mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia

Neuropharmacology

Volumn 40, Issue 1, 2001, Pages 10-19

  Walker, K ^a,b   Reeve, A ^a,b   Bowes, M ^a,b   Winter, J ^a,b   Wotherspoon, G ^a,b   Davis, A ^a,b   Schmid, P ^a   Gasparini, F ^a   Kuhn, R ^a   Urban, L ^a,b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Novatis Inst for Medical Sciences   (United Kingdom)

Author keywords

Inflammation; Ionotropic glutamate receptor; Metabotropic glutamate receptor; MPEP; Pain

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2 CHLORO 5 HYDROXYPHENYLGLYCINE; 2 METHYL 6 (PHENYLETHYNYL) PYRIDINE; 3,5 DIHYDROPHENYLGLYCINE; 4 CARBOXYPHENYLGLYCINE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; EGLUMETAD; GLUTAMATE 5 RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; L AP4; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; TUBULIN; UNCLASSIFIED DRUG; VANILLOID RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ELECTROPHYSIOLOGY; GENE EXPRESSION; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; SENSORY NERVE CELL; SPINAL CORD DORSAL HORN; SPINAL GANGLION;

EID: 0033763535     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00114-3     Document Type: Article

References (45)

1. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems
2. Activation of N-methyl-D-aspartate receptors reverses desensitisation of metabotropic glutamate receptor mGluR5, in native and recombinant systems
3. Involvement of capsaicin-sensitive neurones in hyperalgesia and enhanced opioid antinociception in inflammation
4. Distribution and developmental changes in metabotropic glutamate receptor messenger RNA expression in the rat lumbar spinal cord
5. Pharmacology of metabotropic glutamate receptor-mediated enhancement of responses to excitatory and inhibitory amino acids on rat spinal neurones in vivo
6. Enhanced expression of metabotropic glutamate receptor 3 messenger RNA in the rat spinal cord during ultraviolet irradiation induced peripheral inflammation
7. MGluR activation reveals a tonic NMDA component in inflammatory hyperalgesia
8. Phenylglycine derivatives discriminate between mGluR1 and mGluR5-mediated responses
9. Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin
10. Pharmacology and functions of metabotropic glutamate receptors
11. Mobilization of intracellular Ca2+ by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones
12. Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test
13. Sciatic nerve stimulation releases glutamate in the rat hindpaw
14. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of deep rat dorsal horn nociceptive neurones following C fibre stimulation
15. Development of inflammation after application of mustard oil or glutamate to the rat temporomandibular joint
16. The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception
17. Comparison of nociceptive effects produced by intrathecal administration of mGluR agonists
18. Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats
19. 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) a potent selective and systemically active mGlu5 receptor antagonist
20. Intrathecal morphine in mice: A new technique
21. Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats
22. Metabotropic glutamate receptors in superficial laminae of the rat dorsal horn
23. Pharmacological analysis of 4-carboxyphenylglycine derivatives: Comparison of effects on mGluR1a and mGluR5α subtypes
24. Excitatory amino acid receptor involvement in peripheral nociceptive transmission in rats
25. Metabotropic glutamate receptors novel targets for drug development
26. Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): A potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties
27. Role of metabotropic glutamate receptor subtype mGluR1 in brief nociception and central sensitization of primate STT cells
28. Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw
29. The enhancement of morphine antinociception by a CCKB receptor antagonist in the rat depends on the phase of inflammation and the intensity of carrageenin-induced hyperalgesia
30. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain
31. Mediation of thalamic sensory input by both NMDA receptors and non-NMDA receptors
32. Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor-1-selective antagonists 2-methyl-4-carboxy-phenylglycine
33. Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus
34. Pharmacological agents acting at subtypes of metabotropic glutamate receptors
35. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
36. Inflammation alters the effects of mGlu receptor agonists on spinal nociceptive neurones
37. Unilateral inflammation of the hindpaw in rats as a model of prolonged noxious stimulation: Alterations in behavior and nociceptive thresholds
38. The cloned capsaicin receptor integrates multiple pain producing stimuli
39. mGluR5 metabotropic glutamate receptor distribution in rat and human spinal cord: A developmental study
40. Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
41. Development of hyperthermia following intracerebroventricular administration of endotoxin in the rat: Effect of kinin B1 and B2 receptor antagonists
42. Antisense ablation of type I metabotropic glutamate receptor mGluR(1) inhibits spinal nociceptive transmission
43. Behavioural and electrophysiological evidence supporting a role for group I metabotropic glutamate receptors in the mediation of nociceptive inputs to the rat spinal cord
44. Intrathecal metabotropic glutamate receptor antagonists do not decrease mechanical hyperalgesia in a rat model of postoperative pain
45. Peripheral administration of NMDA, AMPA or KA results in pain behaviors in rats