The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol- 4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 2, 2005, Pages 590-600

  Cowen, Michael S ^a   Djouma, Elvan ^b   Lawrence, Andrew J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; ALCOHOL; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; GLUTAMATE RECEPTOR 2; MESSENGER RNA; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN SUBUNIT;

ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN REGION; CINGULATE GYRUS; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG DOSE REDUCTION; DRUG SELF ADMINISTRATION; GENE EXPRESSION; GENETIC CODE; MALE; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; PROTEIN BINDING; PYRIFORM CORTEX; RAT; RAT STRAIN; SEDATION; SMELLING; STATISTICAL SIGNIFICANCE;

ALCOHOL DRINKING; ALCOHOLISM; ANIMALS; AUTORADIOGRAPHY; BIOLOGICAL MARKERS; BRAIN CHEMISTRY; CONDITIONING, OPERANT; DEPRESSION; DRINKING; GLUTAMIC ACID; IN SITU HYBRIDIZATION; MALE; MOTOR ACTIVITY; PYRIDINES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; SMELL; SWIMMING; THIAZOLES;

EID: 27144492737     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.090449     Document Type: Article

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