Importance of the P4′ Residue in Human Granzyme B Inhibitors and Substrates Revealed by Scanning Mutagenesis of the Proteinase Inhibitor 9 Reactive Center Loop

Journal of Biological Chemistry

Volumn 276, Issue 18, 2001, Pages 15177-15184

  Sun, Jiuru ^a   Whisstock, James C ^a   Harriott, Patrick ^b   Walker, Brian ^b   Novak, Andrea ^a   Thompson, Philip E ^c   Smith, A Ian ^d   Bird, Phillip I ^a  

^a MONASH UNIVERSITY   (Australia)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c BOX HILL HOSPITAL   (Australia)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; MUTAGENESIS; PROTEINS;

LYMPHOCYTES;

BIOCHEMISTRY;

CASPASE; ENZYME INHIBITOR; GRANZYME B; PROTEINASE INHIBITOR 9; UNCLASSIFIED DRUG; GRANZYME; GZMB PROTEIN, HUMAN; RECOMBINANT PROTEIN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SERPINB9 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; BINDING AFFINITY; ENZYME ACTIVE SITE; ENZYME INHIBITOR INTERACTION; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; MOLECULAR RECOGNITION; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; HUMAN; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

FELIS CATUS;

AMINO ACID SEQUENCE; GRANZYMES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SERINE ENDOPEPTIDASES; SERPINS; SUBSTRATE SPECIFICITY;

EID: 0035805613     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M006645200     Document Type: Article

References (48)

1. Trapani, J. A., and Bird, P. I. (2000) in Cytotoxic Cells: Basic Mechanisms and Medical Applications (Sitkovsky, M. V., and Henkart, P. A., eds) pp. 179-196, Lippincott, Williams & Wilkins, Philadelphia
2. Darmon, A. J., and Bleackley, R. C. (1998) Crit. Rev. Immunol. 18, 255-273
3. Froelich, C. J., Orth, K., Turbov, J., Seth, P., Gottleib, R., Babior, B., Shah, G. M., Bleackley, R. C., Dixit, V. M., and Hanna, W. (1996) J. Biol. Chem. 271, 29073-29079
4. Pinkoski, M. J., Hobman, M., Heibein, J. A., Tomaselli, K., Li, F., Seth, P., Froelich, C. J., and Bleackley, R. C. (1998) Blood 92, 1044-1054
5. Andrade, F., Roy, S., Nicholson, D., Thornberry, N., Rosen, A., and Casciola-Rosen, L. (1998) Immunity 8, 451-460
6. Heussel, J. W., Wesselschmidt, R. L., Shresta, S., Russell, J. H., and Ley, T. J. (1994) Cell 76, 977-987
7. Talanian, R. V., Yang, X., Turbov, J., Seth, P., Ghayur, T., Casiano, C. A., Orth, K., and Froelich, C. J. (1997) J. Exp. Med. 186, 1323-1331
8. Atkinson, E. A., Barry, M., Darmon, A. J., Shostak, I., Turner, P. C., Moyer, R. W., and Bleackley, R. C. (1998) J. Biol. Chem. 273, 21261-21266
9. Medema, J. P., Toes, R. E. M., Scaffidi, C., Zheng, T. S., Flavell, R. A., Melief, J. M., Offringa, R., and Krammer, P. H. (1997) Eur. J. Immunol. 27, 3492-3498
10. Barry, M., Heibein, J. A., Pinkoski, M. J., Lee, S. F., Moyer, R. W., Green, D. R., and Bleackley, R. C. (2000) Mol. Cell. Biol. 20, 3781-3794
11. Casciola-Rosen, L., Andrade, F., Ulanet, D., Bang, Wong, W., and Rosen, A. (1999) J. Exp. Med. 190, 815-825
12. Thornberry, N. A., Rano, T. A., Peterson, E. P., Rasper, D. M., Timkey, T., Garcia-Calvo, M., Houtzager, V. M., Nordstrom, P. A., Roy, S., Vaillancourt, J. P., Chapman, K. T., and Nicholson, D. W. (1997) J. Biol. Chem. 272, 17907-17911
13. Harris, J. L., Peterson, E. P., Hudig, D., Thornberry, N. A., and Craik, C. S. (1998) J. Biol. Chem. 273, 27364-27373
14. Potempa, J., Korzus, E., and Travis, J. (1994) J. Biol. Chem. 269, 15957-15960
15. Whisstock, J., Skinner, R., and Lesk, A. M. (1998) Trends Biochem. Sci. 23, 63-67
16. Bird, C. H., Sutton, V. R., Sun, J., Hirst, C. E., Novak, A., Trapani, J. A., and Bird, P. I. (1998) Mol. Cell. Biol. 18, 6387-6398
17. Sun, J., Bird, C. H., Buzza, M. S., McKee, K. E., Whisstock, J. C., and Bird, P. I. (1999) Biochem. Biophys. Res. Commun. 261, 251-255
18. Deng, W. P., and Nickoloff, J. A. (1992) Anal. Biochem. 200, 81
19. Hopkins, P. C. R., and Stone, S. R. (1995) Biochemistry 3, 15872-15879
20. Salvesen, G., and Nagase, H. (1989) in Proteolytic Enzymes: A Practical Approach (Beynon, R. J., and Bond, J. S., eds) pp. 83-104, IRL Press, Oxford
21. Walker, B. (1994) in Peptide Antigens: A Practical Approach (Wisdom, G. B., ed) pp. 27-81, Oxford University Press, Oxford
22. Knorr, R., Trzecaik, A., Bannwarth, W., and Gillessen, D. (1989) Tetrahedron Lett. 30, 1927-1930
23. Meldal, M., and Breddam, K. (1991) Anal. Biochem. 195, 141-147
24. Bodansky, M., and Kwei, J. Z. (1978) Int. J. Pept. Protein Res. 12, 69-74
25. Waugh, S. M., Harris, J. L., Fletterick, R., and Craik, C. S. (2000) Nat. Struct. Biol. 7, 762-765
26. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
27. Whisstock, J., Lesk, A. M., and Carrell, R. (1996) Proteins 26, 288-303
28. Lesk, A. M. (1986) in Biosequences: Perspectives and User Services in Europe (Saccone, C., ed) pp. 23-28, European Economic Community, Bruxelles
29. McGrath, M. E., Erpel, T., Bystroff, C., and Fletterick, R. J. (1994) EMBO J. 13, 1502-1507
30. Hubbard, S. J., Campbell, S. F., and Thornton, J. M. (1991) J. Mol. Biol. 220, 507-530
31. Sun, J., Bird, C. H., Sutton, V., McDonald, L., Coughlin, P. B., De Jong, T. A., Trapani, J. A., and Bird, P. I. (1996) J. Biol. Chem. 271, 27802-27809
32. Poe, M., Blake, J. T., Boulton, D. A., Gammon, N. H., Sigal, N. H., Wu, J. K., and Zweerink, H. J. (1991) J. Biol. Chem. 266, 98-103
33. Riewald, M., and Schleef, R. R. (1996) J. Biol. Chem. 271, 14526-14532
34. Patston, P. A., Gettins, P. G. W., and Schapira, M. (1994) Semin. Thromb. Hemostasis 20, 410-416
35. Lawrence, D. A., Ginsburg, D., Day, D. E., Berkenpas, M. B., Verhamme, I. M., Kvassman, J.-O., and Shore, J. D. (1995) J. Biol. Chem. 270, 25309-25312
36. Huntington, J. A., Read, R. A., and Carrell, R. W. (2000) Nature 407, 923-926
37. Hood, D. B., Huntington, J. A., and Gettins, P. G. W. (1994) Biochemistry 33, 8538-8547
38. Chaillan-Huntington, C. E., and Patston, P. A. (1998) J. Biol. Chem. 273, 4569-4573
39. Travis, J., and Salvesen, G. S. (1983) Annu. Rev. Biochem. 52, 655-709
40. Stein, P. E., and Carrell, R. W. (1995) Struct. Biol. 2, 96-113
41. Odake, S., Kam, C. M., Narasimhan, L., Poe, M., Blake, J. T., Krahenbuhl, O., Tschopp, J., and Powers, J. C. (1991) Biochemistry 30, 2217-2227
42. Sun, J., Ooms, L., Bird, C. H., Sutton, V. R., Trapani, J. A., and Bird, P. I. (1997) J. Biol. Chem. 272, 15434-15441
43. Quan, L. T., Caputo, A., Bleackley, R. C., Pickup, D. J., and Salvesen, G. S. (1995) J. Biol. Chem. 270, 10377-10379
44. Darmon, A. J., Ley, T. J., Nicholson, D. W., and Bleackley, R. C. (1996) J. Biol. Chem. 271, 21709-21712
45. Kam, C.-M., Hudig, D., and Powers, J. C. (2000) Biochim. Biophys. Acta 1477, 307-323
46. Tucker, H. M., and Gerard, R. D. (1996) Eur. J. Biochem. 237, 180-187
47. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950
48. Stennicke, H. R., and Salvesen, G. S. (1999) Cell Death Differ. 6, 1054-1059