;41:490-4.
9. Combe B, Pope R, Darnell B, Talal N. Modulation of natural killer cell activity in the rheumatoid joint and peripheral blood. Scand J Immunol 1984;20:551-8.
10. Moretta A, Biassoni R, Bottino C, Mingari MC, Moretta L. Natural cytotoxicity receptors that trigger human NK-cell-mediated cytolysis. Immunol Today 2000; 21:228-34.
11. Pende D, Parolini S, Pessino A et al. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J Exp Med 1999; 190:1505-16.
12. Cantoni C, Bottino C, Vitale M et al. NKp44, a triggering receptor involved in tumour cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J Exp Med 1999;189:787-95.
13. Pessino A, Sivori S, Bottino C et al. Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med 1998;188:953-60.
14. Kärre K. How to recognize a foreign submarine. Immunol Rev 1997;155:5-9.
15. Kärre K, Ljunggren HG, Piontek G, Kiessling R. Selective rejection of H-2 deficient lymphoma variants suggests alternative immune defence strategy. Nature 1986; 319:675-8.
16. Moretta A, Biassoni R, Bottino C et al. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol Rev 1997; 155:105-17.
17. André P, Biassoni R, Colonna M et al. New nomenclature for MHC receptors. Nature Immunol 2001;2:661.
18. Vitale M, Sivori S, Pende D, Moretta L, Moretta A. Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells. Proc Natl Acad Sci USA 1995;92:3536-40.
19. Rajagopallan S, Long EO. A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells. J Exp Med 1999;189:1093-9.
20. Dohring C, Scheidegger D, Samaridis J, Cella M, Colonna M. A human killer inhibitory receptor specific for HLA-A. J Immunol 1996;156:3098-101.
21. Litwin J, Gumperz J, Parham P, Phillips JH, Lanier LL. NKB1: an NK cell receptor involved in the recognition of polymorphic HLA-B molecules. J Exp Med 1994; 180:537-43.
22. Cosman D, Fanger N, Borges L et al. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity 1997;7:273-82.
23. Cosman D, Müllberg J, Sutherland CL et al. ULBPs, novel class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity 2001;14:123-33.
24. Lee N, Llano M, Carretero M et al. HLA-E is a major ligand for the natural killer inhibitory receptor CD94/ NKG2A. Immunology 1998;95:5199-204.
25. Valiante NM, Uhrberg M, Shilling HG et al. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity 1997; 7:739-51.
26. López-Botet M, Bellón T. Natural killer cell activation and inhibition by receptors for MHC class I. Current Opin Immunol 1999;11:301-7.
27. Biassoni R, Cantoni C, Falco M et al. The human leukocyte antigen (HLA)-C-specific 'activator' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J Exp Med 1996;183:645-50.
28. Ferrini S, Cambiaggi A, Meazza R et al. T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol 1994;24:2994-8.
29. Mingari MC, Vitale C, Cambiaggi A et al. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int Immunol 1995;7:697-703.
30. Mingari MC, Moretta A, Moretta L. Regulation of KIR expression in human T cells: a safety mechanism that may impair protective T-cell responses. Immunol Today 1998; 19:153-7.
31. Frohn C, Schlenke P, Kirchner H. The repertoire, of HLA-Cw-specific NK cell receptors CD158a/b (EB6 and GL183) in individuals with different HLA phenotypes. Immunology 1997;92:567-70.
32. Moretta A, Bottino C, Vitale M et al. Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol 1996;14:619-48.
33. Huard B, Karisson L, Triebel F. KIR down-regulation on NK cells is associated with down-regulation of activating receptors and NK cell inactivation. Eur J Immunol 2001;31:1728-35.
34. Mingari MC, Vitale C, Cantoni C et al. Interleukin-15-induced maturation of human natural killer cells from early thymic precursors: selective expression of CD94/ NKG2-A as the only class I-specific inhibitory receptor. Eur J Immunol 1997;27:1374-80.
35. McInnes IB, al-Mughales J, Field M et al. The role of interleukin-15 in T cell migration and activation in rheumatoid arthritis. Nature Med 1996;2:175-82.
36. Dalbeth N, Callan MFC. A subset of natural killer cells is greatly expanded within inflamed joints. Arthritis Rheum 2002;46:1763-72.
37. Caligiuri MA, Zmuidzinas A, Manley TJ, Levine H, Smith KA, Ritz J. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. J Exp Med 1990; 171:1509-26.
38. dim cells. Eur J Immunol 2001;31:3121-6.
39. Fehniger TA, Shah MH, Turner MJ et al. Differential cytokine and chemokine gene expression by NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J Immunol 1999;162:4511-20.
40. Wilson BS, Kent SC, Patton KT et al. Extreme Th1 bias of invariant Vα24JαQ T cells in type I diabetes. Nature 1998;391:177-81.
41. Yanagihara Y, Shiozawa K, Takai M, Kyogoku M, Shiozawa S. Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA). Clin Exp Immunol 1999; 118:131-6.
42. + cells: a naturally occurring population of regulatory T cells. Blood 2001;98:2736-44.